Contribution of Tyr712 and Phe716 to the activity of human RNase L

European Journal of Biochemistry

Volumn 271, Issue 13, 2004, Pages 2737-2744

  Nakanishi, Masayuki ^a   Yoshimura, Akihiro ^a   Ishida, Norihisa ^a   Ueno, Yoshihito ^a   Kitade, Yukio ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

2 5A system; Interferon; RNase L; Scanning mutagenesis

Indexed keywords

2',5' OLIGOADENYLIC ACID; GLUTATHIONE TRANSFERASE; PHENYLALANINE; RIBONUCLEASE L; TYROSINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; DELETION MUTANT; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; ENZYME METABOLISM; ENZYME REGULATION; ENZYME SUBSTRATE; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; RNA BINDING;

AMINO ACID SEQUENCE; BASE SEQUENCE; CATALYSIS; DNA PRIMERS; ENDORIBONUCLEASES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; PHENYLALANINE; PLASMIDS; SEQUENCE HOMOLOGY, AMINO ACID; TYROSINE;

EID: 3042805459     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04202.x     Document Type: Article

References (33)

1. Player, M.R. & Torrence, P.F. (1998) The 2-5A system: Modulation of viral and cellular processes through acceleration of RNA degradation. Pharmacol. Ther. 2, 55-113.
2. Hassel, B.A., Zhou, A., Sotomayor, C., Maran, A. & Silverman, R.H. (1993) A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12, 3297-3304.
3. Castelli, J.C., Hassel, B.A., Maran, A., Paranjape, J., Hewitt, J.A., Li, X.L., Hsu, Y.T., Silverman, R.H. & Youle, R.J. (1998) The role of 2′-5′ oligoadenylate-activated ribonuclease L in apoptosis. Cell Death Differ. 5, 313-320.
4. Li, X.L., Blackford, J.A., Judge, C.S., Liu, M., Xiao, W., Kalvakolanu, D.V. & Hassel, B.A. (2000) RNase L-dependent destabilization of interferon-induced mRNAs. A role for the 2-5A system in attenuation of the interferon response. J. Biol. Chem. 275, 8880-8888.
5. Casey, G., Neville, P.J., Plummer, S.J., Xiang, Y., Krumroy, L.M., Klein, E.A., Catalona, W.J., Nupponen, N., Carpten, J.D., Trent, J.M., Silverman, R.H. & Witte, J.S. (2002) RNaseL Arg462Gln variant is implicated in up to 13% of prostate cancer cases. Nat. Genet. 32, 581-583.
6. Zhou, A., Hassel, B.A. & Silverman, R.H. (1993) Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell 72, 753-765.
7. Dong, B., Niwa, M., Walter, P. & Silverman, R.H. (2001) Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p. RNA 7, 361-373.
8. Dong, B. & Silverman, R.H. (1997) A bipartite model of 2-5A-dependent RNase L. J. Biol. Chem. 272, 22236-22242.
9. Dong, B. & Silverman, R.H. (1999) Alternative function of a protein kinase homology domain in 2′,5′-oligoadenylate dependent RNase L. Nucleic Acids Res. 27, 439-445.
10. Yoshimura, A., Nakanishi, M., Yatome, C. & Kitade, Y. (2002) Comparative study on the biological properties of 2′,5′- oligoadenylate derivatives with purified human RNase L expressed in E. coli. J. Biochem. 132, 643-648.
11. Kitade, Y., Wakana, M., Tsuboi, T., Yatome, C., Bayly, S.F., Player, M.R. & Torrence, P.F. (2000) 2-Methyladenosine-substituted 2′,5′- oligoadenylates: Conformations, 2-5A binding and catalytic activities with human ribonuclease L. Bioorg. Med. Chem. Lett. 10, 329-331.
12. Kitade, Y., Wakana, M., Terai, S., Tsuboi, T., Nakanishi, M., Yatome, C., Dong, B., Silverman, R.H. & Torrence, P.F. (1998) 2-Bromoadenosine- substituted 2′,5′-oligoadenylates modulate binding and activation abilities of human recombinant RNase L. Nucleosides Nucleotides 17, 2323-2333.
13. Kitade, Y., Nakata, Y., Hirota, K., Maki, Y., Pabuccuoglu, A. & Torrence, P.F. (1991) 8-Methyladenosine-substituted analogues of 2-5A: synthesis and their biological activities. Nucleic Acids Res. 19, 4103-4108.
14. Lesiak, K. & Torrence, P.F. (1986) Synthesis and biological activities of oligo (8-bromoadenylates) as analogues of 5′-O- triphosphoadenylyl (2′-5′) adenylyl (2′-5′) adenosine. J. Med. Chem. 29, 1015-1022.
15. Sidrauski, C. & Walter, P. (1997) The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response. Cell 90, 1031-1039.
16. Mori, K., Ma, W., Gething, M.J. & Sambrook, J. (1993) A transmembrane protein with cdc2+/CDC28-related kinase activity is required for signaling from the ER to the nucleus. Cell 74, 743-756.
17. Cuchillo, C.M., Vilanova, M. & Nogues, M.V. (1997) Pancreatic ribonucleases. In Ribonucleases: Structures and Functions (D'Alessio, G. & Riordan, J.F., eds), pp. 271-304. Academic Press, New York.
18. Irie, M. (1997) RNase T1/RNase T2 family RNases. In Ribonucleases: Structures and Functions (D'Alessio, G. & Riordan, J.F., eds), pp. 101-130. Academic Press, New York.
19. Nishikawa, K. & Takemura, S. (1974) Structure and function of 5S ribosomal ribonucleic acid from Torulopsis utilis. I. Purification and complete digestion with pancreatic ribonuclease A and ribonuclease T. J. Biochem. 76, 925-934.
20. Geselowitz, D.A., Cramer, H., Wondrak, E.M., Player, M.R. & Torrence, P.F. (2000) Fluorescence resonance energy transfer analysis of RNase L-catalyzed oligonucleotide cleavage. Antisense Nucleic Acid Drug Dev. 10, 45-51.
21. Vitali, J., Ding, J., Jiang, J., Zhang, J., Krainer, A.R. & Xu, R. (2002) Correlated alternative side chain conformations in the RNA-recognition motif of heterogeneous nuclear ribonucleoprotein A1. Nucleic Acids Res. 30, 1531-1538.
22. Arion, D., Sluis-Cremer, N., Min, K.L., Abram, M.E., Fletcher, R.S. & Parniak, M.A. (2002) Mutational analysis of Tyr-501 of HIV-1 reverse transcriptase. Effects on ribonuclease H activity and inhibition of this activity by N-acylhydrazones. J. Biol. Chem. 277, 1370-1374.
23. Black, S.D. & Mould, D.R. (1991) Development of hydrophobicity parameters to analyze proteins which bear post- or cotranslational modifications. Anal. Biochem. 193, 72-82.
24. Zhou, A., Nie, H. & Silverman, R.H. (2000) Analysis and origins of human and mouse RNase L: Mediators of interferon action. Mammalian Genome 11, 989-992.
25. Niwa, M., Sidrauski, C., Kaufman, R.J. & Walter, P. (1999) A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell 99, 691-702.
26. Wang, X.Z., Harding, H.P., Zhang, Y., Jolicoeur, E.M., Kuroda, M. & Ron, D. (1998) Cloning of mammalian Ire1 reveals diversity in the ER stress responses. EMBO J. 17, 5708-5717.
27. Tirasophon, W., Welihinda, A.A. & Kaufman, R.J. (1998) A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes Dev. 12, 1812-1824.
28. Adams, M.D. et al. (2000) The genome sequence of Drosophila melanogaster. Science 287, 2185-2195.
29. Tanaka, N., Arai, J., Inokuchi, N., Koyama, T., Ohgi, K., Irie, M. & Nakamura, K.T. (2000) Crystal structure of a plant ribonuclease, RNase LE. J. Mol. Biol. 298, 859-873.
30. Nakamura, K.T., Ishikawa, N., Hamashima, M., Kurihara, H., Nonaka, T., Mitsui, Y., Ohgi, K. & Irie, M. (1993) Protein nucleic acid recognition in a ribonuclease Rh-2′-adenylic acid complex. In Third International Meeting, Ribonucleases: Chemistry, Biology, Biotechnology, Capri, Italy. Abstract no. P56.
31. Dong, B., Xu, L., Zhou, A., Hassel, B.A., Lee, X., Torrence, P.F. & Silverman, R.H. (1994) Intrinsic molecular activity of the interferon-induced 2-5A-dependent RNase. J. Biol. Chem. 269, 14153-14158.
32. Carroll, S.S., Chen, E., Viscount, T., Geib, J., Sardana, M.K., Gehman, J. & Kuo, L.C. (1996) Cleavage of oligoribonucleotides by the 2′,5′-oligoadenylate-dependent ribonuclease L. J. Biol. Chem. 271, 4988-4992.
33. Ueno, Y., Yamada, Y., Nakanishi, M. & Kitade, Y. (2003) A specific substrate-inhibitor, a 2′-deoxy-2′-fluorouridine-containing oligoribonucleotide, against human RNase L. Bioorg. Med. Chem. 11, 5069-5073.