메뉴 건너뛰기




Volumn 22, Issue 5, 2011, Pages 879-886

Synthesis and characterization of a theranostic vascular disrupting agent for in vivo MR imaging

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL PROLIFERATION; DIAGNOSIS; GADOLINIUM COMPOUNDS; HISTOLOGY; MAGNETIC RESONANCE IMAGING; TUMORS;

EID: 80052995735     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100329t     Document Type: Article
Times cited : (20)

References (43)
  • 1
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P., Kallinowski, F., and Okunieff, P. (1989) Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human. tumors: a review. Cancer Res. 49, 6449-6465. (Pubitemid 20008770)
    • (1989) Cancer Research , vol.49 , Issue.23 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 2
    • 0027563591 scopus 로고
    • Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy
    • Denekamp, J. (1993) Review article: angiogenesis, neovascular. proliferation and vascular pathophysiology as targets for cancer therapy. Br. J. Radiol. 66, 181-196. (Pubitemid 23096969)
    • (1993) British Journal of Radiology , vol.66 , Issue.783 , pp. 181-196
    • Denekamp, J.1
  • 3
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and. other diseases
    • Carmeliet, P., and Jain, R. K. (2000) Angiogenesis in cancer and. other diseases. Nature 407, 249-257.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 4
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the. angiogenic switch
    • Bergers, G., and Benjamin, L. E. (2003) Tumorigenesis and the. angiogenic switch. Nat. Rev. Cancer 3, 401-410.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 5
    • 2642571660 scopus 로고    scopus 로고
    • Vascular-targeting therapies for treatment of malignant disease
    • DOI 10.1002/cncr.20299
    • Siemann, D. W., Chaplin, D. J., and Horsman, M. R. (2004). Vascular-targeting therapies for treatment of malignant disease. Cancer. 100, 2491-2499. (Pubitemid 38715753)
    • (2004) Cancer , vol.100 , Issue.12 , pp. 2491-2499
    • Siemann, D.W.1    Chaplin, D.J.2    Horsman, M.R.3
  • 8
    • 0031770618 scopus 로고    scopus 로고
    • The effect of combretastatin A-4 disodium phosphate in a C3H mouse mammary carcinoma and a variety of murine spontaneous tumors
    • DOI 10.1016/S0360-3016(98)00299-5, PII S0360301698002995
    • Horsman, M. R., Ehrnrooth, E., Ladekarl, M., and Overgaard, J. (1998) The effect of combretastatin A-4 disodium phosphate in a C3H. mouse mammary carcinoma and a variety of murine spontaneous. tumors. Int. J. Radiat. Oncol. Biol. Phys. 42, 895-898. (Pubitemid 28559438)
    • (1998) International Journal of Radiation Oncology Biology Physics , vol.42 , Issue.4 , pp. 895-898
    • Horsman, M.R.1    Ehrnrooth, E.2    Ladekarl, M.3    Overgaard, J.4
  • 10
    • 0033119771 scopus 로고    scopus 로고
    • Combretastatin A-4 phosphate as a tumor vascular-targeting agent: Early effects in tumors and normal tissues
    • Tozer, G. M., Prise, V. E., Wilson, J., Locke, R. J., Vojnovic, B.,. Stratford, M. R., Dennis, M. F., and Chaplin, D. J. (1999) Combretastatin. A-4 phosphate as a tumor vascular-targeting agent: early effects in. tumors and normal tissues. Cancer Res. 59, 1626-1634. (Pubitemid 29160136)
    • (1999) Cancer Research , vol.59 , Issue.7 , pp. 1626-1634
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3    Locke, R.J.4    Vojnovic, B.5    Stratford, M.R.L.6    Dennis, M.F.7    Chaplin, D.J.8
  • 11
    • 0036881356 scopus 로고    scopus 로고
    • Enhancement of radiation therapy by vascular targeting agents
    • Siemann, D. W., and Horsman, M. R. (2002) Enhancement of. radiation therapy by vascular targeting agents. Curr. Opin. Invest. Drugs. 3, 1660-1665. (Pubitemid 36266744)
    • (2002) Current Opinion in Investigational Drugs , vol.3 , Issue.11 , pp. 1660-1665
    • Siemann, D.W.1    Horsman, M.R.2
  • 12
    • 0030951899 scopus 로고    scopus 로고
    • Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature
    • Dark, G. G., Hill, S. A., Prise, V. E., Tozer, G. M., Pettit, G. R., and Chaplin, D. J. (1997) Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res. 57, 1829-1834. (Pubitemid 27209705)
    • (1997) Cancer Research , vol.57 , Issue.10 , pp. 1829-1834
    • Dark, G.G.1    Hill, S.A.2    Prise, V.E.3    Tozer, G.M.4    Pettit, G.R.5    Chaplin, D.J.6
  • 14
    • 0035884395 scopus 로고    scopus 로고
    • The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability
    • Beauregard, D. A., Hill, S. A., Chaplin, D. J., and Brindle, K. M. (2001) The susceptibility of tumors to the antivascular drug combretastatin A4 phosphate correlates with vascular permeability. Cancer Res. 61, 6811-6815. (Pubitemid 32896505)
    • (2001) Cancer Research , vol.61 , Issue.18 , pp. 6811-6815
    • Beauregard, D.A.1    Hill, S.A.2    Chaplin, D.J.3    Brindle, K.M.4
  • 15
    • 0036197311 scopus 로고    scopus 로고
    • Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI
    • DOI 10.1002/nbm.754
    • Maxwell, R. J., Wilson, J., Prise, V. E., Vojnovic, B., Rustin, G. J., Lodge, M. A., and Tozer, G. M. (2002) Evaluation of the anti-vascular effects of combretastatin in rodent tumours by dynamic contrast enhanced MRI. NMR Biomed. 15, 89-98. (Pubitemid 34213398)
    • (2002) NMR in Biomedicine , vol.15 , Issue.2 , pp. 89-98
    • Maxwell, R.J.1    Wilson, J.2    Prise, V.E.3    Vojnovic, B.4    Rustin, G.J.5    Lodge, M.A.6    Tozer, G.M.7
  • 21
    • 13844256814 scopus 로고    scopus 로고
    • Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats
    • DOI 10.1148/radiol.2343031721
    • Thoeny, H. C., De Keyzer, F., Chen, F., Ni, Y., Landuyt, W., Verbeken, E. K., Bosmans, H., Marchal, G., and Hermans, R. (2005)Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. Radiology 234, 756-764. (Pubitemid 40250819)
    • (2005) Radiology , vol.234 , Issue.3 , pp. 756-764
    • Thoeny, H.C.1    De Keyzer, F.2    Chen, F.3    Ni, Y.4    Landuyt, W.5    Verbeken, E.K.6    Bosmans, H.7    Marchal, G.8    Hermans, R.9
  • 22
    • 63449111973 scopus 로고    scopus 로고
    • Treatment of rodent liver tumor with combretastatin a4 phosphate: Noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology
    • Wang, H., Sun, X., Chen, F., De Keyzer, F., Yu, J., Landuyt, W., Vandecaveye, V., Peeters, R., Bosmans, H., Hermans, R., Marchal, G., and Ni, Y. (2009) Treatment of rodent liver tumor with combretastatin a4 phosphate: noninvasive therapeutic evaluation using multiparametric magnetic resonance imaging in correlation with microangiography and histology. Invest. Radiol. 44, 44-53.
    • (2009) Invest. Radiol. , vol.44 , pp. 44-53
    • Wang, H.1    Sun, X.2    Chen, F.3    De Keyzer, F.4    Yu, J.5    Landuyt, W.6    Vandecaveye, V.7    Peeters, R.8    Bosmans, H.9    Hermans, R.10    Marchal, G.11    Ni, Y.12
  • 23
    • 22844434974 scopus 로고    scopus 로고
    • Necrosis avid contrast agents: Functional similarity versus structural diversity
    • DOI 10.1097/01.rli.0000171811.48991.5a
    • Ni, Y., Bormans, G., Chen, F., Verbruggen, A., and Marchal, G. (2005) Necrosis avid contrast agents: functional similarity versus structural diversity. Invest. Radiol. 40, 526-535. (Pubitemid 41040690)
    • (2005) Investigative Radiology , vol.40 , Issue.8 , pp. 526-535
    • Ni, Y.1    Bormans, G.2    Chen, F.3    Verbruggen, A.4    Marchal, G.5
  • 24
    • 33745964355 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy
    • DOI 10.1593/neo.06319
    • Madhu, B., Waterton, J. C., Griffiths, J. R., Ryan, A. J., and Robinson, S. P. (2006) The response of RIF-1 fibrosarcomas to the vascular-disrupting agent ZD6126 assessed by in vivo and ex vivo 1H magnetic resonance spectroscopy. Neoplasia 8, 560-567. (Pubitemid 44061311)
    • (2006) Neoplasia , vol.8 , Issue.7 , pp. 560-567
    • Madhu, B.1    Waterton, J.C.2    Griffiths, J.R.3    Ryan, A.J.4    Robinson, S.P.5
  • 25
    • 0035173736 scopus 로고    scopus 로고
    • Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent
    • DOI 10.1038/nm1101-1241
    • Zhao, M., Beauregard, D. A., Loizou, L., Davletov, B., and Brindle, K. M. (2001) Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat. Med. 7, 1241-1244. (Pubitemid 33063780)
    • (2001) Nature Medicine , vol.7 , Issue.11 , pp. 1241-1244
    • Zhao, M.1    Beauregard, D.A.2    Loizou, L.3    Davletov, B.4    Brindle, K.M.5
  • 27
    • 0017851298 scopus 로고
    • Fluorescein colchicine. Synthesis, purification, and biological activity
    • Clark, J. I., and Garland, D. (1978) Fluorescein colchicine. Synthesis, purification, and biological activity. J. Cell Biol. 76, 619-627. (Pubitemid 8295904)
    • (1978) Journal of Cell Biology , vol.76 , Issue.3 , pp. 619-627
    • Clark, J.I.1    Garland, D.2
  • 28
    • 10844268815 scopus 로고    scopus 로고
    • Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin
    • DOI 10.1021/jo049953w
    • Bagnato, J. D., Eilers, A. L., Horton, R. A., and Grissom, C. B. (2004) Synthesis and characterization of a cobalamin-colchicine conjugate as a novel tumor-targeted cytotoxin. J. Org. Chem. 69, 8987-8996. (Pubitemid 40004017)
    • (2004) Journal of Organic Chemistry , vol.69 , Issue.26 , pp. 8987-8996
    • Bagnato, J.D.1    Eilers, A.L.2    Horton, R.A.3    Grissom, C.B.4
  • 31
    • 28844449330 scopus 로고    scopus 로고
    • 99mTc-labeling of colchicine using [99mTc(CO) 3(H2O) 3]+ and [99mTc triple bond N]2+ core for the preparation of potential tumor-targeting agents
    • Korde, A., Satpati, D., Mathur, A., Mallia, M., Banerjee, S., Kothari, K., Sarma, H. D., Choudhari, P., and Venkatesh, M. (2006) 99mTc-labeling of colchicine using [99mTc(CO)3(H2O)3]+ and [99mTc triple bond N]2+ core for the preparation of potential tumor-targeting agents. Bioorg. Med. Chem. 14, 793-799.
    • (2006) Bioorg. Med. Chem. 14 , pp. 793-799
    • Korde, A.1    Satpati, D.2    Mathur, A.3    Mallia, M.4    Banerjee, S.5    Kothari, K.6    Sarma, H.D.7    Choudhari, P.8    Venkatesh, M.9
  • 33
    • 33947726713 scopus 로고    scopus 로고
    • How to determine free Gd and free ligand in solution of Gd chelates. A technical note
    • Barge, A., Cravotto, G., Gianolio, E., and Fedeli, F. (2006) How to determine free Gd and free ligand in solution of Gd chelates. A technical note. Contrast Media Mol. Imaging 1, 184-188.
    • (2006) Contrast Media Mol. Imaging , vol.1 , pp. 184-188
    • Barge, A.1    Cravotto, G.2    Gianolio, E.3    Fedeli, F.4
  • 34
    • 44649100611 scopus 로고    scopus 로고
    • J U.S National Institutes of Health, Bethesda, MD
    • Rasband, W. S. (1997-2008) ImageJ, U.S. National Institutes of Health, Bethesda, MD, http://rsb.info.nih.gov/ij/.
    • (1997) Image
    • Rasband, W.S.1
  • 37
    • 0035064594 scopus 로고    scopus 로고
    • Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo
    • Galbraith, S. M., Chaplin, D. J., Lee, F., Stratford, M. R., Locke, R. J., Vojnovic, B., and Tozer, G. M. (2001) Effects of combretastatin A4 phosphate on endothelial cell morphology in vitro and relationship to tumour vascular targeting activity in vivo. Anticancer Res. 21, 93-102. (Pubitemid 32267629)
    • (2001) Anticancer Research , vol.21 , Issue.1 A , pp. 93-102
    • Galbraith, S.M.1    Chaplin, D.J.2    Lee, F.3    Stratford, M.R.L.4    Locke, R.J.5    Vojnovic, B.6    Tozer, G.M.7
  • 38
    • 0024427745 scopus 로고
    • Antimitotic natural products combretastatin A-4 and combretastatin A-2: Studies on the mechanism of their inhibition of the binding of colchicine to tubulin
    • Lin, C. M., Ho, H. H., Pettit, G. R., and Hamel, E. (1989) Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. Biochemistry 28, 6984-6991. (Pubitemid 19219888)
    • (1989) Biochemistry , vol.28 , Issue.17 , pp. 6984-6991
    • Lin, C.M.1    Ho, H.H.2    Pettit, G.R.3    Hamel, E.4
  • 39
    • 0024510343 scopus 로고
    • Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile
    • McGown, A. T., and Fox, B. W. (1989) Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile. Anti-Cancer Drug Des. 3, 249-254. (Pubitemid 19100902)
    • (1989) Anti-Cancer Drug Design , vol.3 , Issue.4 , pp. 249-254
    • McGown, A.T.1    Fox, B.W.2
  • 40
    • 20344379950 scopus 로고    scopus 로고
    • Disrupting tumour blood vessels
    • DOI 10.1038/nrc1628
    • Tozer, G. M., Kanthou, C., and Baguley, B. C. (2005) Disrupting tumour blood vessels. Nat. Rev. Cancer 5, 423-435. (Pubitemid 40791485)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.6 , pp. 423-435
    • Tozer, G.M.1    Kanthou, C.2    Baguley, B.C.3
  • 41
    • 40749092915 scopus 로고    scopus 로고
    • 14C]-ZD6126 in rat and dog
    • DOI 10.1080/00498250701861742, PII 790392784
    • Partridge, E. A., D'Souza, R. A., Lenz, E. M., Smith, S. M., Clarkson-Jones, J., and Roberts, D. W. (2008) Disposition and metabolism of the colchicine derivative [14C]-ZD6126 in rat and dog. Xenobiotica 38, 399-421. (Pubitemid 351380286)
    • (2008) Xenobiotica , vol.38 , Issue.4 , pp. 399-421
    • Partridge, E.A.1    D'Souza, R.A.2    Lenz, E.M.3    Smith, S.M.4    Clarkson-Jones, J.5    Roberts, D.W.6
  • 42
    • 33947329661 scopus 로고    scopus 로고
    • 14C-ZD6126) to tumour-bearing mice
    • DOI 10.1080/00498250601169824, PII 773288235
    • D'Souza, R. A., Partridge, E. A., Roberts, D. W., Ashton, S., Ryan, A., Patterson, A. B., Wilson, Z., and Thurrell, C. C. (2007) Distribution of radioactivity and metabolite profiling in tumour and plasma following intravenous administration of a colchicine derivative (14C-ZD6126) to tumour-bearing mice. Xenobiotica 37, 328-340. (Pubitemid 46439677)
    • (2007) Xenobiotica , vol.37 , Issue.3 , pp. 328-340
    • D'Souza, R.A.1    Partridge, E.A.2    Roberts, D.W.3    Ashton, S.4    Ryan, A.5    Patterson, A.B.6    Wilson, Z.7    Thurrell, C.C.8
  • 43
    • 2142642207 scopus 로고    scopus 로고
    • Single Dose of the Antivascular Agent, ZD6126 (N-Acetylcolchinol-O- Phosphate), Reduces Perfusion for at Least 96 Hours in the GH3 Prolactinoma Rat Tumor Model
    • DOI 10.1593/neo.03247
    • McIntyre, D. J., Robinson, S. P., Howe, F. A., Griffiths, J. R., Ryan, A. J., Blakey, D. C., Peers, I. S., and Waterton, J. C. (2004) Single dose of the antivascular agent, ZD6126 (N-acetylcolchinol-O-phosphate), reduces perfusion for at least 96 h in the GH3 prolactinoma rat tumor model. Neoplasia 6, 150-157. (Pubitemid 38544603)
    • (2004) Neoplasia , vol.6 , Issue.2 , pp. 150-157
    • McIntyre, D.J.O.1    Robinson, S.P.2    Howe, F.A.3    Griffiths, J.R.4    Ryan, A.J.5    Blakey, D.C.6    Peers, I.S.7    Waterton, J.C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.