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Volumn 436, Issue 1, 2011, Pages 91-100

Impaired hepatic insulin signalling in P0N2-deficient mice: A novel role for the P0N2/apoE axis on the macrophage inflammatory response

Author keywords

Apolipoprotein E (apoE); Insulin receptor substrate 1 (IRS 1); Liver; Macrophage; Paraoxonase; Paraoxonase 2 (PON2)

Indexed keywords

APOLIPOPROTEIN E; ARYLDIALKYLPHOSPHATASE 2; INSULIN; INSULIN RECEPTOR SUBSTRATE 1;

EID: 79955549305     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101891     Document Type: Article
Times cited : (29)

References (30)
  • 1
    • 0004442926 scopus 로고    scopus 로고
    • Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: Prospective results from the Bruneck Study
    • Bonora, E, Kiechl, S., Oberhollenzer, F., Egger, G., Bonadonna, R. C, Muggeo, M. and Willeit, J. (2000) Impaired glucose tolerance, Type II diabetes mellitus and carotid atherosclerosis: prospective results from the Bruneck Study. Diabetologia 43, 156-164 (Pubitemid 30126819)
    • (2000) Diabetologia , vol.43 , Issue.2 , pp. 156-164
    • Bonora, E.1    Kiechl, S.2    Oberhollenzer, F.3    Egger, G.4    Bonadonna, R.C.5    Muggeo, M.6    Willeit, J.7
  • 4
    • 1842454052 scopus 로고    scopus 로고
    • Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes
    • DOI 10.1016/j.metabol.2003.10.009
    • Tsuzura, S., Ikeda, Y., Suehiro, T., Ota, K., Osaki, F., Arii, K., Kumon, Y. and Hashimoto, K. (2004) Correlation of plasma oxidized low-density lipoprotein levels to vascular complications and human serum paraoxonase in patients with type 2 diabetes. Metab. Clin. Exp. 53, 297-302 (Pubitemid 38684688)
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.3 , pp. 297-302
    • Tsuzura, S.1    Ikeda, Y.2    Suehiro, T.3    Ota, K.4    Osaki, F.5    Arii, K.6    Kumon, Y.7    Hashimoto, K.8
  • 5
    • 0029832485 scopus 로고    scopus 로고
    • Oxidized low density lipoprotein induces activation of the transcription factor NFκB in fibroblasts, endothelial and smooth muscle cells
    • Maziere, C., Auclair, M., Djavaheri-Mergny, M., Packer, L. and Maziere, J. C. (1996) Oxidized low density lipoprotein induces activation of the transcription factor NFκBin fibroblasts, endothelial and smooth muscle cells. Biochem. Mol. Biol. Int. 39, 1201-1207 (Pubitemid 26306517)
    • (1996) Biochemistry and Molecular Biology International , vol.39 , Issue.6 , pp. 1201-1207
    • Maziere, C.1    Auclair, M.2    Djavaheri-Mergny, M.3    Packer, L.4    Maziere, J.-C.5
  • 6
    • 0040119632 scopus 로고    scopus 로고
    • Oxidized LDL activates STAT1 and STAT3 transcription factors: Possible involvement of reactive oxygen species
    • DOI 10.1016/S0014-5793(99)00324-5, PII S0014579399003245
    • Maziere, C., Alimardani, G., Dantin, F., Dubois, F., Conte, M. A. and Maziere, J. C. (1999) Oxidized LDL activates STAT1 and STAT3 transcription factors: possible involvement of reactive oxygen species. FEBS Lett. 448, 49-52 (Pubitemid 29151629)
    • (1999) FEBS Letters , vol.448 , Issue.1 , pp. 49-52
    • Maziere, C.1    Alimardani, G.2    Dantin, F.3    Dubois, F.4    Conte, M.-A.5    Maziere, J.-C.6
  • 7
    • 0031875852 scopus 로고    scopus 로고
    • Ox-LDL induces apoptosis in human coronary artery endothelial cells: Role of PKC, PTK, bcl-2, and Fas
    • Li, D., Yang, B. and Mehta, J. L. (1998) Ox-LDL induces apoptosis in human coronary artery endothelial cells: role of PKC, PTK, bcl-2, and Fas. Am. J. Physiol. 275, H568-H576
    • (1998) Am. J. Physiol. , vol.275
    • Li, D.1    Yang, B.2    Mehta, J.L.3
  • 10
    • 33749544927 scopus 로고    scopus 로고
    • Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: Anti-atherogenic role for paraoxonase-2
    • DOI 10.1074/jbc.M605379200
    • Ng, C. J., Bourquard, N., Grijalva, V., Hama, S., Shih, D. M., Navab, M., Fogelman, A. M., Lusis, A. J., Young, S. and Reddy, S. T. (2006) Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B- containing lipoproteins: anti-atherogenic role for paraoxonase-2. J. Biol. Chem. 281, 29491-29500 (Pubitemid 44536957)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.40 , pp. 29491-29500
    • Ng, C.J.1    Bourquard, N.2    Grijalva, V.3    Hama, S.4    Shih, D.M.5    Navab, M.6    Fogelman, A.M.7    Lusis, A.J.8    Young, S.9    Reddy, S.T.10
  • 13
    • 67649690455 scopus 로고    scopus 로고
    • Paraoxonase 2 attenuates macrophage triglyceride accumulation via Inhibition of dlacylglycerol acyltransferase 1
    • Rosenblat, M., Coleman, R., Reddy, S. T. and Aviram, M. (2009) Paraoxonase 2 attenuates macrophage triglyceride accumulation via Inhibition of dlacylglycerol acyltransferase 1. J. Lipid Res. 50, 870-879
    • (2009) J. Lipid Res. , vol.50 , pp. 870-879
    • Rosenblat, M.1    Coleman, R.2    Reddy, S.T.3    Aviram, M.4
  • 14
    • 0033636523 scopus 로고    scopus 로고
    • Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction
    • Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F, Shulman, G. I., Magnuson, M. A. and Kahn, C. R. (2000) Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97
    • (2000) Mol. Cell , vol.6 , pp. 87-97
    • Michael, M.D.1    Kulkarni, R.N.2    Postic, C.3    Previs, S.F.4    Shulman, G.I.5    Magnuson, M.A.6    Kahn, C.R.7
  • 15
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
    • DOI 10.1038/nm1166
    • Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J. and Shoelson, S. E. (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-β andNF-κB. Nat. Med. 11, 183-190 (Pubitemid 40321354)
    • (2005) Nature Medicine , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 17
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li, B., Nolte, L. A., Ju, J. S., Han, D. H., Coleman, T., Holloszy, J. O. and Semenkovich, C. F. (2000) Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat. Med. 6, 1115-1120
    • (2000) Nat. Med. , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 20
    • 0035976903 scopus 로고    scopus 로고
    • Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein
    • Ng, C. J., Wadleigh, D. J., Gangopadhyay, A., Hama, S., Grijalva, V. R., Navab, M., Fogelman, A. M. and Reddy, S. T. (2001) Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein. J. Biol. Chem. 276, 44444-44449
    • (2001) J. Biol. Chem. , vol.276 , pp. 44444-44449
    • Ng, C.J.1    Wadleigh, D.J.2    Gangopadhyay, A.3    Hama, S.4    Grijalva, V.R.5    Navab, M.6    Fogelman, A.M.7    Reddy, S.T.8
  • 21
    • 0030061922 scopus 로고    scopus 로고
    • IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α-and obesity-induced insulin resistance
    • Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F. and Spiegelman, B. M. (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 271, 665-668 (Pubitemid 26052915)
    • (1996) Science , vol.271 , Issue.5249 , pp. 665-668
    • Hotamisligil, G.S.1    Peraldi, P.2    Budavari, A.3    Ellis, R.4    White, M.F.5    Spiegelman, B.M.6
  • 22
    • 2942574528 scopus 로고    scopus 로고
    • NO suppresses while peroxynitrite sustains NF-κB: A paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO
    • DOI 10.1016/j.cardiores.2004.03.014, PII S0008636304001300
    • Hattori, Y., Kasai, K. and Gross, S. S. (2004) NO suppresses while peroxynitrite sustains NF-κB: a paradigm to rationalize cytoprotective and cytotoxic actions attributed to NO. Cardiovasc. Res. 63, 31-40 (Pubitemid 38759807)
    • (2004) Cardiovascular Research , vol.63 , Issue.1 , pp. 31-40
    • Hattori, Y.1    Kasai, K.2    Gross, S.S.3
  • 24
    • 0242268894 scopus 로고    scopus 로고
    • Chronic Exposure to Interleukin-6 Causes Hepatic Insulin Resistance in Mice
    • DOI 10.2337/diabetes.52.11.2784
    • Klover, P. J., Zimmers, T. A., Koniaris, L. G. and Mooney, R. A. (2003) Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 52, 2784-2789 (Pubitemid 37339708)
    • (2003) Diabetes , vol.52 , Issue.11 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 26
    • 0029765553 scopus 로고    scopus 로고
    • Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides
    • DOI 10.1038/ng0996-55
    • Miyata, M. and Smith, J. D. (1996) Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and β-amyloid peptides. Nat. Genet. 14, 55-61 (Pubitemid 26301547)
    • (1996) Nature Genetics , vol.14 , Issue.1 , pp. 55-61
    • Miyata, M.1    Smith, J.D.2
  • 28
    • 0034770292 scopus 로고    scopus 로고
    • Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
    • DOI 10.1038/nm1001-1138
    • Perreault, M. and Marette, A. (2001) Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat. Med. 7, 1138-1143 (Pubitemid 33010023)
    • (2001) Nature Medicine , vol.7 , Issue.10 , pp. 1138-1143
    • Perreault, M.1    Marette, A.2
  • 29
    • 15944378147 scopus 로고    scopus 로고
    • S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: A novel mechanism of insulin resistance
    • DOI 10.2337/diabetes.54.4.959
    • Carvalho-Filho, M. A., Ueno, M., Hirabara, S. M., Seabra, A. B., Carvalheira, J. B., de Oliveira, M. G., Velloso, L. A., Curi, R. and Saad, M. J. (2005) S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes 54, 959-967 (Pubitemid 40446309)
    • (2005) Diabetes , vol.54 , Issue.4 , pp. 959-967
    • Carvalho-Filho, M.A.1    Ueno, M.2    Hirabara, S.M.3    Seabra, A.B.4    Carvalheira, J.B.C.5    De Oliveira, M.G.6    Velloso, L.A.7    Curi, R.8    Saad, M.J.A.9
  • 30
    • 0037339957 scopus 로고    scopus 로고
    • Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress
    • DOI 10.1161/01.ATV.0000059385.95664.4D
    • Rosenblat, M., Draganov, D., Watson, C. E., Bisgaier, C. L., La Du, B. N. and Aviram, M. (2003) Mouse macrophage paraoxonase 2 activity is increased whereas cellular paraoxonase 3 activity is decreased under oxidative stress. Arterioscler. Thromb. Vasc. Biol. 23, 468-474 (Pubitemid 36337224)
    • (2003) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.23 , Issue.3 , pp. 468-474
    • Rosenblat, M.1    Draganov, D.2    Watson, C.E.3    Bisgaier, C.L.4    La Du, B.N.5    Aviram, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.