Induction of gene mutations by 5-(2-chloroethyl)-2′-deoxyuridine (CEDU), an antiviral pyrimidine nucleoside analogue

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 568, Issue 2, 2004, Pages 195-209

  Suter, Willi ^a   Plappert Helbig, Ulla ^a   Glowienke, Susanne ^a   Poetter Locher, Franziska ^a   Staedtler, Frank ^a   Racine, Robert ^a   Martus, Hans Joerg ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antiviral drug; Gene mutations; In vivo; Micronucleus test; Mouse spot test; Muta Mouse; Nucleoside analogue

Indexed keywords

5 (2 CHLOROETHYL) 2' DEOXYURIDINE;

ANIMAL CELL; ARTICLE; BONE MARROW; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA REPAIR; FEMALE; GENE MUTATION; GENOTOXICITY; HUMAN; HUMAN CELL; INDUCED MUTATION; LEUKOCYTE; LIVER CELL; LUNG; MICRONUCLEUS TEST; MOUSE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVERTANT; SALMONELLA TYPHIMURIUM; SPLEEN; STRAIN DIFFERENCE;

ANIMALS; ANTIVIRAL AGENTS; COMET ASSAY; DEOXYURIDINE; DNA REPAIR; FEMALE; MALE; MICE; MICRONUCLEUS TESTS; MUTATION; PREGNANCY; RATS; SALMONELLA; SKIN PIGMENTATION;

ANIMALIA; SALMONELLA;

EID: 8144220488     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.08.013     Document Type: Article

References (43)

1. E. de Clercq, and B. Rosenwirth Selective in vitro and in vivo activities of 5-(2-haloalkyl)pyrimidine nucleoside analogs, particularly 5-(2-chloroethyl)-2′-deoxyuridine, against Herpes simplex virus Antimicrob. Agents Chemother. 28 1985 246 251
2. H. Griengl, M. Bodenteich, W. Hayden, E. Wanek, W. Streicher, P. Stütz, H. Bachmayer, I. Ghazzouli, and B. Rosenwirth 5-(haloalkyl)- 2′-deoxyuridines: a novel type of potent antiviral nucleoside analogue J. Med. Chem. 28 1985 1679 1684
3. E. de Clercq, R. Benearts, A. Merta, and B. Rosenwirth Mechanism of action of 5-(2-chloroethyl)-2′-deoxyuridine, a selective inhibitor of herpes simplex virus replication Molec. Pharmacol. 37 1990 658 664
4. Hi. Marquardt, J. Westendorf, A. Schaefer, J. Boldt, E. De Clercq, and H. Marquardt Mutagenic and antimutagenic effects of 5-substituted 2′-deoxyuridines depending on the nature of the 5-substituent Arzneimittelforschung 38 1988 1820 1824
5. R. Fahrig The mammalian spot test (Fellfleckentest) with mice Arch. Toxicol. 38 1977 87 98
6. J.A. Styles, and M.G. Penman The mouse spot test. Evaluation of its performance in identifying chemical mutagens and carcinogens Mut. Res. 154 1985 183 204
7. S.W. Kohler, G.S. Provost, P.L. Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman, and J.M. Short Spectra of spontaneous and mutagen induced mutations in the lacI gene in transgenic mice Proc. Natl. Acad. Sci. U.S.A. 88 1991 7958 7962
8. G.S. Provost, P.L. Kretz, R.T. Hamner, C.D. Matthews, B.J. Rogers, K.S. Lundberg, M.J. Dycaico, and J.M. Short Transgenic systems for in vivo mutation analysis Mut. Res. 288 1993 133 149
9. J.A. Gossen, W.J.F. De Leeuw, C.T.H. Tan, E.C. Zwarthoff, F. Berends, P.H.M. Lohman, D.L. Knook, and J. Vijg Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo Proc. Natl. Acad. Sci. U.S.A. 86 1989 7971 7995
10. A.J.W. Hoorn, L.L. Custer, B.C. Myhr, D. Brusick, J. Gossen, and J. Vijg Detection of chemical mutagens using Muta™Mouse: a transgenic mouse model Mutagenesis 8 1993 7 10
11. M.J. Dycaico, G.S. Provost, P.L. Kretz, S.L. Ransom, J.C. Morres, and J.M. Short The use of shuttle vectors for mutation analysis in transgenic mice and rats Mut. Res. 307 1994 461 478
12. N.J. Gorelick Overview of mutation assays in transgenic mice for routine testing Environ. Molec. Mut. 25 1995 218 230
13. V. Thybaud, S. Dean, T. Nohmi, J. De Boer, G.R. Douglas, B.W. Glickman, N.J. Gorelick, J.A. Heddle, R.H. Heflich, I. Lambert, H.-J. Martus, J.C. Mirsalis, T. Suzuki, and N. Yajima In vivo transgenic mutation assays Mut. Res. 540 2003 141 151
14. D.M. Maron, and B.N. Ames Revised methods for the Salmonella mutagenicity tests Mut. Res. 113 1983 173 215
15. B.N. Ames, J. McCann, and E. Yamasaki Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test Mut. Res. 31 1975 347 364
16. B. Miller, S. Albertini, F. Locher, V. Thybaud, and E. Lorge Comparative evaluation of the in vitro micronucleus test and the in vitro chromosome aberration test: industrial experience Mut. Res. 392 1997 45 59
17. W. Frieauff, F. Poetter-Locher, A. Cordier, and W. Suter Automatic analysis of the in vitro micronucleus test on V79 cells Mut. Res. 413 1998 57 68
18. The single cell gel/comet assay: guidelines for in vitro and in vivo genetic toxicology testing Environ. Molec. Mut. 35 2000 206 221
19. P.O. Seglen Preparation of isolated rat liver cells D.M. Prescott Methods in Cell Biology 13 1976 Academic Press New York 29 82
20. G.M. Williams, M.F. Laspia, and V.C. Dunkel Reliability of the hepatocyte primary culture/DNA repair test in testing of coded carcinogens and noncarcinogens Mut. Res. 97 1982 359 370
21. B.E. Matter, and W. Schmid Trenimon-induced chromosomal damage in bone marrow cells of six mammalian species, evaluated by the micronucleus test Mut. Res. 12 1971 417 425
22. B.E. Matter, and J. Grauwiler Micronuclei in mouse bone marrow cells. A simple in vivo model for the evaluation of drug-induced chromosomal aberrations Mut. Res. 23 1974 239 249
23. OECD Guideline for the Testing of Chemicals, 474, Genetic Toxicology: Mammalian Erythrocyte Micronucleus Test, adopted May 26, 1983.
24. F. Romagna, and C.D. Staniforth The automated bone marrow micronucleus test Mut. Res. 213 1989 91 104
25. L.B. Russell, P.B. Shelby, E. von Halle, W. Sheridan, and L. Valcovic Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work Mut. Res. 86 1981 355 379
26. E. Gocke, D. Wild, K. Eckardt, and M.-T. King Mutagenicity studies with the mouse spot test Mut. Res. 117 1983 201 212
27. BigBlue™ Transgenic Mouse Mutagenesis Assay system, Stratagene, May 1, 1994.
28. Muta™Mouse: Mutation Assay Instruction Manual, Corning Hazleton, Version obtained on 15 July, 1996.
29. --phage using a galactose-sensitive E. coli host Biotechniques 14 1993 326 330
30. D.E. Levin, M. Hollstein, M.F. Christman, E.A. Schwiers, and B.N. Ames A new Salmonella tester strain (TA102) with A:T base pairs at the site of mutation detects oxidative mutagens Proc. Natl. Acad. Sci. U.S.A. 79 1982 7445 7449
31. F. Staedtler, W. Suter, H.-J. Martus, Induction of A:T to G:C transitions mutations by 5-(2-chloroethyl)-2′-deoxyuridine (CEDU), an anti-viral pyrimidine nucleoside analogue, in the bone marrow of Muta™Mouse, Mutat. Res. (2004) doi:10.1016/j.mrfmmm.2004.08.014.
32. P. Wutzler, and R. Thust Genetic risks of antiviral nucleoside analogues: a survey Antiviral Res. 49 2001 55 74
33. ICH Harmonized Tripartite Guideline S2B, Genotoxicity: a standard battery for genotoxicity testing of pharmaceuticals, 1997.
34. Y. Oshiro, C.E. Piper, S.G. Soelter, P.S. Balwierz, and M.L. Garriot Genotoxic properties of (E)-5-(2-bromovinyl)-2′-deoxyuridine (BVDU) Fundam. Appl. Toxicol. 18 1992 491 498
35. ICH Harmonized Tripartite Guideline S2A, Guidance on specific aspects of regulatory genotoxicity tests for pharmaceuticals, 1995.
36. H. Marquardt, J. Westendorf, E. De Clercq, and H. Marquardt Potent anti-viral 5-(2-bromovinyl) uracil nucleosides are inactive at inducing gene mutations in Salmonella typhimurium and V79 Chinese hamster cells and unscheduled DNA synthesis in primary rat hepatocytes Carcinogenesis 6 1985 1207 1209
37. M. Tomicic, E. Bey, P. Wutzler, R. Thust, and B. Kaina Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues, acyclovir, ganciclovir and penciclovir Mut. Res. 505 2002 1 11
38. Physician's Desk Reference, PDR® Electronic LibraryTM, Thomson Micromedex., entry for Retrovir®, GlaxoSmithKline (zidovudine), 2004.
39. M.D. Phillips, B. Nascimbeni, R.R. Tice, and M.D. Shelby Induction of micronuclei in mouse bone marrow cells: an evaluation of nucleoside analogues use in the treatment of AIDS Environ. Molec. Mut. 18 1991 168 183
40. M. Cosentino, and J.A. Heddle A comparison of the effects of diverse mutagens at the lacZ transgene and Dlb-1 locus in vivo Mutagenesis 14 1999 113 119
41. S. Takahashy, Y. Ikeda, N. Kimoto, E. Okochi, L. Cui, M. Nagao, T. Ushijima, and T. Shirai Mutation induction by mechanical irritation caused bay uracil-induced urolithiasis in BigBlue™ rats Mut. Res. 447 2000 275 280
42. ®Blue rats Environ. Molec. Mut. 37 2001 195 202
43. L. Cosentino, and J.A. Heddle Differential mutation of transgenic and endogenous loci in vivo Mut. Res. 454 2000 1 10