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Volumn 317, Issue 20, 2011, Pages 2925-2937

Zac1, an Sp1-like protein, regulates human p21WAF1/Cip1 gene expression in HeLa cells

Author keywords

Gene regulation; HDAC1; P21; P53; Sp1; Zac1

Indexed keywords

PROTEIN P21; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR ZAC1; UNCLASSIFIED DRUG;

EID: 82555170344     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.09.018     Document Type: Article
Times cited : (17)

References (56)
  • 3
    • 0030955765 scopus 로고    scopus 로고
    • Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain
    • Spengler D., Villalba M., Hoffmann A., Pantaloni C., Houssami S., Bockaert J., Journot L. Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997, 16:2814-2825.
    • (1997) EMBO J. , vol.16 , pp. 2814-2825
    • Spengler, D.1    Villalba, M.2    Hoffmann, A.3    Pantaloni, C.4    Houssami, S.5    Bockaert, J.6    Journot, L.7
  • 6
    • 33846214379 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation
    • Barz T., Hoffmann A., Panhuysen M., Spengler D. Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation. Cancer Res. 2006, 66:11975-11982.
    • (2006) Cancer Res. , vol.66 , pp. 11975-11982
    • Barz, T.1    Hoffmann, A.2    Panhuysen, M.3    Spengler, D.4
  • 7
    • 0037306261 scopus 로고    scopus 로고
    • Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding
    • Hoffmann A., Ciani E., Boeckardt J., Holsboer F., Journot L., Spengler D. Transcriptional activities of the zinc finger protein Zac are differentially controlled by DNA binding. Mol. Cell. Biol. 2003, 23:988-1003.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 988-1003
    • Hoffmann, A.1    Ciani, E.2    Boeckardt, J.3    Holsboer, F.4    Journot, L.5    Spengler, D.6
  • 8
    • 77953808790 scopus 로고    scopus 로고
    • Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations
    • Ho C.L., Huang Y.C., Tai C.K., Liu S.T., Wang J.K., Wang W.M., Huang S.M. Modulation of the Zac1's transactivation and coactivation functions via PML and Daxx within distinct subcellular localizations. Int. J. Biochem. Cell Biol. 2010, 42:902-910.
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 902-910
    • Ho, C.L.1    Huang, Y.C.2    Tai, C.K.3    Liu, S.T.4    Wang, J.K.5    Wang, W.M.6    Huang, S.M.7
  • 9
    • 33847765717 scopus 로고    scopus 로고
    • Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1
    • Huang S.M., Huang S.P., Wang S.L., Liu P.Y. Importin alpha1 is involved in the nuclear localization of Zac1 and the induction of p21WAF1/CIP1 by Zac1. Biochem. J. 2007, 402:359-366.
    • (2007) Biochem. J. , vol.402 , pp. 359-366
    • Huang, S.M.1    Huang, S.P.2    Wang, S.L.3    Liu, P.Y.4
  • 10
    • 0035912063 scopus 로고    scopus 로고
    • Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1
    • Huang S.M., Schonthal A.H., Stallcup M.R. Enhancement of p53-dependent gene activation by the transcriptional coactivator Zac1. Oncogene 2001, 20:2134-2143.
    • (2001) Oncogene , vol.20 , pp. 2134-2143
    • Huang, S.M.1    Schonthal, A.H.2    Stallcup, M.R.3
  • 11
    • 0032483441 scopus 로고    scopus 로고
    • Transcriptional activation capacity of the novel PLAG family of zinc finger proteins
    • Kas K., Voz M.L., Hensen K., Meyen E., Van de Ven W.J. Transcriptional activation capacity of the novel PLAG family of zinc finger proteins. J. Biol. Chem. 1998, 273:23026-23032.
    • (1998) J. Biol. Chem. , vol.273 , pp. 23026-23032
    • Kas, K.1    Voz, M.L.2    Hensen, K.3    Meyen, E.4    Van de Ven, W.J.5
  • 12
    • 0031038873 scopus 로고    scopus 로고
    • Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations
    • Kas K., Voz M.L., Roijer E., Astrom A.K., Meyen E., Stenman G., Van de Ven W.J. Promoter swapping between the genes for a novel zinc finger protein and beta-catenin in pleiomorphic adenomas with t(3;8)(p21;q12) translocations. Nat. Genet. 1997, 15:170-174.
    • (1997) Nat. Genet. , vol.15 , pp. 170-174
    • Kas, K.1    Voz, M.L.2    Roijer, E.3    Astrom, A.K.4    Meyen, E.5    Stenman, G.6    Van de Ven, W.J.7
  • 13
    • 0037432638 scopus 로고    scopus 로고
    • Regulation of nuclear receptor activities by two human papillomavirus type 18 oncoproteins, E6 and E7
    • Wang W.M., Chung M.H., Huang S.M. Regulation of nuclear receptor activities by two human papillomavirus type 18 oncoproteins, E6 and E7. Biochem. Biophys. Res. Commun. 2003, 303:932-939.
    • (2003) Biochem. Biophys. Res. Commun. , vol.303 , pp. 932-939
    • Wang, W.M.1    Chung, M.H.2    Huang, S.M.3
  • 14
    • 33947635043 scopus 로고    scopus 로고
    • Physical and functional interactions of human papillomavirus E2 protein with nuclear receptor coactivators
    • Wu M.H., Huang C.J., Liu S.T., Liu P.Y., Ho C.L., Huang S.M. Physical and functional interactions of human papillomavirus E2 protein with nuclear receptor coactivators. Biochem. Biophys. Res. Commun. 2007, 356:523-528.
    • (2007) Biochem. Biophys. Res. Commun. , vol.356 , pp. 523-528
    • Wu, M.H.1    Huang, C.J.2    Liu, S.T.3    Liu, P.Y.4    Ho, C.L.5    Huang, S.M.6
  • 15
    • 85047696901 scopus 로고    scopus 로고
    • A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1
    • Rozenfeld-Granot G., Krishnamurthy J., Kannan K., Toren A., Amariglio N., Givol D., Rechavi G. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1. Oncogene 2002, 21:1469-1476.
    • (2002) Oncogene , vol.21 , pp. 1469-1476
    • Rozenfeld-Granot, G.1    Krishnamurthy, J.2    Kannan, K.3    Toren, A.4    Amariglio, N.5    Givol, D.6    Rechavi, G.7
  • 16
    • 0033955282 scopus 로고    scopus 로고
    • Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors
    • Huang S.M., Stallcup M.R. Mouse Zac1, a transcriptional coactivator and repressor for nuclear receptors. Mol. Cell. Biol. 2000, 20:1855-1867.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 1855-1867
    • Huang, S.M.1    Stallcup, M.R.2
  • 17
    • 51649119917 scopus 로고    scopus 로고
    • Modulation of the cyclin-dependent kinase inhibitor p21WAF1/Cip1 gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa cells
    • Liu P.Y., Chan J.Y., Lin H.C., Wang S.L., Liu S.T., Ho C.L., Chang L.C., Huang S.M. Modulation of the cyclin-dependent kinase inhibitor p21WAF1/Cip1 gene by Zac1 through the antagonistic regulators p53 and histone deacetylase 1 in HeLa cells. Mol. Cancer Res. 2008, 6:1204-1214.
    • (2008) Mol. Cancer Res. , vol.6 , pp. 1204-1214
    • Liu, P.Y.1    Chan, J.Y.2    Lin, H.C.3    Wang, S.L.4    Liu, S.T.5    Ho, C.L.6    Chang, L.C.7    Huang, S.M.8
  • 18
    • 0024290265 scopus 로고
    • Distinct regions of Sp1 modulate DNA binding and transcriptional activation
    • Kadonaga J.T., Courey A.J., Ladika J., Tjian R. Distinct regions of Sp1 modulate DNA binding and transcriptional activation. Science 1988, 242:1566-1570.
    • (1988) Science , vol.242 , pp. 1566-1570
    • Kadonaga, J.T.1    Courey, A.J.2    Ladika, J.3    Tjian, R.4
  • 19
    • 0023663884 scopus 로고
    • Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain
    • Kadonaga J.T., Carner K.R., Masiarz F.R., Tjian R. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 1987, 51:1079-1090.
    • (1987) Cell , vol.51 , pp. 1079-1090
    • Kadonaga, J.T.1    Carner, K.R.2    Masiarz, F.R.3    Tjian, R.4
  • 20
    • 44749090905 scopus 로고    scopus 로고
    • Sp1: emerging roles-beyond constitutive activation of TATA-less housekeeping genes
    • Wierstra I. Sp1: emerging roles-beyond constitutive activation of TATA-less housekeeping genes. Biochem. Biophys. Res. Commun. 2008, 372:1-13.
    • (2008) Biochem. Biophys. Res. Commun. , vol.372 , pp. 1-13
    • Wierstra, I.1
  • 21
    • 0033178330 scopus 로고    scopus 로고
    • A tale of three fingers: the family of mammalian Sp/XKLF transcription factors
    • Philipsen S., Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 1999, 27:2991-3000.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 2991-3000
    • Philipsen, S.1    Suske, G.2
  • 23
    • 0025995937 scopus 로고
    • Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism
    • Pascal E., Tjian R. Different activation domains of Sp1 govern formation of multimers and mediate transcriptional synergism. Genes Dev. 1991, 5:1646-1656.
    • (1991) Genes Dev. , vol.5 , pp. 1646-1656
    • Pascal, E.1    Tjian, R.2
  • 24
    • 0024811686 scopus 로고
    • Synergistic activation by the glutamine-rich domains of human transcription factor Sp1
    • Courey A.J., Holtzman D.A., Jackson S.P., Tjian R. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 1989, 59:827-836.
    • (1989) Cell , vol.59 , pp. 827-836
    • Courey, A.J.1    Holtzman, D.A.2    Jackson, S.P.3    Tjian, R.4
  • 25
    • 23044439366 scopus 로고    scopus 로고
    • Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK
    • Lee J.A., Suh D.C., Kang J.E., Kim M.H., Park H., Lee M.N., Kim J.M., Jeon B.N., Roh H.E., Yu M.Y., Choi K.Y., Kim K.Y., Hur M.W. Transcriptional activity of Sp1 is regulated by molecular interactions between the zinc finger DNA binding domain and the inhibitory domain with corepressors, and this interaction is modulated by MEK. J. Biol. Chem. 2005, 280:28061-28071.
    • (2005) J. Biol. Chem. , vol.280 , pp. 28061-28071
    • Lee, J.A.1    Suh, D.C.2    Kang, J.E.3    Kim, M.H.4    Park, H.5    Lee, M.N.6    Kim, J.M.7    Jeon, B.N.8    Roh, H.E.9    Yu, M.Y.10    Choi, K.Y.11    Kim, K.Y.12    Hur, M.W.13
  • 26
    • 41849083427 scopus 로고    scopus 로고
    • Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation
    • Spengler M.L., Guo L.W., Brattain M.G. Phosphorylation mediates Sp1 coupled activities of proteolytic processing, desumoylation and degradation. Cell Cycle 2008, 7:623-630.
    • (2008) Cell Cycle , vol.7 , pp. 623-630
    • Spengler, M.L.1    Guo, L.W.2    Brattain, M.G.3
  • 27
    • 33646838989 scopus 로고    scopus 로고
    • Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription
    • Spengler M.L., Brattain M.G. Sumoylation inhibits cleavage of Sp1 N-terminal negative regulatory domain and inhibits Sp1-dependent transcription. J. Biol. Chem. 2006, 281:5567-5574.
    • (2006) J. Biol. Chem. , vol.281 , pp. 5567-5574
    • Spengler, M.L.1    Brattain, M.G.2
  • 28
    • 0037201722 scopus 로고    scopus 로고
    • Regulation of the activity of Sp1-related transcription factors
    • Bouwman P., Philipsen S. Regulation of the activity of Sp1-related transcription factors. Mol. Cell. Endocrinol. 2002, 195:27-38.
    • (2002) Mol. Cell. Endocrinol. , vol.195 , pp. 27-38
    • Bouwman, P.1    Philipsen, S.2
  • 30
    • 0034532675 scopus 로고    scopus 로고
    • The biology of the mammalian Kruppel-like family of transcription factors
    • Dang D.T., Pevsner J., Yang V.W. The biology of the mammalian Kruppel-like family of transcription factors. Int. J. Biochem. Cell Biol. 2000, 32:1103-1121.
    • (2000) Int. J. Biochem. Cell Biol. , vol.32 , pp. 1103-1121
    • Dang, D.T.1    Pevsner, J.2    Yang, V.W.3
  • 31
    • 0028043272 scopus 로고
    • Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain
    • Murata Y., Kim H.G., Rogers K.T., Udvadia A.J., Horowitz J.M. Negative regulation of Sp1 trans-activation is correlated with the binding of cellular proteins to the amino terminus of the Sp1 trans-activation domain. J. Biol. Chem. 1994, 269:20674-20681.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20674-20681
    • Murata, Y.1    Kim, H.G.2    Rogers, K.T.3    Udvadia, A.J.4    Horowitz, J.M.5
  • 32
    • 0026558692 scopus 로고
    • Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1a
    • Weintraub S.J., Dean D.C. Interaction of a common factor with ATF, Sp1, or TATAA promoter elements is required for these sequences to mediate transactivation by the adenoviral oncogene E1a. Mol. Cell. Biol. 1992, 12:512-517.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 512-517
    • Weintraub, S.J.1    Dean, D.C.2
  • 33
    • 0025351398 scopus 로고
    • Mechanism of transcriptional activation by Sp1: evidence for coactivators
    • Pugh B.F., Tjian R. Mechanism of transcriptional activation by Sp1: evidence for coactivators. Cell 1990, 61:1187-1197.
    • (1990) Cell , vol.61 , pp. 1187-1197
    • Pugh, B.F.1    Tjian, R.2
  • 34
    • 0030772457 scopus 로고    scopus 로고
    • O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions
    • Roos M.D., Su K., Baker J.R., Kudlow J.E. O glycosylation of an Sp1-derived peptide blocks known Sp1 protein interactions. Mol. Cell. Biol. 1997, 17:6472-6480.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 6472-6480
    • Roos, M.D.1    Su, K.2    Baker, J.R.3    Kudlow, J.E.4
  • 35
    • 0030907389 scopus 로고    scopus 로고
    • Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility
    • Han I., Kudlow J.E. Reduced O glycosylation of Sp1 is associated with increased proteasome susceptibility. Mol. Cell. Biol. 1997, 17:2550-2558.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2550-2558
    • Han, I.1    Kudlow, J.E.2
  • 37
    • 33644750203 scopus 로고    scopus 로고
    • Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes
    • Mogal A., Abdulkadir S.A. Effects of Histone Deacetylase Inhibitor (HDACi); Trichostatin-A (TSA) on the expression of housekeeping genes. Mol. Cell. Probes 2006, 20:81-86.
    • (2006) Mol. Cell. Probes , vol.20 , pp. 81-86
    • Mogal, A.1    Abdulkadir, S.A.2
  • 38
    • 23944442199 scopus 로고    scopus 로고
    • Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1
    • Kang J.E., Kim M.H., Lee J.A., Park H., Min-Nyung L., Auh C.K., Hur M.W. Histone deacetylase-1 represses transcription by interacting with zinc-fingers and interfering with the DNA binding activity of Sp1. Cell. Physiol. Biochem. 2005, 16:23-30.
    • (2005) Cell. Physiol. Biochem. , vol.16 , pp. 23-30
    • Kang, J.E.1    Kim, M.H.2    Lee, J.A.3    Park, H.4    Min-Nyung, L.5    Auh, C.K.6    Hur, M.W.7
  • 41
    • 0028829465 scopus 로고
    • Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter
    • Datto M.B., Yu Y., Wang X.F. Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter. J. Biol. Chem. 1995, 270:28623-28628.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28623-28628
    • Datto, M.B.1    Yu, Y.2    Wang, X.F.3
  • 43
    • 33845204274 scopus 로고    scopus 로고
    • Human papillomavirus E2 protein associates with nuclear receptors to stimulate nuclear receptor- and E2-dependent transcriptional activations in human cervical carcinoma cells
    • Wu M.H., Chan J.Y., Liu P.Y., Liu S.T., Huang S.M. Human papillomavirus E2 protein associates with nuclear receptors to stimulate nuclear receptor- and E2-dependent transcriptional activations in human cervical carcinoma cells. Int. J. Biochem. Cell Biol. 2007, 39:413-425.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 413-425
    • Wu, M.H.1    Chan, J.Y.2    Liu, P.Y.3    Liu, S.T.4    Huang, S.M.5
  • 45
    • 0025828042 scopus 로고
    • Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription
    • Li R., Knight J.D., Jackson S.P., Tjian R., Botchan M.R. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell 1991, 65:493-505.
    • (1991) Cell , vol.65 , pp. 493-505
    • Li, R.1    Knight, J.D.2    Jackson, S.P.3    Tjian, R.4    Botchan, M.R.5
  • 48
  • 49
    • 33845678142 scopus 로고    scopus 로고
    • Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells
    • Januchowski R., Dabrowski M., Ofori H., Jagodzinski P.P. Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells. Cancer Lett. 2007, 246:313-317.
    • (2007) Cancer Lett. , vol.246 , pp. 313-317
    • Januchowski, R.1    Dabrowski, M.2    Ofori, H.3    Jagodzinski, P.P.4
  • 50
    • 16844370410 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells
    • Xiong Y., Dowdy S.C., Podratz K.C., Jin F., Attewell J.R., Eberhardt N.L., Jiang S.W. Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. Cancer Res. 2005, 65:2684-2689.
    • (2005) Cancer Res. , vol.65 , pp. 2684-2689
    • Xiong, Y.1    Dowdy, S.C.2    Podratz, K.C.3    Jin, F.4    Attewell, J.R.5    Eberhardt, N.L.6    Jiang, S.W.7
  • 51
    • 34250171437 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: signalling towards p21cip1/waf1
    • Ocker M., Schneider-Stock R. Histone deacetylase inhibitors: signalling towards p21cip1/waf1. Int. J. Biochem. Cell Biol. 2007, 39:1367-1374.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1367-1374
    • Ocker, M.1    Schneider-Stock, R.2
  • 52
    • 33749236250 scopus 로고    scopus 로고
    • A fungal family of transcriptional regulators: the zinc cluster proteins
    • MacPherson S., Larochelle M., Turcotte B. A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol. Mol. Biol. Rev. 2006, 70:583-604.
    • (2006) Microbiol. Mol. Biol. Rev. , vol.70 , pp. 583-604
    • MacPherson, S.1    Larochelle, M.2    Turcotte, B.3
  • 53
    • 0035253047 scopus 로고    scopus 로고
    • Zinc finger proteins: new insights into structural and functional diversity
    • Laity J.H., Lee B.M., Wright P.E. Zinc finger proteins: new insights into structural and functional diversity. Curr. Opin. Struct. Biol. 2001, 11:39-46.
    • (2001) Curr. Opin. Struct. Biol. , vol.11 , pp. 39-46
    • Laity, J.H.1    Lee, B.M.2    Wright, P.E.3
  • 54
    • 33745814786 scopus 로고    scopus 로고
    • 2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity
    • 2 zinc fingers link Zac DNA binding to coordinated regulation of p300-histone acetyltransferase activity. Mol. Cell. Biol. 2006, 26:5544-5557.
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 5544-5557
    • Hoffmann, A.1    Barz, T.2    Spengler, D.3
  • 55
    • 0033952803 scopus 로고    scopus 로고
    • Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding
    • Suzuki T., Kimura A., Nagai R., Horikoshi M. Regulation of interaction of the acetyltransferase region of p300 and the DNA-binding domain of Sp1 on and through DNA binding. Genes Cells 2000, 5:29-41.
    • (2000) Genes Cells , vol.5 , pp. 29-41
    • Suzuki, T.1    Kimura, A.2    Nagai, R.3    Horikoshi, M.4
  • 56
    • 0035800746 scopus 로고    scopus 로고
    • Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein
    • Koutsodontis G., Tentes I., Papakosta P., Moustakas A., Kardassis D. Sp1 plays a critical role in the transcriptional activation of the human cyclin-dependent kinase inhibitor p21(WAF1/Cip1) gene by the p53 tumor suppressor protein. J. Biol. Chem. 2001, 276:29116-29125.
    • (2001) J. Biol. Chem. , vol.276 , pp. 29116-29125
    • Koutsodontis, G.1    Tentes, I.2    Papakosta, P.3    Moustakas, A.4    Kardassis, D.5


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