Cross talk between glucocorticoid and estrogen receptors occurs at a subset of proinflammatory genes

Journal of Immunology

Volumn 186, Issue 7, 2011, Pages 4354-4360

  Cvoro, Aleksandra ^a,b   Yuan, Chaoshen ^c   Paruthiyil, Sreenivasan ^a,b   Miller, Oliver H ^a,b   Yamamoto, Keith R ^a   Leitman, Dale C ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; GLUCOCORTICOID RECEPTOR; INTERLEUKIN 8; TUMOR NECROSIS FACTOR;

ARTICLE; CELL STRAIN; CELL STRAIN U2OS; CONTROLLED STUDY; DRUG MECHANISM; GENE; GENE ACTIVATION; GENE CONTROL; GENE REPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROINFLAMMATORY GENE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADENOVIRUSES, HUMAN; CELL LINE, TUMOR; DEXAMETHASONE; ESTRADIOL; ESTROGEN ANTAGONISTS; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; LUNG; RECEPTOR CROSS-TALK; RECEPTORS, ESTROGEN; RECEPTORS, GLUCOCORTICOID;

EID: 79955018223     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1002205     Document Type: Article

References (24)

1. Beck, I. M., W. Vanden Berghe, L. Vermeulen, K. R. Yamamoto, G. Haegeman, and K. De Bosscher. 2009. Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases. Endocr. Rev. 30: 830-882.
2. Ghosh, S., M. J. May, and E. B. Kopp. 1998. NF-kappa B and Rel proteins: Evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16: 225-260. (Pubitemid 28183365)
3. Smale, S. T. 2010. Selective transcription in response to an inflammatory stimulus. Cell 140: 833-844.
4. Ray, A., and K. E. Prefontaine. 1994. Physical association and functional antagonism between the p65 subunit of transcription factor NF-kappa B and the glucocorticoid receptor. Proc. Natl. Acad. Sci. USA 91: 752-756. (Pubitemid 24041480)
5. Webster, J. C., and J. A. Cidlowski. 1999. Mechanisms of Glucocorticoid-receptormediated Repression of Gene Expression. Trends Endocrinol. Metab. 10: 396-402.
6. De Bosscher, K., and G. Haegeman. 2009. Minireview: Latest perspectives on antiinflammatory actions of glucocorticoids. Mol. Endocrinol. 23: 281-291.
7. Nissen, R. M., and K. R. Yamamoto. 2000. The glucocorticoid receptor inhibits NFkappaB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain. Genes Dev. 14: 2314-2329.
8. Luecke, H. F., and K. R. Yamamoto. 2005. The glucocorticoid receptor blocks P-TEFb recruitment by NFkappaB to effect promoter-specific transcriptional repression. Genes Dev. 19: 1116-1127. (Pubitemid 40632456)
9. Price, D. H. 2000. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol. Cell. Biol. 20: 2629-2634. (Pubitemid 30183481)
10. Straub, R. H. 2007. The complex role of estrogens in inflammation. Endocr. Rev. 28: 521-574. (Pubitemid 47236336)
11. Heldring, N., A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Ström, E. Treuter,M.Warner, and J. A. Gustafsson. 2007. Estrogen receptors: How do they signal and what are their targets. Physiol. Rev. 87: 905-931. (Pubitemid 47084672)
12. Stein, B., and M. X. Yang. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol. Cell. Biol. 15: 4971-4979.
13. Ray, P., S. K. Ghosh, D. H. Zhang, and A. Ray. 1997. Repression of interleukin-6 gene expression by 17 beta-estradiol: inhibition of the DNA-binding activity of the transcription factors NF-IL6 and NF-kappa B by the estrogen receptor. FEBS Lett. 409: 79-85. (Pubitemid 27248571)
14. An, J., R. C. Ribeiro, P. Webb, J. A. Gustafsson, P. J. Kushner, J. D. Baxter, and D. C. Leitman. 1999. Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. Proc. Natl. Acad. Sci. USA 96: 15161-15166. (Pubitemid 30019782)
15. An, J., C. Tzagarakis-Foster, T. C. Scharschmidt, N. Lomri, and D. C. Leitman. 2001. Estrogen receptor beta-selective transcriptional activity and recruitment of coregulators by phytoestrogens. J. Biol. Chem. 276: 17808-17814.
16. Cvoro, A., C. Tzagarakis-Foster, D. Tatomer, S. Paruthiyil, M. S. Fox, and D. C. Leitman. 2006. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol. Cell 21: 555-564. (Pubitemid 43228010)
17. Rogatsky, I., K. A. Zarember, and K. R. Yamamoto. 2001. Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 20: 6071-6083. (Pubitemid 33049282)
18. Nettles, K. W., G. Gil, J. Nowak, R. Métivier, V. B. Sharma, and G. L. Greene. 2008. CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor. Mol. Endocrinol. 22: 263-272. (Pubitemid 351185930)
19. Cuzzocrea, S., S. Bruscoli, C. Crisafulli, E. Mazzon, M. Agostini, C. Muià, E. Esposito, R. Di Virgilio, R. Meli, E. Vegeto, et al. 2007. Estrogen receptor antagonist fulvestrant (ICI 182,780) inhibits the anti-inflammatory effect of glucocorticoids. Mol. Pharmacol. 71: 132-144. (Pubitemid 46020983)
20. Kian Tee, M., I. Rogatsky, C. Tzagarakis-Foster, A. Cvoro, J. An, R. J. Christy, K. R. Yamamoto, and D. C. Leitman. 2004. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol. Biol. Cell 15: 1262-1272. (Pubitemid 38316233)
21. Leitman, D. C., R. C. Ribeiro, E. R. Mackow, J. D. Baxter, and B. L. West. 1991. Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene. J. Biol. Chem. 266: 9343-9346. (Pubitemid 21906659)
22. Levy, N., D. Tatomer, C. B. Herber, X. Zhao, H. Tang, T. Sargeant, L. J. Ball, J. Summers, T. P. Speed, and D. C. Leitman. 2008. Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene. Mol. Endocrinol. 22: 287-303. (Pubitemid 351185932)
23. Cvoro, A., D. Tatomer, M. K. Tee, T. Zogovic, H. A. Harris, and D. C. Leitman. 2008. Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes. J. Immunol. 180: 630-636.
24. Diamond, M. I., J. N. Miner, S. K. Yoshinaga, and K. R. Yamamoto. 1990. Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249: 1266-1272.