Potential candidate genomic biomarkers of drug induced vascular injury in the rat

Toxicology and Applied Pharmacology

Volumn 257, Issue 2, 2011, Pages 284-300

  Dalmas, Deidre A ^a   Scicchitano, Marshall S ^a   Mullins, David ^a   Hughes Earle, Angela ^a   Tatsuoka, Kay ^b   Magid Slav, Michal ^b   Frazier, Kendall S ^a   Thomas, Heath C ^a  

^a Department of Safety Assessment ^*  (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

Biomarker; Drug; Endothelial cells; Transcriptional profiling; Vascular injury; Vascular smooth muscle cells

Indexed keywords

3 AMINOPROPIONITRILE; 6 [4 (1,4 DIHYDRO 4 OXO 1 PYRIDYL)PHENYL] 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; ADRENALIN; ALLYLAMINE; AMPHETAMINE; ATORVASTATIN; BIOLOGICAL MARKER; DIAZOXIDE; DOPAMINE; ENRASENTAN; FENOLDOPAM; GSK 157007A; GW 788388; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HYDRALAZINE; KETANSERIN; METHOXAMINE; MIDODRINE; MINOXIDIL; MONOCROTALINE; N [2 (1 MERCAPTOCYCLOHEXYL)ACETYL] DEXTRO O ETHYLTYROSYLPHENYLALANYLVALYLASPARAGINYLCYSTEINYLPROLYLARGININAMIDE DISULFIDE; NITROPRUSSIDE SODIUM; PENTOXIFYLLINE; PHOSPHOTRANSFERASE INHIBITOR; PRAZOSIN; PROPRANOLOL; RNA; SEROTONIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASOPRESSIN; YOHIMBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE AMPLIFICATION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GENOMICS; MALE; MESENTERIC ARTERY; MICRODISSECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA ISOLATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOXICITY; FENOLDOPAM; GENETIC MARKERS; GENOME-WIDE ASSOCIATION STUDY; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, SPRAGUE-DAWLEY; VASCULAR SYSTEM INJURIES;

RATTUS;

EID: 81855221959     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.09.015     Document Type: Article

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