메뉴 건너뛰기




Volumn 2, Issue 22, 2011, Pages 2834-2839

New perspective on how and why immunophilin FK506-related ligands work

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE BOND; BINDING AFFINITIES; BULK SOLUTIONS; CARBONYL GROUPS; CIS-TRANS ISOMERIZATION; CONFORMATIONAL ENTROPY; COOPERATIVE MECHANISMS; CYTOSOLIC ENZYMES; EXPERIMENTAL CHARACTERIZATION; EXPERIMENTAL DATA; FLUORESCENCE QUENCHING; H-BONDS; IMMUNOPHILINS; IN-SILICO; INHIBITORY ACTIVITY; MACROLIDES; NEURONAL FUNCTIONING; PROTEIN BINDING; TACROLIMUS;

EID: 81755187733     PISSN: None     EISSN: 19487185     Source Type: Journal    
DOI: 10.1021/jz201037u     Document Type: Article
Times cited : (15)

References (27)
  • 1
    • 0026575583 scopus 로고
    • Natural Products As Probes of Cellular Function Studies of Immunophilins
    • Rosen, M. K.; Schreiber, S. L. Natural Products As Probes of Cellular Function Studies of Immunophilins Angew. Chem., Int. Ed. Engl. 1992, 31, 384-400
    • (1992) Angew. Chem., Int. Ed. Engl. , vol.31 , pp. 384-400
    • Rosen, M.K.1    Schreiber, S.L.2
  • 4
    • 42449147105 scopus 로고    scopus 로고
    • Fragment-Based Synthesis and SAR of Modified FKBP Ligands: Influence of Different Linking on Binding Affinity
    • Roehrig, C. H.; Loch, C.; Guan, J.-Y.; Siegal, G.; Overhand, M. Fragment-Based Synthesis and SAR of Modified FKBP Ligands: Influence of Different Linking on Binding Affinity ChemMedChem 2007, 2, 1054-1070
    • (2007) ChemMedChem , vol.2 , pp. 1054-1070
    • Roehrig, C.H.1    Loch, C.2    Guan, J.-Y.3    Siegal, G.4    Overhand, M.5
  • 5
    • 3242814526 scopus 로고    scopus 로고
    • FK506 and a nonimmunosuppressant derivative reduce axonal and myelin damage in experimental autoimmune encephalomyelitis: Neuroimmunophilin ligand-mediated neuroprotection in a model of multiple sclerosis
    • DOI 10.1002/jnr.20165
    • Gold, B. G.; Voda, J.; Yu, X.; McKeon, G.; Bourdette, D. FK506 and a Nonimmunosuppressant Derivative Reduce Axonal and Myelin Damage in Experimental Autoimmune Encephalomyelitis: Neuroimmunophilin Ligand-Mediated Neuroprotection in a Model of Multiple Sclerosis J. Neurosci. Res. 2004, 77, 367-377 (Pubitemid 38970981)
    • (2004) Journal of Neuroscience Research , vol.77 , Issue.3 , pp. 367-377
    • Gold, B.G.1    Voda, J.2    Yu, X.3    McKeon, G.4    Bourdette, D.N.5
  • 6
    • 77949264184 scopus 로고    scopus 로고
    • Rapamycin Inhibits Relapsing Experimental Autoimmune Encephalomyelitis by Both Effector and Regulatory T Cells Modulation
    • Esposito, M.; Ruffini, F.; Bellone, M.; Gagliani, N.; Battaglia, M.; Martino, G.; Furlan, R. Rapamycin Inhibits Relapsing Experimental Autoimmune Encephalomyelitis by Both Effector and Regulatory T Cells Modulation J. Neuroimmunol. 2010, 220, 52-63
    • (2010) J. Neuroimmunol. , vol.220 , pp. 52-63
    • Esposito, M.1    Ruffini, F.2    Bellone, M.3    Gagliani, N.4    Battaglia, M.5    Martino, G.6    Furlan, R.7
  • 7
    • 35748940261 scopus 로고    scopus 로고
    • Improvement of multiple sclerosis on tacrolimus plus mycophenolate mofetil after liver transplantation: Clinical improvement of multiple sclerosis in a patient requiring liver transplantation for acute liver failure following interferon-β therapy [3]
    • DOI 10.1111/j.1432-2277.2007.00544.x
    • Behrbohm, J.; Neid, M.; Stolzel, U.; Wittekind, C.; Hauss, J. P.; Tillmann, H. L. Improvement of Multiple Sclerosis on Tacrolimus Plus Mycophenolate Mofetil after Liver Transplantation. Clinical Improvement of Multiple Sclerosis in a Patient Requiring Liver Transplantation for Acute Liver Failure Following Interferon-Beta Therapy Transplant Int. 2007, 20, 1077-1079 (Pubitemid 350043841)
    • (2007) Transplant International , vol.20 , Issue.12 , pp. 1077-1079
    • Behrbohm, J.1    Neid, M.2    Stolzel, U.3    Wittekind, C.4    Hauss, J.P.5    Tillmann, H.L.6
  • 8
    • 49649102097 scopus 로고    scopus 로고
    • Remission of Multiple Sclerosis in a Patient with Insulin Dependent Diabetes Mellitus Following Combined Kidney-Pancreas Transplantation
    • Bonatti, H.; Gillis, J.; Berger, N.; Mark, W.; Kofler, H.-J.; Margreiter, R.; Pfausler, B. Remission of Multiple Sclerosis in a Patient with Insulin Dependent Diabetes Mellitus Following Combined Kidney-Pancreas Transplantation Transplant Int. 2008, 21, 916-918
    • (2008) Transplant Int. , vol.21 , pp. 916-918
    • Bonatti, H.1    Gillis, J.2    Berger, N.3    Mark, W.4    Kofler, H.-J.5    Margreiter, R.6    Pfausler, B.7
  • 9
    • 0028956418 scopus 로고
    • Neuronal Regeneration Enhances the Expression of the immunophilin FKBP-12
    • Lyons, W.; Steiner, J. P.; Snyder, S. H.; Dawson, T. M. Neuronal Regeneration Enhances the Expression of the immunophilin FKBP-12 J. Nuerosci. 1995, 15, 2985-2994
    • (1995) J. Nuerosci. , vol.15 , pp. 2985-2994
    • Lyons, W.1    Steiner, J.P.2    Snyder, S.H.3    Dawson, T.M.4
  • 11
    • 33645832333 scopus 로고    scopus 로고
    • The aggregation of alpha-synuclein is stimulated by FK506 binding proteins as shown by fluorescence correlation spectroscopy
    • DOI 10.1096/fj.05-5126fje
    • Gerard, M.; Debyser, Z.; Desender, L.; Kahle, P. J.; Baert, J.; Baekelandt, V.; Engelborghs, Y. The Aggregation of Alpha-Synuclein Is Stimulated by FK506 Binding Proteins As Shown by Fluorescence Correlation Spectroscopy FASEB J. 2006, 20, 524-526 (Pubitemid 46671237)
    • (2006) FASEB Journal , vol.20 , Issue.3 , pp. 524-526
    • Gerard, M.1    Debyser, Z.2    Desender, L.3    Kahle, P.J.4    Baert, J.5    Baekelandt, V.6    Engelborghs, Y.7
  • 13
    • 33645741621 scopus 로고    scopus 로고
    • Peptidyl-Prolyl Isomerase Inhibitors
    • Wang, X.; Etzkorn, F. Peptidyl-Prolyl Isomerase Inhibitors Biopolymers 2006, 84, 125-146
    • (2006) Biopolymers , vol.84 , pp. 125-146
    • Wang, X.1    Etzkorn, F.2
  • 14
    • 71249154019 scopus 로고    scopus 로고
    • Enhanced FK506 Production in Streptomyces clavuligerus CKD1119 by Engineering the Supply of Methylmalonyl-CoA Precursor
    • Mo, S. J.; Ban, Y. H.; Park, J. W.; Yoo, Y. J.; Yoon, Y. J. Enhanced FK506 Production in Streptomyces clavuligerus CKD1119 by Engineering the Supply of Methylmalonyl-CoA Precursor J. Ind. Microbiol. Biotechnol. 2009, 36, 1473-1482
    • (2009) J. Ind. Microbiol. Biotechnol. , vol.36 , pp. 1473-1482
    • Mo, S.J.1    Ban, Y.H.2    Park, J.W.3    Yoo, Y.J.4    Yoon, Y.J.5
  • 15
    • 0025955186 scopus 로고
    • Atomic Structure of the Rapamycin Human Immunophilin FKBP-12 Complex
    • Van-Duyne, G.; Standaert, R. F.; Schreiber, S. L.; Clardy, J Atomic Structure of the Rapamycin Human Immunophilin FKBP-12 Complex J. Am. Che. Soc. 1991, 113, 7433-7434
    • (1991) J. Am. Che. Soc. , vol.113 , pp. 7433-7434
    • Van-Duyne, G.1    Standaert, R.F.2    Schreiber, S.L.3    Clardy, J.4
  • 16
    • 79956069862 scopus 로고    scopus 로고
    • Intraligand Hydrophobic Interactions Rationalize Drug Affinities for Peptidyl-Prolyl Cis-Trans Isomerase Protein
    • Bizzarri, M.; Marsili, S.; Procacci, P. Intraligand Hydrophobic Interactions Rationalize Drug Affinities for Peptidyl-Prolyl Cis-Trans Isomerase Protein J. Phys. Chem. B 2011, 115, 6193-6201
    • (2011) J. Phys. Chem. B , vol.115 , pp. 6193-6201
    • Bizzarri, M.1    Marsili, S.2    Procacci, P.3
  • 18
    • 77953056324 scopus 로고    scopus 로고
    • Orac: A Molecular Dynamics Simulation Program to Explore Free Energy Surfaces in Biomolecular Systems at the Atomistic Level
    • Marsili, S.; Signorini, G. F.; Chelli, R.; Marchi, M.; Procacci, P. Orac: A Molecular Dynamics Simulation Program to Explore Free Energy Surfaces in Biomolecular Systems at the Atomistic Level J. Comput. Chem. 2010, 31, 1106-1161
    • (2010) J. Comput. Chem. , vol.31 , pp. 1106-1161
    • Marsili, S.1    Signorini, G.F.2    Chelli, R.3    Marchi, M.4    Procacci, P.5
  • 19
    • 79956069862 scopus 로고    scopus 로고
    • The conformations of sb3 diastereoisomers in water were obtained using the trajectory data of a previous work: Bizzarri, M. J. Phys. Chem. B 2011, 115, 6193-6201
    • (2011) J. Phys. Chem. B , vol.115 , pp. 6193-6201
    • Bizzarri, M.1
  • 20
    • 67651163643 scopus 로고    scopus 로고
    • Fluorescent Probes to Characterise Fk506-Binding Proteins
    • Kozany, C.; Maerz, A.; Kress, C.; Hausch, F. Fluorescent Probes to Characterise Fk506-Binding Proteins ChemBioChem 2009, 10, 1402-1410
    • (2009) ChemBioChem , vol.10 , pp. 1402-1410
    • Kozany, C.1    Maerz, A.2    Kress, C.3    Hausch, F.4
  • 21
  • 22
    • 77956583186 scopus 로고    scopus 로고
    • How Can Hydrophobic Association Be Enthalpy-Driven?
    • Setny, P.; Baron, R.; McCammon, J. A. How Can Hydrophobic Association Be Enthalpy-Driven? J. Chem. Theory Comput. 2010, 6, 2866-2871
    • (2010) J. Chem. Theory Comput. , vol.6 , pp. 2866-2871
    • Setny, P.1    Baron, R.2    McCammon, J.A.3
  • 23
    • 78049348054 scopus 로고    scopus 로고
    • Molecular Binding: Under Water'S Influence
    • Hummer, G. Molecular Binding: Under Water'S Influence Nat. Chem. 2010, 2, 906-906
    • (2010) Nat. Chem. , vol.2 , pp. 906-906
    • Hummer, G.1
  • 26
    • 0035899738 scopus 로고    scopus 로고
    • Determination of the potential of mean force of aromatic amino acid complexes in various solvents using molecular dynamics simulations: The case of the tryptophan-histidine pair
    • DOI 10.1021/jp010434w
    • Gervasio, F. L.; Chelli, R.; marchi, M.; Procacci, P.; Schettino, V. Determination of the Potential of Mean Force of Aromatic Aminoacid Complexes in Various Solvents Using Molecular Dynamics Simulations: The Case of the Tryptophan-Histidine Pair J. Phys. Chem. A 2001, 105, 7835-7846 (Pubitemid 35338907)
    • (2001) Journal of Physical Chemistry B , vol.105 , Issue.32 , pp. 7835-7846
    • Luigi Gervasio, F.1    Chelli, R.2    Marchi, M.3    Procacci, P.4    Schettino, V.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.