Development of novel enkephalin analogues that have enhanced opioid activities at both μ and δ opioid receptors

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5528-5532

  Yeon, Sun Lee ^a   Petrov, Ravil ^a   Park, Chad K ^a   Ma, Shou Wu ^b   Davis, Peg ^b   Lai, Josephine ^b   Porreca, Frank ^b   Vardanyan, Ruben ^a   Hruby, Victor J ^a  

^a University of Arizona   (United States)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 DIMETHYLTYROSINE; ENKEPHALIN DERIVATIVE; MU OPIATE RECEPTOR; N PHENYL N PIPERIDIN 4 YL PROPIONAMIDE; PIPERIDINE DERIVATIVE; PROPIONAMIDE DERIVATIVE; SIGMA OPIATE RECEPTOR; TERT BUTYLOXYCARBONYL BETA TYROSYLALANYLGLYCYLPHENYLALANINAMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HUMAN; HYDROPHOBICITY; LIGAND BINDING; LIPOPHILICITY; NEUROPATHIC PAIN; NONHUMAN; PAIN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING, COMPETITIVE; CELL LINE; CRICETINAE; CRICETULUS; ENKEPHALINS; GUINEA PIGS; HUMANS; ILEUM; MALE; MICE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; VAS DEFERENS;

EID: 35848948878     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061465o     Document Type: Article

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