Pathology and pathophysiology of drug-induced arterial injury in laboratory animals and its implications on the evaluation of novel chemical entities for human clinical trials

Pharmacology and Toxicology

Volumn 89, Issue 4, 2001, Pages 158-170

  Louden, Calvcrt ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINOPROPIONITRILE; ADRENALIN; ALLYLAMINE; ANOREXIGENIC AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; DIGOXIN; DOPAMINE RECEPTOR STIMULATING AGENT; ENDOTHELIN 1; ENDOTHELIN RECEPTOR AGONIST; INOTROPIC AGENT; MITOMYCIN; MONOCROTALINE PYRROLE; NORADRENALIN; PHOSPHODIESTERASE INHIBITOR; VASOACTIVE AGENT; VASOCONSTRICTOR AGENT; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INJURY; CARDIOVASCULAR FUNCTION; CORRELATION FUNCTION; DOG; DRUG MECHANISM; GENE EXPRESSION; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK ASSESSMENT; SHORT SURVEY; TOXICITY TESTING;

ANIMALIA; CANIS FAMILIARIS;

EID: 0035165794     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0901-9928.2001.890404.x     Document Type: Short Survey

References (7)

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2. Battistini, B., D'Orleans-Juste, P. & Sirois, P. Endothelins: Circulating plasma levels and presence in other biologic fluids. Lab. Invest. 1993, 68, 600-628.
3. Blann, A., H. Midgley & G. Burrows.: Free radicals, antioxidants, and endothelial cell damage after percutaneous transluminal coronary angioplasty. Coron. Artery Dis. 1993, 4, 905-910.
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6. Boor, P. J., A. I. Gotlieb, E. C. Joseph, W. D. Kerns, R. A. Roth & K. E. Tomaszewski: Chemical-induced vascular injury. Toxicol Appl. Pharmacol. 1995, 132, 177-195.
7. Bourdois, P. S., J. L. Dancla, J. M. Faccini, J. Nachbaur & A. M. Monro: The subacute toxicology of digoxin in dogs: clinical chemistry and histopathology of heart and kidneys. Arch. Toxicol. 1982, 51, 273-283.