-
1
-
-
1042290329
-
Impact of shared epitope genotype and ethnicity on erosive disease. A meta-analysis of 3,240 rheumatoid arthritis patients
-
Gorman JD, Lum RF, Chen JJ, Suarez-Almazor ME, Thomson G, Criswell LA. Impact of shared epitope genotype and ethnicity on erosive disease. A meta-analysis of 3,240 rheumatoid arthritis patients. Arthritis Rheum 2004; 50: 400-12.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 400-412
-
-
Gorman, J.D.1
Lum, R.F.2
Chen, J.J.3
Suarez-Almazor, M.E.4
Thomson, G.5
Criswell, L.A.6
-
2
-
-
65249103342
-
Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-nagative rheumatoid arthritis
-
van der Woude D, Houwing-Duistermaat JJ, et al. Quantitative heritability of anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-nagative rheumatoid arthritis. Arthritis Rheum 2009; 60: 916-23.
-
(2009)
Arthritis Rheum
, vol.60
, pp. 916-923
-
-
van der Woude, D.1
Houwing-Duistermaat, J.J.2
-
3
-
-
31044445025
-
A new model for an etiology of rheumatoid arthritis. Smoking may trigger HLA-DR (sharedepitope)-restricted immune reactions to autoantigens modified by citrullination
-
Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis. Smoking may trigger HLA-DR (sharedepitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006; 54: 38-46.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 38-46
-
-
Klareskog, L.1
Stolt, P.2
Lundberg, K.3
-
4
-
-
45349090538
-
American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis
-
Saag KG, Teng GG, Patkar NM, et al. American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum 2008; 59: 762-84.
-
(2008)
Arthritis Rheum
, vol.59
, pp. 762-784
-
-
Saag, K.G.1
Teng, G.G.2
Patkar, N.M.3
-
5
-
-
33644895018
-
Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab. Results from the ASPIRE trial
-
Smolen JS, van der Heijde DMFM, St.Clair EW, et al. Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate with or without concomitant infliximab. Results from the ASPIRE trial. Arthritis Rheum 2006; 54: 702-10.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 702-710
-
-
Smolen, J.S.1
van der Heijde, D.M.F.M.2
Clair St., E.W.3
-
6
-
-
0034746919
-
NF-κB: A key role in inflammatory diseases
-
Tak PP, Firestein GS. NF-κB: a key role in inflammatory diseases. J Clin Invest 2001; 107: 7-11.
-
(2001)
J Clin Invest
, vol.107
, pp. 7-11
-
-
Tak, P.P.1
Firestein, G.S.2
-
7
-
-
0029563524
-
Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65
-
Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-κB in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum 1995; 38: 1762-70.
-
(1995)
Arthritis Rheum
, vol.38
, pp. 1762-1770
-
-
Handel, M.L.1
McMorrow, L.B.2
Gravallese, E.M.3
-
8
-
-
15844384253
-
Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue
-
Marok R, Winyard PG, Coumbe A, et al. Activation of the transcription factor nuclear factor-κB in human inflamed synovial tissue. Arthritis Rheum 1996; 39: 583-91.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 583-591
-
-
Marok, R.1
Winyard, P.G.2
Coumbe, A.3
-
9
-
-
2642517290
-
Increased synovial tissue NF-κB1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
-
Benito MJ, Murphy E, Murphy EP, van den Berg WB, FitzGerald O, Bresnihan B. Increased synovial tissue NF-κB1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1781-7.
-
(2004)
Arthritis Rheum
, vol.50
, pp. 1781-1787
-
-
Benito, M.J.1
Murphy, E.2
Murphy, E.P.3
van den Berg, W.B.4
Fitzgerald, O.5
Bresnihan, B.6
-
10
-
-
0030044619
-
Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α
-
Fujisawa K, Aono H, Hasunuma T, Yamamoto K, Mita S, Nishioka K. Activation of transcription factor NF-κB in human synovial cells in response to tumor necrosis factor α. Arthritis Rheum 1996; 39: 197-203.
-
(1996)
Arthritis Rheum
, vol.39
, pp. 197-203
-
-
Fujisawa, K.1
Aono, H.2
Hasunuma, T.3
Yamamoto, K.4
Mita, S.5
Nishioka, K.6
-
11
-
-
0035865090
-
NF-κB regulation by IκB kinase-2 in rheumatoid arthritis synoviocytes
-
Aupperle KR, Bennett BL, Han Z, Boyle DL, Manning AM, Firestein GS. NF-κB regulation by IκB kinase-2 in rheumatoid arthritis synoviocytes. J Immunol 2001; 166: 2705-11.
-
(2001)
J Immunol
, vol.166
, pp. 2705-2711
-
-
Aupperle, K.R.1
Bennett, B.L.2
Han, Z.3
Boyle, D.L.4
Manning, A.M.5
Firestein, G.S.6
-
13
-
-
0031782069
-
Cycloepoxydon,1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene 1-hydroxy-2-hydroxy-methyl-3-pent-1, 3-dienylbenzene, new inhibitors of eukaryotic signal transduction
-
Gehrt A, Erkel, G, Anke, T, SternerO.Cycloepoxydon,1-hydroxy-2-hydroxymethyl-3-pent-1-enylbenzene 1-hydroxy-2-hydroxy-methyl-3-pent-1, 3-dienylbenzene, new inhibitors of eukaryotic signal transduction. J Antibiot 1998; 51: 455-63.
-
(1998)
J Antibiot
, vol.51
, pp. 455-463
-
-
Gehrt, A.1
Erkel, G.2
Anke, T.3
Sterner, O.4
-
14
-
-
0034178264
-
Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C
-
Matsumoto N, Ariga A, To-e S, et al. Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C. Bioorg Med Chem Lett 2000; 10: 865-9.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 865-869
-
-
Matsumoto, N.1
Ariga, A.2
To-E, S.3
-
15
-
-
33748326108
-
Inhibition of TNF-α-induced nuclear translocation and activation of NF-κB by dehydroxymethyl-epoxyquinomicin
-
Ariga A, Namekawa J, Matsumoto N, Inoue J, Umezawa K. Inhibition of TNF-α-induced nuclear translocation and activation of NF-κB by dehydroxymethyl-epoxyquinomicin. J Biol Chem 2002; 277: 27625-30.
-
(2002)
J Biol Chem
, vol.277
, pp. 27625-30
-
-
Ariga, A.1
Namekawa, J.2
Matsumoto, N.3
Inoue, J.4
Umezawa, K.5
-
16
-
-
3242671837
-
Preparation and biological activities of optically active dehydroxymethylepoxy-quinomicin, a novel NF-κB inhibitor
-
Suzuki Y, Sugiyama C, Ohno O, Umezawa K. Preparation and biological activities of optically active dehydroxymethylepoxy-quinomicin, a novel NF-κB inhibitor. Tetrahedron 2004; 60: 7061-6.
-
(2004)
Tetrahedron
, vol.60
, pp. 7061-7066
-
-
Suzuki, Y.1
Sugiyama, C.2
Ohno, O.3
Umezawa, K.4
-
17
-
-
33748311907
-
Inhibition of tumor growth by NF-κB inhibitors
-
Umezawa K. Inhibition of tumor growth by NF-κB inhibitors. Cancer Sci 2006; 97: 990-5.
-
(2006)
Cancer Sci
, vol.97
, pp. 990-995
-
-
Umezawa, K.1
-
18
-
-
34548343614
-
A selective NF-κB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice
-
Chiba T, Kondo Y, Shinozaki S, et al. A selective NF-κB inhibitor, DHMEQ, reduced atherosclerosis in ApoE-deficient mice. J Atheroscler Thromb 2006; 13: 308-13.
-
(2006)
J Atheroscler Thromb
, vol.13
, pp. 308-313
-
-
Chiba, T.1
Kondo, Y.2
Shinozaki, S.3
-
19
-
-
35148898712
-
Suppression of diabetes induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway
-
Nagai N, Oike Y, Izumi-Nagai K, et al. Suppression of diabetes induced retinal inflammation by blocking angiotensin II type 1 receptor or its downstream NF-κB pathway. Invest Ophthal Vis Sci 2007; 48: 4342-50.
-
(2007)
Invest Ophthal Vis Sci
, vol.48
, pp. 4342-4350
-
-
Nagai, N.1
Oike, Y.2
Izumi-Nagai, K.3
-
20
-
-
33845947853
-
Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethyl-epoxyquinomicin
-
Ueki S, Yamashita K, Aoyagi T, et al. Control of allograft rejection by applying a novel NF-κB inhibitor, dehydroxymethyl-epoxyquinomicin. Transplantation 2006; 82: 1720-7.
-
(2006)
Transplantation
, vol.82
, pp. 1720-1727
-
-
Ueki, S.1
Yamashita, K.2
Aoyagi, T.3
-
21
-
-
48949096764
-
The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats
-
Suzuki T, Yamashita K, Jomen W, et al.The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats. J Surg Res 2008; 149: 69-75.
-
(2008)
J Surg Res
, vol.149
, pp. 69-75
-
-
Suzuki, T.1
Yamashita, K.2
Jomen, W.3
-
22
-
-
33947526496
-
IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells
-
Watanabe M, Dewan MZ, Taira M, et al. IκBα independent induction of NF-κB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab Invest 2007; 87: 372-82.
-
(2007)
Lab Invest
, vol.87
, pp. 372-382
-
-
Watanabe, M.1
Dewan, M.Z.2
Taira, M.3
-
23
-
-
33644644326
-
Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-κB inhibitor
-
Matsumoto G, Muta M, Umezawa K, et al. Enhancement of the caspase-independent apoptotic sensitivity of pancreatic cancer cells by DHMEQ, an NF-κB inhibitor. Int J Oncology 2005; 27: 1247-55.
-
(2005)
Int J Oncology
, vol.27
, pp. 1247-1255
-
-
Matsumoto, G.1
Muta, M.2
Umezawa, K.3
-
24
-
-
45849151698
-
Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-κB inhibitor DHMEQ
-
Miyake A, Dewan Z, Ishida T, et al. Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-κB inhibitor DHMEQ. Microbes Infect 2008; 10: 748-56.
-
(2008)
Microbes Infect
, vol.10
, pp. 748-756
-
-
Miyake, A.1
Dewan, Z.2
Ishida, T.3
-
25
-
-
52449131840
-
Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues
-
Yamamoto M, Horie R, Takeiri M, Kozawa I, Umezawa K. Inactivation of nuclear factor kappa B components by covalent binding of (-)-dehydroxymethylepoxyquinomicin to specific cysteine residues. J Med Chem 2008; 51: 5780-8.
-
(2008)
J Med Chem
, vol.51
, pp. 5780-5788
-
-
Yamamoto, M.1
Horie, R.2
Takeiri, M.3
Kozawa, I.4
Umezawa, K.5
-
26
-
-
0032428729
-
AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis
-
Han Z, Boyle DL, Manning AM, Firestein GS. AP-1 and NF-κB regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998; 28: 197-208.
-
(1998)
Autoimmunity
, vol.28
, pp. 197-208
-
-
Han, Z.1
Boyle, D.L.2
Manning, A.M.3
Firestein, G.S.4
-
27
-
-
0034892866
-
Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation
-
Tak PP, Gerlag DM, Aupperle KR, et al. Inhibitor of nuclear factor κB kinase β is a key regulator of synovial inflammation. Arthritis Rheum 2001; 44: 1897-907.
-
(2001)
Arthritis Rheum
, vol.44
, pp. 1897-1907
-
-
Tak, P.P.1
Gerlag, D.M.2
Aupperle, K.R.3
-
28
-
-
0032505870
-
NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint
-
Miagkov AV, Kovalenko DV, Brown CE, et al. NF-κB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA 1998; 95: 13859-64.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13859-64
-
-
Miagkov, A.V.1
Kovalenko, D.V.2
Brown, C.E.3
-
29
-
-
0033506335
-
Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor κB decoy oligodeoxynucleotides as a gene therapy
-
Tomita T, Takeuchi E, Tomita N, et al. Suppressed severity of collagen-induced arthritis by in vivo transfection of nuclear factor κB decoy oligodeoxynucleotides as a gene therapy. Arthtitis Rheum 1999; 42: 2532-42.
-
(1999)
Arthtitis Rheum
, vol.42
, pp. 2532-2542
-
-
Tomita, T.1
Takeuchi, E.2
Tomita, N.3
-
30
-
-
13044316560
-
Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
-
Palombella VJ, Conner EM, Fuseler JW, et al. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci USA 1998; 95: 15671-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15671-15676
-
-
Palombella, V.J.1
Conner, E.M.2
Fuseler, J.W.3
-
31
-
-
0141676361
-
A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice
-
McIntyre KW, Shuster DJ, Gillooly KM, et al. A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. Arthritis Rheum 2003; 48: 2652-9.
-
(2003)
Arthritis Rheum
, vol.48
, pp. 2652-2659
-
-
McIntyre, K.W.1
Shuster, D.J.2
Gillooly, K.M.3
-
32
-
-
0034254439
-
The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis
-
Gerlag DM, Ransone L, Tak PP, et al. The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis. J Immunol 2000; 165: 1652-8.
-
(2000)
J Immunol
, vol.165
, pp. 1652-1658
-
-
Gerlag, D.M.1
Ransone, L.2
Tak, P.P.3
-
33
-
-
73349121258
-
Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables
-
Aramaki T, Kawakami A, Iwamoto N, et al. Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables. Mod Rheumatol 2009; 19: 652-6.
-
(2009)
Mod Rheumatol
, vol.19
, pp. 652-656
-
-
Aramaki, T.1
Kawakami, A.2
Iwamoto, N.3
-
34
-
-
62549154024
-
Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis
-
Korhonen R, Moilanen E. Abatacept, a novel CD80/86-CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis. Basic Clin Pharmacol Toxicol 2009; 104: 276-84.
-
(2009)
Basic Clin Pharmacol Toxicol
, vol.104
, pp. 276-284
-
-
Korhonen, R.1
Moilanen, E.2
-
35
-
-
33644671435
-
Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells
-
Wakamatsu K, Nanki T, Miyasaka N, Umezawa K, Kubota T. Effect of a small molecule inhibitor of nuclear factor-κB nuclear translocation in a murine model of arthritis and cultured human synovial cells. Arthritis Res Ther 2005; 7: R1348-59.
-
(2005)
Arthritis Res Ther
, vol.7
, pp. 1348-1359
-
-
Wakamatsu, K.1
Nanki, T.2
Miyasaka, N.3
Umezawa, K.4
Kubota, T.5
-
36
-
-
20144373896
-
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1
-
Takatsuna H, Asagiri M, Kubota T, et al. Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-κB inhibitor, through downregulation of NFATc1. J Bone Miner Res 2005; 20: 653-62.
-
(2005)
J Bone Miner Res
, vol.20
, pp. 653-662
-
-
Takatsuna, H.1
Asagiri, M.2
Kubota, T.3
-
37
-
-
16844377831
-
Mechanistic insight into osteoclast differentiation in osteoimmunology
-
Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med 2005;83:170-9.
-
(2005)
J Mol Med
, vol.83
, pp. 170-179
-
-
Takayanagi, H.1
-
38
-
-
35948958589
-
NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor
-
Kubota T, Hoshino M, Aoki K, et al. NF-κB inhibitor dehydroxymethylepoxyquinomicin suppresses osteoclastogenesis and expression of NFATc1 in mouse arthritis without affecting expression of RANKL, osteoprotegerin or macrophage colony-stimulating factor. Arthritis Res Ther 2007;9:R97.
-
(2007)
Arthritis Res Ther
, vol.9
-
-
Kubota, T.1
Hoshino, M.2
Aoki, K.3
-
39
-
-
2942703810
-
Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
-
Jimi E, Aoki K, Saito H, et al. Selective inhibition of NF-κB blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med 2004; 10: 617-24.
-
(2004)
Nat Med
, vol.10
, pp. 617-624
-
-
Jimi, E.1
Aoki, K.2
Saito, H.3
|