Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines

Biochemical Pharmacology

Volumn 73, Issue 9, 2007, Pages 1297-1307

  Ou, Jing Ni ^a   Torrisani, Jérôme ^a   Unterberger, Alexander ^a   Provençal, Nadine ^a   Shikimi, Keisuke ^a   Karimi, Mohsen ^b   Ekström, Tomas J ^b   Szyf, Moshe ^a  

^a MCGILL UNIVERSITY   (Canada)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

DNA methylation; Histone acetylation; Histone deacetylase inhibitor; Hydroxyurea; Hypomethylation; Tumor suppressor gene

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; HYDROXYUREA; TRICHOSTATIN A; UVOMORULIN;

ARTICLE; BLADDER CARCINOMA; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INHIBITION; CHROMATIN; CONTROLLED STUDY; DEMETHYLATION; DNA METHYLATION; E CADHERIN GENE; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METHYLATION; PRIORITY JOURNAL; RARBETA2 GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE;

5' FLANKING REGION; ACETYLATION; BREAST NEOPLASMS; CADHERINS; DNA METHYLATION; DNA REPLICATION; ENZYME INHIBITORS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; INTERSPERSED REPETITIVE SEQUENCES; TRANSCRIPTION INITIATION SITE; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS;

EID: 33947368681     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.12.032     Document Type: Article

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