Pomegranate juice polyphenols increase recombinant paraoxonase-1 binding to high-density lipoprotein: Studies in vitro and in diabetic patients

Nutrition

Volumn 26, Issue 4, 2010, Pages 359-366

  Fuhrman, Bianca ^a   Volkova, Nina ^a   Aviram, Michael ^a  

^a RAMBAM MEDICAL CENTER   (Israel)

Author keywords

High density lipoprotein; Oxidative stress; Paraoxonase 1; Polyphenols; Pomegranate juice; Vitamin E

Indexed keywords

ALPHA TOCOPHEROL; ARYLDIALKYLPHOSPHATASE 1; ELLAGIC ACID; FLUORESCEIN ISOTHIOCYANATE; GALLIC ACID; HIGH DENSITY LIPOPROTEIN; POLYPHENOL; POMEGRANATE EXTRACT; PUNICALAGIN; RECOMBINANT ENZYME; UNCLASSIFIED DRUG;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; ENZYME ACTIVITY; ENZYME ISOLATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MALE; OXIDATION; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; POMEGRANATE JUICE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION;

ANTIOXIDANTS; ARYLDIALKYLPHOSPHATASE; BEVERAGES; DIABETES MELLITUS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME ACTIVATION; FLAVONOIDS; GALLIC ACID; HUMANS; LIPOPROTEINS, HDL; MALE; MIDDLE AGED; OXIDATIVE STRESS; PHENOLS; PLANT EXTRACTS; PUNICACEAE;

LYTHRACEAE;

EID: 77349101573     PISSN: 08999007     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nut.2009.05.003     Document Type: Article

References (33)

1. La Du B.N. Structural and functional diversity of paraoxonases. Nat Med 2 (1996) 1186-1187
2. Ng C.J., Shih D.M., Hama S.Y., Villa N., Navab M., and Reddy S.T. The paraoxonase gene family and atherosclerosis. Free Radic Biol Med 38 (2005) 153-163
3. Aviram M., and Rosenblat M. Paraoxonases 1, 2 and 3, oxidative stress, and macrophage foam cell formation during atherosclerosis development. Free Radic Biol Med 37 (2004) 1304-1316
4. Aviram M., and Rosenblat M. Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences. Curr Opin Lipidol 16 (2005) 393-399
5. Getz G.S., and Reardon C.A. Paraoxonase, a cardioprotective enzyme: continuing issues. Curr Opin Lipidol 15 (2004) 261-267
6. Gaidukov L., Rosenblat M., Aviram M., and Tawfik D.S. The 192R/Q polymorphs of serum paraoxonase PON1 differ in HDL binding, lipolactonase stimulation, and cholesterol efflux. J Lipid Res 47 (2006) 2492-2502
7. Aviram M., Billecke S., Sorenson R., Bisgaier C., Newton R., Rosenblat M., et al. Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R. Arterioscler Thromb Vasc Biol 18 (1998) 1617-1624
8. Aviram M., Kaplan M., Rosenblat M., and Fuhrman B. Dietary antioxidants and paraoxonases against LDL oxidation and atherosclerosis development. Handb Exp Pharmacol 170 (2005) 263-300
9. Aviram M., Rosenblat M., Bisgaier C.L., Newton R.S., Primo-Parmo S.L., and La Du B.N. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions, A possible peroxidative role for paraoxonase. J Clin Invest 10 (1998) 1581-1590
10. Rozenberg O., Shih D.M., and Aviram M. Paraoxonase 1 (PON1) attenuates macrophage oxidative status: studies in PON1 transfected cells and in PON1 transgenic mice. Atherosclerosis 181 (2005) 9-18
11. Aviram M., Hardak E., Vaya J., Mahmood S., Milo S., Hoffman A., et al. Human serum paraoxonases (PON1) Q and R selectively decrease lipid peroxides in human coronary and carotid atherosclerotic lesions: PON1 esterase and peroxidase-like activities. Circulation 101 (2000) 2510-2517
12. Rozenberg O., Shih D.M., and Aviram M. Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation. Arterioscler Thromb Vasc Biol 23 (2003) 461-467
13. Rosenblat M., Gaidukov L., Khersonsky O., Vaya J., Oren R., Tawfik D.S., and Aviram M. The catalytic histidine dyad of high density lipoprotein-associated serum paraoxonase-1 (PON1) is essential for PON1-mediated inhibition of low density lipoprotein oxidation and stimulation of macrophage cholesterol efflux. J Biol Chem 281 (2006) 7657-7665
14. Rozenberg O., Shiner M., Aviram M., and Hayek T. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Free RadicBiol Med 44 (2008) 1951-1959
15. Lakshman M.R., Gottipati C.S., Narasimhan S.J., Munoz J., Marmillot P., and Nylen E.S. Inverse correlation of serum paraoxonase and homocysteine thiolactonase activities and antioxidant capacity of high-density lipoprotein with the severity of cardiovascular disease in persons with type 2 diabetes mellitus. Metabolism 55 (2006) 1201-1206
16. Rosenblat M., Karry R., and Aviram M. Paraoxonase 1 (PON1) is a more potent antioxidant and stimulant of macrophage cholesterol efflux, when present in HDL than in lipoprotein-deficient serum: relevance to diabetes. Atherosclerosis 187 (2006) 74-81
17. Rosenblat M., Sapir O., and Aviram M. Glucose inactivates Paraoxonase 1 (PON1) and displaces it from high density lipoprotein (HDL) to a free PON1 form. In: Mackness B., Mackness M., Aviram M., and Paragh G. (Eds). The paraoxonases: their role in disease development and xenobiotic metabolism (2008), Springer, New York 35-51
18. Giugliano D., Ceriello A., and Paolisso G. Oxidative stress and diabetic vascular complications. Diabetes Care 19 (1996) 257-267
19. Ceriello A. Controlling oxidative stress as a novel molecular approach to protecting the vascular wall in diabetes. Curr Opin Lipidol 17 (2006) 510-518
20. Gil M.I., Tomás-Barberán F.A., Hess-Pierce B., Holcroft D.M., and Kader A.A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48 (2000) 4581-4589
21. Tzulker R., Glazer I., Bar-Ilan I., Holland D., Aviram M., and Amir R. Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions. J Agric Food Chem 55 (2007) 9559-9570
22. Rosenblat M., Hayek T., and Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis 187 (2006) 363-371
23. Rock W., Rosenblat M., Miller-Lotan R., Levy A.P., Elias M., and Aviram M. Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. J Agric Food Chem 56 (2008) 8704-8713
24. Aviram M. Plasma lipoprotein separation by discontinuous density gradient ultracentrifugation in hyperlipoproteinemic patients. Biochem Med 30 (1983) 111-118
25. Lowry O.H., Rosebrough N.J., Farr L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
26. Aviram M., and Vaya J. Markers for low-density lipoprotein oxidation. Methods Enzymol 335 (2001) 244-256
27. Singleton V.L., and Rossi J.A. Colorimetry of total phenolics with phosphomolybdic phosphotungstic acid reagents. Am J Enol Viticult 16 (1965) 144-158
28. Aharoni A., Gaidukov L., Yagur S., Toker L., Silman I., and Tawfik D.S. Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization. Proc Natl Acad Sci U S A 101 (2004) 482-487
29. Gaidukov L., and Tawfik D.S. High affinity, stability, and lactonase activity of serum paraoxonase PON1 anchored on HDL with ApoA-I. Biochemistry 44 (2005) 11843-11854
30. Sorenson R.C., Bisgaier C.L., Aviram M., Hsu C., Billecke S., and La Du B.N. Human serum paraoxonase/arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids; apolipoprotein A 1 stabilizes activity. Arterioscler Thromb Vasc Biol 19 (1999) 2214-2225
31. Sanguinetti S.M., Brites F.D., Fasulo V., Verona J., Elbert A., Wikinski R.L., and Schreier L.E. HDL oxidability and its protective effect against LDL oxidation in type 2 diabetic patients. Diabetes Nutr Metab 14 (2001) 27-36
32. Esterbauer H., Striegl G., Puhl H., and Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun 6 (1989) 67-75
33. Frei B., and Gaziano J.M. Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and -independent oxidation. J Lipid Res 34 (1993) 2135-2145