Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

Biochemical Journal

Volumn 430, Issue 1, 2010, Pages 79-86

  Kveiborg, Marie ^a   Jacobsen, Jonas ^a   Meng Huee, Lee ^b   Nagase, Hideaki ^c   Wewer, Ulla M ^a   Murphy, Gillian ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

A disintegrin and metalloprotease 12 (ADAM12); Ectodomain shedding; Therapeutic target; Tissue inhibitor of metalloproteinase (TIMP); Tumour necrosis factor converting enzyme (TACE)

Indexed keywords

ECTODOMAIN SHEDDING; METALLO-PROTEASE; NECROSIS FACTORS; THERAPEUTIC TARGET; TISSUE INHIBITOR OF METALLOPROTEINASE (TIMP);

BLOOD VESSELS; CATALYST ACTIVITY; ENZYMES; GLYCOPROTEINS; MACROPHAGES; PEPTIDES; TISSUE ENGINEERING; TUMORS;

ENZYME INHIBITION;

ADAM PROTEIN; ADAM12; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; UNCLASSIFIED DRUG; ADAM 12 PROTEIN; EPIDERMAL GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; MEMBRANE PROTEIN; RECOMBINANT PROTEIN; SIGNAL PEPTIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CATALYSIS; CELL ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; FLUORESCENCE; HUMAN; HUMAN CELL; MOLECULAR INTERACTION; MUTAGENESIS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TISSUE ENGINEERING; CELL LINE; CELL MEMBRANE; DRUG ANTAGONISM; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE;

ADAM PROTEINS; CATALYSIS; CELL LINE; CELL MEMBRANE; EPIDERMAL GROWTH FACTOR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; MEMBRANE PROTEINS; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 77955505776     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20100649     Document Type: Article

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