Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor

Tetrahedron

Volumn 60, Issue 33, 2004, Pages 7061-7066

  Suzuki, Yoshikazu ^a   Sugiyama, Chie ^a   Ohno, Osamu ^a   Umezawa, Kazuo ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Apoptosis; DHMEQ; Inflammation; NF B; Nuclear transport; Optical resolution

Indexed keywords

2,5 DIMETHOXYANILINE; ANILINE DERIVATIVE; ANTIBIOTIC AGENT; DEHYDROXYMETHYLEPOXYQUINOMICIN; EPOXYQUINOMICIN C; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CHIRALITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; INHIBITION KINETICS; MACROPHAGE; MONOCYTE; OPTICS; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

EID: 3242671837     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2004.01.103     Document Type: Article

References (13)

1. Sen R., Baltimore D. Cell. 46:1986;705-716
2. Baeuerle P.A., Baltimore D. Cell. 87:1996;13-20
3. Baeuerle P.A., Henkel T. Annu. Rev. Immunol. 12:1994;141-179
4. Antwerp D.J.V., Martin S.J., Kafri T., Green D.R., Verma I.M. Science. 274:1996;787-789
5. Beg A.A., Baltimore D. Science. 274:1996;782-784
6. Wang C.Y., Mayo M.W., Baldwin A.S. Jr. Science. 274:1996;784-787
7. Baldwin A.S. Jr. Annu. Rev. Immunol. 14:1996;649-683
8. Erkel G., Anke T., Sterner O. Biochem. Biophys. Res. Commun. 226:1996;214-221
9. Gehrt A., Erkel G., Anke T., Sterner O. J. Antibiot. 51:1998;455-463
10. Matsumoto N., Tsuchida T., Umekita M., Kinoshita N., Iimuma H., Sawa T., Hamada M., Takeuchi T. J. Antibiot. 50:1997;900-905
11. Matsumoto N., Ariga A., To-e S., Nakamura H., Agata N., Hirano S., Inoue J., Umezawa K. Bioorg. Med. Chem. Lett. 10:2000;865-869
12. Wipf P., Kim Y. J. Org. Chem. 59:1994;3518-3519
13. Wipf P., Kim Y., Jahn H. Synthesis. 1995;1549-1561