Modulation of immune response to Toxoplasma gondii in sheep by immunization with a DNA vaccine encoding ROP1 antigen as a fusion protein with ovine CD154

Veterinary Parasitology

Volumn 183, Issue 1-2, 2011, Pages 72-78

  Hiszczyńska Sawicka, Elzbieta ^a,b   Li, Hong ^a   Xu, Janet Boyu ^a   Holec Gasior, Lucyna ^b   Kur, Józef ^b   Sedcole, Richard ^a   Bickerstaffe, Roy ^a   Stankiewicz, Mirosław ^a  

^a LINCOLN UNIVERSITY   (New Zealand)

^b GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

Author keywords

CD40 ligand (CD154); DNA vaccine; ROP1 antigen; Toxoplasma gondii

Indexed keywords

DNA VACCINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; RECOMBINANT ANTIGEN; RECOMBINANT ROP1 ANTIGEN; ROP1 CD154 ANTIGEN FUSION PROTEIN; UNCLASSIFIED DRUG;

ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; DNA IMMUNIZATION; EWE; FEMALE; GENE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOMODULATION; NONHUMAN; RHOPTRY PROTEIN 1 GENE; SHEEP; TH1 TH2 BALANCE; TOXOPLASMA GONDII; TOXOPLASMOSIS; TRANSGENE;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; CATTLE; CD40 LIGAND; CHO CELLS; CRICETINAE; CRICETULUS; FEMALE; IMMUNIZATION; INJECTIONS, INTRAMUSCULAR; MEMBRANE PROTEINS; NEW ZEALAND; PLASMIDS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; RECOMBINANT FUSION PROTEINS; SHEEP; SHEEP DISEASES; SHEEP, DOMESTIC; TOXOPLASMA; TOXOPLASMOSIS, ANIMAL; VACCINES, DNA;

ANIMALIA; OVIS; OVIS ARIES; TOXOPLASMA GONDII;

EID: 82755182915     PISSN: 03044017     EISSN: 18732550     Source Type: Journal    
DOI: 10.1016/j.vetpar.2011.06.010     Document Type: Article

References (44)

1. Angus C.W., Klivington-Evans D., Dubey J.P., Kovacs J.A. Immunization with a DNA plasmid encoding the SAG1 (P30) protein of Toxoplasma gondii is immunogenic and protective in rodents. J. Infect. Dis. 2000, 181:317-324.
2. Babiuk L.A., van Drunen Littel-van den Hurk S., Babiuk S.L. Immunization of animals: from DNA to the dinner plate. Vet. Immunol. Immunopathol. 1999, 72:189-202.
3. Beláková J., Horynová M., Krupka M., Weigl E., Raska M. DNA vaccines: are they still just a powerful tool for the future?. Arch. Immunol. Ther. Exp. 2007, 55:387-398.
4. Bessieres M.H., Swierczynski B., Cassaing S., Miedouge M., Olle P., Seguela J.P., Pipy B. Role of IFN-gamma, TNF-alpha, IL-4 and IL-10 in the regulation of experimental Toxoplasma gondii infection. J. Eukaryot. Microbiol. 1997, 44:87S.
5. Burger J.A., Mendoza R.B., Kipps T.J. Plasmids encoding granulocyte macrophage colony-stimulating factor and CD154 enhance the immune response to genetic vaccines. Vaccine 2001, 19:2181-2189.
6. Chen G., Guo H., Lu F., Zheng H. Construction of a recombinant plasmid harbouring the rhoptry protein 1 gene of Toxoplasma gondii and preliminary observations on DNA immunity. Chin. Med. J. 2001, 114:837-840.
7. Dubey J.P. Strategies to reduce transmission of Toxoplasma gondii to animals and humans. Vet. Parasitol. 1996, 64:65-70.
8. Durie F.H., Foy T.M., Masters S.R., Laman J.D., Noelle R.J. The role of CD40 in the regulation of humoral and cell-mediated immunity. Immunol. Today 1994, 15:406-411.
9. Egan M.A., Israel Z.R. The use of cytokines and chemokines as genetic adjuvants for plasmid DNA vaccines. Clin. Appl. Immunol. Rev. 2002, 2:255-287.
10. Finkelman F.D., Holmes J., Katona I.M., Urban J.F., Beckman P., Park L.S., Schooley K.A., Coffman R.L., Mosmann T.R., Paul W.E. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 1990, 8:303-333.
11. Gaddi P.J., Yap G.S. Cytokine regulation of immunopathology in toxoplasmosis. Immunol. Cell Biol. 2007, 85:155-159.
12. Guo H., Chen G., Lu F., Chen H., Zheng H. Immunity induced by DNA vaccine of plasmid encoding the rhoptry protein 1 gene combined with the genetic adjuvant of pcIFN-gamma against Toxoplasma gondii in mice. Chin. Med. J. 2001, 114:317-320.
13. Gurunathan S., Irvine K.R., Wu C.Y., Cohen J.I., Thomas E., Prussin C., Restifo N.P., Seder R.A. CD40 ligand/trimer DNA enhances both humoral and cellular immune responses and induces protective immunity to infectious and tumor challenge. J. Immunol. 1998, 161:4563-4571.
14. Haddad D., Liljeqvist S., Stahl S., Perlman P., Barzins K., Ahlborg N. Differential induction of immunoglobulin G subclasses by immunization with DNA vectors containing or lacking a signal sequence. Immunol. Lett. 1998, 61:201-204.
15. Hiszczyńska-Sawicka E., Brillowska-Da{ogonek}browska A., Da{ogonek}browski S., Pietkiewicz H., Myjak P., Kur J. High yield expression and single step purification of Toxoplasma gondii SAG1, GRA1 and GRA7 antigens in Escherichia coli. Protein Expr. Purif. 2003, 27:150-157.
16. Hiszczyńska-Sawicka E., Kur J., Pietkiewicz H., Holec L., Ga{ogonek}sior A., Myjak P. Efficient production of the Toxoplasma gondii GRA6, p35 and SAG2 recombinant antigens and their applications in the serodiagnosis of toxoplasmosis. Acta Parasitol. 2005, 50:249-254.
17. Hiszczyńska-Sawicka E., Hong L., Xu J.B., Ole{ogonek}dzka G., Kur J., Bickerstaffe R., Stankiewicz M. Comparison of immune response in sheep immunized with DNA vaccine encoding Toxoplasma gondii GRA7 antigen in different adjuvant formulations. Exp. Parasitol. 2010, 124:365-372.
18. Holec L., Hiszczyńska-Sawicka E., Gasior A., Brillowska-Dabrowska A., Kur J. Use of MAG1 recombinant antigen for diagnosis of Toxoplasma gondii infection in humans. Clin. Vaccine Immunol. 2007, 14:220-225.
19. Holec L., Kur J., Hiszczynska-Sawicka E. GRA2 and ROP1 recombinant antigens as potential markers for detection of Toxoplasma gondii-specific immunoglobulin G in human with acute toxoplasmosis. Clin. Vaccine Immunol. 2009, 16:510-514.
20. Kaufmann E., Geisler N., Weber K. SDS-PAGE strongly overestimates the molecular masses of the neurofilament proteins. FEBS Lett. 1984, 170:81-84.
21. Klaus S.J., Berberich I., Shu G., Clark E.A. CD40 and its ligand in the regulation of humoral immunity. Semin. Immunol. 1994, 6:279-286.
22. Kur J., Holec-Ga{ogonek}sior L., Hiszczyńska-Sawicka E. Current status of toxoplasmosis vaccine development. Expert Rev. Vaccines 2009, 8:791-808.
23. Li B., Oledzka G., McFarlane R.G., Spellerberg M.B., Smith S.M., Gelder F.B., Kur J., Stankiewicz M. Immunological response of sheep to injections of plasmids encoding Toxoplasma gondii SAG1 and ROP1 genes. Parasite Immunol. 2010, 32:671-683.
24. Li W. Synergistic antibody induction by antigen-CD40 ligand fusion protein as improved immunogen. Immunology 2005, 115:215-222.
25. Manoj S., Griebel P.J., Babiuk L.A., van Drunen Littel-van den Hurk S. Targeting with bovine CD154 enhances humoral immune responses induced by a DNA vaccine in sheep. J. Immunol. 2003, 170:989-996.
26. Manoj S., Griebel P.J., Babiuk L.A., van Drunen Littel-van den Hurk S. Modulation of immune responses to bovine herpesvirus-1 in cattle by immunization with a DNA vaccine encoding glycoprotein D as a fusion protein with bovine CD154. Immunology 2004, 112:328-338.
27. Mendoza R.B., Cantwell M.J., Kipps T.J. Immunostimulatory effects of a plasmid expressing CD40 ligand (CD154) on gene immunization. J. Immunol. 1997, 159:5777-5781.
28. Montoya J.G., Liesenfeld O. Toxoplasmosis. Lancet 2004, 363:1965-1976.
29. Noelle R.J. CD40 and its ligand in cell-mediated immunity. Agents Actions 1998, 49:17-22.
30. Nielsen H.V., Lauemoller S.L., Christiansen L., Buus S., Fomsgaard A., Petersen E. Complete protection against lethal Toxoplasma gondii infection in mice immunized with a plasmid encoding the SAG1 gene. Infect. Immun. 1999, 67:6358-6363.
31. Oledzka G., Li B., Kay G.W., Chomicz L., Stankiewicz M. Cloning, sequence analysis and expression of ovine CD154 (CD40 ligand). Mol. Immunol. 2007, 44:741-746.
32. Ossorio P.N., Schwartzman J.D., Boothroyd J.C. A Toxoplasma gondii rhoptry protein associated with host cell penetration has unusual charge asymmetry. Mol. Biochem. Parasitol. 1992, 50:1-15.
33. ® Release 12. Part 2: Statistics 2009, VSN International, UK. R.W. Payne (Ed.).
34. Petersen E., Nielsen H.V., Christiansen L., Spenter J. Immunization with E. coli produced recombinant T. gondii SAG1 with alum as adjuvant protect mice against lethal infection with Toxoplasma gondii. Vaccine 1998, 16:1283-1289.
35. Pietkiewicz H., Kur J., Hiszczyńska-Sawicka E., Petersen E., Nielsen H., Stankiewicz M., Andrzejewska I., Myjak P. Usefulness of Toxoplasma gondii recombinant antigens in serodiagnosis of human toxoplasmosis. J. Clin. Microbiol. 2004, 42:1779-1781.
36. Pontarollo R.A., Rankin R., Babiuk L.A., Godson D.L., Griebel P.J., Hecker R., Krieg A.M., van Drunen Littel-van den Hurk S. Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs. Vet. Immunol. Immunopathol. 2002, 84:43-59.
37. Scheerlinck J.P. Genetic adjuvants for DNA vaccines. Vaccine 2001, 19:2647-2656.
38. + T cell-mediated protective immunity against herpes simplex virus type 2 in vivo. Hum. Gene Ther. 2001, 12:1091-1102.
39. Tenter A.M., Heckeroth A.R., Weiss L.M. Toxoplasma gondii: from animals to humans. Int. J. Parasitol. 2000, 30:1217-1258.
40. Tripp R.A., Jones L., Anderson L.J., Brown M.P. CD40 ligand (CD154) enhances the Th1 and antibody responses to respiratory syncytial virus in the BALB/c mouse. J. Immunol. 2000, 164:5913-5921.
41. Van Kooten C., Banchereau J. CD40-CD40 ligand: a multifunctional receptor-ligand pair. Adv. Immunol. 1996, 61:1-77.
42. Vercammen M., Scorza T., Huygen K., De Braekeleer J., Diet R., Jacobs D., Saman E., Verschueren H. DNA vaccination with genes encoding Toxoplasma gondii antigens GRA1, GRA7, and ROP2 induces partially protective immunity against lethal challenge in mice. Infect. Immun. 2000, 68:38-45.
43. Wood P.R., Jones S.L. BOVIGAM: an in vitro cellular diagnostic test for bovine tuberculosis. Tuberculosis 2001, 81:147-155.
44. Xu H., Zhao G., Huang X., Ding Z., Wang J., Wang X., Cheng Y., Kang Y., Wang B. CD40-expressing plasmid induces anti-CD40 antibody and enhances immune responses to DNA vaccination. J. Gene Med. 2010, 12:97-106.