The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 20, 2002, Pages 13260-13265

  Martinez, Sergio E ^a   Wu, Albert Y ^a   Glavas, Natalie A ^a   Tang, Xiao Bo ^a   Turley, Stewart ^b   Hol, Wim G J ^a,b   Beavo, Joseph A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2A; RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; ATOM; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME STRUCTURE; GENOME ANALYSIS; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC GMP; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; MICE; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

ANABAENA; BACTERIA (MICROORGANISMS);

EID: 0036790852     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.192374899     Document Type: Article

References (34)

1. Aravind, L. & Ponting, C. P. (1997) Trends Biochem. Sci. 22, 458-459.
2. Ho, Y. S., Burden, L. M. & Hurley, J. H. (2000) EMBO J. 19, 5288-5299.
3. Gillespie, P. G. & Beavo, J. A. (1989) Proc. Natl. Acad. Sci. USA 86, 4311-4315.
4. Turko, I. V., Francis, S. H. & Corbin, J. D. (1998) Biochem. J. 329.
5. Corbin, J. D., Turko, I. V., Beasley, A. & Francis, S. H. (2000) Eur. J. Biochem. 267, 2760-2767.
6. Martins, T. J., Mumby, M. C. & Beavo, J. A. (1982) J. Biol. Chem. 257, 1973-1979.
7. Rosman, G. J., Martins, T. J., Sonnenburg, W. K., Beavo, J. A., Ferguson, K. & Loughney, K. (1997) Gene 191, 89-95.
8. Juilfs, D. M., Fulle, H. J., Zhao, A. Z., Houslay, M. D., Garbers, D. L. & Beavo, J. A. (1997) Proc. Natl. Acad. Sci. USA 94, 3388-3395.
9. Repaske, D. R., Corbin, J. G., Conti, M. & Goy, M. F. (1993) Neuroscience 56, 673-686.
10. Rivet-Bastide, M., Vandecasteele, G., Hatem, S., Verde, I., Benardeau, A., Mercadier, J. J. & Fischmeister, R. (1997) J. Clin. Invest. 99, 2710-2718.
11. Goaillard, J. M., Vincent, P. & Fischmeister, R. (2001) J. Physiol. (London) 530, 79-91.
12. Dickinson, N. T., Jang, E. K. & Haslam, R. J. (1997) Biochem. J. 323, 371-377.
13. MacFarland, R. T., Zelus, B. D. & Beavo, J. A. (1991) J. Biol. Chem. 266, 136-142.
14. Kanacher, T., Schultz, A., Linder, J. U. & Schultz, J. E. (2002)EMBO J. 21,1-9.
15. Terwilliger, T. C. & Berendzen, J. (1999) Acta Crystallogr. D 55, 849-861.
16. Terwilliger, T. C. (2000) Acta Crystallogr. D 56, 965-972.
17. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
18. Stroop, S. D. & Beavo, J. A. (1991) J. Biol. Chem. 266, 23802-23809.
19. Leon, D. A., Herberg, F. W., Banky, P. & Taylor, S. S. (1997) J. Biol. Chem. 272, 28431-28437.
20. Erneux, C. & Miot, F. (1988) Methods Enzymol. 159, 520-540.
21. Erneux, C., Miot, F., Van, H. P. J. & Jastorff, B. (1985) J. Cyclic Nucleotide Protein Phosphor. Res. 10, 463-472.
22. Miot, F., Van, H. P. J. & Erneux, C. (1985) Eur. J. Biochem. 149, 59-65.
23. Yamamoto, T., Manganiello, V. C. & Vaughan, M. (1983) J. Biol. Chem. 258, 12526-12533.
24. Whalin, M. E., Strada, S. J. & Thompson, W. J. (1988) Biochim. Biophys. Acta 972, 79-94.
25. Moss, J., Manganiello, V. C. & Vaughan, M. (1977) J. Biol. Chem. 252, 5211-5215.
26. Erneux, C., Couchie, D., Dumont, J. E., Baraniak, J., Stec, W. J., Abbad, E. G., Petridis, G. & Jastorff, B. (1981) Eur J. Biochem. 115, 503-510.
27. Wada, H., Osborne, J. J. & Manganiello, V. C. (1987) Biochemistry 26, 6565-6570.
28. Charbonneau, H., Prusti, R. K., LeTrong, H., Sonnenburg, W. K., Mullaney, P. J., Walsh, K. A. & Beavo, J. A. (1990) Proc. Natl. Acad. Sci. USA 87, 288-292.
29. Turko, I. V., Haik, T. L., McAllister-Lucas, L. M., Burns, F., Francis, S. H. & Corbin, J. D. (1996) J. Biol. Chem. 271, 22240-22244.
30. Liu, L., Underwood, T., Li, H., Pamukcu, R. & Thompson, W. J. (2002) Cell. Signalling 14, 45-51.
31. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
32. Merritt, E. A. & Bacon, D. J. (1997) Methods Enzymol. 277, 505-524.
33. Wallace, A. C., Laskowski, R. A. & Thornton, J. M. (1995) Protein Eng. 8, 127-134.
34. Hebert, M. C., Schwede, F., Jastorff, B. & Cote, R. H. (1998) J. Biol. Chem. 273, 5557-5565.