CD146+ T lymphocytes are increased in both the peripheral circulation and in the synovial effusions of patients with various musculoskeletal diseases and display pro-inflammatory gene profiles

Cytometry Part B - Clinical Cytometry

Volumn 78, Issue 2, 2010, Pages 88-95

  Dagur, Pradeep Kumar ^a   Tatlici, Gulnaz ^a   Gourley, Mark ^b   Samsel, Leigh ^a   Raghavachari, Nalini ^a   Liu, Poching ^a   Liu, Delong ^c   McCoy Jr , J Philip ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Arthritis; CD146; Synovial effusion; T cells

Indexed keywords

CD146 ANTIGEN; CD2 ANTIGEN; CD3 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; CXCL13 CHEMOKINE; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; GLYCOPROTEIN GP 130; GRANZYME; GRANZYME B; GRANZYME H; GRANZYME K; INTERLEUKIN 6 RECEPTOR; LEUKOCYTE ASSOCIATED IMMUNOGLOBULIN LIKE RECEPTOR 2; LYMPHOCYTE ANTIGEN; MESSENGER RNA; PERFORIN; RANTES; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 4; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CD146+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMAN; IMMUNOPHENOTYPING; JOINT EFFUSION; MALE; MUSCULOSKELETAL DISEASE; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION;

ANTIGENS, CD146; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HUMANS; INFLAMMATION; MUSCULOSKELETAL DISEASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SYNOVIAL FLUID; T-LYMPHOCYTES;

EID: 77749301926     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.20502     Document Type: Article

References (27)

1. Shih IE. The role of CD146 (MelCAM) in biology and pathology. J Pathol 1999;189:4-11.
2. Bardin N, Anfosso F, Masse JM, Cramer E, Sabatier F, Le Bivic A, Sampol J. Dignat-George F. Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion. Blood 2001;98:3677-3684.
3. Pickl WF, Fischer GF, Petzelbauer P, Fae I, Waclavicek M. Stockl J, Scheinecker C, Vidicki T, Aschauer H, Johnson JP, Knapp W. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol 1997;158:2107-2115.
4. Elshal MF, Khan SS, Takahashi Y, Solomon MA, McCoy JP. CD146 (Mel-CAM), an adhesion marker of endothelial cells, is a novel marker of lymphocyte subset activation in normal peripheral blood. Blood 2005;106:2923-2924.
5. Elshal MF, Khan SS, Raghavachari N, Takahashi Y, Barb J, Bailey JJ, Munson PJ, Solomon MA, Danner RL McCoy JP. A Unique Population of Effector Memory Lymphocytes Identified by CD146 having a distinct immunophenotypic and genomic profile. BMC Immunol 2007;8:29.
6. Guezguez B, Vigneron P, Lamerant N, Kieda C, Jaffredo T, Dunon D. Dual role of melanoma cell adhesion molecule (MCAM)/CD146 in lymphocyte endothelium interaction: MCAM/CD146 promotes rolling via microvilli induction in lymphocyte and is an endothelial adhesion receptor. J Immunol 2007;179:6673-6685.
7. Buckley CD. Why do leukocytes accumulate within chronically inflamed joints? Rheumatology 2003;42:1433-1444.
8. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003;423:356-361.
9. Neidhart M, Wehrli R, Bruhlmann P, Michel BA, Gay RE, Gay S. Synovial fluid CD146 (MUC18, a marker for synovial membrane angiogenesis in rheumatoid arthritis. Arthritis Rheum 1999;42:622-630.
10. Middleton J, Americh L, Gayon R, Julien D, Mansat M, Mansat P, Anract P, Cantagrel A, Cattan P, Reimund JM, Aguilar L, Amalric F, Girard JP. A comaprative study of endothelial cell markers expressed in chronically inflamed human tissues: MECA-79, duffy antigen receptor for chemokines, von Willebrand factor, CD31, CD34, CD105, and CD146. J Pathology 2005;206:260-268.
11. Gattorno M, Prigione I, Morandi F, Gregorio A, Chiesa S, Ferlito F, Favre A, Uccelli A, Gambini C, Martini A, Pistoia V. Phenotypic and functional characterization of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis. Arthritis Res Ther 2005;7:R256-R267.
12. Liu MF, Wang CR, Fung LL, Lin LH Tsai CN. The presence of cytokine-suppressive CD4+CD25+ T cells in the peripheral blood and synovial fluid of patients with rheumatoid arthritis. Scand J Immunol 2005;62:312-317.
13. Lundy SK, Sarkar S, Tesmer LA, Fox DA. Cells of the synovium in rheumatoid arthritis: T lymphocytes. Arthritis Res Ther 2007;9: 202.
14. Ueki Y, Eguchi K, Shimada H, Nakashima M, Ida H, Miyake S, Nagataki S, Tominaga Y. Increase in adhesion molecules on CD4+ cells and CD4+ cell subsets in synovial fluid from patients with rheumatoid arthritis. J Rheumatol 1994;21:1003-1010.
15. Agarwal SK, Brenner MB. Role of adhesion molecules in synovial inflammation. Curr Opin Rheumatol 2006;18:268-276.
16. Cui Y, Liao YC, Lo SH. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res 2004;2:225-232.
17. Kanemitsu N, Ebisuno Y, Tanaka T, Otani K, Hayasaka H, Kaisho T, Akira S, Katagiri K, Kinashi T, Fujita N, Tsuruo T, Miyasaka M. CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood 2005;106:2613-2618.
18. Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M, Montecucco C, Pitzalis C: Mature antigen-experienced T helper cells synthesize and secrete the B cell chemo-attractant CXCL13 in the inflammatory environment of the rheumatoid joint. Arthritis Rheum 2008;58:3377-3387.
19. hi CD4T cells and is independent of CD57 expression. Eur J Immunol 2006;36:1892-1903.
20. Lin M, Sutherland DR, Horsfall W, Totty N, Yeo E, Nayar R, Wu XF, Schuh AC. Cell surface antigen CD109 is a novel member of the α2 macroglobulin/C3, C4, C5 family of thioester-containing proteins. Blood 2002;99:1683-1691.
21. Suciu-Foca S, Reed E, Rubinstein P, MacKenzie W, Ng A, King DW. A late-differentiation antigen associated with the helper inducer function of human T cells. Nature 1985;318:465-467.
22. Bade B, Boettcher HE, Lohrmann J, Hink-Schauer C, Bratke K, Jenne DE, Virchow JC Jr, Luttmann W. Differential expression of the granzymes A, K and M and perforin in human peripheral blood lymphocytes. Int Immunol 2005;17:1419-1428.
23. Pharoah DS, Varsani H, Tatham RW, Newton KR, de Jager W, Prakken BJ, Klein N, Wedderburn LR. Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells. Arthritis Res Ther 2006;8:R50.
24. Brennan FM, McInnes IB. Evidence that cytokines play a role in rheumatoid arthritis. J Clin Invest 2008;118:3537-3545.
25. Choy EHS, Isenberg DA, Garrood T, Farrow S, Ioannou Y, Bird H, Cheung N, Williams B, Hazelman B, Price R, Yoshizaki K, Nishimoto N, Kishimoto T, Panayi GS. Therapeutic benefit of blocking interleukin-6 activity with an anti-interleukin-6 receptor monoclonal antibody in rheumatoid arthritis. Arthritis Rheum 2002;46:3143-3150.
26. Hennigan S, Kavanaugh A. Interleukin-6 Inhibitors in the treatment of rheumatoid arthritis. Ther Clin Risk Manage 2008;4:767-775.
27. Cayrol R, Kebir H, Ifergan I, Dodelet-Devillers A, Terouz S, Haqqani A, Poirier J, Stanimirovic D, Duquette P, Arbour N, Prat A. MCAM/CD146 is expressed by brain endothelial cells and defines a unique effector memory lymphocyte subset involved in neuroinflammation. Clin Immunol 2009;131(Suppl) S12:OR21.