Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 24, 2011, Pages 7711-7719

  Vijaya Bhaskar Reddy, M ^a   Tsai, Wei Jern ^b   Qian, Keduo ^c   Lee, Kuo Hsiung ^c,d   Wu, Tian Shung ^a,c,d  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^c University of North Carolina   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Antiplatelet aggregation activity; Mannich bases of heterocyclic chalcone analogs; Oxyprenylated and oxyallylated chalcones

Indexed keywords

1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 (2,3,4 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 (3 HYDROXY 4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL] 3 PHENYLPROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (2,3 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (2,3,4 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (2,4 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (2,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (2,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (3,4,5 TRIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (3,5 DIMETHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (4 METHOXYPHENYL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 (BENZO[D][1,3]DIOXO 5 YL)PROP 2 EN 1 ONE; 1 [4 (ALLYLOXY) 2 HYDROXYPHENYL] 3 PHENYLPROP 2 EN 1 ONE; 3 (2,3 DIMETHOXYPHENYL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (2,4 DIMETHOXYPHENYL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (2,5 DIMETHOXYPHENYL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (3 BENZO[D][1,3]DIOXO 5 YL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (3,4 DIMETHOXYPHENYL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; 3 (3,5 DIMETHOXYPHENYL) 1 [2 HYDROXY 4 (3 METHYLBUT 2 ENYLOXY)PHENYL]PROP 2 EN 1 ONE; ADENOSINE DIPHOSPHATE; CHALCONE DERIVATIVE; COLLAGEN; HYDROXYL GROUP; MANNICH BASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; RABBIT; STRUCTURE ACTIVITY RELATION; THROMBOCYTE AGGREGATION INHIBITION;

ANIMALS; BLOOD PLATELETS; CHALCONE; COLLAGEN; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP;

ORYCTOLAGUS CUNICULUS;

EID: 82255175514     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.004     Document Type: Article

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