Impact of bulking agents on the stability of a lyophilized monoclonal antibody

European Journal of Pharmaceutical Sciences

Volumn 38, Issue 1, 2009, Pages 29-38

  Meyer, Jeffrey D ^a   Nayar, Rajiv ^b   Manning, Mark Cornell ^a,c  

^a UNIVERSITY OF COLORADO   (United States)

^b HTD Biosystems   (United States)

^c Legacy BioDesign LLC   (United States)

Author keywords

Bulking agents; Glycine; Lyophilization; Mannitol; Monoclonal antibody

Indexed keywords

BULKING AGENT; GLYCINE; MANNITOL; MONOCLONAL ANTIBODY; PLASTICIZER; STABILIZING AGENT; SUCROSE;

ANTIBODY STRUCTURE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DEAMINATION; DRUG DEGRADATION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; FREEZE DRYING; GLASS TRANSITION TEMPERATURE; INFRARED SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; SOLID STATE; WATER CONTENT;

AMIDES; ANTIBODIES, MONOCLONAL; ASPARAGINE; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; EXCIPIENTS; FREEZE DRYING; GLUTAMINE; GLYCINE; MANNOSE; PHARMACEUTIC AIDS; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SUCROSE; TRANSITION TEMPERATURE; TUMOR NECROSIS FACTOR-ALPHA; WATER;

EID: 67650257183     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.05.008     Document Type: Article

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