Impact of polymers on dissolution performance of an amorphous gelleable drug from surface-coated beads

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 1, 2009, Pages 1-10

  Fan, Chong ^a   Pai Thakur, Rashmi ^b   Phuapradit, Wantanee ^c   Zhang, Lin ^c   Tian, Hung ^c   Malick, Waseem ^c   Shah, Navnit ^c   Kislalioglu, M Serpil ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c Pharmaceutical and Analytical Research and Development   (United States)

Author keywords

Applicability of Higuchi Model; Model independent similarity (f2); Oral delivery of amorphous drugs; Oral delivery of gelleable drugs; Polymer effect on dissolution; Polymer effect on drug layering; Surface coating; Use of Eudragit L100 and PVP K30 in surface coating of drugs; Water uptake of polymers

Indexed keywords

3 (3 OXOCYCLOPENTYL) 2 [3 CHLORO 4 METHYL SULFONYL]PHENYL N PYROZIN 2YLPROPANAMIDE; ANION; CELLULOSE; EUDRAGIT; GELLING AGENT; POLYMER; POVIDONE; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; CULTURE MEDIUM; DISSOLUTION; DRUG DELIVERY SYSTEM; ENGINEERING; HUMIDITY; IMAGING; INFRARED SPECTROSCOPY; MOISTURE; MORPHOLOGY; PRIORITY JOURNAL; PROTECTION; SUSTAINED DRUG RELEASE; TRANSITION TEMPERATURE; WATER TRANSPORT;

BIOLOGICAL AVAILABILITY; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; EXCIPIENTS; GELS; HUMIDITY; MICROSCOPY; MICROSPHERES; MODELS, CHEMICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; POLYMERS; POLYMETHACRYLIC ACIDS; POVIDONE; SALTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTROSCOPY, NEAR-INFRARED; TRANSITION TEMPERATURE; WATER; X-RAY DIFFRACTION;

EID: 61349098480     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.10.012     Document Type: Article

References (27)

1. Al-Taani B.M., and Tashtoush B.M. Effect of microenvironment pH of swellable and erodable buffered matrices on the release characteristics of diclofenac sodium. AAPS Pharm. Sci. Technol. 4 3 (2003) 1-6
2. Aso Y., Yoshioka S., and Kojima S. Molecular mobility-based estimation of the crystallization rates of amorphous nifedipine and phenobarbital in poly(vinylpyrrolidone) solid dispersions. J. Pharm. Sci. 93 (2004) 384-391
3. Bodmeier R., and Chen H. Preparation and characterization of microspheres containing the anti-inflammatory agents, indomethacin, ibuprofen, and ketoprofen. J. Control. Release 10 (1989) 167-175
4. Chokshi R.J., Sandhu H.K., Iyer R.M., and Shah N.H. Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion process as means to manufacture solid dispersion/solution. J. Pharm. Sci. 94 (2005) 2463-2474
5. Costa P., and Lobo J.M.S. Modeling and comparison of dissolution profiles. E. J. Pharm. Sci. 13 (2001) 123-133
6. Craig D.M.Q. The mechanisms of drug release from solid dispersions in water-soluble polymers. Int. J. Pharm. 231 (2002) 131-144
7. Devarajan P.V., and Sonavane G.S. Preparation and in vitro/in vivo evaluation of gliclazide loaded Eudragit nanoparticles as sustained release carriers. Drug Dev. Ind. Pharm. 33 (2007) 101-111
8. Dumanli, I., 1998. Characterization of gelling phenomenon of a lipid based formulation. Masters Thesis. University of Rhode Island, p. 71.
9. Gohel M.C., and Patel L.D. Processing of Nimesulide-PEG 400-PG and PVP Solid Dispersions. Drug. Dev. Ind. Pharm. 29 3 (2003) 299-310
10. Hancock B.C., and Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J. Pharm. Sci. 86 (1997) 1-12
11. Hasegawa A., Kawamura R., Nagagawa H., and Sugimoto I. Physical properties of solid dispersions of poorly soluble drugs with enteric coating agents. Chem. Pharm. Bull. 33 (1985) 3429-3435
12. Huang J., Wigent R.J., Bentzley C.M., and Schwartz J.B. Nifedipine solid dispersion in microparticles of ammonio methacrylate copolymer and ethylcellulose binary blend for controlled drug delivery; effect of loading on release kinetics. Int. J. Pharm. 319 1,2 (2006) 44-54
13. Hülsmann S., Backensfeld T., Keitel S., and Bodmeier R. Melt-extrusion-an alternative method for enhancing the dissolution rate of 17β estradiol-hemihydrate. Eur. J. Pharm. Biopharm. 49 3 (2000) 237-242
14. Karavas E., Georgarakis E., Sigalas M.P., Avgoustakis K., and Bikiaris D. Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. Eur. J. Pharm. Biopharm. 66 (2007) 334-347
15. Kislalioglu M.S., Khan M.A., Blount C., Goettsch R.W., and Bolton S. Physical characterization and dissolution properties of ibuprofen: Eudragit coprecipitates. J. Pharm. Sci. 80 8 (1991) 799-804
16. Lecomte F., Siepmann J., Walther M., MacRea R.J., and Bodmeier R. Blends of enteric and GIT-insoluble polymers used for film coating: physicochemical characterization and drug release patterns. J. Control. Release 89 (2003) 457-471
17. Mehramizi A., Alijani B., Pourfarzib M., Dorkoosh F.A., and Rafiee-Tehrani M. Solid carriers for improved solubility of glipizide in osmotically controlled oral drug delivery system. Drug Dev. Ind. Pharm. 33 (2007) 812-823
18. Mehta K.A., Kislalioglu M.S., Phuapradit W., Malick A.W., and Shah N.H. Release performance of a poorly soluble drug from a novel, Eudragit-based multi-unit erosion matrix. Int. J. Pharm. 213 (2001) 7-12
19. Nozawa Y., Mizumoto T., and Higashide F. Increases in dissolution rate of nifedipine by roll mixing with polyvinylpyrrolidone. Pharm. Acta Helv. 61 (1986) 337-341
20. Rahman N., Yuen K.H., Khan N., and Wong J. Drug-polymer mixed coating: a new approach for controlling drug release rates in pellets. Pharm. Dev. Technol. 11 (2006) 71-77
21. Samani S.M., Montaseri H., and Kazemi A. The effect of polymer blends on release profiles of diclofenac sodium from matrices. Eur. J. Pharm. Biopharm. 55 (2003) 351-355
22. Sekikawa K., Fukuda N., Takada M., Ohtani K., Arita T., and Nakano M. Dissolution behavior and gastrointestinal absorption of dicumarol from solid dispersion systems of dicumarol-polyvinylpyrrolidone and dicumarol-beta-cyclodextrin. Chem. Pharm. Bull. (Tokyo) 31 (1983) 1350-1356
23. Shah R.B., Tawakkul M.A., and Khan M.A. Process analytical technology: chemometric analysis of Raman and near infra-red spectroscopic data for predicting physical properties of extended release matrix tablets. J. Pharm. Sci. 96 (2007) 1356-1365
24. Tantishaiyakul V., Kaewnopparat N., and Ingkatawornwong S. Properties of solid dispersions of piroxicam in polyvinylpyrrolidone. Intel. J. Pharm. 181 (1999) 143-151
25. Vasanthavada M., Tong W.Q., Joshi Y., and Kislalioglu M.S. Phase behaviors of amorphous molecular dispersions I; determination and mechanism of solid solubility. Pharm. Res. 21 8 (2004) 1598-2160
26. Vasanthavada M., Tong W.Q., Joshi Y., and Kislalioglu M.S. Phase behaviour of amorphous molecular dispersions II: Role of hydrogen bonding in solid solubility and phase separation kinetics. Pharm. Res. 22 3 (2005) 440-448
27. Yu l. Amorphous pharmaceutical solids; preparation, characterization and stabilization. Adv. Drug Deliv. Rev. 48 (2001) 27-42