Imaging progesterone receptor in breast tumors: Synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of Tanaproget

Journal of Medicinal Chemistry

Volumn 53, Issue 8, 2010, Pages 3349-3360

  Zhou, Hai Bing ^a,b   Lee, Jae Hak ^a   Mayne, Christopher G ^a   Carlson, Kathryn E ^a   Katzenellenbogen, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b WUHAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4,4 DIMETHYL 2 THIOXO 1,4 DIHYDRO 2H BENZO[D][1,3]OXAZIN 6 YL) 1 (2 FLUOROETHYL) 1H PYRROLE 2 CARBONITRILE; 5 (4,4 DIMETHYL 2 THIOXO 1,4 DIHYDRO 2H BENZO[D][1,3]OXAZIN 6 YL) 1 (2 FLUOROPROPYL) 1H PYRROLE 2 CARBONITRILE; 5 [4 (2 FLUOROETHYL) 4 METHYL 2 THIOXO 1,4 DIHYDRO 2H BENZO[D][1,3]OXAZIN 6 YL] 1 METHYL 1H PYRROLE 2 CARBONITRILE; 5 [4 (3 FLUOROPROPYL) 4 METHYL 2 THIOXO 1,4 DIHYDRO 2H BENZO [D][1,3]OXAZIN 6 YL] 1 METHYL 1H PYRROLE 2 CARBONITRILE; 5 [4 (3 FLUOROPROPYL) 4 METHYL 2 THIOXO 1,4 DIHYDRO 2H BENZO[D][1,3]OXAZIN 6 YL] 1H PYRROLE 2 CARBONITRILE; ESTROGEN; ESTROGEN RECEPTOR; FLUORINE DERIVATIVE; METRIBOLONE; OXAZINE DERIVATIVE; PROGESTERONE RECEPTOR; PROMEGESTONE; PYRROLE DERIVATIVE; RADIOPHARMACEUTICAL AGENT; TANAPROGET; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BREAST TUMOR; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MOLECULAR MODEL; POSITRON EMISSION TOMOGRAPHY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZOXAZINES; BINDING, COMPETITIVE; BREAST NEOPLASMS; FEMALE; FLUORINE; FLUORINE RADIOISOTOPES; MODELS, MOLECULAR; PROMEGESTONE; RADIOLIGAND ASSAY; RATS; RECEPTORS, PROGESTERONE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THIONES;

EID: 77951130159     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100052k     Document Type: Article

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