SK&F 95654-Induced Acute Cardiovascular Toxicity in Sprague-Dawley Rats—Histopathologic, Electron Microscopic, and Immunohistochemical Studies

Toxicologic Pathology

Volumn 30, Issue 1, 2002, Pages 28-40

  Jun Zhang, Sheila A ^a   Herman, Eugene H ^a   Knapton, Alan ^a   Chadwick, Douglas P ^a   Whitehurst, Virgil E ^a   Koerner, John E ^a   Papoian, Thomas ^a   Ferrans, Victor J ^b   Sistare, Frank D ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

drug induced vasculitis; endothelial and smooth muscle cell apoptosis; endothelial cell activation; intercellular adhesion molecule 1 (ICAM 1); mast cell degranulation; Myocardial necrosis and inflammation; vasodilatation; von Willebrand factor

Indexed keywords

6 [4 (1,4 DIHYDRO 4 OXO 1 PYRIDYL)PHENYL] 4,5 DIHYDRO 5 METHYL 3(2H) PYRIDAZINONE; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHODIESTERASE INHIBITOR; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ELECTRON MICROSCOPY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOOD VESSELS; CARDIOVASCULAR DISEASES; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LEUKOCYTE ADHERENCE INHIBITION TEST; MALE; MAST CELLS; MICROSCOPY, ELECTRON; MUSCLE, SMOOTH, VASCULAR; MYOCARDIUM; PHOSPHODIESTERASE INHIBITORS; PLATELET ADHESIVENESS; PYRIDAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA;

EID: 0036191401     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230252824680     Document Type: Article

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