AKAP-mediated targeting of protein kinase A regulates contractility in cardiac myocytes

Circulation Research

Volumn 88, Issue 3, 2001, Pages 291-297

  Fink, Mary A ^a   Zakhary, Daniel R ^a   Mackey, Julie A ^a   Desnoyer, Russell W ^a   Apperson Hansen, Carolyn ^a   Damron, Derek S ^a   Bond, Meredith ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

Author keywords

A kinase anchoring proteins; Cardiac myocyte; Contractility; Protein kinase A; adrenergic receptor

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; MYOSIN BINDING PROTEIN C; PROLINE DERIVATIVE; TROPONIN I;

ADENOVIRUS; ARTICLE; BETA ADRENERGIC STIMULATION; CALCIUM TRANSPORT; CELL COMPARTMENTALIZATION; CELL FUNCTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME REGULATION; ENZYME SUBUNIT; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS INFECTION;

EID: 0035895592     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.88.3.291     Document Type: Article

References (40)

1. Modification of calcium requirements for activation of cardiac myofibrillar ATPase by cyclic AMP dependent phosphorylation
2. Phosphorylation of troponin I and phospholamban during catecholamine stimulation of rabbit heart
3. β-adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp
4. Phosphorylation of C-protein, troponin-I and phospholamban in isolated rabbit hearts
5. PKA phosphorylation dissociated FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
6. Effects of forskolin on contractile responses and protein phosphorylation in the isolated perfused rat heart
7. AKAPs: From structure to function
8. Adenylyl cyclases and the interaction between calcium and cAMP signalling
9. A-kinase anchoring protein 100 (AKAP100) is localized in multiple subcellular compartments in the adult rat heart
10. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain
11. Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins
12. Cloning and characterization of A-kinase anchor protein 100 (AKAP 100)
13. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels
14. A novel lipid-anchored A-kinase anchoring protein facilitates cAMP-responsive membrane events
15. MAKAP: An A-kinase anchoring protein targeted to the nuclear membrane of differentiated myocytes
16. Techniques for human adenovirus vector construction and characterization
17. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein
18. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion
19. 2+ transients in individual rat ventricular myocytes
20. Adenovirus-mediated myofilament gene transfer into adult cardiac myocytes
21. Isolation and preparation of single mouse cardiomyocytes for confocal microscopy
22. Regulation of PKA binding to AKAPs in the heart, alterations in human heart failure
23. 2+ sensitivity in rabbit single ventricular cardiomyocytes loaded with indo-1/AM: Comparison with the effects of phenylephrine and angiotension II
24. 2+ release involved in positive inotropic effect mediated by cGRP in ventricular myocytes
25. Cultured adult cardiac myocytes: Future applications, culture methods, morphological and electrophysiological properties
26. Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart
27. Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart
28. Myosin binding protein C, a phosphorylation-dependent force regulator in muscle that controls the attachment of myosin heads by its interaction with myosin S2
29. Phosphorylation of phospholamban and troponin I in β-adrenergic-induced acceleration of cardiac relaxation
30. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits
31. Primary structure and function of an A kinase anchoring protein associated with calcium channels
32. Voltage-independent calcium release in heart muscle
33. Selectivity and regulation of A-kinase anchoring proteins in the heart: The role of autophosphorylation of the type II regulatory subunit of cAMP-dependent protein kinase
34. Regulation of phospholamban and troponin-I phosphorylation in the intact rat cardiomyocytes by adrenergic and cholinergic stimuli: Roles of cyclic nucleotides, calcium, protein kinases and phosphatases and depolarization
35. β-adrenergic receptor stimulation increases unloaded shortening velocity of skinned single ventricular myocytes from rats
36. Cytoskeletal regulation of membrane function: Dissection of protein kinase and phosphatase targeting interactions
37. Regulation of cAMP-dependent protein kinase: Enzyme activation without dissociation
38. A-kinase anchor protein 75 increases the rate and magnitude of cAMP signaling to the nucleus
39. Calcium sensitizing agents in heart failure
40. Cellular and molecular aspects of contractile dysfunction in heart failure