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Volumn 280, Issue 1, 2009, Pages 1-14

MET receptor tyrosine kinase as a therapeutic anticancer target

Author keywords

Hepatocyte growth factor; Met; Receptor tyrosine kinase; Targeted therapy

Indexed keywords

3 [1 (2,6 DICHLORO 3 FLUOROPHENYL)ETHOXY] 5 [1 (4 PIPERIDINYL) 1H PYRAZOL 4 YL] 2 PYRIDINYLAMINE; 5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; AMG 102; ANTINEOPLASTIC AGENT; ARQ 197; CE 355621; CNF 1010; CORDYCEPIN; FLAVOPIRIDOL; GELDANAMYCIN; GSK 1363089; INCBO 28060; MGCD 265; MP 470; N (3 CHLOROPHENYL) 3 [3,5 DIMETHYL 4 (4 METHYL 1 PIPERAZINYLCARBONYL) 1H PYRROL 2 YLMETHYLENE] 2,3 DIHYDRO N METHYL 2 OXO 1H INDOLE 5 SULFONAMIDE; PF 04217903; PF 4254644; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SGX 126; SNX 5422; SU 11271; SU 11606; TANESPIMYCIN; TANESPIMYCIN HYDROQUINONE; UNCLASSIFIED DRUG; UNINDEXED DRUG; XL 184; XL 880;

EID: 67349189814     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.10.045     Document Type: Review
Times cited : (54)

References (118)
  • 4
    • 0034693753 scopus 로고    scopus 로고
    • Met receptor tyrosine kinase: enhanced signaling through adapter proteins
    • Furge K.A., Zhang Y.W., and Vande Woude G.F. Met receptor tyrosine kinase: enhanced signaling through adapter proteins. Oncogene 19 (2000) 5582-5589
    • (2000) Oncogene , vol.19 , pp. 5582-5589
    • Furge, K.A.1    Zhang, Y.W.2    Vande Woude, G.F.3
  • 6
    • 38549115197 scopus 로고    scopus 로고
    • The Met tyrosine kinase receptor in development and cancer
    • Gentile A., Trusolino L., and Comoglio P.M. The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev. 27 (2008) 85-94
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 85-94
    • Gentile, A.1    Trusolino, L.2    Comoglio, P.M.3
  • 7
    • 19544389146 scopus 로고    scopus 로고
    • c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention
    • Christensen J.G., Burrows J., and Salgia R. c-Met as a target for human cancer and characterization of inhibitors for therapeutic intervention. Cancer Lett. 225 (2005) 1-26
    • (2005) Cancer Lett. , vol.225 , pp. 1-26
    • Christensen, J.G.1    Burrows, J.2    Salgia, R.3
  • 8
    • 0038724909 scopus 로고    scopus 로고
    • c-Met: structure, functions and potential for therapeutic inhibition
    • Ma P.C., Maulik G., Christensen J., and Salgia R. c-Met: structure, functions and potential for therapeutic inhibition. Cancer Metastasis Rev. 22 (2003) 309-325
    • (2003) Cancer Metastasis Rev. , vol.22 , pp. 309-325
    • Ma, P.C.1    Maulik, G.2    Christensen, J.3    Salgia, R.4
  • 10
    • 0032541006 scopus 로고    scopus 로고
    • The human hepatocyte growth factor receptor gene: complete structural organization and promoter characterization
    • Liu Y. The human hepatocyte growth factor receptor gene: complete structural organization and promoter characterization. Gene 215 (1998) 159-169
    • (1998) Gene , vol.215 , pp. 159-169
    • Liu, Y.1
  • 11
    • 0030474899 scopus 로고    scopus 로고
    • Role of hepatocyte growth factor in hemopoiesis
    • Ikehara S. Role of hepatocyte growth factor in hemopoiesis. Leuk. Lymphoma 23 (1996) 297-303
    • (1996) Leuk. Lymphoma , vol.23 , pp. 297-303
    • Ikehara, S.1
  • 13
    • 0030956759 scopus 로고    scopus 로고
    • Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway
    • van der Voort R., Taher T.E., Keehnen R.M., Smit L., Groenink M., and Pals S.T. Paracrine regulation of germinal center B cell adhesion through the c-met-hepatocyte growth factor/scatter factor pathway. J. Exp. Med. 185 (1997) 2121-2131
    • (1997) J. Exp. Med. , vol.185 , pp. 2121-2131
    • van der Voort, R.1    Taher, T.E.2    Keehnen, R.M.3    Smit, L.4    Groenink, M.5    Pals, S.T.6
  • 15
    • 0034939549 scopus 로고    scopus 로고
    • Pathway specificity for Met signalling
    • Comoglio P.M. Pathway specificity for Met signalling. Nat. Cell Biol. 3 (2001) E161-E162
    • (2001) Nat. Cell Biol. , vol.3
    • Comoglio, P.M.1
  • 16
    • 0033020148 scopus 로고    scopus 로고
    • The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase
    • Maroun C.R., Holgado-Madruga M., Royal I., Naujokas M.A., Fournier T.M., Wong A.J., and Park M. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Mol. Cell. Biol. 19 (1999) 1784-1799
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1784-1799
    • Maroun, C.R.1    Holgado-Madruga, M.2    Royal, I.3    Naujokas, M.A.4    Fournier, T.M.5    Wong, A.J.6    Park, M.7
  • 17
    • 0029997180 scopus 로고    scopus 로고
    • Constitutive activation of the RON gene promotes invasive growth but not transformation
    • Santoro M.M., Collesi C., Grisendi S., Gaudino G., and Comoglio P.M. Constitutive activation of the RON gene promotes invasive growth but not transformation. Mol. Cell. Biol. 16 (1996) 7072-7083
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 7072-7083
    • Santoro, M.M.1    Collesi, C.2    Grisendi, S.3    Gaudino, G.4    Comoglio, P.M.5
  • 18
    • 0038604793 scopus 로고    scopus 로고
    • Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin
    • Herynk M.H., Tsan R., Radinsky R., and Gallick G.E. Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. Clin. Exp. Metastasis 20 (2003) 291-300
    • (2003) Clin. Exp. Metastasis , vol.20 , pp. 291-300
    • Herynk, M.H.1    Tsan, R.2    Radinsky, R.3    Gallick, G.E.4
  • 19
    • 0036007194 scopus 로고    scopus 로고
    • Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis
    • Muller M., Morotti A., and Ponzetto C. Activation of NF-kappaB is essential for hepatocyte growth factor-mediated proliferation and tubulogenesis. Mol. Cell. Biol. 22 (2002) 1060-1072
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 1060-1072
    • Muller, M.1    Morotti, A.2    Ponzetto, C.3
  • 20
    • 25444461165 scopus 로고    scopus 로고
    • C-Met signalling: spatio-temporal decisions
    • Kermorgant S., and Parker P.J. C-Met signalling: spatio-temporal decisions. Cell Cycle 4 (2005) 352-355
    • (2005) Cell Cycle , vol.4 , pp. 352-355
    • Kermorgant, S.1    Parker, P.J.2
  • 21
    • 0034708826 scopus 로고    scopus 로고
    • Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells
    • Jo M., Stolz D.B., Esplen J.E., Dorko K., Michalopoulos G.K., and Strom S.C. Cross-talk between epidermal growth factor receptor and c-Met signal pathways in transformed cells. J. Biol. Chem. 275 (2000) 8806-8811
    • (2000) J. Biol. Chem. , vol.275 , pp. 8806-8811
    • Jo, M.1    Stolz, D.B.2    Esplen, J.E.3    Dorko, K.4    Michalopoulos, G.K.5    Strom, S.C.6
  • 23
    • 40749101512 scopus 로고    scopus 로고
    • Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
    • %R 10.1158/1541-7786.MCR-07-0236
    • Reznik T.E., Sang Y., Ma Y., Abounader R., Rosen E.M., Xia S., and Laterra J. Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor. Mol Cancer Res 6 (2008) 139-150 %R 10.1158/1541-7786.MCR-07-0236
    • (2008) Mol Cancer Res , vol.6 , pp. 139-150
    • Reznik, T.E.1    Sang, Y.2    Ma, Y.3    Abounader, R.4    Rosen, E.M.5    Xia, S.6    Laterra, J.7
  • 25
    • 33845697707 scopus 로고    scopus 로고
    • Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
    • Bertotti A., Comoglio P.M., and Trusolino L. Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J. Cell Biol. 175 (2006) 993-1003
    • (2006) J. Cell Biol. , vol.175 , pp. 993-1003
    • Bertotti, A.1    Comoglio, P.M.2    Trusolino, L.3
  • 28
    • 0026485023 scopus 로고
    • A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis
    • Hartmann G., Naldini L., Weidner K.M., Sachs M., Vigna E., Comoglio P.M., and Birchmeier W. A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc. Natl. Acad. Sci. USA 89 (1992) 11574-11578
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11574-11578
    • Hartmann, G.1    Naldini, L.2    Weidner, K.M.3    Sachs, M.4    Vigna, E.5    Comoglio, P.M.6    Birchmeier, W.7
  • 29
    • 0034709650 scopus 로고    scopus 로고
    • An antagonist of scatter factor/hepatocyte growth factor, Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor
    • Guerin C., Luddy C., Abounader R., Lal B., and Laterra J. An antagonist of scatter factor/hepatocyte growth factor, Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor. Biochem. Biophys. Res. Commun. 273 (2000) 287-293
    • (2000) Biochem. Biophys. Res. Commun. , vol.273 , pp. 287-293
    • Guerin, C.1    Luddy, C.2    Abounader, R.3    Lal, B.4    Laterra, J.5
  • 30
    • 15844393132 scopus 로고    scopus 로고
    • Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity
    • Cioce V., Csaky K.G., Chan A.M., Bottaro D.P., Taylor W.G., Jensen R., Aaronson S.A., and Rubin J.S. Hepatocyte growth factor (HGF)/NK1 is a naturally occurring HGF/scatter factor variant with partial agonist/antagonist activity. J. Biol. Chem. 271 (1996) 13110-13115
    • (1996) J. Biol. Chem. , vol.271 , pp. 13110-13115
    • Cioce, V.1    Csaky, K.G.2    Chan, A.M.3    Bottaro, D.P.4    Taylor, W.G.5    Jensen, R.6    Aaronson, S.A.7    Rubin, J.S.8
  • 33
    • 0031583998 scopus 로고    scopus 로고
    • HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor
    • Date K., Matsumoto K., Shimura H., Tanaka M., and Nakamura T. HGF/NK4 is a specific antagonist for pleiotrophic actions of hepatocyte growth factor. FEBS Lett. 420 (1997) 1-6
    • (1997) FEBS Lett. , vol.420 , pp. 1-6
    • Date, K.1    Matsumoto, K.2    Shimura, H.3    Tanaka, M.4    Nakamura, T.5
  • 34
    • 38449111543 scopus 로고    scopus 로고
    • NK4 gene therapy targeting HGF-Met and angiogenesis
    • Matsumoto K., and Nakamura T. NK4 gene therapy targeting HGF-Met and angiogenesis. Front. Biosci. 13 (2008) 1943-1951
    • (2008) Front. Biosci. , vol.13 , pp. 1943-1951
    • Matsumoto, K.1    Nakamura, T.2
  • 36
    • 3142619403 scopus 로고    scopus 로고
    • The Sema domain of Met is necessary for receptor dimerization and activation
    • Kong-Beltran M., Stamos J., and Wickramasinghe D. The Sema domain of Met is necessary for receptor dimerization and activation. Cancer Cell 6 (2004) 75-84
    • (2004) Cancer Cell , vol.6 , pp. 75-84
    • Kong-Beltran, M.1    Stamos, J.2    Wickramasinghe, D.3
  • 38
    • 0035912757 scopus 로고    scopus 로고
    • Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models
    • Cao B., Su Y., Oskarsson M., Zhao P., Kort E.J., Fisher R.J., Wang L.M., and Vande Woude G.F. Neutralizing monoclonal antibodies to hepatocyte growth factor/scatter factor (HGF/SF) display antitumor activity in animal models. Proc. Natl. Acad. Sci. USA 98 (2001) 7443-7448
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7443-7448
    • Cao, B.1    Su, Y.2    Oskarsson, M.3    Zhao, P.4    Kort, E.J.5    Fisher, R.J.6    Wang, L.M.7    Vande Woude, G.F.8
  • 39
    • 33644769210 scopus 로고    scopus 로고
    • Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
    • Kim K.J., Wang L., Su Y.C., Gillespie G.Y., Salhotra A., Lal B., and Laterra J. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin. Cancer Res. 12 (2006) 1292-1298
    • (2006) Clin. Cancer Res. , vol.12 , pp. 1292-1298
    • Kim, K.J.1    Wang, L.2    Su, Y.C.3    Gillespie, G.Y.4    Salhotra, A.5    Lal, B.6    Laterra, J.7
  • 41
    • 36749042647 scopus 로고    scopus 로고
    • AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts
    • Jun H.T., Sun J., Rex K., Radinsky R., Kendall R., Coxon A., and Burgess T.L. AMG 102, a fully human anti-hepatocyte growth factor/scatter factor neutralizing antibody, enhances the efficacy of temozolomide or docetaxel in U-87 MG cells and xenografts. Clin Cancer Res. 13 (2007) 6735-6742
    • (2007) Clin Cancer Res. , vol.13 , pp. 6735-6742
    • Jun, H.T.1    Sun, J.2    Rex, K.3    Radinsky, R.4    Kendall, R.5    Coxon, A.6    Burgess, T.L.7
  • 42
    • 55749088519 scopus 로고    scopus 로고
    • Phase II study of AMG 102 a fully human neutralizing antibody against hepatocyte growth factor/scatter factor in patients with recurrent glioblastoma multiforme
    • Reardon D.A., Cloughsey T.F., Raizer J.J., Laterra J., Schiff D., Yang X., Loh E., and Wen P.Y. Phase II study of AMG 102 a fully human neutralizing antibody against hepatocyte growth factor/scatter factor in patients with recurrent glioblastoma multiforme. J. Clin. Oncol. (Meeting Abstr.) 26 (2008) 2051
    • (2008) J. Clin. Oncol. (Meeting Abstr.) , vol.26 , pp. 2051
    • Reardon, D.A.1    Cloughsey, T.F.2    Raizer, J.J.3    Laterra, J.4    Schiff, D.5    Yang, X.6    Loh, E.7    Wen, P.Y.8
  • 48
    • 29244482571 scopus 로고    scopus 로고
    • Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia
    • Giles F.J., Cortes J.E., and Kantarjian H.M. Targeting the kinase activity of the BCR-ABL fusion protein in patients with chronic myeloid leukemia. Curr. Mol. Med. 5 (2005) 615-623
    • (2005) Curr. Mol. Med. , vol.5 , pp. 615-623
    • Giles, F.J.1    Cortes, J.E.2    Kantarjian, H.M.3
  • 49
    • 5144226615 scopus 로고    scopus 로고
    • A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
    • Hov H., Holt R.U., Ro T.B., Fagerli U.M., Hjorth-Hansen H., Baykov V., Christensen J.G., Waage A., Sundan A., and Borset M. A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells. Clin. Cancer Res. 10 (2004) 6686-6694
    • (2004) Clin. Cancer Res. , vol.10 , pp. 6686-6694
    • Hov, H.1    Holt, R.U.2    Ro, T.B.3    Fagerli, U.M.4    Hjorth-Hansen, H.5    Baykov, V.6    Christensen, J.G.7    Waage, A.8    Sundan, A.9    Borset, M.10
  • 50
    • 16844374901 scopus 로고    scopus 로고
    • A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin
    • Ma P.C., Schaefer E., Christensen J.G., and Salgia R. A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin. Clin. Cancer Res. 11 (2005) 2312-2319
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2312-2319
    • Ma, P.C.1    Schaefer, E.2    Christensen, J.G.3    Salgia, R.4
  • 53
    • 51749095291 scopus 로고    scopus 로고
    • Effect of a c-Met-specific ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth motility and invasion
    • Koon E.C., Ma P.C., Salgia R., Welch W.R., Christensen J.G., Berkowitz R.S., and Mok S.C. Effect of a c-Met-specific ATP-competitive small-molecule inhibitor SU11274 on human ovarian carcinoma cell growth motility and invasion. Int. J. Gynecol. Cancer 18 (2008) 976-984
    • (2008) Int. J. Gynecol. Cancer , vol.18 , pp. 976-984
    • Koon, E.C.1    Ma, P.C.2    Salgia, R.3    Welch, W.R.4    Christensen, J.G.5    Berkowitz, R.S.6    Mok, S.C.7
  • 60
    • 67349243424 scopus 로고    scopus 로고
    • Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule
    • Yap T.A., Harris D., Barriuso J., Wright M., Riisnaes R., Clark J., Ledaki I., Savage R., Chen T., and De Bono J.S. Phase I trial to determine the dose range for the c-Met inhibitor ARQ 197 that inhibits c-Met and FAK phosphorylation, when administered by an oral twice-a-day schedule. J. Clin. Oncol. 26 (2008) 3584
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3584
    • Yap, T.A.1    Harris, D.2    Barriuso, J.3    Wright, M.4    Riisnaes, R.5    Clark, J.6    Ledaki, I.7    Savage, R.8    Chen, T.9    De Bono, J.S.10
  • 64
    • 0034650543 scopus 로고    scopus 로고
    • The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network
    • Webb C.P., Hose C.D., Koochekpour S., Jeffers M., Oskarsson M., Sausville E., Monks A., and Vande Woude G.F. The geldanamycins are potent inhibitors of the hepatocyte growth factor/scatter factor-met-urokinase plasminogen activator-plasmin proteolytic network. Cancer Res. 60 (2000) 342-349
    • (2000) Cancer Res. , vol.60 , pp. 342-349
    • Webb, C.P.1    Hose, C.D.2    Koochekpour, S.3    Jeffers, M.4    Oskarsson, M.5    Sausville, E.6    Monks, A.7    Vande Woude, G.F.8
  • 66
    • 0033568455 scopus 로고    scopus 로고
    • Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression
    • Abounader R., Ranganathan S., Lal B., Fielding K., Book A., Dietz H., Burger P., and Laterra J. Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression. J. Natl. Cancer Inst. 91 (1999) 1548-1556
    • (1999) J. Natl. Cancer Inst. , vol.91 , pp. 1548-1556
    • Abounader, R.1    Ranganathan, S.2    Lal, B.3    Fielding, K.4    Book, A.5    Dietz, H.6    Burger, P.7    Laterra, J.8
  • 68
    • 35448969250 scopus 로고    scopus 로고
    • Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase
    • Stellrecht C.M., Phillip C.J., Cervantes-Gomez F., and Gandhi V. Multiple myeloma cell killing by depletion of the MET receptor tyrosine kinase. Cancer Res. 67 (2007) 9913-9920
    • (2007) Cancer Res. , vol.67 , pp. 9913-9920
    • Stellrecht, C.M.1    Phillip, C.J.2    Cervantes-Gomez, F.3    Gandhi, V.4
  • 69
    • 0034881625 scopus 로고    scopus 로고
    • A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells
    • Jiang W.G., Grimshaw D., Lane J., Martin T.A., Abounader R., Laterra J., and Mansel R.E. A hammerhead ribozyme suppresses expression of hepatocyte growth factor/scatter factor receptor c-MET and reduces migration and invasiveness of breast cancer cells. Clin. Cancer Res. 7 (2001) 2555-2562
    • (2001) Clin. Cancer Res. , vol.7 , pp. 2555-2562
    • Jiang, W.G.1    Grimshaw, D.2    Lane, J.3    Martin, T.A.4    Abounader, R.5    Laterra, J.6    Mansel, R.E.7
  • 71
    • 0038572603 scopus 로고    scopus 로고
    • Reduced c-Met expression by an adenovirus expressing a c-Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model
    • Kim S.J., Johnson M., Koterba K., Herynk M.H., Uehara H., and Gallick G.E. Reduced c-Met expression by an adenovirus expressing a c-Met ribozyme inhibits tumorigenic growth and lymph node metastases of PC3-LN4 prostate tumor cells in an orthotopic nude mouse model. Clin. Cancer Res. 9 (2003) 5161-5170
    • (2003) Clin. Cancer Res. , vol.9 , pp. 5161-5170
    • Kim, S.J.1    Johnson, M.2    Koterba, K.3    Herynk, M.H.4    Uehara, H.5    Gallick, G.E.6
  • 72
    • 0141566669 scopus 로고    scopus 로고
    • Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET
    • Jiang W.G., Grimshaw D., Martin T.A., Davies G., Parr C., Watkins G., Lane J., Abounader R., Laterra J., and Mansel R.E. Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET. Clin. Cancer Res. 9 (2003) 4274-4281
    • (2003) Clin. Cancer Res. , vol.9 , pp. 4274-4281
    • Jiang, W.G.1    Grimshaw, D.2    Martin, T.A.3    Davies, G.4    Parr, C.5    Watkins, G.6    Lane, J.7    Abounader, R.8    Laterra, J.9    Mansel, R.E.10
  • 73
    • 0036365052 scopus 로고    scopus 로고
    • In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis
    • Abounader R., Lal B., Luddy C., Koe G., Davidson B., Rosen E.M., and Laterra J. In vivo targeting of SF/HGF and c-met expression via U1snRNA/ribozymes inhibits glioma growth and angiogenesis and promotes apoptosis. FASEB J. 16 (2002) 108-110
    • (2002) FASEB J. , vol.16 , pp. 108-110
    • Abounader, R.1    Lal, B.2    Luddy, C.3    Koe, G.4    Davidson, B.5    Rosen, E.M.6    Laterra, J.7
  • 74
    • 0033882022 scopus 로고    scopus 로고
    • Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways
    • Bowers D.C., Fan S., Walter K.A., Abounader R., Williams J.A., Rosen E.M., and Laterra J. Scatter factor/hepatocyte growth factor protects against cytotoxic death in human glioblastoma via phosphatidylinositol 3-kinase- and AKT-dependent pathways. Cancer Res. 60 (2000) 4277-4283
    • (2000) Cancer Res. , vol.60 , pp. 4277-4283
    • Bowers, D.C.1    Fan, S.2    Walter, K.A.3    Abounader, R.4    Williams, J.A.5    Rosen, E.M.6    Laterra, J.7
  • 76
    • 7444231680 scopus 로고    scopus 로고
    • RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival
    • Shinomiya N., Gao C.F., Xie Q., Gustafson M., Waters D.J., Zhang Y.W., and Vande Woude G.F. RNA interference reveals that ligand-independent met activity is required for tumor cell signaling and survival. Cancer Res. 64 (2004) 7962-7970
    • (2004) Cancer Res. , vol.64 , pp. 7962-7970
    • Shinomiya, N.1    Gao, C.F.2    Xie, Q.3    Gustafson, M.4    Waters, D.J.5    Zhang, Y.W.6    Vande Woude, G.F.7
  • 78
    • 38549156012 scopus 로고    scopus 로고
    • Silencing the MET oncogene leads to regression of experimental tumors and metastases
    • Corso S., Migliore C., Ghiso E., De Rosa G., Comoglio P.M., and Giordano S. Silencing the MET oncogene leads to regression of experimental tumors and metastases. Oncogene 27 (2008) 684-693
    • (2008) Oncogene , vol.27 , pp. 684-693
    • Corso, S.1    Migliore, C.2    Ghiso, E.3    De Rosa, G.4    Comoglio, P.M.5    Giordano, S.6
  • 79
    • 33750287121 scopus 로고    scopus 로고
    • Involvement of c-Met/hepatocyte growth factor pathway in cholangiocarcinoma cell invasion and its therapeutic inhibition with small interfering RNA specific for c-Met
    • Leelawat K., Leelawat S., Tepaksorn P., Rattanasinganchan P., Leungchaweng A., Tohtong R., and Sobhon P. Involvement of c-Met/hepatocyte growth factor pathway in cholangiocarcinoma cell invasion and its therapeutic inhibition with small interfering RNA specific for c-Met. J. Surg. Res. 136 (2006) 78-84
    • (2006) J. Surg. Res. , vol.136 , pp. 78-84
    • Leelawat, K.1    Leelawat, S.2    Tepaksorn, P.3    Rattanasinganchan, P.4    Leungchaweng, A.5    Tohtong, R.6    Sobhon, P.7
  • 80
    • 58849145656 scopus 로고    scopus 로고
    • Targeting MET transcription as a therapeutic strategy in multiple myeloma
    • in press, doi:10.1007/300280-008-0770-2
    • C.J. Phillip, C.M. Stellrecht, R. Nimmanapalli, V. Gandhi, Targeting MET transcription as a therapeutic strategy in multiple myeloma, Cancer Chemother, Pharmacol. (2008), in press, doi:10.1007/300280-008-0770-2.
    • (2008) Cancer Chemother, Pharmacol
    • Phillip, C.J.1    Stellrecht, C.M.2    Nimmanapalli, R.3    Gandhi, V.4
  • 81
    • 0037025173 scopus 로고    scopus 로고
    • Addiction to oncogenes - the Achilles heal of cancer
    • Weinstein I.B. Addiction to oncogenes - the Achilles heal of cancer. Science 297 (2002) 63-64
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 82
    • 44849093562 scopus 로고    scopus 로고
    • Oncogene addiction
    • discussion 3080
    • Weinstein I.B., and Joe A. Oncogene addiction. Cancer Res. 68 (2008) 3077-3080 discussion 3080
    • (2008) Cancer Res. , vol.68 , pp. 3077-3080
    • Weinstein, I.B.1    Joe, A.2
  • 84
    • 27544457328 scopus 로고    scopus 로고
    • Transcription inhibition: a potential strategy for cancer therapeutics
    • Derheimer F.A., Chang C.W., and Ljungman M. Transcription inhibition: a potential strategy for cancer therapeutics. Eur. J Cancer 41 (2005) 2569-2576
    • (2005) Eur. J Cancer , vol.41 , pp. 2569-2576
    • Derheimer, F.A.1    Chang, C.W.2    Ljungman, M.3
  • 85
    • 33644746743 scopus 로고    scopus 로고
    • A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity
    • Radhakrishnan S.K., and Gartel A.L. A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity. Cancer Res. 66 (2006) 3264-3270
    • (2006) Cancer Res. , vol.66 , pp. 3264-3270
    • Radhakrishnan, S.K.1    Gartel, A.L.2
  • 86
    • 0028788194 scopus 로고
    • AU-rich elements: characterization and importance in mRNA degradation
    • Chen C.Y., and Shyu A.B. AU-rich elements: characterization and importance in mRNA degradation. Trends Biochem. Sci. 20 (1995) 465-470
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 465-470
    • Chen, C.Y.1    Shyu, A.B.2
  • 87
    • 0028318915 scopus 로고
    • Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript
    • Moghul A., Lin L., Beedle A., Kanbour-Shakir A., DeFrances M.C., Liu Y., and Zarnegar R. Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript. Oncogene 9 (1994) 2045-2052
    • (1994) Oncogene , vol.9 , pp. 2045-2052
    • Moghul, A.1    Lin, L.2    Beedle, A.3    Kanbour-Shakir, A.4    DeFrances, M.C.5    Liu, Y.6    Zarnegar, R.7
  • 88
    • 0345012136 scopus 로고    scopus 로고
    • 8-Chloro-cAMP serves as a prodrug for the RNA directed nucleoside analog 8-chloro-adenosine
    • Hiddemann W., Büchner T., Ritter J., Unterhalt M., and Haferlach T. (Eds), Springer-Verlag, Heidelberg, Germany
    • Stellrecht C.M., Krett N., Ayres M., Rosen S., and Gandhi V. 8-Chloro-cAMP serves as a prodrug for the RNA directed nucleoside analog 8-chloro-adenosine. In: Hiddemann W., Büchner T., Ritter J., Unterhalt M., and Haferlach T. (Eds). Acute Leukemia IX: Basic Research Experimental Approaches and Novel Therapies (2003), Springer-Verlag, Heidelberg, Germany 193-199
    • (2003) Acute Leukemia IX: Basic Research Experimental Approaches and Novel Therapies , pp. 193-199
    • Stellrecht, C.M.1    Krett, N.2    Ayres, M.3    Rosen, S.4    Gandhi, V.5
  • 89
    • 0345275863 scopus 로고    scopus 로고
    • RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells
    • Stellrecht C.M., Rodriguez Jr. C.O., Ayres M., and Gandhi V. RNA-directed actions of 8-chloro-adenosine in multiple myeloma cells. Cancer Res. 63 (2003) 7968-7974
    • (2003) Cancer Res. , vol.63 , pp. 7968-7974
    • Stellrecht, C.M.1    Rodriguez Jr., C.O.2    Ayres, M.3    Gandhi, V.4
  • 90
    • 4644355516 scopus 로고    scopus 로고
    • Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs
    • Chen L.S., and Sheppard T.L. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J. Biol. Chem. 279 (2004) 40405-40411
    • (2004) J. Biol. Chem. , vol.279 , pp. 40405-40411
    • Chen, L.S.1    Sheppard, T.L.2
  • 91
    • 0033646291 scopus 로고    scopus 로고
    • Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status
    • Kelland L.R. Flavopiridol, the first cyclin-dependent kinase inhibitor to enter the clinic: current status,. Expert Opin. Investig. Drugs 9 (2000) 2903-2911
    • (2000) Expert Opin. Investig. Drugs , vol.9 , pp. 2903-2911
    • Kelland, L.R.1
  • 93
    • 0035943710 scopus 로고    scopus 로고
    • Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
    • Chao S.H., and Price D.H. Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J. Biol. Chem. 276 (2001) 31793-31799
    • (2001) J. Biol. Chem. , vol.276 , pp. 31793-31799
    • Chao, S.H.1    Price, D.H.2
  • 94
    • 39749115845 scopus 로고    scopus 로고
    • RNA-directed agent Cordycepin, induces cell death in multiple myeloma cells
    • Chen L.S., Stellrecht C.M., and Gandhi V. RNA-directed agent Cordycepin, induces cell death in multiple myeloma cells. Br. J. Haematol. 140 (2008) 682-691
    • (2008) Br. J. Haematol. , vol.140 , pp. 682-691
    • Chen, L.S.1    Stellrecht, C.M.2    Gandhi, V.3
  • 95
    • 33845285906 scopus 로고    scopus 로고
    • A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia
    • Chen R., Gandhi V., and Plunkett W. A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia. Cancer Res. 66 (2006) 10959-10966
    • (2006) Cancer Res. , vol.66 , pp. 10959-10966
    • Chen, R.1    Gandhi, V.2    Plunkett, W.3
  • 101
    • 67349159787 scopus 로고    scopus 로고
    • Inhibition of erlotinib resistance on HER-family tyrosine kinases by combination with MP470 a multi-targeted TK inhibitor in prostate and breast cancer
    • Qi W., Cooke L., Stejskal A., Bearss D., and Mahadevan D. Inhibition of erlotinib resistance on HER-family tyrosine kinases by combination with MP470 a multi-targeted TK inhibitor in prostate and breast cancer. Proc. Am. Assoc. Cancer Res. 49 (2008) 671
    • (2008) Proc. Am. Assoc. Cancer Res. , vol.49 , pp. 671
    • Qi, W.1    Cooke, L.2    Stejskal, A.3    Bearss, D.4    Mahadevan, D.5
  • 102
    • 67349117755 scopus 로고    scopus 로고
    • Activity of the multi-targeted, receptor tyrosine kinase inhibitor MP470 against synovial sarcoma cells
    • Trevor K., Combs D., Mahadevan D., Bearss D., and Cranmer L. Activity of the multi-targeted, receptor tyrosine kinase inhibitor MP470 against synovial sarcoma cells. Proc. Am. Assoc. Cancer Res. 49 (2008) 4891
    • (2008) Proc. Am. Assoc. Cancer Res. , vol.49 , pp. 4891
    • Trevor, K.1    Combs, D.2    Mahadevan, D.3    Bearss, D.4    Cranmer, L.5
  • 103
    • 37549059613 scopus 로고    scopus 로고
    • Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma
    • Christensen J.G., Zou H.Y., Arango M.E., Li Q., Lee J.H., McDonnell S.R., Yamazaki S., Alton G.R., Mroczkowski B., and Los G. Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma,. Mol. Cancer Ther. 6 (2007) 3314-3322
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 3314-3322
    • Christensen, J.G.1    Zou, H.Y.2    Arango, M.E.3    Li, Q.4    Lee, J.H.5    McDonnell, S.R.6    Yamazaki, S.7    Alton, G.R.8    Mroczkowski, B.9    Los, G.10
  • 107
    • 36549021634 scopus 로고    scopus 로고
    • A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184 a VEGFR and MET kinase inhibitor administered orally to patients (pts) with advanced malignancies
    • Salgia R., Hong D.S., Camacho L.H., Ng C.S., Janisch L., Ratain M.J., and Kurzrock R. A phase I dose-escalation study of the safety and pharmacokinetics (PK) of XL184 a VEGFR and MET kinase inhibitor administered orally to patients (pts) with advanced malignancies. J. Clin. Oncol. 25 (2007) 14031
    • (2007) J. Clin. Oncol. , vol.25 , pp. 14031
    • Salgia, R.1    Hong, D.S.2    Camacho, L.H.3    Ng, C.S.4    Janisch, L.5    Ratain, M.J.6    Kurzrock, R.7
  • 108
    • 56849132326 scopus 로고    scopus 로고
    • A phase I study of XL184 a RET VEGFR2 and MET kinase inhibitor in patients (pts) with advanced malignancies including pts with medullary thyroid cancer (MTC)
    • Salgia R., Sherman S., Hong D.S., Ng C.S., Frye J., Janisch L., Ratain M.J., and Kurzrock R. A phase I study of XL184 a RET VEGFR2 and MET kinase inhibitor in patients (pts) with advanced malignancies including pts with medullary thyroid cancer (MTC). J. Clin. Oncol. 26 (2008) 3522
    • (2008) J. Clin. Oncol. , vol.26 , pp. 3522
    • Salgia, R.1    Sherman, S.2    Hong, D.S.3    Ng, C.S.4    Frye, J.5    Janisch, L.6    Ratain, M.J.7    Kurzrock, R.8
  • 112
    • 33947280591 scopus 로고    scopus 로고
    • Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions
    • Anderson K.C. Targeted therapy of multiple myeloma based upon tumor-microenvironmental interactions. Exp. Hematol. 35 (2007) 155-162
    • (2007) Exp. Hematol. , vol.35 , pp. 155-162
    • Anderson, K.C.1
  • 114
    • 41049105321 scopus 로고    scopus 로고
    • IPI-504 a novel and soluble HSP-90 inhibitor blocks the unfolded protein response in multiple myeloma cells
    • Patterson J., Palombella V.J., Fritz C., and Normant E. IPI-504 a novel and soluble HSP-90 inhibitor blocks the unfolded protein response in multiple myeloma cells. Cancer Chemother. Pharmacol. 61 (2008) 923-932
    • (2008) Cancer Chemother. Pharmacol. , vol.61 , pp. 923-932
    • Patterson, J.1    Palombella, V.J.2    Fritz, C.3    Normant, E.4
  • 116
  • 118
    • 59349095516 scopus 로고    scopus 로고
    • Preliminary activity of XL880 a dual MET/VEGFR2 inhibitor in MET amplified poorly differentiated gastric cancer (PDGC): interim results of a multicenter phase II study
    • Jhawer M.P., Kindler H.L., Wainberg Z.A., Hecht J.R., Kerr R.O., Ford J.M., Henderson C., Mueller T., Keer H.N., and Shah M.A. Preliminary activity of XL880 a dual MET/VEGFR2 inhibitor in MET amplified poorly differentiated gastric cancer (PDGC): interim results of a multicenter phase II study. J. Clin. Oncol. 26 (2008) 4572
    • (2008) J. Clin. Oncol. , vol.26 , pp. 4572
    • Jhawer, M.P.1    Kindler, H.L.2    Wainberg, Z.A.3    Hecht, J.R.4    Kerr, R.O.5    Ford, J.M.6    Henderson, C.7    Mueller, T.8    Keer, H.N.9    Shah, M.A.10


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