Priming with very low-affinity peptide ligands gives rise to CD8 + T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression

Cancer Immunology, Immunotherapy

Volumn 60, Issue 11, 2011, Pages 1543-1551

  O'Sullivan, Jeremy A ^a   Zloza, Andrew ^a   Kohlhapp, Frederick J ^a   Moore, Tamson V ^a   Lacek, Andrew T ^a   Dulin, Nickolai O ^a   Guevara Patiño, José A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

CD8 + T cells; RGS3; T cell receptor affinity; TGF ; Tumor induced suppression

Indexed keywords

CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CANCER IMMUNOLOGY; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; EFFECTOR CELL; IMMUNOREGULATION; LIGAND BINDING; LYMPHOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; DOWN-REGULATION; GTP-BINDING PROTEINS; GTPASE-ACTIVATING PROTEINS; HUMANS; LIGANDS; MICE; MICE, INBRED C57BL; OLIGOPEPTIDES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

EID: 82355185990     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-011-1043-1     Document Type: Article

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