An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway

Journal of Biological Chemistry

Volumn 278, Issue 16, 2003, Pages 13944-13951

  Lidell, Martin E ^a   Johansson, Malin E V ^a   Hansson, Gunnar C ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; CHEMICAL BONDS; CROSSLINKING; ENZYMES; PH EFFECTS; PROTEINS;

AUTOCATALYTIC CLEAVAGE;

GENETIC ENGINEERING;

ASPARTIC ACID; MUCIN 2; PROLINE; PROTEINASE INHIBITOR; ANTIINFECTIVE AGENT; BAFILOMYCIN A1; BIOTIN; CROSS LINKING REAGENT; DISULFIDE; MACROLIDE; MUC 2 PROTEIN; MUCIN; PEPTIDE; RECOMBINANT PROTEIN;

ALKALINITY; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; CROSS LINKING; DISULFIDE BOND; HUMAN; NONHUMAN; PH MEASUREMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SECRETION; REACTION ANALYSIS; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; BIOTINYLATION; CATALYSIS; CHEMISTRY; HAMSTER; METABOLISM; MOLECULAR GENETICS; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SERODIAGNOSIS; TIME; WESTERN BLOTTING;

ANIMALIA;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BINDING SITES; BIOTIN; BIOTINYLATION; BLOTTING, WESTERN; CATALYSIS; CHO CELLS; CRICETINAE; CROSS-LINKING REAGENTS; DISULFIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; HYDROGEN-ION CONCENTRATION; MACROLIDES; MOLECULAR SEQUENCE DATA; MUCINS; PEPTIDES; PRECIPITIN TESTS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TIME FACTORS;

EID: 0038751861     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210069200     Document Type: Article

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