-
1
-
-
33646348736
-
A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
-
Shore, E.M. et al 2006. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat. Genet. 38: 525-527.
-
(2006)
Nat. Genet.
, vol.38
, pp. 525-527
-
-
Shore, E.M.1
-
2
-
-
61649084689
-
Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1
-
Kaplan, F.S. et al 2009. Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum. Mutat. 30: 379-390.
-
(2009)
Hum. Mutat.
, vol.30
, pp. 379-390
-
-
Kaplan, F.S.1
-
3
-
-
70449366408
-
Fibrodysplasia ossificans progressiva ACVR1 (R206H) mutation activates BMP-independent chondrogenesis and ventralization of zebrafish embryos
-
Shen, Q. et al 2009. Fibrodysplasia ossificans progressiva ACVR1 (R206H) mutation activates BMP-independent chondrogenesis and ventralization of zebrafish embryos. J. Clin. Invest. 119: 3462-3472.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3462-3472
-
-
Shen, Q.1
-
4
-
-
65449139561
-
Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva
-
Fukada, T. et al 2009. Constitutively activated ALK2 and increased SMAD1/5 cooperatively induce bone morphogenetic protein signaling in fibrodysplasia ossificans progressiva. J. Biol. Chem. 284: 7149-7156.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 7149-7156
-
-
Fukada, T.1
-
5
-
-
77954588190
-
Molecular consequences of the ACVR1 R206H mutation of fibrodysplasia ossificans progressiva
-
Song, G.-A. et al 2010. Molecular consequences of the ACVR1 R206H mutation of fibrodysplasia ossificans progressiva. J. Biol. Chem. 285: 22542-22553.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22542-22553
-
-
Song, G.-A.1
-
6
-
-
77953497987
-
ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation
-
Van Dinther, M. et al 2010. ALK2 R206H mutation linked to fibrodysplasia ossificans progressiva confers constitutive activity to the BMP type I receptor and sensitizes mesenchymal cells to BMP-induced osteoblast differentiation and bone formation. J. Bone Miner. Res. 25: 1208-1215.
-
(2010)
J. Bone Miner. Res.
, vol.25
, pp. 1208-1215
-
-
Van Dinther, M.1
-
7
-
-
25844487690
-
The phenotype of fibrodysplasia ossificans progressiva
-
Kaplan, F.S. et al 2005. The phenotype of fibrodysplasia ossificans progressiva. Clin. Rev. Bone & Miner. Metab. 3: 183-188.
-
(2005)
Clin. Rev. Bone & Miner. Metab.
, vol.3
, pp. 183-188
-
-
Kaplan, F.S.1
-
8
-
-
37249082497
-
Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis
-
Kaplan, F.S. & E.M. Shore 2007. Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis. Ann. N.Y. Acad. Sci. 1116: 113-133.
-
(2007)
Ann. N.Y. Acad. Sci.
, vol.1116
, pp. 113-133
-
-
Kaplan, F.S.1
Shore, E.M.2
-
9
-
-
58149253167
-
Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP)
-
Kaplan, F.S. et al 2008. Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP). J. Bone Miner. Metab. 26: 521-530.
-
(2008)
J. Bone Miner. Metab.
, vol.26
, pp. 521-530
-
-
Kaplan, F.S.1
-
10
-
-
70649090107
-
The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling
-
Kaplan, F.S. et al 2009. The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling. Cytokine Growth Factor Rev. 20: 399-407.
-
(2009)
Cytokine Growth Factor Rev.
, vol.20
, pp. 399-407
-
-
Kaplan, F.S.1
-
11
-
-
77956275161
-
Inherited human diseases of heterotopic bone formation
-
Shore, E.M. & F.S. Kaplan 2010. Inherited human diseases of heterotopic bone formation. Nat. Rev. Rheumatol. 6: 518-527.
-
(2010)
Nat. Rev. Rheumatol.
, vol.6
, pp. 518-527
-
-
Shore, E.M.1
Kaplan, F.S.2
-
12
-
-
79957448134
-
Fibrodysplasia ossificans progressiva: developmental implications of a novel metamorphogene
-
In (Chapter 14). Bronner, Farach-Carson & Roach, Eds.: Springer-Verlag. London
-
Kaplan, F.S. et al 2010. Fibrodysplasia ossificans progressiva: developmental implications of a novel metamorphogene. In Bone and Development. (Chapter 14). Bronner, Farach-Carson & Roach, Eds.: 233-249. Springer-Verlag. London
-
(2010)
Bone and Development
, pp. 233-249
-
-
Kaplan, F.S.1
-
13
-
-
33846004405
-
Bone morphogenetic proteins and their antagonists
-
Gazzerro, E. & E. Canalis 2006. Bone morphogenetic proteins and their antagonists. Rev. Endocr. Metab. Disord. 7: 51-65.
-
(2006)
Rev. Endocr. Metab. Disord.
, vol.7
, pp. 51-65
-
-
Gazzerro, E.1
Canalis, E.2
-
14
-
-
34548329486
-
Differentiation plasticity regulated by the TGF-β family proteins in development and disease
-
Derynck, R. & R. J. Akhurst 2007. Differentiation plasticity regulated by the TGF-β family proteins in development and disease. Nat. Cell Biol. 9: 1000-1004.
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1000-1004
-
-
Derynck, R.1
Akhurst, R.J.2
-
15
-
-
70649083092
-
Recent advances in BMP receptor signaling
-
Sieber, C. et al 2009. Recent advances in BMP receptor signaling. Cytokine & Growth Factor Rev. 20: 343-355.
-
(2009)
Cytokine & Growth Factor Rev.
, vol.20
, pp. 343-355
-
-
Sieber, C.1
-
16
-
-
70649113726
-
Smad signaling in skeletal development and regeneration
-
Song, B. et al 2009. Smad signaling in skeletal development and regeneration. Cytokine & Growth Factor Rev. 20: 379-388.
-
(2009)
Cytokine & Growth Factor Rev.
, vol.20
, pp. 379-388
-
-
Song, B.1
-
17
-
-
0027477670
-
The histopathology of fibrodysplasia ossificans progressiva: an endochondral process
-
Kaplan, F.S. et al 1993. The histopathology of fibrodysplasia ossificans progressiva: an endochondral process. J. Bone Joint Surg. Am. 75: 220-230.
-
(1993)
J. Bone Joint Surg. Am.
, vol.75
, pp. 220-230
-
-
Kaplan, F.S.1
-
18
-
-
0031984796
-
Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva
-
Gannon, F.H. et al 1998. Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva. Clin. Orthop. Rel. Res. 346: 19-25.
-
(1998)
Clin. Orthop. Rel. Res.
, vol.346
, pp. 19-25
-
-
Gannon, F.H.1
-
19
-
-
0034878150
-
Mast cell involvement in fibrodysplasia ossificans progressiva
-
Gannon F.H. et al 2001. Mast cell involvement in fibrodysplasia ossificans progressiva. Hum. Pathol. 32: 842-848.
-
(2001)
Hum. Pathol.
, vol.32
, pp. 842-848
-
-
Gannon, F.H.1
-
20
-
-
25844469044
-
Immunological features of fibrodysplasia ossificans progressiva (FOP) and the dysregulated BMP4 pathway
-
Kaplan, F.S. et al 2005. Immunological features of fibrodysplasia ossificans progressiva (FOP) and the dysregulated BMP4 pathway. Clin. Rev. Bone Miner. Metab. 3: 189-193.
-
(2005)
Clin. Rev. Bone Miner. Metab.
, vol.3
, pp. 189-193
-
-
Kaplan, F.S.1
-
21
-
-
10744229194
-
In vivosomatic cell gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification
-
Glaser, D.L. et al 2003. In vivosomatic cell gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification. J. Bone Joint Surg. 85-A: 2332-2342.
-
(2003)
J. Bone Joint Surg.
, vol.85 A
, pp. 2332-2342
-
-
Glaser, D.L.1
-
22
-
-
0141626663
-
Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification
-
Hegyi, L. et al 2003. Stromal cells of fibrodysplasia ossificans progressiva lesions express smooth muscle lineage markers and the osteogenic transcription factor Runx2/Cbfa-1: clues to a vascular origin of heterotopic ossification. J. Pathol. 201: 141-148.
-
(2003)
J. Pathol.
, vol.201
, pp. 141-148
-
-
Hegyi, L.1
-
23
-
-
34249913942
-
Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine
-
Stoick-Cooper, C.L. 2007. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes & Development 21: 1292-1315.
-
(2007)
Genes & Development
, vol.21
, pp. 1292-1315
-
-
Stoick-Cooper, C.L.1
-
24
-
-
33846839273
-
Hematopoietic stem-cell contribution to ectopic skeletogenesis
-
Kaplan, F.S. et al 2007. Hematopoietic stem-cell contribution to ectopic skeletogenesis. J. Bone Joint Surg. Am. 89: 347-357.
-
(2007)
J. Bone Joint Surg. Am.
, vol.89
, pp. 347-357
-
-
Kaplan, F.S.1
-
25
-
-
4644264945
-
Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
-
Kan, L. et al 2004. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Pathol. 165: 1107-1115.
-
(2004)
Am. J. Pathol.
, vol.165
, pp. 1107-1115
-
-
Kan, L.1
-
26
-
-
59849119987
-
Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification
-
Kan, L. et al 2009. Dysregulation of local stem/progenitor cells as a common cellular mechanism for heterotopic ossification. Stem Cells 27:150-156.
-
(2009)
Stem Cells
, vol.27
, pp. 150-156
-
-
Kan, L.1
-
27
-
-
57349171954
-
BMP type I receptor inhibition prevents ectopic ossification in mouse model of fibrodysplasia ossificans progressiva (FOP)
-
Yu, P.B. et al 2008. BMP type I receptor inhibition prevents ectopic ossification in mouse model of fibrodysplasia ossificans progressiva (FOP). Nat. Med. 14: 1363-1369.
-
(2008)
Nat. Med.
, vol.14
, pp. 1363-1369
-
-
Yu, P.B.1
-
28
-
-
62549145351
-
Identification of progenitor cells that contribute to heterotopic skeletogenesis
-
Lounev, V.Y. et al 2009. Identification of progenitor cells that contribute to heterotopic skeletogenesis. J. Bone Joint Surgery Am. 91: 652-663.
-
(2009)
J. Bone Joint Surgery Am.
, vol.91
, pp. 652-663
-
-
Lounev, V.Y.1
-
30
-
-
33947509956
-
Hypoxic adipocytes pattern early heterotopic bone formation
-
Olmsted-Davis, E. et al 2007. Hypoxic adipocytes pattern early heterotopic bone formation. Am. J. Pathol. 170: 620-632.
-
(2007)
Am. J. Pathol.
, vol.170
, pp. 620-632
-
-
Olmsted-Davis, E.1
-
31
-
-
70649111404
-
Hypoxia promotes ligand-independent activation of the ACVR1 (R206H) mutant receptor in C2C12 cells
-
Wang, H. et al 2008. Hypoxia promotes ligand-independent activation of the ACVR1 (R206H) mutant receptor in C2C12 cells. J. Bone Miner. Res. 23: s433.
-
(2008)
J. Bone Miner. Res.
, vol.23
-
-
Wang, H.1
-
32
-
-
37249016863
-
Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva
-
Billings, P.C. et al 2008. Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva. J. Bone Miner. Res. 23: 305-313.
-
(2008)
J. Bone Miner. Res.
, vol.23
, pp. 305-313
-
-
Billings, P.C.1
-
33
-
-
78650018824
-
Conversion of vascular endothelial cells into multipotent stem-like cells
-
Medici, D. et al 2010. Conversion of vascular endothelial cells into multipotent stem-like cells. Nat. Med. 12: 1400-1406.
-
(2010)
Nat. Med.
, vol.12
, pp. 1400-1406
-
-
Medici, D.1
-
34
-
-
70349883784
-
Circulating osteogenic precursor cells in heterotopic bone
-
Suda, R.K. et al 2009. Circulating osteogenic precursor cells in heterotopic bone. Stem Cells 27: 2209-2219.
-
(2009)
Stem Cells
, vol.27
, pp. 2209-2219
-
-
Suda, R.K.1
-
35
-
-
40149099148
-
Fibrodysplasia ossificans progressiva
-
Kaplan, F.S. et al 2008. Fibrodysplasia ossificans progressiva. Best Pract. Res. Clin. Rheumatol. 22: 191-205.
-
(2008)
Best Pract. Res. Clin. Rheumatol.
, vol.22
, pp. 191-205
-
-
Kaplan, F.S.1
-
36
-
-
71649100825
-
When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva
-
Kaplan, F.S. et al 2009. When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva. Drug Disc. Today: Therapeutic Strategies 5: 255-262.
-
(2009)
Drug Disc. Today: Therapeutic Strategies
, vol.5
, pp. 255-262
-
-
Kaplan, F.S.1
-
37
-
-
70849128432
-
Applications of small molecule BMP inhibitors in physiology and disease
-
Hong, C.C. & P.B. Yu 2009. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine & Growth Factor Rev. 20: 409-418.
-
(2009)
Cytokine & Growth Factor Rev.
, vol.20
, pp. 409-418
-
-
Hong, C.C.1
Yu, P.B.2
-
38
-
-
79953736346
-
Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor γ agonists
-
Shimono, K. et al 2011. Potent inhibition of heterotopic ossification by nuclear retinoic acid receptor γ agonists. Nat. Med. 17: 454-460.
-
(2011)
Nat. Med.
, vol.17
, pp. 454-460
-
-
Shimono, K.1
-
39
-
-
79953730788
-
Derailing heterotopic ossification and RARing to go
-
Kaplan, F.S. & E.M. Shore 2011. Derailing heterotopic ossification and RARing to go. Nat. Med. 217: 420-421.
-
(2011)
Nat. Med.
, vol.217
, pp. 420-421
-
-
Kaplan, F.S.1
Shore, E.M.2
-
40
-
-
81255213770
-
Tools for thinking
-
March 28
-
Brooks, D. Tools for thinking. New York Times March 28, 2011.
-
(2011)
New York Times
-
-
Brooks, D.1
|