Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury

Circulation

Volumn 120, Issue 13, 2009, Pages 1255-1265

  Hirahashi, Junichi ^a,b   Hishikawa, Keiichi ^a   Kaname, Shinya ^a   Tsuboi, Naotake ^b   Wang, Yunmei ^c   Simon, Daniel I ^c   Stavrakis, George ^b   Shimosawa, Tatsuo ^a   Xiao, Ling ^b   Nagahama, Yutaka ^d   Suzuki, Kazuo ^e   Fujita, Toshiro ^a   Mayadas, Tanya N ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d LSI MEDIENCE CORPORATION   (Japan)

^e CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cell adhesion molecules; Inflammation; Kidney; Leukocytes; Thrombosis

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CD34 ANTIGEN; COLONY STIMULATING FACTOR 1; FIBROBLAST GROWTH FACTOR; GLYCOPROTEIN IB ALPHA; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LEUKOCYTE ELASTASE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 1; PLATELET DERIVED GROWTH FACTOR; RANTES;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; GLOMERULONEPHRITIS; GLOMERULUS; HEMATURIA; INFLAMMATION; KIDNEY DYSFUNCTION; MALE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; THROMBOCYTE; THROMBOCYTOPENIA; THROMBOSIS;

ANIMALS; ANTIBODIES; BLOOD PLATELETS; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; FIBRIN; GLOMERULONEPHRITIS; KIDNEY FAILURE, ACUTE; LEUKOCYTE ELASTASE; MACROPHAGE-1 ANTIGEN; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEUTROPHILS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; THROMBOCYTOPENIA; THROMBOSIS;

EID: 70349694116     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.109.873695     Document Type: Article

References (40)

1. Stave GM, Croker BP. Thrombotic microangiopathy in anti-glomerular basement membrane glomerulonephritis. Arch Pathol Lab Med. 1984; 108:747-751.
2. Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, Remuzzi G, Rizzoni G, Taylor CM, Van de Kar N, Zimmerhackl LB. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney Int. 2006;70:423-431. (Pubitemid 44141568)
3. Ruggenenti P, Noris M, Remuzzi G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 2001;60:831-846. (Pubitemid 34205784)
4. Forsyth KD, Simpson AC, Fitzpatrick MM, Barratt TM, Levinsky RJ. Neutrophil-mediated endothelial injury in haemolytic uraemic syndrome. Lancet. 1989;2:411-414.
5. Fernandez GC, Rubel C, Dran G, Gomez S, Isturiz MA, Palermo MS. Shiga toxin-2 induces neutrophilia and neutrophil activation in a murine model of hemolytic uremic syndrome. Clin Immunol. 2000;95:227-234.
6. Ponticelli C. De novo thrombotic microangiopathy: an underrated complication of renal transplantation. Clin Nephrol. 2007;67:335-340.
7. Mayer SA, Aledort LM. Thrombotic microangiopathy: differential diagnosis, pathophysiology and therapeutic strategies. Mt Sinai J Med. 2005;72:166-175.
8. Cohen JA, Brecher ME, Bandarenko N. Cellular source of serum lactate dehydrogenase elevation in patients with thrombotic thrombocytopenic purpura. J Clin Apher. 1998;13:16-19.
9. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996;5:653-666.
10. Belaaouaj A, McCarthy R, Baumann M, Gao Z, Ley TJ, Abraham SN, Shapiro SD. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nat Med. 1998;4: 615-618.
11. Wang Y, Sakuma M, Chen Z, Ustinov V, Shi C, Croce K, Zago AC, Lopez J, Andre P, Plow E, Simon DI. Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury. Circulation. 2005;112:2993-3000.
12. Kondo C, Mizuno M, Nishikawa K, Yuzawa Y, Hotta N, Matsuo S. The role of C5a in the development of thrombotic glomerulonephritis in rats. Clin Exp Immunol. 2001;124:323-329.
13. Kohno I, Inuzuka K, Itoh Y, Nakahara K, Eguchi Y, Sugo T, Soe G, Sakata Y, Murayama H, Matsuda M. A monoclonal antibody specific to the granulocyte-derived elastase-fragment D species of human fibrinogen and fibrin: its application to the measurement of granulocyte-derived elastase digests in plasma. Blood. 2000;95:1721-1728.
14. Tang T, Rosenkranz A, Assmann KJ, Goodman MJ, Gutierrez-Ramos JC, Carroll MC, Cotran RS, Mayadas TN. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulone-phritis. J Exp Med. 1997;186:1853-1863.
15. Norton J, Sloane JP, Delia D, Greaves MF. Reciprocal expression of CD34 and cell adhesion molecule ELAM-1 on vascular endothelium in acute cutaneous graft-versus-host disease. J Pathol. 1993;170:173-177.
16. Delia D, Lampugnani MG, Resnati M, Dejana E, Aiello A, Fontanella E, Soligo D, Pierotti MA, Greaves MF. CD34 expression is regulated reciprocally with adhesion molecules in vascular endothelial cells in vitro. Blood. 1993;81:1001-1008.
17. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and
18. Ross GD. Regulation of the adhesion versus cytotoxic functions of the Mac-1/CR3/alphaMbeta2-integrin glycoprotein. Crit Rev Immunol. 2000; 20:197-222.
19. Goerge T, Ho-Tin-Noe B, Carbo C, Benarafa C, Remold-O?Donnell E, Zhao BQ, Cifuni SM, Wagner DD. Inflammation induces hemorrhage in thrombocytopenia. Blood. 2008;111:4958-4964.
20. Nieswandt B, Bergmeier W, Rackebrandt K, Gessner JE, Zirngibl H. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. Blood. 2000;96: 2520-2527.
21. Tomosugi NI, Cashman SJ, Hay H, Pusey CD, Evans DJ, Shaw A, Rees AJ. Modulation of antibody-mediated glomerular injury in vivo by bacterial lipopolysaccharide, tumor necrosis factor, and IL-1. J Immunol. 1989;142:3083-3090.
22. Naruse T, Tsuchida A, Ogawa S, Yano S, Maekawa T. Selective glomer-ular thrombosis in rats induced by combined injections of nephrotoxic antiserum and lipopolysaccharide. J Lab Clin Med. 1985;105:146-156.
23. Hohenstein B, Braun A, Amann KU, Johnson RJ, Hugo CP. A murine model of site-specific renal microvascular endothelial injury and thrombotic microangiopathy. Nephrol Dial Transplant. 2008;23: 1144-1156.
24. Berger SP, Seelen MA, Hiemstra PS, Gerritsma JS, Heemskerk E, van der Woude FJ, Daha MR. Proteinase 3, the major autoantigen of Wegener?s granulomatosis, enhances IL-8 production by endothelial cells in vitro. J Am Soc Nephrol. 1996;7:694-701.
25. Leavell KJ, Peterson MW, Gross TJ. The role of fibrin degradation products in neutrophil recruitment to the lung. Am J Respir Cell Mol Biol. 1996;14:53-60.
26. Ley K, Laudanna C, Cybulsky MI, Nourshargh S. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol. 2007;7:678-689.
27. Afshar-Kharghan V, Thiagarajan P. Leukocyte adhesion and thrombosis. Curr Opin Hematol. 2006;13:34-39.
28. Drews RE. Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med. 2003;24:607-622.
29. Ikeguchi H, Maruyama S, Morita Y, Fujita Y, Kato T, Natori Y, Akatsu H, Campbell W, Okada N, Okada H, Yuzawa Y, Matsuo S. Effects of human soluble thrombomodulin on experimental glomerulonephritis. Kidney Int. 2002;61:490-501.
30. Gimbrone MA Jr, Aster RH, Cotran RS, Corkery J, Jandl JH, Folkman J. Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature. 1969;222:33-36.
31. Danielli JF. Capillary permeability and oedema in the perfused frog. J Physiol. 1940;98:109-129.
32. Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, Ruggeri ZM, Jain RK, Folkman J, Wagner DD. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A. 2006;103:855-860.
33. Nieswandt B. How do platelets prevent bleeding? Blood. 2008;111:4835.
34. Dominguez V, Govezensky T, Gevorkian G, Larralde C. Low platelet counts alone do not cause bleeding in an experimental immune throm-bocytopenic purpura in mice. Haematologica. 2003;88:679-687.
35. Ho-Tin-Noe B, Goerge T, Cifuni SM, Duerschmied D, Wagner DD. Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res. 2008;68:6851-6858.
36. Brady HR, Serhan CN. Lipoxins: putative braking signals in host defense, inflammation and hypersensitivity. Curr Opin Nephrol Hypertens. 1996; 5:20-27.
37. Santoso S, Sachs UJ, Kroll H, Linder M, Ruf A, Preissner KT, Chavakis T. The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1. J Exp Med. 2002;196: 679-691.
38. Simon DI, Chen Z, Xu H, Li CQ, Dong J, McIntire LV, Ballantyne CM, Zhang L, Furman MI, Berndt MC, Lopez JA. Platelet glycoprotein ibalpha is a counterreceptor for the leukocyte integrin Mac-1 (CD11b/ CD18). J Exp Med. 2000;192:193-204.
39. Weber C, Springer TA. Neutrophil accumulation on activated, surface-adherent platelets in flow is mediated by interaction of Mac-1 with fibrinogen bound to alphaIIbbeta3 and stimulated by platelet-activating factor. J Clin Invest. 1997;100:2085-2093.
40. Pluskota E, Woody NM, Szpak D, Ballantyne CM, Soloviev DA, Simon DI, Plow EF. Expression, activation, and function of integrin alpha-Mbeta2 (Mac-1) on neutrophil-derived microparticles. Blood. 2008;112: 2327-2335.