-
1
-
-
42949150113
-
High-throughput kinase profiling as a platform for drug discovery
-
DOI 10.1038/nrd2541, PII NRD2541
-
Goldstein DM, Gray NS, Zarrinkar PP. High-throughput kinase profiling as a platform for drug discovery. Nat Rev Drug Discov 2008; 7 : 391-7. (Pubitemid 351619111)
-
(2008)
Nature Reviews Drug Discovery
, vol.7
, Issue.5
, pp. 391-397
-
-
Goldstein, D.M.1
Gray, N.S.2
Zarrinkar, P.P.3
-
2
-
-
2342591455
-
The discovery of receptor tyrosine kinases: Targets for cancer therapy
-
Gschwind A, Fischer OM, Ullrich A. The discovery of receptor tyrosine kinases: targets for cancer therapy. Nat Rev Cancer 2004; 4 : 361-70. (Pubitemid 38579482)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.5
, pp. 361-370
-
-
Gschwind, A.1
Fischer, O.M.2
Ullrich, A.3
-
3
-
-
69949151386
-
Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
-
Jänne PA, Gray N, Settleman J. Factors underlying sensitivity of cancers to small-molecule kinase inhibitors. Nat Rev Drug Discov 2009; 8 : 709-23.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 709-723
-
-
Jänne, P.A.1
Gray, N.2
Settleman, J.3
-
4
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Knight ZA, Lin H, Shokat KM. Targeting the cancer kinome through polypharmacology. Nat Rev Cancer 2010; 10 : 130-7.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
5
-
-
72849127628
-
Kinase mutations in human disease: Interpreting genotype-phenotype relationships
-
Lahiry P, Torkamani A, Schork NJ, Hegele RA. Kinase mutations in human disease: interpreting genotype-phenotype relationships. Nat Rev Genet 2010; 11 : 60-74.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 60-74
-
-
Lahiry, P.1
Torkamani, A.2
Schork, N.J.3
Hegele, R.A.4
-
6
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang J, Yang PL, Gray NS. Targeting cancer with small molecule kinase inhibitors. Nat Rev Cancer 2009; 9 : 28-39.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
7
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G. EGFR antagonists in cancer treatment. N Engl J Med 2008; 358 : 1160-74.
-
(2008)
N Engl J Med
, vol.358
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
8
-
-
73349096261
-
Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
-
Hammerman PS, Jänne PA, Johnson BE. Resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer. Clin Cancer Res 2009; 15 : 7502-9.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7502-7509
-
-
Hammerman, P.S.1
Jänne, P.A.2
Johnson, B.E.3
-
9
-
-
18344390418
-
ERBB receptors and cancer: The complexity of targeted inhibitors
-
DOI 10.1038/nrc1609
-
Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005; 5 : 341-54. (Pubitemid 40637826)
-
(2005)
Nature Reviews Cancer
, vol.5
, Issue.5
, pp. 341-354
-
-
Hynes, N.E.1
Lane, H.A.2
-
10
-
-
63749086305
-
ErbB receptors and signaling pathways in cancer
-
Hynes NE, MacDonald G. ErbB receptors and signaling pathways in cancer. Curr Opin Cell Biol 2009; 21 : 177-84.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 177-184
-
-
Hynes, N.E.1
MacDonald, G.2
-
11
-
-
43249096031
-
Structure and clinical relevance of the epidermal growth factor receptor in human cancer
-
Kumar A, Petri ET, Halmos B, Boggon TJ. Structure and clinical relevance of the epidermal growth factor receptor in human cancer. J Clin Oncol 2008; 26 : 1742-51.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1742-1751
-
-
Kumar, A.1
Petri, E.T.2
Halmos, B.3
Boggon, T.J.4
-
12
-
-
77958478674
-
Rational, biologically based treatment of EGFRmutant non-small-cell lung cancer
-
PaoW, Chmielecki J. Rational, biologically based treatment of EGFRmutant non-small-cell lung cancer. Nat Rev Cancer 2010; 10 : 760- 74.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 760-774
-
-
Pao, W.1
Chmielecki, J.2
-
13
-
-
39649116928
-
EGFR tyrosine kinase inhibitors in lung cancer: An evolving story
-
DOI 10.1146/annurev.med.59.090506.202405
-
Sequist LV, Lynch TJ. EGFR tyrosine kinase inhibitors in lung cancer: an evolving story. Annu Rev Med 2008; 59 : 429-42. (Pubitemid 351287947)
-
(2008)
Annual Review of Medicine
, vol.59
, pp. 429-442
-
-
Sequist, L.V.1
Lynch, T.J.2
-
14
-
-
77958457521
-
Epidermal growth factor receptor inhibitors in oncology
-
Vivanco I, Mellinghoff IK. Epidermal growth factor receptor inhibitors in oncology. Curr Opin Oncol 2010; 22 : 573-8.
-
(2010)
Curr Opin Oncol
, vol.22
, pp. 573-578
-
-
Vivanco, I.1
Mellinghoff, I.K.2
-
15
-
-
75149170979
-
Fibroblast growth factor signalling: From development to cancer
-
Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 2010; 10 : 116-129.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 116-129
-
-
Turner, N.1
Grose, R.2
-
16
-
-
61649100307
-
The FGF family: Biology, pathophysiology and therapy
-
Beenken A, Mohammadi M. The FGF family: biology, pathophysiology and therapy. Nat Rev Drug Discov 2009; 8 : 235-53.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 235-253
-
-
Beenken, A.1
Mohammadi, M.2
-
17
-
-
77951709259
-
Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy
-
Zha J, Lackner MR. Targeting the insulin-like growth factor receptor-1R pathway for cancer therapy. Clin Cancer Res 2010; 16 : 2512-7.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2512-2517
-
-
Zha, J.1
Lackner, M.R.2
-
18
-
-
79951678633
-
IGF system in cancer: From bench to clinic
-
Chaves J, Saif MW. IGF system in cancer: from bench to clinic. Anticancer Drugs 2011; 22 : 206-12.
-
(2011)
Anticancer Drugs
, vol.22
, pp. 206-212
-
-
Chaves, J.1
Saif, M.W.2
-
19
-
-
56749110996
-
The type 1 insulin-like growth factor receptor pathway
-
Chitnis MM, Yuen JS, Protheroe AS, Pollak M, Macaulay VM. The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res 2008; 14 : 6364-70.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 6364-6370
-
-
Chitnis, M.M.1
Yuen, J.S.2
Protheroe, A.S.3
Pollak, M.4
Macaulay, V.M.5
-
20
-
-
69449097339
-
Emerging role of insulin-like growth factor receptor inhibitors in oncology: Early clinical trial results and future directions
-
Gualberto A, Pollak M. Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions. Oncogene 2009; 28 : 3009-21.
-
(2009)
Oncogene
, vol.28
, pp. 3009-3021
-
-
Gualberto, A.1
Pollak, M.2
-
21
-
-
77950552463
-
Targeting the HGF/Met signalling pathway in cancer
-
Cecchi F, Rabe DC, Bottaro DP. Targeting the HGF/Met signalling pathway in cancer. Eur J Cancer 2010; 46 : 1260-70.
-
(2010)
Eur J Cancer
, vol.46
, pp. 1260-1270
-
-
Cecchi, F.1
Rabe, D.C.2
Bottaro, D.P.3
-
22
-
-
67349189814
-
MET receptor tyrosine kinase as a therapeutic anticancer target
-
Stellrecht CM, Gandhi V. MET receptor tyrosine kinase as a therapeutic anticancer target. Cancer Lett 2009; 280 : 1-14.
-
(2009)
Cancer Lett
, vol.280
, pp. 1-14
-
-
Stellrecht, C.M.1
Gandhi, V.2
-
23
-
-
78650026375
-
ALK inhibition for non-small cell lung cancer: From discovery to therapy in record time
-
Gerber DE, Minna JD. ALK inhibition for non-small cell lung cancer: from discovery to therapy in record time. Cancer Cell 2010; 18 : 548-51.
-
(2010)
Cancer Cell
, vol.18
, pp. 548-551
-
-
Gerber, D.E.1
Minna, J.D.2
-
24
-
-
79954606778
-
Targeting anaplastic lymphoma kinase in lung cancer
-
Shaw AT, Solomon B. Targeting anaplastic lymphoma kinase in lung cancer. Clin Cancer Res 2011; 17 : 2081-6.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2081-2086
-
-
Shaw, A.T.1
Solomon, B.2
-
25
-
-
78449266238
-
Perspective on updated treatment guidelines for patients with gastrointestinal stromal tumors
-
Blay JY, von Mehren M, Blackstein ME. Perspective on updated treatment guidelines for patients with gastrointestinal stromal tumors. Cancer 2010; 116 : 5126-37.
-
(2010)
Cancer
, vol.116
, pp. 5126-5137
-
-
Blay, J.Y.1
Von Mehren, M.2
Blackstein, M.E.3
-
26
-
-
73349131387
-
Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors
-
Gramza AW, Corless CL, Heinrich MC. Resistance to tyrosine kinase inhibitors in gastrointestinal stromal tumors. Clin Cancer Res 2009; 15 : 7510-7518.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7510-7518
-
-
Gramza, A.W.1
Corless, C.L.2
Heinrich, M.C.3
-
27
-
-
78650073854
-
FLT3 as a therapeutic target in AML: Still challenging after all these years
-
Kindler T, Lipka DB, Fischer T. FLT3 as a therapeutic target in AML: still challenging after all these years. Blood 2010; 116 : 5089-102.
-
(2010)
Blood
, vol.116
, pp. 5089-5102
-
-
Kindler, T.1
Lipka, D.B.2
Fischer, T.3
-
28
-
-
78650412305
-
Targeting RET receptor tyrosine kinase activation in cancer
-
Phay JE, Shah MH. Targeting RET receptor tyrosine kinase activation in cancer. Clin Cancer Res 2010; 16 : 5936-41.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 5936-5941
-
-
Phay, J.E.1
Shah, M.H.2
-
29
-
-
73149115248
-
Targeting the RET pathway in thyroid cancer
-
Wells SA Jr, Santoro M. Targeting the RET pathway in thyroid cancer. Clin Cancer Res 2009; 15 : 7119-23.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7119-7123
-
-
Wells Jr., S.A.1
Santoro, M.2
-
30
-
-
58149398623
-
Translation of the Philadelphia chromosome into therapy for CML
-
Druker BJ. Translation of the Philadelphia chromosome into therapy for CML. Blood 2008; 112 : 4808-17.
-
(2008)
Blood
, vol.112
, pp. 4808-4817
-
-
Druker, B.J.1
-
31
-
-
34848929062
-
Flying under the radar: The new wave of BCR-ABL inhibitors
-
DOI 10.1038/nrd2324, PII NRD2324
-
Quintás-Cardama A, Kantarjian H, Cortes J. Flying under the radar: the new wave of BCR-ABL inhibitors. Nat Rev Drug Discov 2007; 6 : 834-48. (Pubitemid 47500507)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.10
, pp. 834-848
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
Cortes, J.3
-
32
-
-
77954690732
-
Advances in targeting SRC in the treatment of breast cancer and other solid malignancies
-
Mayer EL, Krop IE. Advances in targeting SRC in the treatment of breast cancer and other solid malignancies. Clin Cancer Res 2010; 16 : 3526-32.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3526-3532
-
-
Mayer, E.L.1
Krop, I.E.2
-
33
-
-
79952042862
-
Targeting myeloproliferative neoplasms with JAK inhibitors
-
Pardanani A, Tefferi A.Targeting myeloproliferative neoplasms with JAK inhibitors. Curr Opin Hematol 2011; 18 : 105-10.
-
(2011)
Curr Opin Hematol
, vol.18
, pp. 105-110
-
-
Pardanani, A.1
Tefferi, A.2
|