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Volumn 34, Issue 11, 2010, Pages 1410-1416

Practical use of azacitidine in higher-risk myelodysplastic syndromes: An expert panel opinion

Author keywords

Azacitidine; High risk; Int 2; MDS; Myelodysplastic syndromes; Recommendations

Indexed keywords

ANTIBIOTIC AGENT; AZACITIDINE; CYTARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; LAXATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PRIMROSE OIL; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SEROTONIN 3 ANTAGONIST; ANTINEOPLASTIC ANTIMETABOLITE;

EID: 77957018936     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2010.05.021     Document Type: Review
Times cited : (49)

References (43)
  • 1
    • 33750020532 scopus 로고    scopus 로고
    • The incidence and outcome of myeloid malignancies in 2,112 adult patients in southeast England
    • Phekoo K.J., Richards M.A., Moller H., Schey S.A. The incidence and outcome of myeloid malignancies in 2,112 adult patients in southeast England. Haematologica 2006, 91(10):1400-1404.
    • (2006) Haematologica , vol.91 , Issue.10 , pp. 1400-1404
    • Phekoo, K.J.1    Richards, M.A.2    Moller, H.3    Schey, S.A.4
  • 3
    • 62249219780 scopus 로고    scopus 로고
    • Optimal sequencing of treatments for patients with myelodysplastic syndromes
    • Itzykson R., Fenaux P. Optimal sequencing of treatments for patients with myelodysplastic syndromes. Curr Opin Hematol 2009, 16(2):77-83.
    • (2009) Curr Opin Hematol , vol.16 , Issue.2 , pp. 77-83
    • Itzykson, R.1    Fenaux, P.2
  • 4
    • 77957018372 scopus 로고    scopus 로고
    • NCCN Clinical Practice Guidelines in Oncology™: Myelodysplastic Syndromes [computer program]. Version
    • NCCN Clinical Practice Guidelines in Oncology™: Myelodysplastic Syndromes [computer program]. Version 2 2010.
    • (2010)
  • 6
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman J.W., Harris N.L., Brunning R.D. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood 2002, 100(7):2292-2302.
    • (2002) Blood , vol.100 , Issue.7 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 7
    • 70349256226 scopus 로고    scopus 로고
    • The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
    • Vardiman J.W., Thiele J., Arber D.A., Brunning R.D., Borowitz M.J., Porwit A., et al. The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes. Blood 2009, 114(5):937-951.
    • (2009) Blood , vol.114 , Issue.5 , pp. 937-951
    • Vardiman, J.W.1    Thiele, J.2    Arber, D.A.3    Brunning, R.D.4    Borowitz, M.J.5    Porwit, A.6
  • 8
    • 0030781495 scopus 로고    scopus 로고
    • International prognostic scoring system and other prognostic systems for myelodysplastic syndromes
    • Balduini C.L., Guarnone R., Pecci A., Centenara E., Ascari E. International prognostic scoring system and other prognostic systems for myelodysplastic syndromes. Blood 1997, 90(10):4232-4234.
    • (1997) Blood , vol.90 , Issue.10 , pp. 4232-4234
    • Balduini, C.L.1    Guarnone, R.2    Pecci, A.3    Centenara, E.4    Ascari, E.5
  • 9
    • 34548219420 scopus 로고    scopus 로고
    • Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes
    • Malcovati L., Germing U., Kuendgen A., la Porta M.G., Pascutto C., Invernizzi R., et al. Time-dependent prognostic scoring system for predicting survival and leukemic evolution in myelodysplastic syndromes. J Clin Oncol 2007, 25(23):3503-3510.
    • (2007) J Clin Oncol , vol.25 , Issue.23 , pp. 3503-3510
    • Malcovati, L.1    Germing, U.2    Kuendgen, A.3    la Porta, M.G.4    Pascutto, C.5    Invernizzi, R.6
  • 10
    • 0030897009 scopus 로고    scopus 로고
    • International scoring system for evaluating prognosis in myelodysplastic syndromes
    • Greenberg P., Cox C., LeBeau M.M., Fenaux P., Morel P., Sanz G., et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood 1997, 89(6):2079-2088.
    • (1997) Blood , vol.89 , Issue.6 , pp. 2079-2088
    • Greenberg, P.1    Cox, C.2    LeBeau, M.M.3    Fenaux, P.4    Morel, P.5    Sanz, G.6
  • 11
    • 55749114037 scopus 로고    scopus 로고
    • Characteristics of US patients with myelodysplastic syndromes: results of six cross-sectional physician surveys
    • Sekeres M.A., Schoonen W.M., Kantarjian H., List A., Fryzek J., Paquette R., et al. Characteristics of US patients with myelodysplastic syndromes: results of six cross-sectional physician surveys. J Natl Cancer Inst 2008, 100(21):1542-1551.
    • (2008) J Natl Cancer Inst , vol.100 , Issue.21 , pp. 1542-1551
    • Sekeres, M.A.1    Schoonen, W.M.2    Kantarjian, H.3    List, A.4    Fryzek, J.5    Paquette, R.6
  • 12
    • 0026481129 scopus 로고
    • The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study
    • Miller K.B., Kim K., Morrison F.S., Winter J.N., Bennett J.M., Neiman R.S., et al. The evaluation of low-dose cytarabine in the treatment of myelodysplastic syndromes: a phase-III intergroup study. Ann Hematol 1992, 65(4):162-168.
    • (1992) Ann Hematol , vol.65 , Issue.4 , pp. 162-168
    • Miller, K.B.1    Kim, K.2    Morrison, F.S.3    Winter, J.N.4    Bennett, J.M.5    Neiman, R.S.6
  • 13
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study
    • Kantarjian H., Issa J.P., Rosenfeld C.S., Bennett J.M., Albitar M., DiPersio J., et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer 2006, 106(8):1794-1803.
    • (2006) Cancer , vol.106 , Issue.8 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3    Bennett, J.M.4    Albitar, M.5    DiPersio, J.6
  • 14
    • 34547201150 scopus 로고    scopus 로고
    • Intensive chemotherapy is not recommended for patients aged >60 years who have myelodysplastic syndromes or acute myeloid leukemia with high-risk karyotypes
    • Knipp S., Hildebrand B., Kundgen A., Giagounidis A., Kobbe G., Haas R., et al. Intensive chemotherapy is not recommended for patients aged >60 years who have myelodysplastic syndromes or acute myeloid leukemia with high-risk karyotypes. Cancer 2007, 110(2):345-352.
    • (2007) Cancer , vol.110 , Issue.2 , pp. 345-352
    • Knipp, S.1    Hildebrand, B.2    Kundgen, A.3    Giagounidis, A.4    Kobbe, G.5    Haas, R.6
  • 15
    • 0032523011 scopus 로고    scopus 로고
    • Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression
    • Quesnel B., Guillerm G., Vereecque R., Wattel E., Preudhomme C., Bauters F., et al. Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood 1998, 91(8):2985-2990.
    • (1998) Blood , vol.91 , Issue.8 , pp. 2985-2990
    • Quesnel, B.1    Guillerm, G.2    Vereecque, R.3    Wattel, E.4    Preudhomme, C.5    Bauters, F.6
  • 16
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
    • Jiang Y., Dunbar A., Gondek L.P., Mohan S., Rataul M., O'Keefe C., et al. Aberrant DNA methylation is a dominant mechanism in MDS progression to AML. Blood 2009, 113(6):1315-1325.
    • (2009) Blood , vol.113 , Issue.6 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.P.3    Mohan, S.4    Rataul, M.5    O'Keefe, C.6
  • 17
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications
    • Santini V., Kantarjian H.M., Issa J.P. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001, 134(7):573-586.
    • (2001) Ann Intern Med , vol.134 , Issue.7 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 18
    • 71149098475 scopus 로고    scopus 로고
    • Azacitidine: activity and efficacy as an epigenetic treatment of myelodysplastic syndromes
    • Santini V. Azacitidine: activity and efficacy as an epigenetic treatment of myelodysplastic syndromes. Expert Rev Hematol 2009, 2(2):121-127.
    • (2009) Expert Rev Hematol , vol.2 , Issue.2 , pp. 121-127
    • Santini, V.1
  • 19
    • 54049147814 scopus 로고    scopus 로고
    • Azacytidine causes complex DNA methylation responses in myeloid leukemia
    • Stresemann C., Bokelmann I., Mahlknecht U., Lyko F. Azacytidine causes complex DNA methylation responses in myeloid leukemia. Mol Cancer Ther 2008, 7(9):2998-3005.
    • (2008) Mol Cancer Ther , vol.7 , Issue.9 , pp. 2998-3005
    • Stresemann, C.1    Bokelmann, I.2    Mahlknecht, U.3    Lyko, F.4
  • 20
    • 62849104641 scopus 로고    scopus 로고
    • Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study
    • Fenaux P., Mufti G.J., Hellström-Lindberg E., Santini V., Finelli C., Giagounidis A., et al. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study. Lancet Oncol 2009, 10(3):223-232.
    • (2009) Lancet Oncol , vol.10 , Issue.3 , pp. 223-232
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3    Santini, V.4    Finelli, C.5    Giagounidis, A.6
  • 21
    • 77957019625 scopus 로고    scopus 로고
    • Celgene Europe Ltd. Vidaza® Summary of product characteristics
    • Celgene Europe Ltd. Vidaza® Summary of product characteristics; 2008.
    • (2008)
  • 22
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B
    • Silverman L.R., Demakos E.P., Peterson B.L., Kornblith A.B., Holland J.C., Odchimar-Reissig R., et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol 2002, 20(10):2429-2440.
    • (2002) J Clin Oncol , vol.20 , Issue.10 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3    Kornblith, A.B.4    Holland, J.C.5    Odchimar-Reissig, R.6
  • 23
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman L.R., McKenzie D.R., Peterson B.L., Holland J.F., Backstrom J.T., Beach C.L., et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol 2006, 24(24):3895-3903.
    • (2006) J Clin Oncol , vol.24 , Issue.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3    Holland, J.F.4    Backstrom, J.T.5    Beach, C.L.6
  • 25
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study
    • Kornblith A.B., Herndon J.E., Silverman L.R., Demakos E.P., Odchimar-Reissig R., Holland J.F., et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol 2002, 20(10):2441-2452.
    • (2002) J Clin Oncol , vol.20 , Issue.10 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon, J.E.2    Silverman, L.R.3    Demakos, E.P.4    Odchimar-Reissig, R.5    Holland, J.F.6
  • 26
    • 77957021267 scopus 로고    scopus 로고
    • Effects of azacitidine compared with conventional care regimens in elderly (≥75 years) patients with higher-risk myelodysplastic syndromes
    • in press
    • Seymour JF, Fenaux P, Silverman LR, Mufti SJ, Hellström-Lindberg E, Santini V, et al. Effects of azacitidine compared with conventional care regimens in elderly (≥75 years) patients with higher-risk myelodysplastic syndromes. Crit Rev Oncol Hematol 2010; in press.
    • (2010) Crit Rev Oncol Hematol
    • Seymour, J.F.1    Fenaux, P.2    Silverman, L.R.3    Mufti, S.J.4    Hellström-Lindberg, E.5    Santini, V.6
  • 27
    • 77449149373 scopus 로고    scopus 로고
    • Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia
    • Fenaux P., Mufti G.J., Hellström-Lindberg E., Santini V., Gattermann N., Germin U., et al. Azacitidine prolongs overall survival compared with conventional care regimens in elderly patients with low bone marrow blast count acute myeloid leukemia. J Clin Oncol 2010, 28(4):562-569.
    • (2010) J Clin Oncol , vol.28 , Issue.4 , pp. 562-569
    • Fenaux, P.1    Mufti, G.J.2    Hellström-Lindberg, E.3    Santini, V.4    Gattermann, N.5    Germin, U.6
  • 28
    • 64649097534 scopus 로고    scopus 로고
    • Hematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes
    • Lyons R.M., Cosgriff T.M., Modi S.S., Gersh R.H., Hainsworth J.D., Cohn A.L., et al. Hematologic response to three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes. J Clin Oncol 2009, 27(11):1850-1856.
    • (2009) J Clin Oncol , vol.27 , Issue.11 , pp. 1850-1856
    • Lyons, R.M.1    Cosgriff, T.M.2    Modi, S.S.3    Gersh, R.H.4    Hainsworth, J.D.5    Cohn, A.L.6
  • 29
    • 0027154222 scopus 로고
    • Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes
    • Silverman L.R., Holland J.F., Weinberg R.S., Alter B.P., Davis R.B., Ellison R.R., et al. Effects of treatment with 5-azacytidine on the in vivo and in vitro hematopoiesis in patients with myelodysplastic syndromes. Leukemia 1993, 7(Suppl. 1):21-29.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1 , pp. 21-29
    • Silverman, L.R.1    Holland, J.F.2    Weinberg, R.S.3    Alter, B.P.4    Davis, R.B.5    Ellison, R.R.6
  • 30
    • 77955173236 scopus 로고    scopus 로고
    • A study comparing dosing regimens and efficacy of subcutaneous to intravenous azacitidine (AZA) for the treatment of myelodysplastic syndromes (MDS)
    • Sekeres M.A., Maciejewski J.P., Donley D.W., Grinblatt D.L., Narang M., Malone J.M., et al. A study comparing dosing regimens and efficacy of subcutaneous to intravenous azacitidine (AZA) for the treatment of myelodysplastic syndromes (MDS). Blood (ASH Annual Meeting Abstracts) 2009, 114:3797.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 3797
    • Sekeres, M.A.1    Maciejewski, J.P.2    Donley, D.W.3    Grinblatt, D.L.4    Narang, M.5    Malone, J.M.6
  • 31
    • 77954527827 scopus 로고    scopus 로고
    • A Phase 1, Open-Label, Dose-Escalation Study to evaluate the safety, pharmacokinetics, and pharmacodynamics of oral azacitidine in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML)
    • Garcia-Manero G., Gore S.D., Skikne B., Cogle C.R., Ning Y., MacBeth K.J., et al. A Phase 1, Open-Label, Dose-Escalation Study to evaluate the safety, pharmacokinetics, and pharmacodynamics of oral azacitidine in patients with myelodysplastic syndromes (MDS) or acute myelogenous leukemia (AML). Blood (ASH Annual Meeting Abstracts) 2009, 114(22):117.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , Issue.22 , pp. 117
    • Garcia-Manero, G.1    Gore, S.D.2    Skikne, B.3    Cogle, C.R.4    Ning, Y.5    MacBeth, K.J.6
  • 33
    • 54949128600 scopus 로고    scopus 로고
    • Effect of azacitidine (AZA) on overall survival in higher-risk myelodysplastic syndromes (MDS) without complete remission
    • List A.F., Fenaux P., Mufti G.J., Hellström-Lindberg E., Gore S., Bennett J.M., et al. Effect of azacitidine (AZA) on overall survival in higher-risk myelodysplastic syndromes (MDS) without complete remission. J Clin Oncol 2008, 26(Suppl):7006.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL , pp. 7006
    • List, A.F.1    Fenaux, P.2    Mufti, G.J.3    Hellström-Lindberg, E.4    Gore, S.5    Bennett, J.M.6
  • 34
    • 71149119547 scopus 로고    scopus 로고
    • Patient outcome measures during prolonged survival in patients with high-risk myelodysplastic syndromes (MDS) treated with azacitidine (AZA)
    • Santini V., Fenaux P., Mufti G., Hellström-Lindberg E., List A., Silverman L., et al. Patient outcome measures during prolonged survival in patients with high-risk myelodysplastic syndromes (MDS) treated with azacitidine (AZA). J Clin Oncol 2008, 26(Suppl):7028.
    • (2008) J Clin Oncol , vol.26 , Issue.SUPPL , pp. 7028
    • Santini, V.1    Fenaux, P.2    Mufti, G.3    Hellström-Lindberg, E.4    List, A.5    Silverman, L.6
  • 35
    • 27644562303 scopus 로고    scopus 로고
    • Low-dose cytosine arabinoside (LD-AraC) vs LD-AraC plus granulocyte/macrophage colony stimulating factor vs LD-AraC plus interleukin-3 for myelodysplastic syndrome patients with a high risk of developing acute leukemia: final results of a randomized phase III study (06903) of the EORTC Leukemia Cooperative Group
    • Zwierzina H., Suciu S., Loeffler-Ragg J., Neuwirtova R., Fenaux P., Beksac M., et al. Low-dose cytosine arabinoside (LD-AraC) vs LD-AraC plus granulocyte/macrophage colony stimulating factor vs LD-AraC plus interleukin-3 for myelodysplastic syndrome patients with a high risk of developing acute leukemia: final results of a randomized phase III study (06903) of the EORTC Leukemia Cooperative Group. Leukemia 2005, 19(11):1929-1933.
    • (2005) Leukemia , vol.19 , Issue.11 , pp. 1929-1933
    • Zwierzina, H.1    Suciu, S.2    Loeffler-Ragg, J.3    Neuwirtova, R.4    Fenaux, P.5    Beksac, M.6
  • 36
    • 77954753267 scopus 로고    scopus 로고
    • Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine
    • in press
    • Santini V, Fenaux P, Mufti GJ, Hellström-Lindberg E, Silverman LB, List A, et al. Management and supportive care measures for adverse events in patients with myelodysplastic syndromes treated with azacitidine. Eur J Haematol; in press.
    • Eur J Haematol
    • Santini, V.1    Fenaux, P.2    Mufti, G.J.3    Hellström-Lindberg, E.4    Silverman, L.B.5    List, A.6
  • 37
    • 77649296804 scopus 로고    scopus 로고
    • Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil
    • Platzbecker U., Aul C., Ehninger G., Giagounidis A. Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. Ann Hematol 2010, 89(4):427-428.
    • (2010) Ann Hematol , vol.89 , Issue.4 , pp. 427-428
    • Platzbecker, U.1    Aul, C.2    Ehninger, G.3    Giagounidis, A.4
  • 39
    • 77953402801 scopus 로고    scopus 로고
    • Maintenance treatment with 5-azacitidine for patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia following MDS (MDS-AML) in complete remission (CR) after induction chemotherapy
    • Grövdal M., Khan R., Aggerholm A., Antunovic P., Astermark J., Bernell P., et al. Maintenance treatment with 5-azacitidine for patients with high risk myelodysplastic syndrome (MDS) or acute myeloid leukemia following MDS (MDS-AML) in complete remission (CR) after induction chemotherapy. Blood (ASH Annual Meeting Abstracts) 2008, 112:223.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 223
    • Grövdal, M.1    Khan, R.2    Aggerholm, A.3    Antunovic, P.4    Astermark, J.5    Bernell, P.6
  • 40
    • 77955175081 scopus 로고    scopus 로고
    • A Phase II study of post-remission therapy with azacitidine (AZA) in patients with AML post-MDS and high-risk MDS: a GFM Group study
    • Gardin C., Prébet T., Bouabdallah K., Caillot D., Guerci A., Raffoux E., et al. A Phase II study of post-remission therapy with azacitidine (AZA) in patients with AML post-MDS and high-risk MDS: a GFM Group study. Blood (ASH Annual Meeting Abstracts) 2009, 114:844.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 844
    • Gardin, C.1    Prébet, T.2    Bouabdallah, K.3    Caillot, D.4    Guerci, A.5    Raffoux, E.6
  • 41
    • 77952316378 scopus 로고    scopus 로고
    • Phase I combination study of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes
    • Sekeres M.A., List A.F., Cuthbertson D., Paquette R., Latham D., Afable M., et al. Phase I combination study of lenalidomide and azacitidine in patients with higher-risk myelodysplastic syndromes. J Clin Oncol 2010, 28:2253-2258.
    • (2010) J Clin Oncol , vol.28 , pp. 2253-2258
    • Sekeres, M.A.1    List, A.F.2    Cuthbertson, D.3    Paquette, R.4    Latham, D.5    Afable, M.6
  • 42
    • 66749128758 scopus 로고    scopus 로고
    • Effect of romiplostim in patients (pts) with low or intermediate risk myelodysplastic syndrome (MDS) receiving azacytidine
    • Kantarjian H., Giles F., Greenberg P., Paquette R., Wang E., Gabrilove J., et al. Effect of romiplostim in patients (pts) with low or intermediate risk myelodysplastic syndrome (MDS) receiving azacytidine. Blood (ASH Annual Meeting Abstracts) 2008, 112:224.
    • (2008) Blood (ASH Annual Meeting Abstracts) , vol.112 , pp. 224
    • Kantarjian, H.1    Giles, F.2    Greenberg, P.3    Paquette, R.4    Wang, E.5    Gabrilove, J.6
  • 43
    • 77949364616 scopus 로고    scopus 로고
    • Azacitidine for the treatment of lower risk myelodysplastic syndromes: a retrospective study of 74 patients enrolled in an Italian named patient program
    • Musto P., Maurillo L., Spagnoli A., Gozzini A., Rivellini F., Lunghi M., et al. Azacitidine for the treatment of lower risk myelodysplastic syndromes: a retrospective study of 74 patients enrolled in an Italian named patient program. Cancer 2010, 116:1485-1494.
    • (2010) Cancer , vol.116 , pp. 1485-1494
    • Musto, P.1    Maurillo, L.2    Spagnoli, A.3    Gozzini, A.4    Rivellini, F.5    Lunghi, M.6


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