Verapamil: New insight into the molecular mechanism of drug oxidation in the human heart

Journal of Chromatography A

Volumn 970, Issue 1-2, 2002, Pages 117-130

  Walles, Markus ^a   Thum, Thomas ^a   Levsen, Karsten ^a   Borlak, Jürgen ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

Author keywords

Cytochrome P450; Drug oxidation; Heart; Verapamil

Indexed keywords

BIOLOGICAL ORGANS; DRUG PRODUCTS; DRUG THERAPY; ENZYMES; GENES; HYDROXYLATION; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; OXIDATION; TISSUE;

ELECTROSPRAY;

CARDIOLOGY;

AHEMIACETATE VERAPAMIL; CARBINOLAMINE VERAPAMIL; CYTOCHROME P450; FORMATE VERAPAMIL; N FORMYLVERAPAMIL; NORVERAPAMIL; UNCLASSIFIED DRUG; VERAPAMIL; VERAPAMIL DERIVATIVE;

ADOLESCENT; ADULT; ARTICLE; ATOM; CARDIOMYOPATHY; CONTROLLED STUDY; DRUG METABOLISM; DRUG OXIDATION; DRUG TRANSFORMATION; GENE EXPRESSION; HEART MUSCLE CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; HYDROXYLATION; ISOMER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MICROSOME; MOLECULAR MECHANICS; PRIORITY JOURNAL;

CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GENE EXPRESSION PROFILING; HUMANS; MYOCARDIUM; OXIDATION-REDUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; VERAPAMIL;

EID: 0037073078     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(02)00641-6     Document Type: Article

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