Evaluation of the Dmt-Tic pharmacophore: Conversion of a potent δ-opioid receptor antagonist into a potent δ agonist and ligands with mixed properties

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 713-720

  Balboni, Gianfranco ^a   Guerrini, Remo ^b   Salvadori, Severo ^b   Bianchi, Clementina ^b   Rizzi, Daniela ^b   Bryant, Sharon D ^c   Lazarus, Lawrence H ^c  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBOXYLIC ACID; 2',6' DIMETHYLTYROSINE; AROMATIC COMPOUND; BENZIMIDAZOLE DERIVATIVE; BENZYL DERIVATIVE; CARBENE; CARBOXYLIC ACID DERIVATIVE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR AGONIST; DELTA OPIATE RECEPTOR ANTAGONIST; DELTORPHIN; LIGAND; MU OPIATE RECEPTOR; OPIATE PEPTIDE; PHENYL GROUP; TYROSINE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; DRUG POTENCY; DRUG RECEPTOR BINDING; NONHUMAN; PHARMACOPHORE; PROTEIN MODIFICATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; DIPEPTIDES; LIGANDS; MALE; MICE; OLIGOPEPTIDES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES; TETRAHYDROISOQUINOLINES; VAS DEFERENS;

EID: 0037204052     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010449i     Document Type: Article

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