메뉴 건너뛰기




Volumn 219, Issue 2, 2011, Pages 510-518

The antioxidant HDL-associated paraoxonase-1 (PON1) attenuates diabetes development and stimulates β-cell insulin release

Author keywords

Cells; Diabetes; Oxidative stress; Paraoxonase 1

Indexed keywords

ALPHA TOCOPHEROL; ANTIDIABETIC AGENT; ARYLDIALKYLPHOSPHATASE 1; GLUCOSE; HERBACEOUS AGENT; HIGH DENSITY LIPOPROTEIN; INSULIN; MUTANT PROTEIN; POLYPHENOL; PUNICALAGIN; RECOMBINANT ENZYME; RECOMBINANT PARAOXONASE 1; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL GROUP; UNCLASSIFIED DRUG;

EID: 82955195724     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2011.07.119     Document Type: Article
Times cited : (88)

References (50)
  • 1
    • 2642570389 scopus 로고    scopus 로고
    • Paraoxonase, a cardioprotective enzyme: continuing issues
    • Getz G.S., Reardon C.A. Paraoxonase, a cardioprotective enzyme: continuing issues. Curr Opin Lipidol 2004, 15:261-267.
    • (2004) Curr Opin Lipidol , vol.15 , pp. 261-267
    • Getz, G.S.1    Reardon, C.A.2
  • 2
    • 0025096104 scopus 로고
    • Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose
    • Hunt J.V., Smith C.C., Wolff S.P. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 1990, 39:1420-1424.
    • (1990) Diabetes , vol.39 , pp. 1420-1424
    • Hunt, J.V.1    Smith, C.C.2    Wolff, S.P.3
  • 3
    • 0028800370 scopus 로고
    • Immunological detection of glycated proteins in normal and streptozotocin-induced diabetic rats using anti hexitol-lysine IgG
    • Myint T., Hoshi S., Ookawara T., Miyazawa N., Suzuki K., Taniguchi N. Immunological detection of glycated proteins in normal and streptozotocin-induced diabetic rats using anti hexitol-lysine IgG. Biochim Biophys Acta 1995, 1272:73-79.
    • (1995) Biochim Biophys Acta , vol.1272 , pp. 73-79
    • Myint, T.1    Hoshi, S.2    Ookawara, T.3    Miyazawa, N.4    Suzuki, K.5    Taniguchi, N.6
  • 4
    • 0030456403 scopus 로고    scopus 로고
    • Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction
    • Kaneto H., Fujii J., Myint T., Miyazawa N., Islam K.N., Kawasaki Y., et al. Reducing sugars trigger oxidative modification and apoptosis in pancreatic beta-cells by provoking oxidative stress through the glycation reaction. Biochem J 1996, 32(Pt 3):855-863.
    • (1996) Biochem J , vol.32 , Issue.PART 3 , pp. 855-863
    • Kaneto, H.1    Fujii, J.2    Myint, T.3    Miyazawa, N.4    Islam, K.N.5    Kawasaki, Y.6
  • 5
    • 0033499583 scopus 로고    scopus 로고
    • Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity
    • Kaneto H., Kajimoto Y., Miyagawa J., Matsuoka T., Fujitani Y., Umayahara Y., et al. Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity. Diabetes 1999, 48:2398-2406.
    • (1999) Diabetes , vol.48 , pp. 2398-2406
    • Kaneto, H.1    Kajimoto, Y.2    Miyagawa, J.3    Matsuoka, T.4    Fujitani, Y.5    Umayahara, Y.6
  • 6
    • 0032847555 scopus 로고    scopus 로고
    • Overexpression of catalase provides partial protection to transgenic mouse beta cells
    • Xu B., Moritz J.T., Epstein P.N. Overexpression of catalase provides partial protection to transgenic mouse beta cells. Free Radical Biol Med 1999, 27:830-837.
    • (1999) Free Radical Biol Med , vol.27 , pp. 830-837
    • Xu, B.1    Moritz, J.T.2    Epstein, P.N.3
  • 7
    • 0035461380 scopus 로고    scopus 로고
    • Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes
    • Chen H., Carlson E.C., Pellet L., Moritz J.T., Epstein P.N. Overexpression of metallothionein in pancreatic beta-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes 2001, 50:2040-2046.
    • (2001) Diabetes , vol.50 , pp. 2040-2046
    • Chen, H.1    Carlson, E.C.2    Pellet, L.3    Moritz, J.T.4    Epstein, P.N.5
  • 8
    • 41849097354 scopus 로고    scopus 로고
    • Beta cell mass in diabetes: a realistic therapeutic target?
    • Meier J.J. Beta cell mass in diabetes: a realistic therapeutic target?. Diabetologia 2008, 51:703-713.
    • (2008) Diabetologia , vol.51 , pp. 703-713
    • Meier, J.J.1
  • 9
    • 0035130272 scopus 로고    scopus 로고
    • Beta-cell adaptation and decompensation during the progression of diabetes
    • Weir G.C., Laybutt D.R., Kaneto H., Bonner-Weir S., Sharma A. Beta-cell adaptation and decompensation during the progression of diabetes. Diabetes 2001, 50(Suppl. 1):S154-S159.
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Weir, G.C.1    Laybutt, D.R.2    Kaneto, H.3    Bonner-Weir, S.4    Sharma, A.5
  • 10
    • 22544469174 scopus 로고    scopus 로고
    • Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences
    • Aviram M., Rosenblat M. Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences. Curr Opin Lipidol 2005, 16:393-399.
    • (2005) Curr Opin Lipidol , vol.16 , pp. 393-399
    • Aviram, M.1    Rosenblat, M.2
  • 11
    • 17344369784 scopus 로고    scopus 로고
    • Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R
    • Aviram M., Billecke S., Sorenson R., Bisgaier C., Newton R., Rosenblat M., et al. Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R. Arterioscler Thromb Vasc Biol 1998, 18:1617-1624.
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 1617-1624
    • Aviram, M.1    Billecke, S.2    Sorenson, R.3    Bisgaier, C.4    Newton, R.5    Rosenblat, M.6
  • 12
    • 0034738140 scopus 로고    scopus 로고
    • Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities
    • Aviram M., Hardak E., Vaya J., Mahmood S., Milo S., Hoffman A., et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation 2000, 101:2510-2517.
    • (2000) Circulation , vol.101 , pp. 2510-2517
    • Aviram, M.1    Hardak, E.2    Vaya, J.3    Mahmood, S.4    Milo, S.5    Hoffman, A.6
  • 13
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    • Aviram M., Rosenblat M., Bisgaier C.L., Newton R.S., Primo-Parmo S.L., La Du B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 1998, 101:1581-1590.
    • (1998) J Clin Invest , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4    Primo-Parmo, S.L.5    La Du, B.N.6
  • 14
    • 20444419056 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice
    • Rozenberg O., Shih D.M., Aviram M. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice. Atherosclerosis 2005, 181:9-18.
    • (2005) Atherosclerosis , vol.181 , pp. 9-18
    • Rozenberg, O.1    Shih, D.M.2    Aviram, M.3
  • 15
    • 33845530202 scopus 로고    scopus 로고
    • Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes
    • Mastorikou M., Mackness M., Mackness B. Defective metabolism of oxidized phospholipid by HDL from people with type 2 diabetes. Diabetes 2006, 55:3099-3103.
    • (2006) Diabetes , vol.55 , pp. 3099-3103
    • Mastorikou, M.1    Mackness, M.2    Mackness, B.3
  • 16
    • 23644437876 scopus 로고    scopus 로고
    • Paraoxonase-1, (PON-1) genotype and activity and in vivo oxidized plasma low-density lipoprotein in Type II diabetes
    • Sampson M.J., Braschi S., Willis G., Astley S.B. Paraoxonase-1, (PON-1) genotype and activity and in vivo oxidized plasma low-density lipoprotein in Type II diabetes. Clin Sci (Lond) 2005, 109:189-197.
    • (2005) Clin Sci (Lond) , vol.109 , pp. 189-197
    • Sampson, M.J.1    Braschi, S.2    Willis, G.3    Astley, S.B.4
  • 17
    • 43049162677 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties
    • Rozenberg O., Shiner M., Aviram M., Hayek T. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Free Radical Biol Med 2008, 44:1951-1959.
    • (2008) Free Radical Biol Med , vol.44 , pp. 1951-1959
    • Rozenberg, O.1    Shiner, M.2    Aviram, M.3    Hayek, T.4
  • 18
    • 0032537833 scopus 로고    scopus 로고
    • Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis
    • Shih D.M., Gu L., Xia Y.R., Navab M., Li W.F., Hama S., et al. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis. Nature 1998, 394:284-287.
    • (1998) Nature , vol.394 , pp. 284-287
    • Shih, D.M.1    Gu, L.2    Xia, Y.R.3    Navab, M.4    Li, W.F.5    Hama, S.6
  • 19
    • 0017872475 scopus 로고
    • Microsomal lipid peroxidation
    • Buege J.A., Aust S.D. Microsomal lipid peroxidation. Methods Enzymol 1978, 52:302-310.
    • (1978) Methods Enzymol , vol.52 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 20
    • 0024584235 scopus 로고
    • A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent
    • el-Saadani M., Esterbauer H., el-Sayed M., Goher M., Nassar A.Y., Jurgens G. A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent. J Lipid Res 1989, 30:627-630.
    • (1989) J Lipid Res , vol.30 , pp. 627-630
    • el-Saadani, M.1    Esterbauer, H.2    el-Sayed, M.3    Goher, M.4    Nassar, A.Y.5    Jurgens, G.6
  • 21
    • 0023693038 scopus 로고
    • In vivo effects of aurothioglucose and sodium thioglucose on rat tissue sulfhydryl levels and plasma sulfhydryl reactivity
    • Hu M.L., Dillard C.J., Tappel A.L. In vivo effects of aurothioglucose and sodium thioglucose on rat tissue sulfhydryl levels and plasma sulfhydryl reactivity. Agents Actions 1988, 25:132-138.
    • (1988) Agents Actions , vol.25 , pp. 132-138
    • Hu, M.L.1    Dillard, C.J.2    Tappel, A.L.3
  • 22
    • 0347635518 scopus 로고    scopus 로고
    • Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization
    • Aharoni A., Gaidukov L., Yagur S., Toker L., Silman I., Tawfik D.S. Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc Natl Acad Sci U S A 2004, 101:482-487.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 482-487
    • Aharoni, A.1    Gaidukov, L.2    Yagur, S.3    Toker, L.4    Silman, I.5    Tawfik, D.S.6
  • 23
    • 33646373929 scopus 로고    scopus 로고
    • The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases
    • Khersonsky O., Tawfik D.S. The histidine 115-histidine 134 dyad mediates the lactonase activity of mammalian serum paraoxonases. J Biol Chem 2006, 281:7649-7656.
    • (2006) J Biol Chem , vol.281 , pp. 7649-7656
    • Khersonsky, O.1    Tawfik, D.S.2
  • 24
    • 24344460308 scopus 로고    scopus 로고
    • High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I
    • Gaidukov L., Tawfik D.S. High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. Biochemistry 2005, 44:11843-11854.
    • (2005) Biochemistry , vol.44 , pp. 11843-11854
    • Gaidukov, L.1    Tawfik, D.S.2
  • 25
    • 0025374590 scopus 로고
    • Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells
    • D'Ambra R., Surana M., Efrat S., Starr R.G., Fleischer N. Regulation of insulin secretion from beta-cell lines derived from transgenic mice insulinomas resembles that of normal beta-cells. Endocrinology 1990, 126:2815-2822.
    • (1990) Endocrinology , vol.126 , pp. 2815-2822
    • D'Ambra, R.1    Surana, M.2    Efrat, S.3    Starr, R.G.4    Fleischer, N.5
  • 26
    • 0026554428 scopus 로고
    • Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
    • LeBel C.P., Ischiropoulos H., Bondy S.C. Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 1992, 5:227-231.
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • LeBel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 27
    • 0016582569 scopus 로고
    • The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes
    • Johnston R.B., Keele B.B., Misra H.P., Lehmeyer J.E., Webb L.S., Baehner R.L., et al. The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest 1975, 55:1357-1372.
    • (1975) J Clin Invest , vol.55 , pp. 1357-1372
    • Johnston, R.B.1    Keele, B.B.2    Misra, H.P.3    Lehmeyer, J.E.4    Webb, L.S.5    Baehner, R.L.6
  • 29
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 0027364367 scopus 로고
    • Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins
    • Metz S.A., Rabaglia M.E., Stock J.B., Kowluru A. Modulation of insulin secretion from normal rat islets by inhibitors of the post-translational modifications of GTP-binding proteins. Biochem J 1993, 295(Pt 1):31-40.
    • (1993) Biochem J , vol.295 , Issue.PART 1 , pp. 31-40
    • Metz, S.A.1    Rabaglia, M.E.2    Stock, J.B.3    Kowluru, A.4
  • 31
    • 0020610387 scopus 로고
    • Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients
    • Aviram M. Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem Med 1983, 30:111-118.
    • (1983) Biochem Med , vol.30 , pp. 111-118
    • Aviram, M.1
  • 33
    • 26244444682 scopus 로고    scopus 로고
    • Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose
    • Hayek T., Hussein K., Aviram M., Coleman R., Keidar S., Pavoltzky E., et al. Macrophage foam-cell formation in streptozotocin-induced diabetic mice: stimulatory effect of glucose. Atherosclerosis 2005, 183:25-33.
    • (2005) Atherosclerosis , vol.183 , pp. 25-33
    • Hayek, T.1    Hussein, K.2    Aviram, M.3    Coleman, R.4    Keidar, S.5    Pavoltzky, E.6
  • 34
    • 0036965212 scopus 로고    scopus 로고
    • Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families
    • Deakin S., Leviev I., Nicaud V., Brulhart Meynet M.C., Tiret L., James R.W. Paraoxonase-1 L55M polymorphism is associated with an abnormal oral glucose tolerance test and differentiates high risk coronary disease families. J Clin Endocrinol Metab 2002, 87:1268-1273.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1268-1273
    • Deakin, S.1    Leviev, I.2    Nicaud, V.3    Brulhart Meynet, M.C.4    Tiret, L.5    James, R.W.6
  • 35
    • 0032921557 scopus 로고    scopus 로고
    • Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants
    • Aviram M., Rosenblat M., Billecke S., Erogul J., Sorenson R., Bisgaier C.L., et al. Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants. Free Radical Biol Med 1999, 26:892-904.
    • (1999) Free Radical Biol Med , vol.26 , pp. 892-904
    • Aviram, M.1    Rosenblat, M.2    Billecke, S.3    Erogul, J.4    Sorenson, R.5    Bisgaier, C.L.6
  • 37
    • 24144490962 scopus 로고    scopus 로고
    • Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria
    • Kim W.-H., Lee J.W., Suh Y.H., Hong S.H., Choi J.S., Lim J.H., et al. Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria. Diabetes 2005, 54:2602-2611.
    • (2005) Diabetes , vol.54 , pp. 2602-2611
    • Kim, W.-H.1    Lee, J.W.2    Suh, Y.H.3    Hong, S.H.4    Choi, J.S.5    Lim, J.H.6
  • 38
    • 0037341238 scopus 로고    scopus 로고
    • Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection
    • Robertson R.P., Harmon J., Tran P.O., Tanaka Y., Takahashi H. Glucose toxicity in β-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003, 52:581-587.
    • (2003) Diabetes , vol.52 , pp. 581-587
    • Robertson, R.P.1    Harmon, J.2    Tran, P.O.3    Tanaka, Y.4    Takahashi, H.5
  • 39
    • 0034078138 scopus 로고    scopus 로고
    • Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells
    • Moriscot C., Pattou F., Kerr-Conte J., Richard M.J., Lemarchand P., Benhamou P.Y. Contribution of adenoviral-mediated superoxide dismutase gene transfer to the reduction in nitric oxide-induced cytotoxicity on human islets and INS-1 insulin-secreting cells. Diabetologia 2000, 43:625-631.
    • (2000) Diabetologia , vol.43 , pp. 625-631
    • Moriscot, C.1    Pattou, F.2    Kerr-Conte, J.3    Richard, M.J.4    Lemarchand, P.5    Benhamou, P.Y.6
  • 40
    • 0032863183 scopus 로고    scopus 로고
    • Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants
    • Tanaka Y., Gleason C.E., Tran P.O., Harmon J.S., Robertson R.P. Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants. Proc Natl Acad Sci U S A 1999, 96:10857-10862.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10857-10862
    • Tanaka, Y.1    Gleason, C.E.2    Tran, P.O.3    Harmon, J.S.4    Robertson, R.P.5
  • 41
    • 0037443799 scopus 로고    scopus 로고
    • (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice
    • Rozenberg O., Rosenblat M., Coleman R., Shih D.M., Aviram M., Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radical Biol Med 2003, 34:774-784.
    • (2003) Free Radical Biol Med , vol.34 , pp. 774-784
    • Rozenberg, O.1    Rosenblat, M.2    Coleman, R.3    Shih, D.M.4    Aviram, M.5    Paraoxonase6
  • 42
    • 0014836904 scopus 로고
    • Effect of sulfhydryl reagents on permeability of toadfish islet tissue
    • Watkins D., Cooperstein S.J., Lazarow A. Effect of sulfhydryl reagents on permeability of toadfish islet tissue. Am J Physiol 1970, 219:503-509.
    • (1970) Am J Physiol , vol.219 , pp. 503-509
    • Watkins, D.1    Cooperstein, S.J.2    Lazarow, A.3
  • 43
    • 0016155492 scopus 로고
    • Effect of sulfhydryl-binding reagents on insulin release from isolated secretion granules
    • Watkins D.T., Moore M. Effect of sulfhydryl-binding reagents on insulin release from isolated secretion granules. Endocrinology 1974, 95:485-491.
    • (1974) Endocrinology , vol.95 , pp. 485-491
    • Watkins, D.T.1    Moore, M.2
  • 44
    • 0022001647 scopus 로고
    • The inhibition of hexose transport by permeant and impermeant sulfhydryl agents in rat adipocytes
    • May J.M. The inhibition of hexose transport by permeant and impermeant sulfhydryl agents in rat adipocytes. J Biol Chem 1985, 260:462-467.
    • (1985) J Biol Chem , vol.260 , pp. 462-467
    • May, J.M.1
  • 45
    • 2442465761 scopus 로고    scopus 로고
    • The potential biological mechanisms of arsenic-induced diabetes mellitus
    • Tseng C.H. The potential biological mechanisms of arsenic-induced diabetes mellitus. Toxicol Appl Pharmacol 2004, 197:67-83.
    • (2004) Toxicol Appl Pharmacol , vol.197 , pp. 67-83
    • Tseng, C.H.1
  • 46
    • 79955549305 scopus 로고    scopus 로고
    • Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response
    • Bourquard N., Ng C.J., Reddy S.T. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 2011, 436:91-100.
    • (2011) Biochem J , vol.436 , pp. 91-100
    • Bourquard, N.1    Ng, C.J.2    Reddy, S.T.3
  • 47
    • 33744511920 scopus 로고    scopus 로고
    • Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes
    • Rosenblat M., Karry R., Aviram M. Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. Atherosclerosis 2006, 187:74-81.
    • (2006) Atherosclerosis , vol.187 , pp. 74-81
    • Rosenblat, M.1    Karry, R.2    Aviram, M.3
  • 48
    • 77349101573 scopus 로고    scopus 로고
    • Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients
    • Fuhrman B., Volkova N., Aviram M. Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: studies in vitro and in diabetic patients. Nutrition 2010, 26:359-366.
    • (2010) Nutrition , vol.26 , pp. 359-366
    • Fuhrman, B.1    Volkova, N.2    Aviram, M.3
  • 49
    • 78650703449 scopus 로고    scopus 로고
    • HDL-associated paraoxonase-1 can redistribute to cell membranes and influence sensitivity to oxidative stress
    • Deakin S.P., Bioletto S., Bochaton-Piallat M.L., James R.W. HDL-associated paraoxonase-1 can redistribute to cell membranes and influence sensitivity to oxidative stress. Free Radical Biol Med 2011, 50:102-109.
    • (2011) Free Radical Biol Med , vol.50 , pp. 102-109
    • Deakin, S.P.1    Bioletto, S.2    Bochaton-Piallat, M.L.3    James, R.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.