Expression of MUC1 and MUC2 mucins in gastric carcinomas: Their relationship with clinicopathologic parameters and prognosis

Pathology Research and Practice

Volumn 198, Issue 10, 2002, Pages 665-674

  Akyürek, Nalan ^a   Akyol, Gülen ^a   Dursun, Ayşe ^a   Yamaç, Deniz ^a   Günel, Nazan ^a  

^a GAZI UNIVERSITY FACULTY OF MEDICINE   (Turkey)

Author keywords

Gastric carcinoma; Immunohistochemistry; MUC1; MUC2; Prognosis

Indexed keywords

MUCIN 1; MUCIN 2; CA 15-3 ANTIGEN; MUC 2 PROTEIN; MUCIN; TUMOR MARKER;

ADENOCARCINOMA; ADULT; AGED; CANCER CLASSIFICATION; CANCER INVASION; CANCER STAGING; CANCER SURVIVAL; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FOLLOW UP; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTESTINE CARCINOMA; MAJOR CLINICAL STUDY; MALE; MUCINOUS CARCINOMA; PREDICTION; PROGNOSIS; PROTEIN EXPRESSION; REVIEW; SIGNET RING CARCINOMA; STATISTICAL ANALYSIS; STOMACH CARCINOMA; SURVIVAL TIME; TUMOR DIFFERENTIATION; ARTICLE; ENZYME IMMUNOASSAY; LYMPH NODE; LYMPH NODE METASTASIS; METABOLISM; METASTASIS; MIDDLE AGED; MORTALITY; PATHOLOGY; STOMACH TUMOR; SURVIVAL; SURVIVAL RATE;

ADENOCARCINOMA; ADULT; AGED; CA-15-3 ANTIGEN; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MUCINS; NEOPLASM STAGING; PROGNOSIS; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 1842854502     PISSN: 03440338     EISSN: None     Source Type: Journal    
DOI: 10.1078/0344-0338-00318     Document Type: Article

References (50)

1. Agrawal B, Krants MJ, Reddish M, Longenecked BM (1998) Cancer-associated MUC 1 mucin inhibits human T-cell proliferation which is reversible by IL-2. Nat Mod 4: 43-49
2. Baldus SE, Zirbes TK, Engel S, Hanisch FG, Moning SP, Lorenzen J, Glossman J, Fromm S, Thiele J, Pichmaier H, Dienes HP (1998) Corrrelation of the immunohistochemical reactivity of mucin cores MUC1 and MUC2 with histopathological subtype and prognosis of gastric carcinomas. Int J Cancer 79: 133-138
3. Bobek LA, Tsai H, Biesbrock AR, Levine MJ (1993) Molecular cloning, sequence, and specificity of expression of the gene encoding the lower molecular weight human salivary mucin (MUC7). J Biol Chem 268: 20563-20569
4. Borrmann R (1926) Geschwülste des Magens und Duedenums: Handbuch der Speziellen Pathologischen Anatomie und Histologie. Henke F, Lubarsch (Eds) pp 4-865. Springer, Berlin.
5. Bresalier RS, Niv Y, Byrd JC, Duh QY, Toribara NW, Dahiya R, Kim YS (1991) Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of human colon cancer metastasis. J Clin Invest 87: 1037-1045
6. Carrato C, Balagué C, DeBolos C, Gonzalez E, Gambus G, Planas J, Perini JM, Andreu D, Real FX (1994) Differential apomucin expression in normal and neoplastic human gastrointestinal tissues. Gastroenterology 107: 160-172
7. Carraway KL, Freigen N (1995) Mucin structure and function: insights from molecular biology. Trends in Glycoscience and Glycotechnology 33: 31-44
8. Correa P (1988) A human model of gastric carcinogenesis. Cancer Res 48: 3554-3560
9. DeBolos C, Garrido M, Real FX (1995) MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach. Gastroenterology 109: 723-734
10. Duffose J, Porchet N, Audie JP, Guyonnet-Duperat V, Laine A, Van Seuningen I, Marrakchi S, Aubert JP (1993) Degenerate 87-base-pair tandem repeats create hydrophilic/ hydrophobic alternating domains in human mucin peptides mapped to 11p15. Biochem J 293: 329-337
11. Fenoglio-Preiser C, Carneiro F, Correa P, Guilford P, Lambert R, Megraud F, Munoz N, Powell SM, Rugge M, Sasako M, Stolte M, Watanabe H (2000) WHO histological classification of gastric tumours. In: Hamilton SR, Aaltonen LA (Eds) World Health Organization Classification of Tumors. Pathology and Genetics of Tumors of the Digestive System, pp 38. IARC press, Lyon
12. Filipe MI, Linehan JM, Durrant LG, Price MR, Smeeton NC, Pathak S, Swallow DM (1996) Expression of a peptide epitope of the colonic mucin MUC2 in precursor lesions to gastric carcinoma. Eur J Cancer Prev 5: 287-295
13. Gendler SJ, Spicer AP (1995) Epithelial mucin genes. Annu Rev Physiol 57: 607-634
14. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig J, Peat T, Burchell J, Pemberton L, Lalani EN, Wilson D (1990) Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J Biol Chem 265: 15286-15293
15. Gum JR, Hicks JW, Swallow DM, Laglace RL, Byrd JC, Lamport DTA, Siddiki B, Kim YS (1990) Molecular cloning of cDNAs derived from a novel human intestinal mucin gene. Biochem Biophys Res Commun 171: 407-415
16. Gum JR, Byrd JC, Hicks JW, Toribara NW, Lamport DTA, Kim YS (1989) Molecular cloning of human intestinal mucin cDNAs. J Biol Chem 264: 6480-6487
17. Guyonnet-Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galigeue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (1995) Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes? Biochem J 305: 211-219
18. Ho SB, Shekels LL, Toribara NW, Kim YS, Lyftogt C, Cherwitz DL, Niehans GA (1995) Mucin gene expression in normal, pre-neoplastic, and neoplastic human gastric epithelium. Cancer Res 55: 2681-2690
19. Ho SB, Niehans GA, Lyftogt C, Yan PS, Cherwitz DL, Gum ET, Dahiya R, Kim YS (1993) Heterogeneity of mucin expression in normal and neoplastic tissues. Cancer Res 53: 641-651
20. Kondo K, Kohno N, Yokoyama A, Hiwada K (1998) Decreased MUC1 expression induces E-cadherin-mediated cell adhesion of breast cancer cell lines. Cancer Res 58: 2014-2019
21. Lan MS, Batra SK, Qi WN, Metzgar RS, Hollingsworth MA (1990) Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem 265: 15294-15299
22. Lapensee L, Paquette Y, Bleau G (1997) Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Fertil Steril 68: 702-708
23. Lauren P (1965) The two histological main types of gastric carcinoma. Acta Pathol Microbiol Scand 64: 31-49
24. Lee HS, Lee HK, Kim HS, Yang HK, Kim YI, Kim WH (2001) MUC1, MUC2, MUC5AC, and MUC6 expressions in gastric carcinomas. Cancer 92: 1427-1434
25. Lightenberg MJ, Kruijshaar L, Buijs F, Van Meijer M, Litvinov SV, Hilkens J (1992) Cell-associated episialin is a complex containing two proteins derived from a common precursor. J Biol Chem 267: 6171-6177
26. Lightenberg MJ, Buijs F, vos HL, Hilkens J (1992) Suppression of cellular aggregation by high level of episialin. Cancer Res 52: 2318-2324
27. Lightenberg MJ, Vos HL, Gennisen AM, Hilkens J (1990) Episialin, a carcinoma associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J Biol Chem 265: 5573-5578
28. Machado JC, Noguereia AMMF, Carnerio F, Reis CA, Sobrinho-Simoes M (2000) Gastric carcinoma exhibits distinct types of cell differerantiation: An immunohistochemical study of trefoil peptides (TFF 1 and TFF 2) and mucins (MUC1, MUC2, MUC5AC and MUC6). J Pathol 190: 437-443
29. Makiguchi Y, Hinoda Y, Imai K (1996) Effect of MUC1 mucin, and anti-adhesion molecule, on tumor cell growth. Jpn J Cancer 87: 505-511
30. Mannori G, Crottet P, Cecconi, O, Hanasaki K, Aruffo A, Nelson RM, Varki A, Bevilacqua MP (1995) Differential colon cancer cell adhesion to E-, P-, and L- selectin: role of mucin type glycoproteins. Cancer Res 55: 4425-4431
31. Mitsuuchi M, Hinoda Y, Itoh F, Endo T, Satoh M, Xing PX, Imai K (1999) Expression of MUC2 gene in gastric regenerative, metaplastic, and neoplastic epithelia. J Clin Lab Anal 13: 259-265
32. Porchet N, Van-Cong N, Duffosse J, Audie JP, Guyonnet-Duperat V, Gross MS, Denis C, Degand P, Bernheim A, Aubert JP ( 1991) Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs. Biochem Biophys Res Commun 175: 414-422
33. Regimbald LH, Pilarski LM, Longenecker BM, Reddish MA, Zimmermann G, Hugh JC (1996) The breast mucin MUC1 as a novel adhesion ligand for endothelial intercellular adhesion molecule 1 in breast cancer. Cancer Res 56: 4244-4249
34. Reis CA, David L, Carvalho F, Mandel U, Bolos C, Mirgorodskaya E, Clausen H, Sobrinho-Simoes M (2000) Immunohistochemical study of the expression of MUC6 mucin and co-expression of the other secreted mucins (MUC5AC and MUC2) in human gastric carcinomas. J Histochem Cytochem 48: 377-388
35. Reis CA, David L, Correa P, Carneiro F, DeBolos C, Garcia E, Mandel U, Clausen H, Sobrinho-Simoes M (1999) Intestinal metaplasia of the human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, MUC6) expression. Cancer Res 59: 1003-1007
36. Reis CA, David L, Seixas M, Burchell J, Sobrinho Simoes M (1998) Expression of fully and under-glycosylated forms of MUC1 Mucin in gastric carcinoma. Int J Cancer 79: 402-410
37. Reis CA, David L, Nielsen PA, Clausen H, Mirgorodskaya K, Roepstorff P, Sobrinho-Simoes M ( 1997) Immunohistochemical study of MUC5AC expression in human gastric carcinomas using a novel monoclonal antibody. Int J Cancer 74: 112-121
38. Sakamoto H, Yonezawa S, Utsonomiya T, Tanaka S, Kim YS, Sato E (1997) Mucin antigen expression in gastric carcinomas of young and old adults. Hum Pathol 28: 1056-1065
39. Shankar V, Gilmore MS, Elkins RC, Sachdev GP (1994) A novel human airway mucin cDNA encodes a protein with unique tandem-repeat organization. Biochem J 300: 295-298
40. Sobin LH, Wittekind C (1997) TNM classification of malignant tumors. 5th ed. pp 59-62. Wiley-Liss, New York
41. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR, Byrd JC, Siddiki B (1993) Human gastric mucin. Identification of a unique species by expression cloning. J Biol Chem 268: 5879-5885
42. Toribara NW, Gum JR, Culhane PJ, Lagace RE, Hicks JW, Petersen GM, Kim YS (1991) MUC-2 human small intestinal mucin gene structure: Repeated arrays and polymorphism. J Clin Invest 88: 1005-1013
43. Utsunomiya T, Yonezawa S, Sakamoto H, Kitamura H, Hokita S, Aiko T, Tanaka S, Irimura T, Kim YS, Sato E (1998) Expression of MUC1 and MUC2 mucins in gastric carcinomas: its relationship with the prognosis of the patients. Clin Cancer Res 4: 2605-2614
44. Wesseling J, Van Der Valk SW, Hilkens JA (1996) A mechanism for inhibition of E-Cadherin-mediated cell-cell adhesion by the membrane-associated mucin episialin/MUC1. Mol Biol Cell 7: 565-577
45. Wesseling J, Van der Valk SW, Vos HL, Sonnenberg A, Hilkens J (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix componenets. J Cell Biol 129: 255-265
46. Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM (1999) Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res 59: 4083-4089
47. Yamachika T, Inada K, Fujimitsu Y, Nakamura S, Yamamura Y, Kitou T, Itzkowitz SH, Werther JL, Miki K, Tatematsu M (1997) Intestinalization of gastric signet ring cell carcinomas with progression. Virchows Arch 431: 103-110
48. Yin BW, Lloyd KO (2001) Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin (MUC16). J Biol Chem 276: 27371-27375
49. Yonezawa S, Sato E (1997) Expression of mucin antigens in human cancers and its relationship with their malign potential. Pathol Int 47: 813-830
50. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11/12: 55-101