Inhibition of experimental autoimmune uveitis by amino acid copolymers

Journal of Neuroimmunology

Volumn 215, Issue 1-2, 2009, Pages 43-48

  Yin, Hongen ^a   Vistica, Barbara P ^a   Chan, Chi Chao ^a   Strominger, Jack L ^b   Gery, Igal ^a  

^a NATIONAL EYE INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

Autoimmunity; Copolymers; Cytokines; EAU; Glatiramer acetate

Indexed keywords

(PHENYLALANINE TYROSINE ALANINE LYSINE)COPOLYMER; CO 14; COPOLYMER; CYTOKINE; GLATIRAMER; PI 2301; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNOMODULATION; LOW DRUG DOSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; TH2 CELL; UVEITIS;

AMINO ACIDS; ANIMALS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MICE; NERVOUS SYSTEM AUTOIMMUNE DISEASE, EXPERIMENTAL; PEPTIDES; POLYMERS; UVEITIS;

EID: 70349739585     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2009.08.002     Document Type: Article

References (30)

1. Adamus G., and Chan C.C. Experimental autoimmune uveitides: multiple antigens, diverse diseases. Int. Rev. Immunol. 21 (2002) 209-229
2. Aharoni R., Teitelbaum D., Leitner O., Meshorer A., Sela M., and Arnon R. Specific Th2 cells accumulate in the central nervous system of mice protected against experimental autoimmune encephalomyelitis by copolymer 1. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 11472-11477
3. Arnon R., and Aharoni R. Mechanism of action of glatiramer acetate in multiple sclerosis and its potential for the development of new applications. Proc. Natl. Acad. Sci. U. S. A. 101 Suppl 2 (2004) 14593-14598
4. Bettelli E., Oukka M., and Kuchroo V.K. T(H)-17 cells in the circle of immunity and autoimmunity. Nat. Immunol. 8 (2007) 345-350
5. Caspi R.R. Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis. Int. Rev. Immunol. 21 (2002) 197-208
6. de Vos A.F., Fukushima A., Lobanoff M.C., Vistica B.P., Lai J.C., Grivel J.C., Wawrousek E.F., Whitcup S.M., and Gery I. Breakdown of tolerance to a neo-self antigen in double transgenic mice in which B cells present the antigen. J. Immunol. 164 (2000) 4594-4600
7. Dhib-Jalbut S., Chen M., Said A., Zhan M., Johnson K.P., and Martin R. Glatiramer acetate-reactive peripheral blood mononuclear cells respond to multiple myelin antigens with a Th2-biased phenotype. J. Neuroimmunol. 140 (2003) 163-171
8. Duda P.W., Schmied M.C., Cook S.L., Krieger J.I., and Hafler D.A. Glatiramer acetate (Copaxone) induces degenerate, Th2-polarized immune responses in patients with multiple sclerosis. J. Clin. Invest. 105 (2000) 967-976
9. Farina C., Weber M.S., Meinl E., Wekerle H., and Hohlfeld R. Glatiramer acetate in multiple sclerosis: update on potential mechanisms of action. Lancet. Neurol. 4 (2005) 567-575
10. Forrester J.V., Liversidge J., Dua H.S., Towler H., and McMenamin P.G. Comparison of clinical and experimental uveitis. Curr. Eye Res. 9 (1990) 75-84 Suppl
11. Foxman E.F., Zhang M., Hurst S.D., Muchamuel T., Shen D., Wawrousek E.F., Chan C.C., and Gery I. Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. J. Immunol. 168 (2002) 2483-2492
12. Fridkis-Hareli M., and Strominger J.L. Promiscuous binding of synthetic copolymer 1 to purified HLA-DR molecules. J. Immunol. 160 (1998) 4386-4397
13. Fridkis-Hareli M., Teitelbaum D., Gurevich E., Pecht I., Brautbar C., Kwon O.J., Brenner T., Arnon R., and Sela M. Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells - specificity and promiscuity. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 4872-4876
14. Fridkis-Hareli M., Neveu J.M., Robinson R.A., Lane W.S., Gauthier L., Wucherpfennig K.W., Sela M., and Strominger J.L. Binding motifs of copolymer 1 to multiple sclerosis- and rheumatoid arthritis-associated HLA-DR molecules. J. Immunol. 162 (1999) 4697-4704
15. Fridkis-Hareli M., Santambrogio L., Stern J.N., Fugger L., Brosnan C., and Strominger J.L. Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis. J. Clin. Invest. 109 (2002) 1635-1643
16. Gery I., Nussenblatt R.B., Chan C.C., and Caspi R.R. Autoimmune disease of the eye. In: Theofilopoulos A.N., and Bona C.A. (Eds). The molecular pathology of autoimmune diseases (2002), Taylor & Francis, New York, NY 978-998
17. Hong J., Li N., Zhang X., Zheng B., and Zhang J.Z. Induction of CD4 + CD25+ regulatory T cells by copolymer-I through activation of transcription factor Foxp3. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6449-6454
18. Hussien Y., Sanna A., Soderstrom M., Link H., and Huang Y.M. Glatiramer acetate and IFN-beta act on dendritic cells in multiple sclerosis. J. Neuroimmunol. 121 (2001) 102-110
19. Illes Z., Stern J.N., Reddy J., Waldner H., Mycko M.P., Brosnan C.F., Ellmerich S., Altmann D.M., Santambrogio L., Strominger J.L., and Kuchroo V.K. Modified amino acid copolymers suppress myelin basic protein 85-99-induced encephalomyelitis in humanized mice through different effects on T cells. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 11749-11754
20. Kim H.J., Ifergan I., Antel J.P., Seguin R., Duddy M., Lapierre Y., Jalili F., and Bar-Or A. Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J. Immunol. 172 (2004) 7144-7153
21. Neuhaus O., Farina C., Yassouridis A., Wiendl H., Then Bergh F., Dose T., Wekerle H., and Hohlfeld R. Multiple sclerosis: comparison of copolymer-1-reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells. Proc. Natl. Acad. Sci. U. S. A. 97 (2000) 7452-7457
22. Pepperberg D.R., Okajima T.L., Ripps H., Chader G.J., and Wiggert B. Functional properties of interphotoreceptor retinoid-binding protein. Photochem. Photobiol. 54 (1991) 1057-1060
23. Silver P.B., Chan C.C., Wiggert B., and Caspi R.R. The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest. Ophthalmol. Vis. Sci. 40 (1999) 2898-2905
24. Steinman L. A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage. Nat. Med. 13 (2007) 139-145
25. Stern J.N., Illes Z., Reddy J., Keskin D.B., Sheu E., Fridkis-Hareli M., Nishimura H., Brosnan C.F., Santambrogio L., Kuchroo V.K., and Strominger J.L. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 11743-11748
26. Stern J.N., Keskin D.B., Zhang H., Lv H., Kato Z., and Strominger J.L. Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 5172-5176
27. Takase H., Yu C.R., Liu X., Fujimoto C., Gery I., and Egwuagu C.E. Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins. J. Neuroimmunol. 168 (2005) 118-127
28. Vieira P.L., Heystek H.C., Wormmeester J., Wierenga E.A., and Kapsenberg M.L. Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. J. Immunol. 170 (2003) 4483-4488
29. Weber M.S., Prod'homme T., Youssef S., Dunn S.E., Rundle C.D., Lee L., Patarroyo J.C., Stuve O., Sobel R.A., Steinman L., and Zamvil S.S. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 13 (2007) 935-943
30. Zhang M., Chan C.C., Vistica B., Hung V., Wiggert B., and Gery I. Copolymer 1 inhibits experimental autoimmune uveoretinitis. J. Neuroimmunol. 103 (2000) 189-194