Superpotent [Dmt 1]dermorphin tetrapeptides containing the 4-aminotetrahydro-2-benzazepin-3-one scaffold with mixed μ/δ opioid receptor agonistic properties

Journal of Medicinal Chemistry

Volumn 54, Issue 22, 2011, Pages 7848-7859

  Vandormael, Bart ^a   Fourla, Danai Dionysia ^b   Gramowski Voß, Alexandra ^c   Kosson, Piotr ^d   Weiss, Dieter G ^c   Schröder, Olaf H U ^e   Lipkowski, Andrzej ^d   Georgoussi, Zafiroula ^b   Tourwé, Dirk ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

^c UNIVERSITY OF ROSTOCK   (Germany)

^d MOSSAKOWSKI MEDICAL RESEARCH CENTRE   (Poland)

^e NEUROPROOF GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOTETRAHYDRO 2 BENZAZEPIN 3 ONE; CYCLIC AMP; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; DERMORPHIN DERIVATIVE; GABAPENTIN; KAPPA OPIATE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; SUFENTANIL; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; BIOLOGICAL ACTIVITY; BRAIN MEMBRANE; CELL STRAIN HEK293; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; FRONTAL CORTEX; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; METHYLATION; MOUSE; NERVE CELL CULTURE; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROPATHIC PAIN; NONHUMAN; PEPTIDE ANALYSIS; PEPTIDE SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SCREENING; SIGNAL TRANSDUCTION; SPINAL CORD; WESTERN BLOTTING;

ACTION POTENTIALS; ANALGESICS; ANIMALS; ANTICONVULSANTS; BENZAZEPINES; BINDING SITES; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIC AMP; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEURAL NETWORKS (COMPUTER); NEURONS; OLIGOPEPTIDES; PHOSPHORYLATION; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SPINAL CORD; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 81555223840     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200894e     Document Type: Article

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