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Volumn 101, Issue 1, 2012, Pages 342-353

Barrier coated drug layered particles for enhanced performance of amorphous solid dispersion dosage form

Author keywords

Amorphous; Celecoxib; Coating; Dissolution; Physical stability; Solid dispersion; Surface modification

Indexed keywords

EXCIPIENT; INULIN; MICROCRYSTALLINE CELLULOSE; POLYVINYL ACETATE; POLYVINYL ALCOHOL;

EID: 82255175810     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22743     Document Type: Article
Times cited : (16)

References (58)
  • 1
    • 75749094421 scopus 로고    scopus 로고
    • Review: Physical chemistry of solid dispersions
    • Janssens S, Van den Mooter G. 2009. Review: Physical chemistry of solid dispersions. J Pharm Pharmacol 61:1571-1586.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 1571-1586
    • Janssens, S.1    Van den Mooter, G.2
  • 2
    • 77953296607 scopus 로고    scopus 로고
    • Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development
    • Qian F, Huang J, Hussain MA. 2010. Drug-polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development. J Pharm Sci 99:2941-2947.
    • (2010) J Pharm Sci , vol.99 , pp. 2941-2947
    • Qian, F.1    Huang, J.2    Hussain, M.A.3
  • 3
    • 0035897584 scopus 로고    scopus 로고
    • Amorphous pharmaceutical solids: Preparation, characterization and stabilization
    • Yu L. 2001. Amorphous pharmaceutical solids: Preparation, characterization and stabilization. Adv Drug Deliv Rev 48:27-42.
    • (2001) Adv Drug Deliv Rev , vol.48 , pp. 27-42
    • Yu, L.1
  • 4
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersions of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs
    • Serajuddin ATM. 1999. Solid dispersions of poorly water-soluble drugs: Early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 88:1058-1066.
    • (1999) J Pharm Sci , vol.88 , pp. 1058-1066
    • Serajuddin, A.T.M.1
  • 5
    • 0141997759 scopus 로고    scopus 로고
    • Solid dispersions: Revival with greater possibilities and applications in oral drug delivery
    • Sethia S, Squillante E. 2003. Solid dispersions: Revival with greater possibilities and applications in oral drug delivery. Crit Rev Ther Drug Carrier Syst 20:217-249.
    • (2003) Crit Rev Ther Drug Carrier Syst , vol.20 , pp. 217-249
    • Sethia, S.1    Squillante, E.2
  • 6
    • 3042549390 scopus 로고    scopus 로고
    • Anomalous dissolution behavior of tablets prepared from sugar glass-based solid dispersions
    • Drooge DJV, Hinrichs WLJ, Frijlink HW. 2004. Anomalous dissolution behavior of tablets prepared from sugar glass-based solid dispersions. J Control Release 97:441-452.
    • (2004) J Control Release , vol.97 , pp. 441-452
    • Drooge, D.J.V.1    Hinrichs, W.L.J.2    Frijlink, H.W.3
  • 7
    • 0018880447 scopus 로고
    • Formulation and aging of tablets prepared from indomethacin-poly(ethylene glycol) 6000 solid dispersions
    • Ford JL, Rubinstein MH. 1980. Formulation and aging of tablets prepared from indomethacin-poly(ethylene glycol) 6000 solid dispersions. Pharm Acta Helv 55:1-7.
    • (1980) Pharm Acta Helv , vol.55 , pp. 1-7
    • Ford, J.L.1    Rubinstein, M.H.2
  • 8
    • 0024218073 scopus 로고
    • Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions
    • Serajuddin AT, Sheen PC, Mufson D, Bernstein DF, Augustine MA. 1988. Effect of vehicle amphiphilicity on the dissolution and bioavailability of a poorly water-soluble drug from solid dispersions. J Pharm Sci 77:414-417.
    • (1988) J Pharm Sci , vol.77 , pp. 414-417
    • Serajuddin, A.T.1    Sheen, P.C.2    Mufson, D.3    Bernstein, D.F.4    Augustine, M.A.5
  • 10
    • 33746889126 scopus 로고    scopus 로고
    • Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Stability testing of selected solid dispersions
    • Ghebremeskel AN, Vemavarapu C, Lodaya M. 2006. Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Stability testing of selected solid dispersions. Pharm Res 23:1928-1936.
    • (2006) Pharm Res , vol.23 , pp. 1928-1936
    • Ghebremeskel, A.N.1    Vemavarapu, C.2    Lodaya, M.3
  • 13
    • 0032165711 scopus 로고    scopus 로고
    • Study of the surface glass transition behaviour of amorphous polymer film by scanning-force microscopy and surface spectroscopy
    • Kajiyama T, Tanaka K, Takahara A. 1998. Study of the surface glass transition behaviour of amorphous polymer film by scanning-force microscopy and surface spectroscopy. Polymers 39:4665-4673.
    • (1998) Polymers , vol.39 , pp. 4665-4673
    • Kajiyama, T.1    Tanaka, K.2    Takahara, A.3
  • 14
    • 0346686253 scopus 로고    scopus 로고
    • Free surface cause reductions in the glass transition temperature of thin polystyrene films
    • Sharp JS, Forest JA. 2003. Free surface cause reductions in the glass transition temperature of thin polystyrene films. Phys Rev Lett 91:235701.
    • (2003) Phys Rev Lett , vol.91 , pp. 235701
    • Sharp, J.S.1    Forest, J.A.2
  • 15
    • 77954043658 scopus 로고    scopus 로고
    • Glass transition dynamics and surface layer mobility in unentangled polystyrene films
    • Yang Z, Fujii Y, Lee FK, Lam CH, Tsui OKC. 2010. Glass transition dynamics and surface layer mobility in unentangled polystyrene films. Science 328:1676-1679.
    • (2010) Science , vol.328 , pp. 1676-1679
    • Yang, Z.1    Fujii, Y.2    Lee, F.K.3    Lam, C.H.4    Tsui, O.K.C.5
  • 16
    • 38849138653 scopus 로고    scopus 로고
    • Glass surfaces not so glassy
    • Dutcher JR, Ediger MD. 2008. Glass surfaces not so glassy. Science 319:577-578.
    • (2008) Science , vol.319 , pp. 577-578
    • Dutcher, J.R.1    Ediger, M.D.2
  • 20
    • 64649105863 scopus 로고    scopus 로고
    • Surface-enhanced crystallization of amorphous nifedipine
    • Zhu L, Wong L, Yu L. 2008. Surface-enhanced crystallization of amorphous nifedipine. Mol Pharm 5:921-926.
    • (2008) Mol Pharm , vol.5 , pp. 921-926
    • Zhu, L.1    Wong, L.2    Yu, L.3
  • 21
    • 77149157016 scopus 로고    scopus 로고
    • One micrometer length scale controls kinetic stability of low-energy glasses
    • Kearns KL, Ediger MD, Huth H, Schick C. 2010. One micrometer length scale controls kinetic stability of low-energy glasses. J Phys Chem Lett 1:388-392.
    • (2010) J Phys Chem Lett , vol.1 , pp. 388-392
    • Kearns, K.L.1    Ediger, M.D.2    Huth, H.3    Schick, C.4
  • 22
    • 34248334514 scopus 로고    scopus 로고
    • Inhibiting surface crystallization of amorphous indomethacin by nanocoating
    • Wu T, Sun Y, Li N, de Villiers MM, Yu L. 2007. Inhibiting surface crystallization of amorphous indomethacin by nanocoating. Langmuir 23:5148-5153.
    • (2007) Langmuir , vol.23 , pp. 5148-5153
    • Wu, T.1    Sun, Y.2    Li, N.3    Villiers, M.M.4    Yu, L.5
  • 23
    • 79953161265 scopus 로고    scopus 로고
    • Plasma deposited stability enhancement coating for amorphous ketoprofen
    • Owens, Williams
    • Bosselmann S, Owens DE 3rd, Kennedy RL, Herpin MJ, Williams RO 3rd. 2010. Plasma deposited stability enhancement coating for amorphous ketoprofen. Eur J Pharm Biopharm 78:67-74.
    • (2010) Eur J Pharm Biopharm , vol.78 , pp. 67-74
    • Bosselmann, S.1    3rd, D.E.2    Kennedy, R.L.3    Herpin, M.J.4    3rd, R.O.5
  • 24
    • 75149179161 scopus 로고    scopus 로고
    • Aqueous film coating to reduce recrystallization of guaifenesin from hot-melt extruded acrylic matrices
    • Bruce CD, Fegely KA, Rajabi-Siahboomi AR, McGinity JW. 2010. Aqueous film coating to reduce recrystallization of guaifenesin from hot-melt extruded acrylic matrices. Drug Dev Ind Pharm 36:218-226.
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 218-226
    • Bruce, C.D.1    Fegely, K.A.2    Rajabi-Siahboomi, A.R.3    McGinity, J.W.4
  • 26
    • 64649105426 scopus 로고    scopus 로고
    • FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs
    • Kaushal A, Chakraborti AK, Bansal AK. 2008. FTIR studies on differential intermolecular association in crystalline and amorphous states of structurally related non-steroidal anti-inflammatory drugs. Mol Pharm 5:937-945.
    • (2008) Mol Pharm , vol.5 , pp. 937-945
    • Kaushal, A.1    Chakraborti, A.K.2    Bansal, A.K.3
  • 27
    • 77952196842 scopus 로고    scopus 로고
    • Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug
    • Puri V, Dantuluri AK, Kumar M, Karar N, Bansal AK. 2010. Wettability and surface chemistry of crystalline and amorphous forms of a poorly water soluble drug. Eur J Pharm Sci 40:84-93.
    • (2010) Eur J Pharm Sci , vol.40 , pp. 84-93
    • Puri, V.1    Dantuluri, A.K.2    Kumar, M.3    Karar, N.4    Bansal, A.K.5
  • 28
    • 85030497908 scopus 로고    scopus 로고
    • Beads having a core coated with an antifungal and a polymer. Patent US5633015.
    • Gilis PMV, Conde VFVD, Vandecruys RPG. 1997. Beads having a core coated with an antifungal and a polymer. Patent US5633015.
    • (1997)
    • Gilis, P.M.V.1    Conde, V.F.V.D.2    Vandecruys, R.P.G.3
  • 29
    • 43249092894 scopus 로고    scopus 로고
    • Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous state
    • Bhugra C, Pikal MJ. 2008. Role of thermodynamic, molecular, and kinetic factors in crystallization from the amorphous state. J Pharm Sci 97:1329-1349.
    • (2008) J Pharm Sci , vol.97 , pp. 1329-1349
    • Bhugra, C.1    Pikal, M.J.2
  • 30
    • 5144219871 scopus 로고    scopus 로고
    • Amorphous drug delivery systems: Molecular aspects, design and performance
    • Kaushal AM, Gupta P, Bansal AK. 2004. Amorphous drug delivery systems: Molecular aspects, design and performance. Crit Rev Ther Drug Carrier Syst 21:133-193.
    • (2004) Crit Rev Ther Drug Carrier Syst , vol.21 , pp. 133-193
    • Kaushal, A.M.1    Gupta, P.2    Bansal, A.K.3
  • 31
    • 28244474489 scopus 로고    scopus 로고
    • Ternary amorphous composites of celecoxib, poly(vinyl pyrrolidone) and meglumine with enhanced solubility
    • Gupta P, Bansal AK. 2005. Ternary amorphous composites of celecoxib, poly(vinyl pyrrolidone) and meglumine with enhanced solubility. Pharmazie 60:830-836.
    • (2005) Pharmazie , vol.60 , pp. 830-836
    • Gupta, P.1    Bansal, A.K.2
  • 32
    • 79954586183 scopus 로고    scopus 로고
    • Oral bioavailability advantage from stabilized amorphous systems of celecoxib
    • Gupta P, Bansal AK. 2006. Oral bioavailability advantage from stabilized amorphous systems of celecoxib. J Pharm Res 5:15-24.
    • (2006) J Pharm Res , vol.5 , pp. 15-24
    • Gupta, P.1    Bansal, A.K.2
  • 33
    • 79954592839 scopus 로고    scopus 로고
    • Investigation of atypical dissolution behavior of an encapsulated amorphous solid dispersion
    • Puri V, Dhantuluri AK, Bansal AK. 2011. Investigation of atypical dissolution behavior of an encapsulated amorphous solid dispersion. J Pharm Sci 100:2460-2468.
    • (2011) J Pharm Sci , vol.100 , pp. 2460-2468
    • Puri, V.1    Dhantuluri, A.K.2    Bansal, A.K.3
  • 34
    • 78649907151 scopus 로고    scopus 로고
    • Influences of sodium carbonate on physicochemical properties of lansoprazole in designed multiple coating pellets
    • He W, Yang M, Fan JH, Feng CX, Zhang SJ, Wang JX, Guan PP, Wu W. 2010. Influences of sodium carbonate on physicochemical properties of lansoprazole in designed multiple coating pellets. AAPS PharmSciTech 11:1287-1293.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 1287-1293
    • He, W.1    Yang, M.2    Fan, J.H.3    Feng, C.X.4    Zhang, S.J.5    Wang, J.X.6    Guan, P.P.7    Wu, W.8
  • 35
    • 18744397838 scopus 로고    scopus 로고
    • Spray drying for generation of a ternary amorphous system of celecoxib, PVP and meglumine
    • Gupta P, Bansal AK. 2005. Spray drying for generation of a ternary amorphous system of celecoxib, PVP and meglumine. Pharm Dev Technol 10:273-281.
    • (2005) Pharm Dev Technol , vol.10 , pp. 273-281
    • Gupta, P.1    Bansal, A.K.2
  • 36
    • 14644406137 scopus 로고    scopus 로고
    • Molecular interactions in celecoxib-PVP-meglumine amorphous system
    • Gupta P, Bansal AK. 2005. Molecular interactions in celecoxib-PVP-meglumine amorphous system. J Pharm Pharmacol 57:303-310.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 303-310
    • Gupta, P.1    Bansal, A.K.2
  • 37
    • 0028416385 scopus 로고
    • Enthalpy relaxation and recovery in amorphous materials
    • Hodge IM. 1994. Enthalpy relaxation and recovery in amorphous materials. J Non Cryst Solids 169:211-266.
    • (1994) J Non Cryst Solids , vol.169 , pp. 211-266
    • Hodge, I.M.1
  • 38
    • 61449220876 scopus 로고    scopus 로고
    • Quantitative image analysis for evaluating the coating thickness and pore distribution in coated small particles
    • Laksmana FL, Vliet LJV, Kok PJAH, Vromans H, Frijlink HW, Maarschalk KVV. 2009. Quantitative image analysis for evaluating the coating thickness and pore distribution in coated small particles. Pharm Res 26:965-976.
    • (2009) Pharm Res , vol.26 , pp. 965-976
    • Laksmana, F.L.1    Vliet, L.J.V.2    Kok, P.J.A.H.3    Vromans, H.4    Frijlink, H.W.5    Maarschalk, K.V.V.6
  • 39
    • 85030497781 scopus 로고    scopus 로고
    • Accessed December 10, 2009, at
    • Accessed December 10, 2009, at: http://www.accessdata.fda.gov/scripts/cder/dissolution/.
  • 40
    • 85030488224 scopus 로고    scopus 로고
    • ICH guidance for industry: dissolution testing of immediate release solid oral dosage forms. 1997. Rockville, Maryland.
    • ICH guidance for industry: dissolution testing of immediate release solid oral dosage forms. 1997. Rockville, Maryland.
  • 41
    • 0030638567 scopus 로고    scopus 로고
    • Characteristics and significance of the amorphous state in pharmaceutical systems
    • Hancock BC, Zografi G. 1997. Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 86:1-12.
    • (1997) J Pharm Sci , vol.86 , pp. 1-12
    • Hancock, B.C.1    Zografi, G.2
  • 42
    • 0035861398 scopus 로고    scopus 로고
    • Molecular mobility of amorphous pharmaceuticals determined using differential scanning calorimetry
    • Hancock BC, Shamblin SL. 2000. Molecular mobility of amorphous pharmaceuticals determined using differential scanning calorimetry. Thermochim Acta 380:95-107.
    • (2000) Thermochim Acta , vol.380 , pp. 95-107
    • Hancock, B.C.1    Shamblin, S.L.2
  • 43
    • 0842283231 scopus 로고    scopus 로고
    • Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions
    • Aso Y, Yoshioka S, Kojima S. 2004. Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions. J Pharm Sci 93:384-391.
    • (2004) J Pharm Sci , vol.93 , pp. 384-391
    • Aso, Y.1    Yoshioka, S.2    Kojima, S.3
  • 44
    • 56749095481 scopus 로고    scopus 로고
    • Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation
    • Bansal SS, Kaushal AM, Bansal AK. 2008. Co-relationship of physical stability of amorphous dispersions with enthalpy relaxation. Pharmazie 63:812-814.
    • (2008) Pharmazie , vol.63 , pp. 812-814
    • Bansal, S.S.1    Kaushal, A.M.2    Bansal, A.K.3
  • 45
    • 53549126335 scopus 로고    scopus 로고
    • Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and l-proline
    • Korhonen O, Bhugra C, Pikal MJ. 2008. Correlation between molecular mobility and crystal growth of amorphous phenobarbital and phenobarbital with polyvinylpyrrolidone and l-proline. J Pharm Sci 97:3830-3841.
    • (2008) J Pharm Sci , vol.97 , pp. 3830-3841
    • Korhonen, O.1    Bhugra, C.2    Pikal, M.J.3
  • 46
    • 34547310214 scopus 로고    scopus 로고
    • Effect of physical aging on nucleation of amorphous indomethacin
    • Vyazovkin S, Dranca I. 2007. Effect of physical aging on nucleation of amorphous indomethacin. J Phys Chem 111:7283-7287.
    • (2007) J Phys Chem , vol.111 , pp. 7283-7287
    • Vyazovkin, S.1    Dranca, I.2
  • 48
    • 82255167798 scopus 로고    scopus 로고
    • Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation. Patent US7332474.
    • Muskulus F, Kraa P, Burgenmeister A. 2010. Pharmaceutical preparation containing a benzimidazole compound mixed with microcrystalline cellulose and a method for its preparation. Patent US7332474.
    • (2010)
    • Muskulus, F.1    Kraa, P.2    Burgenmeister, A.3
  • 49
    • 0037965636 scopus 로고    scopus 로고
    • Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples
    • Steele DF, Edge S, Tobyn MJ, Moreton RC, Staniforth JN. 2003. Adsorption of an amine drug onto microcrystalline cellulose and silicified microcrystalline cellulose samples. Drug Dev Ind Pharm 29:475-487.
    • (2003) Drug Dev Ind Pharm , vol.29 , pp. 475-487
    • Steele, D.F.1    Edge, S.2    Tobyn, M.J.3    Moreton, R.C.4    Staniforth, J.N.5
  • 50
    • 34547955255 scopus 로고    scopus 로고
    • Rowe RC, Sheskey PJ, Quinn ME, Eds. 6th ed. London: Pharmaceutical Press and American Pharmacists Association.
    • Rowe RC, Sheskey PJ, Quinn ME, Eds. 2009. Handbook of pharmaceutical excipients. 6th ed. London: Pharmaceutical Press and American Pharmacists Association.
    • (2009) Handbook of pharmaceutical excipients
  • 51
    • 36849019024 scopus 로고    scopus 로고
    • Multilayer PVA adsorption onto hydrophobic drug substrates to engineer drug-rich microparticles
    • Buttini F, Soltani A, Colombo P, Marriott C, Jones SA. 2008. Multilayer PVA adsorption onto hydrophobic drug substrates to engineer drug-rich microparticles. Eur J Pharm Sci 33:20-28.
    • (2008) Eur J Pharm Sci , vol.33 , pp. 20-28
    • Buttini, F.1    Soltani, A.2    Colombo, P.3    Marriott, C.4    Jones, S.A.5
  • 52
    • 79955619106 scopus 로고    scopus 로고
    • Vinyl polymer-coated lorazepam particles for drug delivery to the airways
    • Traynora MJ, Zhaob Y, Browna MB, Jones SA. 2011. Vinyl polymer-coated lorazepam particles for drug delivery to the airways. Int J Pharm 410:9-16.
    • (2011) Int J Pharm , vol.410 , pp. 9-16
    • Traynora, M.J.1    Zhaob, Y.2    Browna, M.B.3    Jones, S.A.4
  • 53
    • 53549113334 scopus 로고    scopus 로고
    • Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives
    • Chawla G, Bansal AK. 2008. Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives. Acta Pharm 58:257-274.
    • (2008) Acta Pharm , vol.58 , pp. 257-274
    • Chawla, G.1    Bansal, A.K.2
  • 54
    • 28744441568 scopus 로고    scopus 로고
    • The hygroscopicity of moisture barrier film coatings
    • Mwesigwa E, Buckton G, Basit AW. 2005. The hygroscopicity of moisture barrier film coatings. Drug Dev Ind Pharm 31:959-968.
    • (2005) Drug Dev Ind Pharm , vol.31 , pp. 959-968
    • Mwesigwa, E.1    Buckton, G.2    Basit, A.W.3
  • 55
    • 64649088132 scopus 로고    scopus 로고
    • Amorphous compositions using concentration enhancing polymers for improved bioavailability of itraconazole
    • DiNunzio JC, Miller DA, Yang W, McGinity JW, Williams III RO. 2008. Amorphous compositions using concentration enhancing polymers for improved bioavailability of itraconazole. Mol Pharmaceutics 5:968-980.
    • (2008) Mol Pharmaceutics , vol.5 , pp. 968-980
    • DiNunzio, J.C.1    Miller, D.A.2    Yang, W.3    McGinity, J.W.4    Williams III, R.O.5
  • 56
    • 85030492258 scopus 로고    scopus 로고
    • Pharmaceutical formulation of omeprazole. Patent US6090827.
    • Erickson M, Josefsson L. 2000. Pharmaceutical formulation of omeprazole. Patent US6090827.
    • (2000)
    • Erickson, M.1    Josefsson, L.2
  • 57
    • 0036173224 scopus 로고    scopus 로고
    • Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate
    • Kinoshita M, Baba K, Nagayasu A, Yamabe K, Shimooka T, Takeichi Y, Azuma M, Houchi H, Minakuchi K. 2002. Improvement of solubility and oral bioavailability of a poorly water-soluble drug, TAS-301, by its melt-adsorption on a porous calcium silicate. J Pharm Sci 91:362-370.
    • (2002) J Pharm Sci , vol.91 , pp. 362-370
    • Kinoshita, M.1    Baba, K.2    Nagayasu, A.3    Yamabe, K.4    Shimooka, T.5    Takeichi, Y.6    Azuma, M.7    Houchi, H.8    Minakuchi, K.9
  • 58
    • 0032867416 scopus 로고    scopus 로고
    • Interpolymer complexation. I. Preparation and characterization of a polyvinyl acetate phthalate-polyvinylpyrrolidone (PVAP-PVP) complex
    • Kumar V, Yang T, Yang Y. 1999. Interpolymer complexation. I. Preparation and characterization of a polyvinyl acetate phthalate-polyvinylpyrrolidone (PVAP-PVP) complex. Int J Pharm 188:221-232.
    • (1999) Int J Pharm , vol.188 , pp. 221-232
    • Kumar, V.1    Yang, T.2    Yang, Y.3


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