Fluorinated amino-derivatives of the sesquiterpene lactone, parthenolide, as 19F NMR probes in deuterium-free environments

Journal of Medicinal Chemistry

Volumn 54, Issue 22, 2011, Pages 7934-7941

  Woods, James R ^a   Mo, Huaping ^a,b   Bieberich, Andrew A ^a   Alavanja, Tanja ^b   Colby, David A ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

13 (3 3 DIFLUOROPYRROLIDINE) 11,13 DIHYDROPARTHENOLIDE; 13 (4 FLUOROPIPERDINE) 11,13 DIHYDROPARTHENOLIDE; 13 (4,4 DIFLUOROPIPERDINE) 11,13 DIHYDROPARTHENOLIDE; 13 [3 (TRIFLUOROMETHYL)PIPERDINE] 11,13 DIHYDROPARTHENOLIDE; 13 [4 (TRIFLUOROMETHYL)PIPERDINE] 11,13 DIHYDROPARTHENOLIDE; ALANTOLACTONE; ALPHA SANTONIN; AMBROSIN; ANTILEUKEMIC AGENT; COSTUNOLIDE; DEUTERIUM; GLUTATHIONE; HELENALIN; PARTHENOLIDE; SAUSSERAMINE A; SESQUITERPENE LACTONE; UNCLASSIFIED DRUG;

AMINO ACID ANALYSIS; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BIOLOGICAL ACTIVITY; BIOTRANSFORMATION; CANCER CELL; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIASTEREOISOMER; DRUG METABOLISM; DRUG SYNTHESIS; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICHAEL ADDITION; PROMYELOCYTIC LEUKEMIA; PROTEIN BINDING; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DEUTERIUM; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORINE; GLUTATHIONE; HUMANS; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR PROBES; MOLECULAR STRUCTURE; SESQUITERPENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 81555228200     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201114t     Document Type: Article

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