MCAM-expressing CD4 + T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases

Journal of Autoimmunity

Volumn 37, Issue 4, 2011, Pages 319-327

  Dagur, Pradeep K ^a   Biancotto, Angélique ^a,b   Wei, Lai ^b,c   Nida Sen, H ^c   Yao, Michael ^b   Strober, Warren ^b   Nussenblatt, Robert B ^b,c   Philip McCoy, J ^a,b  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c NATIONAL EYE INSTITUTE   (United States)

Author keywords

CD146 MCAM; Inflammation; Th17

Indexed keywords

CD146 ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; T LYMPHOCYTE RECEPTOR;

ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; BEHCET DISEASE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; PRIORITY JOURNAL; SARCOIDOSIS; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD146; AUTOIMMUNE DISEASES; CD4-POSITIVE T-LYMPHOCYTES; CELL ADHESION; CELL DIFFERENTIATION; CELL MOVEMENT; CYTOKINES; DISEASE PROGRESSION; HUMANS; INFLAMMATION; INTERLEUKIN-17; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTE SUBSETS; TH17 CELLS; UP-REGULATION;

EID: 82955227518     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.09.003     Document Type: Article

References (38)

1. Mosmann T.R., Cherwinski H., Bond M.W., Giedlin M.A., Coffman R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986, 136:2348-2357.
2. Killar L., MacDonald G., West J., Woods A., Bottomly K. Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells. J Immunol 1987, 138:1674-1679.
3. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
4. Bendelac A., Killeen N., Littman D.R., Schwartz R.H. A subset of CD4+ thymocytes selected by MHC class I molecules. Science 1994, 263:1774-1778.
5. Weiner H.L. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev 2001, 182:207-214.
6. Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 1994, 265:1237-1240.
7. Groux H., O'Garra A., Bigler M., Rouleau M., Antonenko S., de Vries J.E., et al. A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 1997, 389:737-742.
8. Veldhoen M., Uyttenhove C., van Snick J., Helmby H., Westendorf A., Buer J., et al. Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset. Nat Immunol 2008, 9:1341-1346.
9. Zaretsky A.G., Taylor J.J., King I.L., Marshall F.A., Mohrs M., Pearce E.J. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J Exp Med 2009, 206:991-999.
10. Eyerich S., Eyerich K., Pennino D., Carbone T., Nasorri F., Pallotta S., et al. Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodeling. J Clin Invest 2009, 119:3573-3585.
11. Annunziato F., Cosmi L., Santarlasci V., Maggi L., Liotta F., Mazzinghi B., et al. Phenotypic and functional features of human Th17 cells. J Exp Med 2007, 204:1849-1861.
12. Zhang F., Meng G., Strober W. Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol 2008, 9:1297-1306.
13. Veldhoen M., Hirota K., Westendorf A.M., Buer J., Dumoutier L., Renauld J.C., et al. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 2008, 453:106-109.
14. Amadi-Obi A., Yu C.R., Liu X., Mahdi R.M., Clarke G.L., Nussenblatt R.B., et al. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat Med 2007, 13:711-718.
15. Brucklacher-Waldert V., Stuerner K., Kolster M., Wolthausen J., Tolosa E. Phenotypical and functional characterization of T helper 17 cells in multiple sclerosis. Brain 2009, 132:3329-3341.
16. Kebir H., Kreymborg K., Ifergan I., Dodelet-Devillers A., Cayrol R., Bernard M., et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med 2007, 13:1173-1175.
17. Kleinschek M.A., Boniface K., Sadekova S., Grein J., Murphy E.E., Turner S.P., et al. Circulating and gut-resident human Th17 cells express CD161 and promote intestinal inflammation. J Exp Med 2009, 206:525-534.
18. Bardin N., Anfosso F., Masse J.M., Cramer E., Sabatier F., Le Bivic A., et al. Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 2001, 98:3677-3684.
19. Elshal M.F., Khan S.S., Takahashi Y., Solomon M.A., McCoy J.P. CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood 2005, 106:2923-2924.
20. Elshal M.F., Khan S.S., Raghavachari N., Takahashi Y., Barb J., Bailey J.J., et al. A unique population of effector memory lymphocytes identified by CD146 having a distinct immunophenotypic and genomic profile. BMC Immunol 2007, 8:29.
21. Dagur P.K., Tatlici G., Gourley M., Samsel L., Raghavachari N., Liu P., et al. CD146 + T lymphocytes are increased in both the peripheral circulation and in the synovial effusions of patients with various musculoskeletal diseases and display pro-inflammatory gene profiles. Cytom B Clin Cytom 2010, 78:88-95.
22. Veldhoen M., Hirota K., Christensen J., O'Garra A., Stockinger B. Natural agonists for aryl hydrocarbon receptor in culture medium are essential for optimal differentiation of Th17 T cells. J Exp Med 2009, 206:43-49.
23. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108.
24. Yoshida E.M. The Crohn's disease activity index, its derivatives and the Inflammatory Bowel Disease Questionnaire: a review of instruments to assess Crohn's disease. Can J Gastroenterol 1999, 13:65-73.
25. Cosmi L., De Palma R., Santarlasci V., Maggi L., Capone M., Frosali F., et al. Human interleukin 17-producing cells originate from a CD161 + CD4 + T cell precursor. J Exp Med 2008, 205:1903-1916.
26. Acosta-Rodriguez E.V., Rivino L., Geginat J., Jarrossay D., Gattorno M., Lanzavecchia A., et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nature Immunol 2007, 8:639-646.
27. Cosmi L., Maggi L., Santarlasci V., Capone M., Cardilicchia E., Frosali F., et al. Identification of a novel subset of human circulating memory CD4(+) T cells that produce both IL-17A and IL-4. J Allergy Clin Immunol 2010, 125:222-230. e1-4.
28. Tormin A., Li O., Brune J.C., Walsh S., Schutz B., Ehinger M., et al. CD146 expression on primary non-hematopoietic bone marrow stem cells correlates to in situ localization. Blood 2011.
29. Guezguez B., Vigneron P., Lamerant N., Kieda C., Jaffredo T., Dunon D. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol 2007, 179:6673-6685.
30. Huppert J., Closhen D., Croxford A., White R., Kulig P., Pietrowski E., et al. Cellular mechanisms of IL-17-induced blood-brain barrier disruption. FASEB J 2010, 24:1023-1034.
31. Takagi R., Higashi T., Hashimoto K., Nakano K., Mizuno Y., Okazaki Y., et al. B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones. J Immunol 2008, 181:186-189.
32. Kim C.H. Migration and function of Th17 cells. Inflamm Allergy Drug Targets 2009, 8:221-228.
33. Mitsdoerffer M., Lee Y., Jager A., Kim H.J., Korn T., Kolls J.K., et al. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci USA 2010, 107:14292-14297.
34. Li A., Dubey S., Varney M.L., Dave B.J., Singh R.K. IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis. J Immunol 2003, 170:3369-3376.
35. Watson C., Whittaker S., Smith N., Vora A.J., Dumonde D.C., Brown K.A. IL-6 acts on endothelial cells to preferentially increase their adherence for lymphocytes. Clin Exp Immunol 1996, 105:112-119.
36. Yin H., Vistica B.P., Chan C.C., Strominger J.L., Gery I. Inhibition of experimental autoimmune uveitis by amino acid copolymers. J Neuroimmunol 2009, 215:43-48.
37. Despoix N., Walzer T., Jouve N., Blot-Chabaud M., Bardin N., Paul P., et al. Mouse CD146/MCAM is a marker of natural killer cell maturation. Eur J Immunol 2008, 38:2855-2864.
38. Taflin C., Favier B., Baudhuin J., Savenay A., Hemon P., Bensussan A., et al. Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditions. Proc Natl Acad Sci USA 2011, 108:2891-2896.