Monocytes are required for optimum in vitro stimulation of bovine peripheral blood mononuclear cells by non-methylated CpG motifs

Veterinary Immunology and Immunopathology

Volumn 84, Issue 1-2, 2002, Pages 43-59

  Pontarollo, R A ^a   Rankin, R ^a   Babiuk, L A ^a   Godson, D L ^a   Griebel, P J ^a   Hecker, R ^b   Krieg, A M ^c,d,e   Van Drunen Littel Van Den Hurk, S ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b QIAGEN GMBH   (Germany)

^c UNIVERSITY OF IOWA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e PFIZER INC   (United States)

Author keywords

Cattle; CpG; Immunostimulation; Monocytes; Oligodeoxynucleotides

Indexed keywords

BACTERIAL DNA; GAMMA INTERFERON; OLIGODEOXYNUCLEOTIDE DERIVATIVE;

ANIMAL CELL; ARTICLE; CATTLE; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; IMMUNE RESPONSE; IMMUNOSTIMULATION; INTERFERON PRODUCTION; LYMPHOCYTE PROLIFERATION; MALE; MONOCYTE; MONONUCLEAR CELL; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; SCREENING;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CATTLE; FEMALE; IMMUNOPHENOTYPING; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MALE; MONOCYTES; OLIGODEOXYRIBONUCLEOTIDES; T-LYMPHOCYTES;

BACTERIA (MICROORGANISMS); BOS TAURUS; BOVINAE; VERTEBRATA;

EID: 0036153566     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-2427(01)00379-8     Document Type: Article

References (40)

1. Effect of recombinant bovine interleukin-1 beta on viral/bacterial pneumonia in cattle
2. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
3. CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells
4. DNA methylation and the frequency of CpG in animal DNA
5. DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells
6. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
7. Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus
8. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
9. The development and analysis of species specific and cross reactive monoclonal antibodies to leukocyte differentiation antigens and antigens of the major histocompatibility complex for use in the study of the immune system in cattle and other species
10. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
11. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
12. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
13. A Toll-like receptor recognizes bacterial DNA
14. Identification of two distinct populations of dendritic cells in afferent lymph that vary in their ability to stimulate T cells
15. Functional and topographical analyses of epitopes on bovine herpesvirus type 1 glycoprotein IV
16. Oligodeoxynucleotides containing palindrome sequences with internal 5′-CpG-3′ act directly on human NK and activated T cells to induce IFN-γ production in vitro
17. Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL-4
18. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
19. Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides
20. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12
21. Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA
22. CpG motifs in bacterial DNA trigger direct B-cell activation
23. CpG motifs in bacterial DNA prevent apoptosis and break self tolerance to DNA
24. Mechanism of action of CpG DNA
25. Responses of human B cells to DNA and phosphorothioate oligodeoxynucleotides
26. Activation of human B cells by phosphorothioate oligodeoxynucleotides
27. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants
28. Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpesvirus 1 in cattle
29. Nonspecific suppression of [3H]thymidine incorporation by 'control' oligonucleotides
30. Identification of a stimulatory CpG motif for veterinary and laboratory species demonstrates that sequence recognition is highly conserved
31. Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides
32. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
33. Macrophages ingest and are activated by bacterial DNA
34. Type I interferon-mediated stimulation of T cells by CpG DNA
35. Effects of intradermally administered plasmid deoxyribonucleic acid on ovine popliteal lymph node morphology
36. Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs
37. IFN-gamma promotes IL and IgM-6 secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
38. Rapid immune activation by CpG motifs in bacterial DNA. Systemic induction of IL-6 transcription through an antioxidant-sensitive pathway
39. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis