Differential induction of immunoglobulin G subclasses by immunization with DNA vectors containing or lacking a signal sequence

Immunology Letters

Volumn 61, Issue 2-3, 1998, Pages 201-204

  Haddad, Diana ^a   Liljeqvist, Sissela ^b   Ståhl, Stefan ^b   Perlmann, Peter ^a   Berzins, Klavs ^a   Ahlborg, Niklas ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

DNA immunization; IgG subclasses; Th cell differentiation

Indexed keywords

IMMUNOGLOBULIN G; MALARIA VACCINE;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; GENE THERAPY; HELPER CELL; IMMUNOGENICITY; IMMUNOSTIMULATION; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING;

ANIMALS; ANTIBODIES, PROTOZOAN; ANTIGENS, PROTOZOAN; GENETIC VECTORS; IMMUNOGLOBULIN G; MICE; PLASMODIUM FALCIPARUM; PROTEIN SORTING SIGNALS; PROTOZOAN PROTEINS; PROTOZOAN VACCINES; VACCINATION; VACCINES, DNA;

EID: 0032052750     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2478(97)00171-5     Document Type: Article

References (15)

1. Mosmann T.R., Coffmann R.L. Th1 and Th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:1989;145-173.
2. Ten Hagen T.L.M., Sulzer A.J., Kidd M.R., Lal A.A., Hunter R.L. Role of adjuvants in the modulation of antibody isotype, specificity and induction of protection by whole blood-stage Plasmodium yoelii vaccines. J. Immunol. 151:1993;7077-7081.
3. Klaus G.G.B., Pepys M.B., Kitajima K., Askonas B.A. Activation of mouse complement by different classes of mouse antibody. Immunology. 38:1979;687-695.
4. Cardoso A.I., Blixenkrone-Moller M., Fayolle J., Liu M., Buckland R.A., Wild T.F. Immunization with plasmid DNA encoding for the measles virus hemagglutinin and nucleoprotein leads to humoral and cell-mediated immunity. Virology. 225:1996;293-299.
5. Lewis P.J., Cox G.J.M., Little-van den Hurk S.D., Babiuk L.A. Polynucleotide vaccines in animals: Enhancing and modulating responses. Vaccine. 15:1997;861-864.
6. Haddad D., Liljeqvist S., Ståhl S., Andersson I., Perlmann P., Berzins K., Ahlborg N. Comparative study of DNA-based immunization vectors: Effect of secretion signals on the antibody responses in mice. FEMS Immunol. Med. Microbiol. 18:1997;193-202.
7. Ahlborg N., Andersson R., Ståhl S., Hansson M., Andersson I., Perlmann P., Berzins K. B- and T-cell responses in congenic mice to repeat sequences of the malarial antigen Pf332: Effects of the number of repeats. Immunol. Lett. 40:1994;147-155.
8. Nilsson B., Moks T., Jansson B., Abrahmsén L., Elmblad A., Holmgren E., Henrichson C., Jones T.A., Uhlén M. A synthetic IgG-binding domain based on staphylococcal protein A. Protein Eng. 1:1987;107-113.
9. Feltquate D.M., Heaney S., Webster R.G., Robinson H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J. Immunol. 158:1997;2278-2284.
10. Pertmer T., Roberts T., Haynes J. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J. Virol. 70:1996;6119-6125.
11. Roman M., Martin-Orozco E., Goodman J.S., Nguyen M.-D., Sato Y., Ronaghy A., Kornbluth R.S., Richman D.D., Carson D.A., Raz E. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:1997;849-854.
12. Leclerc L., Deriaud E., Rojas M., Wahlen R.G. The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA. Cell. Immunol. 179:1997;97-106.
13. Raz E., Watanabe A., Baird S., Eisenberg R., Parr T., Lotz M., Kipps T., Carson D. Systemic immunological effects of cytokine genes injected into skeletal muscle. Proc. Natl. Acad. Sci. USA. 90:1993;4523-4527.
14. Xiang Z., Ertl H. Manipulation of the immune response to a plasmid-encoded viral antigen by coinoculation with plasmids expressing cytokines. Immunity. 2:1995;129-135.
15. Kuklin N., Daheshia M., Karem K., Manickan E., Rouse B. Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization. J. Virol. 71:1997;3138-3145.