Synthesis and in vivo imaging of a 18F-labeled PARP1 inhibitor using a chemically orthogonal scavenger-assisted high-performance method

Angewandte Chemie - International Edition

Volumn 50, Issue 8, 2011, Pages 1922-1925

  Reiner, Thomas ^a   Keliher, Edmund J ^a   Earley, Sarah ^a   Marinelli, Brett ^a   Weissleder, Ralph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

cancer therapy; chemically orthogonal conjugation; in vivo imaging; positron emission tomography; scavenger resin

Indexed keywords

BIOLOGICAL ASSAYS; CANCER THERAPY; CATALYST-FREE; CHEMICALLY ORTHOGONAL CONJUGATION; CYCLOOCTENE; DIELS-ALDER CYCLOADDITIONS; HIGH-PERFORMANCE METHODS; IN VIVO IMAGING; IN-VIVO; PARALLEL SYNTHESIS; PET IMAGING; SCAVENGER RESIN; TETRAZINES;

CYCLOADDITION; DISEASES; LEAD COMPOUNDS; ONCOLOGY; POSITRONS; RESINS;

POSITRON EMISSION TOMOGRAPHY;

CYCLOOCTANE DERIVATIVE; ENZYME INHIBITOR; FLUORINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OLAPARIB; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE; RADIOPHARMACEUTICAL AGENT;

ANIMAL; ARTICLE; CHEMISTRY; DRUG ANTAGONISM; HUMAN; METABOLISM; MOUSE; NEOPLASM; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CYCLOOCTANES; ENZYME INHIBITORS; FLUORINE RADIOISOTOPES; HUMANS; MICE; MICE, NUDE; NEOPLASMS; PHTHALAZINES; PIPERAZINES; POLY(ADP-RIBOSE) POLYMERASES; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS;

EID: 79951808505     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201006579     Document Type: Article

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