A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors

International Journal of Pharmaceutics

Volumn 421, Issue 2, 2011, Pages 379-387

  Shiraishi, Kouichi ^a   Endoh, Reiko ^a   Furuhata, Hiroshi ^a   Nishihara, Masamichi ^b   Suzuki, Ryo ^c   Maruyama, Kazuo ^c   Oda, Yusuke ^c   Jo, Jun Ichiro ^d   Tabata, Yasuhiko ^d   Yamamoto, Jun ^e   Yokoyama, Masayuki ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c TEIKYO UNIVERSITY   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

Emulsion; Perfluorocarbon; Theranostics; Tumor targeting; Ultrasound

Indexed keywords

COPOLYMER; PERFLEXANE; PERFLUOROPENTANE; POLY(ETHYLENE GLYCOL) B POLY(4,4,5,5,6,6,7,7,7 NONAFLUOROHEPTYL ASPARTATE); POLY(ETHYLENE GLYCOL) B POLY(ASPARTIC ACID); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; FEMALE; MOUSE; NANOEMULSION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; SOLID TUMOR; TEMPERATURE MEASUREMENT; ULTRASOUND;

ANIMALS; DRUG COMPOUNDING; EMULSIONS; FEMALE; FLUOROCARBONS; MICE; MICE, INBRED BALB C; NANOPARTICLES; NEOPLASMS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SONICATION;

EID: 81755165811     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.006     Document Type: Article

References (50)

1. H. Ai Layer-by-layer capsules for magnetic resonance imaging and drug delivery Adv. Drug Deliv. Rev. 63 2011 772 788
2. R. Asami, T. Azuma, and K. Kawabata Fluorocarbon droplets as next generation contrast agents - their behavior under 1-3 mhz ultrasound IEEE Proc. Int. Ultrasonics Symp. 2009 1294 1297
3. R. Asami, T. Ikeda, T. Azuma, K. Kawabata, and S. Umemura Acoustic signal characterization of phase change nanodroplets in tissue-mimicking phantom gels Jpn. J. Appl. Phys. 49 2010 07HF16
4. E. Blanco, C.W. Kessinger, B.D. Sumer, and J. Gao Multifunctional micellar nanomedicine for cancer therapy Exp. Biol. Med. 234 2009 123 131
5. J.M. Bryson, K.M. Fichter, W.J. Chu, J.H. Lee, J. Li, L.A. Madsen, P.M. McLendon, and T.M. Reineke Polymer beacons for luminescence and magnetic resonance imaging of DNA delivery Proc. Natl. Acad. Sci. U.S.A. 106 2009 16913 16918
6. Chen, X.S., 2011. Introducing theranostics journal - from the editor-in-chief. Theranostics 1, 1-2.
7. A. Gianella, P.A. Jarzyna, V. Mani, S. Ramachandran, C. Calcagno, J. Tang, B. Kann, W.J. Dijk, V.L. Thijssen, A.W. Griffioen, G. Storm, Z.A. Fayad, and W.J. Mulder A multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer ACS Nano 5 2011 4422 4433
8. D. Grishenkov, C. Pecorari, T.B. Brismar, and G. Paradossi Characterization of acoustic properties of PVA-shelled ultrasound contrast agents: ultrasound-induced fracture (part II) Ultrasound Med. Biol. 35 2009 1139 1147
9. S. Hernot, and A.L. Klibanov Microbubbles in ultrasound-triggered drug and gene delivery Adv. Drug Deliv. Rev. 60 2008 1153 1166
10. O. Ishida, K. Maruyama, K. Sasaki, and M. Iwatsuru Size-dependent extravasation and interstitial localization of polyethyleneglycol liposomes in solid tumor-bearing mice Int. J. Pharm. 190 1999 49 56
11. H. Jeong, M. Huh, S.J. Lee, H. Koo, I.C. Kwon, S.Y. Jeong, and K. Kim Photosensitizer-conjugated human serum albumin nanoparticles for effective photodynamic therapy Theranostics 1 2011 230 239
12. S. Kaida, H. Cabral, M. Kumagai, A. Kishimura, Y. Terada, M. Sekino, I. Aoki, N. Nishiyama, T. Tani, and K. Kataoka Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model Cancer Res. 70 2010 7031 7041
13. T.L. Kalber, N. Kamaly, S.A. Higham, J.A. Pugh, J. Bunch, C.W. McLeod, A.D. Miller, and J.D. Bell Synthesis and characterization of a theranostic vascular disrupting agent for in vivo MR imaging Bioconjug. Chem. 22 2011 879 886
14. N. Kamaly, and A.D. Miller Paramagnetic liposome nanoparticles for cellular and tumour imaging Int. J. Mol. Sci. 11 2010 1759 1776
15. K. Kawabata, N. Sugita, H. Yoshikawa, T. Azuma, and S. Umemura Nanoparticles with multiple perfluorocarbons for controllable ultrasonically induced phase shifting Jpn. J. Appl. Phys. 44 2005 4548 4552
16. K. Kawabata, R. Asami, H. Yoshikawa, T. Azuma, and S. Umemura Acoustic response of microbubbles derived from phase-change nanodroplet Jpn. J. Appl. Phys. 49 2010 07HF18
17. K. Kawabata, R. Asami, H. Yoshikawa, T. Azuma, and S. Umemura Sustaining microbubbles derived from phase change nanodroplet by low-amplitude ultrasound exposure Jpn. J. Appl. Phys. 49 2010 07HF20
18. K. Kim, J.H. Kim, H. Park, Y.S. Kim, K. Park, H. Nam, S. Lee, J.H. Park, R.W. Park, I.S. Kim, K. Choi, S.Y. Kim, K. Park, and I.C. Kwon Tumor-homing multifunctional nanoparticles for cancer theragnosis: simultaneous diagnosis, drug delivery, and therapeutic monitoring J. Contr. Rel. 146 2010 219 227
19. T. Lammers, F. Kiessling, W.E. Hennink, and G. Storm Nanotheranostics and image-guided drug delivery: current concepts and future directions Mol. Pharm. 7 2010 1899 1912
20. T. Lammers, S. Aime, W.E. Hennink, G. Storm, and F. Kiessling Theranostic Nanomedicines Acc. Chem. Res. 44 2011 1029 1038
21. D.C. Litzinger, A.M.J. Buiting, N. van Rooijen, and L. Huang Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes Biochim. Biophys. Acta 1190 1994 99 107
22. J.A. MacKay, and Z. Li Theranostic agents that co-deliver therapeutic and imaging agents? Adv. Drug Deliv. Rev. 62 2010 1003 1004
23. K.H. Min, J.H. Kim, S.M. Bae, H. Shin, M.S. Kim, S. Park, H. Lee, R.W. Park, I.S. Kim, K. Kim, I.C. Kwon, S.Y. Jeong, and D.S. Lee Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy J. Contr. Rel. 144 2010 259 266
24. P. Mohan, and N. Rapoport Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking Mol. Pharm. 6 2010 1959 1973
25. G.D. Moon, S.W. Choi, X. Cai, W. Li, E.C. Cho, U. Jeong, L.V. Wang, and Y. Xia A new theranostic system based on gold nanocages and phase-change materials with unique features for photoacoustic imaging and controlled release J. Am. Chem. Soc. 133 2011 4762 4765
26. A. Nagayasu, K. Uchiyama, T. Nishida, Y. Yamagiwa, Y. Kawai, and H. Kiwada Is control of distribution of liposomes between tumors and bone marrow possible? Biochim. Biophys. Acta 1278 1996 29 34
27. E. Nakamura, K. Makino, T. Okano, T. Yamamoto, and M. Yokoyama A polymeric micelle MRI contrast agent with changeable relaxivity J. Contr. Rel. 114 2006 325 333
28. M. Nishihara, K. Imai, and M. Yokoyama Preparation of perfluorocarbon/fluoroalkyl polymer nanodroplets for cancer-targeted ultrasound contrast agents Chem. Lett. 38 2009 556 557
29. P. Opanasopit, M. Yokoyama, M. Watanabe, K. Kawano, Y. Maitani, and T. Okano Block copolymer design for camptothecin incorporation into polymeric micelles for passive tumor targeting Pharm. Res. 21 2004 2003 2010
30. D. Pan, S.D. Caruthers, G. Hu, A. Senpan, M.J. Scott, P.J. Gaffney, S.A. Wickline, and G.M. Lanza Ligand-directed nanobialys as theranostic agent for drug delivery and manganese-based magnetic resonance imaging of vascular targets J. Am. Chem. Soc. 130 2008 9186 9187
31. N. Rapoport, Z. Gao, and A. Kennedy Multifunctional nanoparticles for combining ultrasonic tumor imaging and targeted chemotherapy J. Natl. Cancer Inst. 99 2007 1095 1106
32. N.Y. Rapoport, A.M. Kennedy, J.E. Shea, C.L. Scaife, and K.H. Nam Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles J. Contr. Rel. 138 2009 268 276
33. N.Y. Rapoport, K.H. Nam, Z. Gao, and A. Kennedy Application of ultrasound for targeted nanotherapy of malignant tumors Acoust. Phys. 55 2009 594 601
34. N. Rapoport, D.A. Christensen, A.M. Kennedy, and K.H. Nam Cavitation properties of block copolymer stabilized phase-shift nanoemulsions used as drug carriers Ultrasound Med. Biol. 36 2010 419 429
35. N. Rapoport, A.M. Kennedy, J.E. Shea, C.L. Scaife, and K.H. Nam Ultrasonic nanotherapy of pancreatic cancer: lessons from ultrasound imaging Mol. Pharm. 7 2010 22 31
36. N. Rapoport, K.H. Nam, R. Gupta, Z. Gao, P. Mohan, A. Payne, N. Todd, X. Liu, T. Kim, J. Shea, C. Scaife, D.L. Parker, E.K. Jeong, and A.M. Kennedy Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions J. Contr. Rel. 153 2011 4 15
37. C. Sanson, O. Diou, J. Thévenot, E. Ibarboure, A. Soum, A. Brûlet, S. Miraux, E. Thiaudire, S. Tan, A. Brisson, V. Dupuis, O. Sandre, and S. Lecommandoux Doxorubicin loaded magnetic polymersomes: theranostic nanocarriers for MR imaging and magneto-chemotherapy ACS Nano 5 2011 1122 1140
38. E.G. Schutt, D.H. Klein, R.M. Mattrey, and J.G. Riess Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: the key role of perfluorochemicals Angew. Chem. Int. Ed. Engl. 42 2003 3218 3235
39. K. Shiraishi, K. Kawano, T. Minowa, Y. Maitani, and M. Yokoyama Preparation and in vivo imaging of PEG-poly(l-lysine)-based polymeric micelle MRI contrast agents J. Contr. Rel. 136 2009 14 20
40. K. Shiraishi, K. Kawano, Y. Maitani, and M. Yokoyama Synthesis of Poly(ethylene glycol)-b-poly(l-lysine) block copolymers having Gd-DOTA as MRI contrast agent and their polymeric micelle formation by polyion complexation J. Contr. Rel. 148 2010 160 167
41. C. Solans, P. Izquierdo, J. Nolla, N. Azemar, and M.J. Garcia-Celma Nano-emulsions Curr. Opin. Colloid Interface Sci. 10 2005 102 110
42. T. Tadros, P. Izuquierdo, J. Esquena, and C. Solans Formation and stability of nano-emulsions Adv. Colloid Interface. Sci. 108-109 2004 303 318
43. T. Tanigo, R. Takaoka, and Y. Tabata Sustained release of water-insoluble simvastatin from biodegradable hydrogel augments bone regeneration J. Contr. Rel. 143 2010 201 206
44. E.C. Unger, T. Porter, W. Culp, R. Labell, T. Matsunaga, and R. Zutshi Therapeutic applications of lipid-coated microbubbles Adv. Drug Deliv. Rev. 56 2004 1291 1314
45. T. Yamamoto, M. Yokoyama, P. Opanasopit, A. Hayama, K. Kawano, and Y. Maitani What are determining factors for stable drug incorporation into polymeric micelle carriers? Consideration on physical and chemical characters of the micelle inner core J. Contr. Rel. 123 2007 11 18
46. M. Yokoyama Polymeric micelles for the targeting of hydrophobic drugs G.S. Kwon, Drug and Pharmaceutical Sciences, Polymeric Drug Delivery Systems 148 2005 Taylor & Francis Boca Raton 533 575
47. M. Yokoyama Polymeric micelles as nano-sized drug carrier systems A.J. Domb, Y. Tabata, M.N.V.R. Kumar, S. Farber, Nanoparticles for Pharmaceutical Applications 2007 American Scientific Publishers Stevenson Ranch 63 72
48. M. Yokoyama, P. Opanasopit, Y. Maitani, K. Kawano, and T. Okano Polymer design and incorporation method for polymeric micelle carrier system containing water-insoluble anti-cancer agent camptothecin J. Drug Target. 12 2004 373 384
49. F. Yuan, M. Dellian, D. Fukumura, M. Leunig, D.A. Berk, V.P. Torchilin, and R.K. Jain Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size Cancer Res. 55 1995 3752 3756
50. M. Watanabe, K. Kawano, M. Yokoyama, P. Opanasopit, T. Okano, and Y. Maitani Preparation of camptothecin-loaded polymeric micelles and evaluation of their incorporation and circulation stability Int. J. Pharm. 308 2006 183 189