2-Bromoadenosine-substituted 2',5'-oligoadenylates modulate binding and activation abilities of human recombinant rnase L

Nucleosides and Nucleotides

Volumn 17, Issue 12, 1998, Pages 2323-2333

  Kitade, Yukio ^a   Wakana, Masaharu ^a   Terai, Shin Ichi ^a   Tsuboi, Takayuki ^a   Nakanishi, Masayuki ^a   Yatome, Chizuko ^a   Dong, Beihua ^b   Silverman, Robert H ^b   Torrence, Paul F ^c  

^a GIFU UNIVERSITY   (Japan)

^b LERNER RESEARCH INSTITUTE   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DERIVATIVE; RECOMBINANT RNA; RIBONUCLEASE;

ARTICLE; BINDING SITE; DRUG CONFORMATION; DRUG PROTEIN BINDING; ENZYME ACTIVATION; VIRUS INFECTION;

EID: 0031786088     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808004320     Document Type: Article

References (18)

1. Kerr, I. M., Brown, R. E. Proc. Natl. Acad. Sci. U.S.A. 1978, 75, 256-260.
2. Drocourt, J.-L; Dieffenbach, C. W.; Ts'o, P. O. ; Justesen, J.; Thang, M. N. Nucleic Acids Res. 1982, 10, 2163-2174.
3. Torrence, P. F.: Imai, J.; Lesiak, K.; Jamoulle, J.-C.; Sawai, H. J. Med. Chem. 1984, 27, 726-733.
4. Imai, J., Torrence, P. F., J. Org. Chem., 1985, 50, 1418-1426.
5. Imai, J., Lesiak, K., Torrence, P. F., J. Biol. Chem. 1985, 260, 1390-1394.
6. Kitade, Y., Alster, D. K., Pabuccuoglu, A., Torrence, P. F., Bioorganic Chem. 1991, 19, 283-299.
7. Lesiak, K.; Torrence, P. F. J. Med. Chem. 1986, 29, 1015-1022.
8. Lesiak, K.; Torrence, P. F. J. Biol. Chem. 1987, 262, 1961-1965.
9. Van den Hoogen, Y. T.; Hilgersom, C. M.; Brozda, D.; Lesiak, K.; Torrence, P. F.; Altona, C. Eur. J. Biochem. 1989, 182, 629-637.
10. Kitade, Y.; Nakata, Y.; Hirota, K.; Maki, Y.; Pabuccuoglu, A.; Torrence, P. F. Nucleic. Acids Res. 1991, 19, 4103-4108.
11. Kitade, Y., Wakana, M., Yatome, C. unpublished results: In fact, the chemical shift of the H2′-proton on 2-bromoadenosine (4.50 ppm) supports an anti-orientation the same as that of adenosine (4.60 ppm). On the other hand, the down field shift of H2′-proton of 8-bromoadenosine (5.08 ppm) and 8-methyladenosine (4.86 ppm) imply a syn-orientation as a result of the deshielding effect of purine ring.
12. Huang, M. C., Avery, T. L., Blakley, R. L., Secrist III, J. A., Montgomery, J. A. J. Med. Chem. 1984, 27, 800-802.
13. Sawai, H., Shibata, T., Ohno, M. Tetrahedron Lett., 1979, 47, 4573-4576.
14. Knight, M., Wreschner, D. H., Silverman, R. H. and Kerr, I. M. (1981) Methods in Enzymol. 79, 216-227.
15. Silverman, R. H., Krause, D. (1987) In Clemens, M. J., Morris, A. G. and Gearing, A. J. H., (eds) Lymphokines and Interferons. IRL Press, Oxford, pp149-193.
16. Silverman, R. H. Anal Biochem. 1985, 144, 450-460.
17. Dong, B., Xu, L., Zhou, A., Hassel, B. A., Lee, X., Torrence, P. F., and Silverman, R. H. J. Biol. Chem. 1994, 269, 14153-14158.
18. Zhou, A., Hassel, B. A., Silverman, R. H. Cell, 1993, 72, 753-765.