Estrogenic plant extracts reverse weight gain and fat accumulation without causing mammary gland or uterine proliferation

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Saunier, Elise F ^a   Vivar, Omar I ^b   Rubenstein, Andrea ^a   Zhao, Xiaoyue ^a,f   Olshansky, Moshe ^c   Baggett, Scott ^a   Staub, Richard E ^a   Tagliaferri, Mary ^a   Cohen, Isaac ^a   Speed, Terence P ^c,d   Baxter, John D ^e   Leitman, Dale C ^b  

^a Bionovo Inc   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e HOUSTON METHODIST RESEARCH INSTITUTE   (United States)

^f GOOGLE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; GLYCYRRHIZA URALENSIS EXTRACT; PLANT EXTRACT; PUERARIA MONTANA EXTRACT; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN; UNCLASSIFIED DRUG; ESTROGEN;

ABDOMINAL FAT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CELL STRAIN MCF 7; CONTROLLED STUDY; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE CONTROL; GENE EXPRESSION PROFILING; HUMAN; HUMAN CELL; LIPID DIET; LIPID STORAGE; MAMMARY GLAND; MOUSE; NONHUMAN; OBESITY; OVARIECTOMY; PUERARIA; PUERARIA MONTANA; TRANSCRIPTION INITIATION; UTERUS; WEIGHT GAIN; ADIPOSE TISSUE; ANIMAL; BIOSYNTHESIS; BODY WEIGHT; BREAST; CANCER TRANSPLANTATION; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION REGULATION; GLYCYRRHIZA URALENSIS; METABOLISM; TUMOR CELL LINE; UDDER;

ADIPOSE TISSUE; ANIMALS; BODY WEIGHT; BREAST; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GLYCYRRHIZA URALENSIS; HUMANS; MAMMARY GLANDS, ANIMAL; MICE; NEOPLASM TRANSPLANTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLANT EXTRACTS; PUERARIA; UTERUS; WEIGHT GAIN;

EID: 82855177860     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028333     Document Type: Article

References (52)

1. Santen RJ, Allred DC, Ardoin SP, Archer DF, Boyd N, et al. (2010) Postmenopausal hormone therapy: an Endocrine Society scientific statement. J Clin Endocrinol Metab 95: s1-s66.
2. Margolis KL, Bonds DE, Rodabough RJ, Tinker L, Phillips LS, et al. (2004) Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women's Health Initiative Hormone Trial. Diabetologia 47: 1175-1187.
3. Bonds DE, Lasser N, Qi L, Brzyski R, Caan B, et al. (2006) The effect of conjugated equine oestrogen on diabetes incidence: the Women's Health Initiative randomised trial. Diabetologia 49: 459-468.
4. Kanaya AM, Herrington D, Vittinghoff E, Lin F, Grady D, et al. (2003) Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial. Ann Intern Med 138: 1-9.
5. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Rosner B, et al. (1991) Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. N Engl J Med 325: 756-762.
6. Espeland MA, Stefanick ML, Kritz-Silverstein D, Fineberg SE, Waclawiw MA, et al. (1997) Effect of postmenopausal hormone therapy on body weight and waist and hip girths. Postmenopausal Estrogen-Progestin Interventions Study Investigators. J Clin Endocrinol Metab 82: 1549-1556.
7. Jensen LB, Vestergaard P, Hermann AP, Gram J, Eiken P, et al. (2003) Hormone replacement therapy dissociates fat mass and bone mass, and tends to reduce weight gain in early postmenopausal women: a randomized controlled 5-year clinical trial of the Danish Osteoporosis Prevention Study. J Bone Miner Res 18: 333-342.
8. Mattiasson I, Rendell M, Tornquist C, Jeppsson S, Hulthen UL, (2002) Effects of estrogen replacement therapy on abdominal fat compartments as related to glucose and lipid metabolism in early postmenopausal women. Horm Metab Res 34: 583-588.
9. Gower BA, Munoz J, Desmond R, Hilario-Hailey T, Jiao X, (2006) Changes in intra-abdominal fat in early postmenopausal women: effects of hormone use. Obesity 14: 1046-1055.
10. Writing Group for Women's Health Initiative (2002) Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women's Health Initiative randomized controlled trial. Jama 288: 321-333.
11. Ettinger B, Grady D, Tosteson AN, Pressman A, Macer JL, (2003) Effect of the Women's Health Initiative on women's decisions to discontinue postmenopausal hormone therapy. Obstet Gynecol 102: 1225-1232.
12. Heldring N, Pike A, Andersson S, Matthews J, Cheng G, et al. (2007) Estrogen receptors: how do they signal and what are their targets. Physiol Rev 87: 905-931.
13. Chlebowski RT, Kuller LH, Prentice RL, Stefanick ML, Manson JE, et al. (2009) Breast cancer after use of estrogen plus progestin in postmenopausal women. N Engl J Med 360: 573-587.
14. Dahlman-Wright K, Cavailles V, Fuqua SA, Jordan VC, Katzenellenbogen JA, et al. (2006) International Union of Pharmacology. LXIV. Estrogen receptors. Pharmacol Rev 58: 773-781.
15. Stauffer SR, Coletta CJ, Tedesco R, Nishiguchi G, Carlson K, et al. (2000) Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists. J Med Chem 43: 4934-4947.
16. Minutolo F, Macchia M, Katzenellenbogen BS, Katzenellenbogen JA, (2009) Estrogen receptor beta ligands: Recent advances and biomedical applications. Med Res Rev 31: 364-442.
17. Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, et al. (2001) Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 44: 4230-4251.
18. Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, et al. (2003) Evaluation of an estrogen receptor-beta agonist in animal models of human disease. Endocrinology 144: 4241-4249.
19. Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, et al. (2007) Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology 148: 538-547.
20. Mersereau JE, Levy N, Staub RE, Baggett S, Zogric T, et al. (2008) Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol 283: 49-57.
21. Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, et al. (2011) Estrogen receptor beta causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat 186: 4354-60.
22. Paruthiyil S, Parmar H, Kerekatte V, Cunha GR, Firestone GL, et al. (2004) Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res 64: 423-428.
23. Hartman J, Edvardsson K, Lindberg K, Zhao C, Williams C, et al. (2009) Tumor repressive functions of estrogen receptor beta in SW480 colon cancer cells. Cancer Res 69: 6100-6106.
24. Mostafaie N, Kallay E, Sauerzapf E, Bonner E, Kriwanek S, et al. (2009) Correlated downregulation of estrogen receptor beta and the circadian clock gene Per1 in human colorectal cancer. Mol Carcinog 48: 642-647.
25. Grady D, Sawaya GF, Johnson KC, Koltun W, Hess R, et al. (2009) MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial. Menopause 16: 458-65.
26. Barros RP, Gustafsson JA, (2011) Estrogen receptors and the metabolic network. Cell Metab 14: 289-299.
27. Leitman DC, Paruthiyil S, Vivar OI, Saunier EF, Herber CB, et al. (2010) Regulation of specific target genes and biological responses by estrogen receptor subtype agonists. Curr Opin Pharmacol 10: 629-636.
28. Bailey CJ, Ahmed-Sorour H, (1980) Role of ovarian hormones in the long-term control of glucose homeostasis. Effects of insulin secretion. Diabetologia 19: 475-481.
29. Louet JF, LeMay C, Mauvais-Jarvis F, (2004) Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep 6: 180-185.
30. Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS, (2000) Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A 97: 12729-12734.
31. Bryzgalova G, Gao H, Ahren B, Zierath JR, Galuska D, et al. (2006) Evidence that oestrogen receptor-alpha plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver. Diabetologia 49: 588-597.
32. Bryzgalova G, Lundholm L, Portwood N, Gustafsson JA, Khan A, et al. (2008) Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab 295: E904-912.
33. Lundholm L, Bryzgalova G, Gao H, Portwood N, Falt S, et al. (2008) The estrogen receptor {alpha}-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms. J Endocrinol 199: 275-286.
34. Gao H, Bryzgalova G, Hedman E, Khan A, Efendic S, et al. (2006) Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 20: 1287-1299.
35. Roesch DM, (2006) Effects of selective estrogen receptor agonists on food intake and body weight gain in rats. Physiol Behav 87: 39-44.
36. Jordan VC, O'Malley BW, (2007) Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. J Clin Oncol 25: 5815-5824.
37. An J, Tzagarakis-Foster C, Scharschmidt TC, Lomri N, Leitman DC, (2001) Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J Biol Chem 276: 17808-17814.
38. Mahady GB, Parrot J, Lee C, Yun GS, Dan A, (2003) Botanical dietary supplement use in peri- and postmenopausal women. Menopause 10: 65-72.
39. Kian Tee M, Rogatsky I, Tzagarakis-Foster C, Cvoro A, An J, et al. (2004) Estradiol and Selective Estrogen Receptor Modulators Differentially Regulate Target Genes with Estrogen Receptors {alpha} and {beta}. Mol Biol Cell 15: 1262-1272.
40. An J, Ribeiro RC, Webb P, Gustafsson JA, Kushner PJ, et al. (1999) Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc Natl Acad Sci U S A 96: 15161-15166.
41. Saunier E, Dif F, Kelly PA, Edery M, (2003) Targeted expression of the dominant-negative prolactin receptor in the mammary gland of transgenic mice results in impaired lactation. Endocrinology 144: 2669-2675.
42. Vivar OI, Zhao X, Saunier EF, Griffin C, Mayba OS, et al. (2010) Estrogen receptor [beta] binds to and regulates three distinct classes of target genes. J Biol Chem 285: 22059-66.
43. Yi ST, Wang XY, (2008) The Clinical Practice of Chinese Medicine: Menstrual Disorders II: Premenstrual Syndrome, Dysmenorrhea, and Perimenopause Beijing People's Medical Publishing House.
44. Levy N, Zhao X, Tang H, Jaffe RB, Speed TP, et al. (2007) Multiple Transcription Factor Elements Collaborate with Estrogen Receptor {alpha} to Activate an Inducible Estrogen Response Element in the NKG2E Gene. Endocrinology 148: 3449-3458.
45. Mo B, Vendrov AE, Palomino WA, DuPont BR, Apparao KB, et al. (2006) ECC-1 cells: a well-differentiated steroid-responsive endometrial cell line with characteristics of luminal epithelium. Biol Reprod 75: 387-394.
46. Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, et al. (2009) Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One 4: e6271.
47. Shang Y, Brown M, (2002) Molecular determinants for the tissue specificity of SERMs. Science 295: 2465-2468.
48. Misiti S, Schomburg L, Yen PM, Chin WW, (1998) Expression and hormonal regulation of coactivator and corepressor genes. Endocrinology 139: 2493-2500.
49. Molenda HA, Kilts CP, Allen RL, Tetel MJ, (2003) Nuclear receptor coactivator function in reproductive physiology and behavior. Biol Reprod 69: 1449-1457.
50. Zhou Y, Jiang L, Rui L, (2009) Identification of MUP1 as a regulator for glucose and lipid metabolism in mice. J Biol Chem 284: 11152-11159.
51. Forster C, Makela S, Warri A, Kietz S, Becker D, et al. (2002) Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci U S A 99: 15578-15583.
52. Couse JF, Lindzey J, Grandien K, Gustafsson JA, Korach KS, (1997) Tissue distribution and quantitative analysis of estrogen receptor- alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology 138: 4613-4621.