Structure, stability, and mobility of a lyophilized IgG1 monoclonal antibody as determined using second-derivative infrared spectroscopy

Journal of Pharmaceutical Sciences

Volumn 101, Issue 1, 2012, Pages 81-91

  Murphy, Brian M ^a,b   Zhang, Ning ^c   Payne, Robert W ^a,b   Davis, Janice M ^d   Abdul fattah, Ahmad M ^e   Matsuura, James E ^c   Herman, Alan C ^c,d   Manning, Mark Cornell ^a,b  

^a Legacy BioDesign LLC   (United States)

^b Veterinary Dentistry and Oral Surgery   (United States)

^c Althea Technologies   (United States)

^d Althea Technologies   (United States)

^e BIOGEN   (United States)

Author keywords

Infrared spectroscopy; Lyophilization; Monoclonal antibody; Protein formulation; Stabilty

Indexed keywords

IMMUNOGLOBULIN G1 ANTIBODY; PLASTICIZER; SORBITOL; SUCROSE;

ARTICLE; BETA SHEET; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; HUMAN; INFRARED SPECTROSCOPY; PROTEIN POLYMORPHISM; STRUCTURE ANALYSIS;

EID: 82255192511     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22753     Document Type: Article

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