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Volumn 1116, Issue , 2007, Pages 113-133

Morphogen receptor genes and metamorphogenes: Skeleton keys to metamorphosis

Author keywords

ACVR1; BMP; BMP receptor; BMP signaling pathways; Bone morphogenetic protein; Fibrodysplasia ossificans progressiva; Heterotopic ossification; Metamorphogene; Metamorphosis; Morphogen; Morphogen receptor

Indexed keywords

MORPHOGEN; MORPHOGEN RECEPTOR; PROCOLLAGEN C PROTEINASE; UNCLASSIFIED DRUG;

EID: 37249082497     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1402.039     Document Type: Conference Paper
Times cited : (33)

References (89)
  • 5
    • 0019945249 scopus 로고
    • Fibrodysplasia ossificans progressiva: The clinical features and natural history of 34 patients
    • CONNOR, J.M. & D.A. EVANS. 1982. Fibrodysplasia ossificans progressiva: the clinical features and natural history of 34 patients. J. Bone Joint Surg. Br. 64: 76-83.
    • (1982) J. Bone Joint Surg. Br , vol.64 , pp. 76-83
    • CONNOR, J.M.1    EVANS, D.A.2
  • 6
    • 0027403045 scopus 로고
    • The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva (FOP)
    • COHEN, R.B. et al. 1993. The natural history of heterotopic ossification in patients who have fibrodysplasia ossificans progressiva (FOP) J. Bone Joint Surg. Am. 75: 215-219.
    • (1993) J. Bone Joint Surg. Am , vol.75 , pp. 215-219
    • COHEN, R.B.1
  • 7
    • 25844487690 scopus 로고    scopus 로고
    • The phenotype of fibrodysplasia ossificans progressiva (FOP)
    • KAPLAN, F.S. et al. 2005. The phenotype of fibrodysplasia ossificans progressiva (FOP). Clin. Rev. Bone Miner. Metab. 3: 183-188.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 183-188
    • KAPLAN, F.S.1
  • 8
    • 25844459979 scopus 로고    scopus 로고
    • Treatment considerations for the management of fibrodysplasia ossificans progressiva
    • GLASER, D.L. & F.S. KAPLAN. 2005. Treatment considerations for the management of fibrodysplasia ossificans progressiva. Clin. Rev. Bone Miner. Metab. 3: 243-250.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 243-250
    • GLASER, D.L.1    KAPLAN, F.S.2
  • 10
    • 25844510176 scopus 로고    scopus 로고
    • Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva
    • KAPLAN, F.S. & D.L. GLASER. 2005. Thoracic insufficiency syndrome in patients with fibrodysplasia ossificans progressiva. Clin. Rev. Bone Miner. Metab. 3: 213-216.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 213-216
    • KAPLAN, F.S.1    GLASER, D.L.2
  • 11
    • 0344345444 scopus 로고
    • A contribution to the study of myositis ossificans progressiva
    • ROSENSTIRN, J.A. 1918. A contribution to the study of myositis ossificans progressiva. Ann. Surg. 68: 485-520; 591-637.
    • (1918) Ann. Surg , vol.68
    • ROSENSTIRN, J.A.1
  • 12
    • 37249002233 scopus 로고    scopus 로고
    • The key to the closet is the key to the kingdom
    • KAPLAN, F.S. 2006. The key to the closet is the key to the kingdom. Orphan Disease Update 24: 1-9.
    • (2006) Orphan Disease Update , vol.24 , pp. 1-9
    • KAPLAN, F.S.1
  • 13
    • 25844522195 scopus 로고    scopus 로고
    • A few hundred people turned to bone
    • MAEDER, T. 1998. A few hundred people turned to bone. Atlantic Monthly 281: 81-89.
    • (1998) Atlantic Monthly , vol.281 , pp. 81-89
    • MAEDER, T.1
  • 14
    • 25844456883 scopus 로고    scopus 로고
    • The fibrodysplasia ossificans progressiva lesion
    • PIGNOLO, R.J. et al. 2005. The fibrodysplasia ossificans progressiva lesion. Clin. Rev. Bone Miner. Metab. 3: 195-200.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 195-200
    • PIGNOLO, R.J.1
  • 15
    • 34250019537 scopus 로고
    • Bone formation by autoinduction
    • URIST, M.R. 1965. Bone formation by autoinduction. Science 150: 893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • URIST, M.R.1
  • 16
    • 0024256133 scopus 로고
    • Novel regulators of bone formation: Molecular clones and activities
    • WOZNEY, J.M. et al. 1988. Novel regulators of bone formation: molecular clones and activities. Science 242: 1528-1534.
    • (1988) Science , vol.242 , pp. 1528-1534
    • WOZNEY, J.M.1
  • 17
    • 0027477670 scopus 로고
    • The histopathology of fibrodysplasia ossificans progressiva: An endochondral process
    • KAPLAN, F.S. et al. 1993. The histopathology of fibrodysplasia ossificans progressiva: an endochondral process. J. Bone Joint Surg. Am. 75: 220-230.
    • (1993) J. Bone Joint Surg. Am , vol.75 , pp. 220-230
    • KAPLAN, F.S.1
  • 18
    • 0031984796 scopus 로고    scopus 로고
    • Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva
    • GANNON, F.H. et al. 1998. Acute lymphocytic infiltration in an extremely early lesion of fibrodysplasia ossificans progressiva. Clin. Orthop. Rel. Res. 346: 19-25.
    • (1998) Clin. Orthop. Rel. Res , vol.346 , pp. 19-25
    • GANNON, F.H.1
  • 19
    • 0034878150 scopus 로고    scopus 로고
    • Mast cell involvement in fibrodysplasia ossificans progressiva
    • GANNON, F.H. et al. 2001. Mast cell involvement in fibrodysplasia ossificans progressiva. Hum. Pathol. 32: 842-848.
    • (2001) Hum. Pathol , vol.32 , pp. 842-848
    • GANNON, F.H.1
  • 20
    • 10744229194 scopus 로고    scopus 로고
    • In vivo somatic call gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification
    • GLASER, D.L. et al. 2003. In vivo somatic call gene transfer of an engineered noggin mutein prevents BMP4-induced heterotopic ossification. J. Bone Joint Surg. Am. 85: 2332-2342.
    • (2003) J. Bone Joint Surg. Am , vol.85 , pp. 2332-2342
    • GLASER, D.L.1
  • 21
    • 4644264945 scopus 로고    scopus 로고
    • Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype
    • KAN, L. et al. 2004. Transgenic mice overexpressing BMP4 develop a fibrodysplasia ossificans progressiva (FOP)-like phenotype. Am. J. Pathol. 165: 1107-1115.
    • (2004) Am. J. Pathol , vol.165 , pp. 1107-1115
    • KAN, L.1
  • 22
    • 0027946689 scopus 로고
    • Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage
    • KATAGIRI, T. et al. 1994. Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J. Cell Biol. 127: 1755-1766.
    • (1994) J. Cell Biol , vol.127 , pp. 1755-1766
    • KATAGIRI, T.1
  • 23
    • 0031572322 scopus 로고    scopus 로고
    • Constitutively active BMP type I receptors transduce BMP2 signals without the ligand in C2C12 myoblasts
    • AKIYAMA, S. et al. 1997. Constitutively active BMP type I receptors transduce BMP2 signals without the ligand in C2C12 myoblasts. Exp. Cell Res. 235: 362-369.
    • (1997) Exp. Cell Res , vol.235 , pp. 362-369
    • AKIYAMA, S.1
  • 24
    • 34249913942 scopus 로고    scopus 로고
    • Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine
    • STOICK-COOPER, C.L. 2007. Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes Dev. 21: 1292-1315.
    • (2007) Genes Dev , vol.21 , pp. 1292-1315
    • STOICK-COOPER, C.L.1
  • 25
    • 0032841147 scopus 로고    scopus 로고
    • Does adult fracture repair recapitulate embryonic skeletal formation?
    • FERGUSON, C. et al. 1999. Does adult fracture repair recapitulate embryonic skeletal formation? Mech. Dev. 87: 57-66.
    • (1999) Mech. Dev , vol.87 , pp. 57-66
    • FERGUSON, C.1
  • 26
    • 34249106502 scopus 로고    scopus 로고
    • Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    • ITO, M. et al. 2007. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature 47: 316-320.
    • (2007) Nature , vol.47 , pp. 316-320
    • ITO, M.1
  • 27
    • 34249029267 scopus 로고    scopus 로고
    • Regenerative biology: Newhair from healing wounds
    • CHUONG, C-M. 2007. Regenerative biology: newhair from healing wounds. Nature 447: 265-266.
    • (2007) Nature , vol.447 , pp. 265-266
    • CHUONG, C.-M.1
  • 28
    • 0036259278 scopus 로고    scopus 로고
    • Cyclooxyenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
    • ZHANG, X. et al. 2002. Cyclooxyenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J. Clin. Invest. 109: 1405-1415.
    • (2002) J. Clin. Invest , vol.109 , pp. 1405-1415
    • ZHANG, X.1
  • 29
    • 33846839273 scopus 로고    scopus 로고
    • Hematopoietic stem-cell contribution to ectopic skeletogenesis
    • KAPLAN, F.S. et al. 2007. Hematopoietic stem-cell contribution to ectopic skeletogenesis. J. Bone Joint Surg. Am. 89: 347-357.
    • (2007) J. Bone Joint Surg. Am , vol.89 , pp. 347-357
    • KAPLAN, F.S.1
  • 30
    • 33751506452 scopus 로고    scopus 로고
    • BMP2 activity, although dispensable for bone formation is required for the initiation of fracture healing
    • TSUJI, K. et al. 2006. BMP2 activity, although dispensable for bone formation is required for the initiation of fracture healing. Nat. Genet. 38: 1424-1429.
    • (2006) Nat. Genet , vol.38 , pp. 1424-1429
    • TSUJI, K.1
  • 31
    • 33846300352 scopus 로고    scopus 로고
    • Morpheus unbound: Reimagining the morphogen gradient
    • LANDER, A.D. 2007. Morpheus unbound: reimagining the morphogen gradient. Cell 128: 245-256.
    • (2007) Cell , vol.128 , pp. 245-256
    • LANDER, A.D.1
  • 32
    • 0027074882 scopus 로고
    • Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta1 mRNA expression
    • CUNNINGHAM, N.S. et al. 1992. Osteogenin and recombinant bone morphogenetic protein 2B are chemotactic for human monocytes and stimulate transforming growth factor beta1 mRNA expression. Proc. Natl. Acad. Sci. USA 89: 11740-11744.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 11740-11744
    • CUNNINGHAM, N.S.1
  • 33
    • 0017853759 scopus 로고
    • Elevated prostaglandin production in cultured cells from a patient with fibrodysplasia ossificans progressiva
    • MAXWELL, W.A. et al. 1978. Elevated prostaglandin production in cultured cells from a patient with fibrodysplasia ossificans progressiva. Prostaglandins 15: 123-129.
    • (1978) Prostaglandins , vol.15 , pp. 123-129
    • MAXWELL, W.A.1
  • 34
    • 25844469044 scopus 로고    scopus 로고
    • Immunological features of fibrodysplasia ossificans progressiva (FOP) and the dysregulated BMP4 pathway
    • KAPLAN, F.S. et al. 2005. Immunological features of fibrodysplasia ossificans progressiva (FOP) and the dysregulated BMP4 pathway. Clin. Rev. Bone Miner. Metab. 3: 189-193.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 189-193
    • KAPLAN, F.S.1
  • 35
    • 25844523629 scopus 로고    scopus 로고
    • Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva (FOP)
    • KITTERMAN, J.A. et al. 2005. Iatrogenic harm caused by diagnostic errors in fibrodysplasia ossificans progressiva (FOP). Pediatrics 116: 654-661.
    • (2005) Pediatrics , vol.116 , pp. 654-661
    • KITTERMAN, J.A.1
  • 36
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGF-β signals
    • MASSAGUÉ, J. 2000. How cells read TGF-β signals. Nat. Rev. Mol. Cell Biol. 1: 169-178.
    • (2000) Nat. Rev. Mol. Cell Biol , vol.1 , pp. 169-178
    • MASSAGUÉ, J.1
  • 37
    • 0034777917 scopus 로고    scopus 로고
    • BMP signaling pathways in cartilage and bone formation. Critical Rev
    • HOFFMAN, A. & G. GROSS. 2001. BMP signaling pathways in cartilage and bone formation. Critical Rev. Eukaryotic Gene Exp. 11: 23-45.
    • (2001) Eukaryotic Gene Exp , vol.11 , pp. 23-45
    • HOFFMAN, A.1    GROSS, G.2
  • 38
    • 0345377805 scopus 로고    scopus 로고
    • Controlling cell fate by bone morphogenetic protein receptors
    • TEN DIJKE, P. et al. 2003. Controlling cell fate by bone morphogenetic protein receptors. Mol. Cell Endocrinol. 211: 105-113.
    • (2003) Mol. Cell Endocrinol , vol.211 , pp. 105-113
    • TEN DIJKE, P.1
  • 39
    • 0042834336 scopus 로고    scopus 로고
    • BMP signaling components are expressed in human fracture callus
    • KLOEN, P. et al. 2003. BMP signaling components are expressed in human fracture callus. Bone 33: 362-371.
    • (2003) Bone , vol.33 , pp. 362-371
    • KLOEN, P.1
  • 40
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • CANALIS, E. et al. 2003. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocrine Rev. 24: 218-235.
    • (2003) Endocrine Rev , vol.24 , pp. 218-235
    • CANALIS, E.1
  • 41
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TFG-β signaling from cell membrane to the nucleus
    • SHI, Y. & J. MASSAGUÉ. 2003. Mechanisms of TFG-β signaling from cell membrane to the nucleus. Cell 113: 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • SHI, Y.1    MASSAGUÉ, J.2
  • 42
    • 27644494876 scopus 로고    scopus 로고
    • Smad transcription factors
    • MASSAGUÉ, J. et al. 2005. Smad transcription factors. Genes Dev. 19: 2783-2810.
    • (2005) Genes Dev , vol.19 , pp. 2783-2810
    • MASSAGUÉ, J.1
  • 43
    • 33750048167 scopus 로고    scopus 로고
    • Yin and yang in BMP signaling: Impact on the pathology of disease and potential for regeneration
    • HARTUNG, A. et al. 2006. Yin and yang in BMP signaling: impact on the pathology of disease and potential for regeneration. Signal Transduction 6: 314-328.
    • (2006) Signal Transduction , vol.6 , pp. 314-328
    • HARTUNG, A.1
  • 44
    • 0025307333 scopus 로고
    • Fibrodysplasia ossificans progressiva (FOP): A clue from the fly?
    • KAPLAN, F.S. et al. 1990. Fibrodysplasia ossificans progressiva (FOP): a clue from the fly? Calcif. Tiss. Int. 47: 117-125.
    • (1990) Calcif. Tiss. Int , vol.47 , pp. 117-125
    • KAPLAN, F.S.1
  • 45
    • 0029746491 scopus 로고    scopus 로고
    • Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva
    • SHAFRITZ, A.B. et al. 1996. Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva. N. Engl. J. Med. 335: 555-561.
    • (1996) N. Engl. J. Med , vol.335 , pp. 555-561
    • SHAFRITZ, A.B.1
  • 46
    • 0031059563 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva (FOP)
    • GANNON, F.H. et al. 1997. Bone morphogenetic protein 2/4 in early fibromatous lesions of fibrodysplasia ossificans progressiva (FOP). Hum. Pathol. 28: 339-343.
    • (1997) Hum. Pathol , vol.28 , pp. 339-343
    • GANNON, F.H.1
  • 47
    • 0038035670 scopus 로고    scopus 로고
    • Paresis of a bone morphogenetic protein - antagonist response in a genetic disorder of heterotopic skeletogenesis
    • AHN, J. et al. 2003. Paresis of a bone morphogenetic protein - antagonist response in a genetic disorder of heterotopic skeletogenesis. J. Bone Joint Surg. Am. 85: 667-674.
    • (2003) J. Bone Joint Surg. Am , vol.85 , pp. 667-674
    • AHN, J.1
  • 48
    • 20844450082 scopus 로고    scopus 로고
    • Fibrodysplasia ossificans progressiva (FOP): A disorder of ectopic osteogenesis misregulates cells surface expression and trafficking of BMPRIA
    • SERRANO DE LA PEÑA, L. et al. 2005. Fibrodysplasia ossificans progressiva (FOP): a disorder of ectopic osteogenesis misregulates cells surface expression and trafficking of BMPRIA. J. Bone Miner. Res. 20: 1168-1176.
    • (2005) J. Bone Miner. Res , vol.20 , pp. 1168-1176
    • SERRANO DE LA PEÑA, L.1
  • 49
    • 33646865518 scopus 로고    scopus 로고
    • Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva
    • FIORI, J.L. et al. 2006. Dysregulation of the BMP-p38 MAPK signaling pathway in cells from patients with fibrodysplasia ossificans progressiva. J. Bone Miner. Res. 21: 902-909.
    • (2006) J. Bone Miner. Res , vol.21 , pp. 902-909
    • FIORI, J.L.1
  • 50
    • 33744773190 scopus 로고    scopus 로고
    • Dysregulation of the BMP4 signaling pathway in fibrodysplasia ossificans progressiva
    • KAPLAN, F.S. et al. 2006. Dysregulation of the BMP4 signaling pathway in fibrodysplasia ossificans progressiva. Ann. N.Y. Acad. Sci. 1068: 54-65.
    • (2006) Ann. N.Y. Acad. Sci , vol.1068 , pp. 54-65
    • KAPLAN, F.S.1
  • 51
    • 37249016863 scopus 로고    scopus 로고
    • Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva
    • Submitted
    • BILLINGS, P.C. et al. 2008. Dysregulated BMP signaling and enhanced osteogenic differentiation of connective tissue progenitor cells from patients with fibrodysplasia ossificans progressiva. J. Bone Miner. Res. Submitted.
    • (2008) J. Bone Miner. Res
    • BILLINGS, P.C.1
  • 52
    • 33646348736 scopus 로고    scopus 로고
    • A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva
    • SHORE, E.M. et al. 2006. A recurrent mutation in the BMP type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva. Nat. Genet. 38: 525-527.
    • (2006) Nat. Genet , vol.38 , pp. 525-527
    • SHORE, E.M.1
  • 53
    • 0042978771 scopus 로고    scopus 로고
    • Alk2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development
    • ZHANG, D. et al. 2003. Alk2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J. Bone Miner. Res. 18: 1593-1604.
    • (2003) J. Bone Miner. Res , vol.18 , pp. 1593-1604
    • ZHANG, D.1
  • 54
    • 33749246730 scopus 로고    scopus 로고
    • Mutations of TFG-β signaling molecules in human disease
    • HARRADINE, K.A. & R.J. AKHURST. 2006. Mutations of TFG-β signaling molecules in human disease. Annals Med. 38: 403-414.
    • (2006) Annals Med , vol.38 , pp. 403-414
    • HARRADINE, K.A.1    AKHURST, R.J.2
  • 55
    • 34548457296 scopus 로고    scopus 로고
    • Functional modeling of the ACVR1 (R206H) mutation in FOP
    • In press
    • GROPPE, J.C. et al. 2007. Functional modeling of the ACVR1 (R206H) mutation in FOP. Clin. Orthop. Rel. Res. In press.
    • (2007) Clin. Orthop. Rel. Res
    • GROPPE, J.C.1
  • 56
    • 0030576525 scopus 로고    scopus 로고
    • The immunophilin FKBP12 functions as a common inhibitor of the TFG-β family type I receptors
    • WANG, T. et al. 1996. The immunophilin FKBP12 functions as a common inhibitor of the TFG-β family type I receptors. Cell 86: 435-444.
    • (1996) Cell , vol.86 , pp. 435-444
    • WANG, T.1
  • 57
    • 0030926004 scopus 로고    scopus 로고
    • Mechanism of TGF-β receptor inhibition by FKBP12
    • CHEN, Y.-G. et al. 1997. Mechanism of TGF-β receptor inhibition by FKBP12. EMBO J. 16: 3866-3876.
    • (1997) EMBO J , vol.16 , pp. 3866-3876
    • CHEN, Y.-G.1
  • 58
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type I TGF- receptor complex with FKBP12
    • HUSE, M. et al. 1999. Crystal structure of the cytoplasmic domain of the type I TGF- receptor complex with FKBP12. Cell 96: 425-436.
    • (1999) Cell , vol.96 , pp. 425-436
    • HUSE, M.1
  • 59
    • 0034796457 scopus 로고    scopus 로고
    • The TGF-β receptor activation process: An inhibitor-tosubstrate binding switch
    • HUSE, M. et al. 2001. The TGF-β receptor activation process: an inhibitor-tosubstrate binding switch. Mol. Cell 8: 671-682.
    • (2001) Mol. Cell , vol.8 , pp. 671-682
    • HUSE, M.1
  • 60
    • 0035918274 scopus 로고    scopus 로고
    • Smurf1 interacts with transforming growth factor-β type 1 receptor through Smad 7 and induces receptor degradation
    • EBISAWA, T. et al. 2001. Smurf1 interacts with transforming growth factor-β type 1 receptor through Smad 7 and induces receptor degradation. J. Biol. Chem. 276: 12477-12480.
    • (2001) J. Biol. Chem , vol.276 , pp. 12477-12480
    • EBISAWA, T.1
  • 61
    • 33745197796 scopus 로고    scopus 로고
    • FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor
    • YAMAGUCHI, T. et al. 2006. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J. Mol. Endocrinol. 36: 569-579.
    • (2006) J. Mol. Endocrinol , vol.36 , pp. 569-579
    • YAMAGUCHI, T.1
  • 62
    • 0032577276 scopus 로고    scopus 로고
    • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
    • BRUNET, L.J. et al. 1998. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science 280: 1455-1457.
    • (1998) Science , vol.280 , pp. 1455-1457
    • BRUNET, L.J.1
  • 63
    • 0037069653 scopus 로고    scopus 로고
    • Structural basis of BMP signaling inhibition by the cystine knot protein noggin
    • GROPPE, J. et al. 2002. Structural basis of BMP signaling inhibition by the cystine knot protein noggin. Nature 420: 636-642.
    • (2002) Nature , vol.420 , pp. 636-642
    • GROPPE, J.1
  • 64
    • 0029919109 scopus 로고    scopus 로고
    • Hereditary cancer: Two hits revisited
    • KNUDSON, A.G. 1996. Hereditary cancer: two hits revisited. J. Cancer Res. Clin. Oncol. 122: 135-140.
    • (1996) J. Cancer Res. Clin. Oncol , vol.122 , pp. 135-140
    • KNUDSON, A.G.1
  • 65
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • KNUDSON, A.G. 2001. Two genetic hits (more or less) to cancer. Nat. Rev. Cancer 1: 157-162.
    • (2001) Nat. Rev. Cancer , vol.1 , pp. 157-162
    • KNUDSON, A.G.1
  • 66
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • JONES, P.A. & S.B. BAYLIN. 2002. The fundamental role of epigenetic events in cancer. Nat. Rev. Cancer 3: 414-428.
    • (2002) Nat. Rev. Cancer , vol.3 , pp. 414-428
    • JONES, P.A.1    BAYLIN, S.B.2
  • 67
    • 1542515338 scopus 로고    scopus 로고
    • A census of human cancer genes
    • FUTREAL, P.A. et al. 2004. A census of human cancer genes. Nat. Rev. Cancer 4: 177-183.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 177-183
    • FUTREAL, P.A.1
  • 68
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • VOGELSTEIN, B. & K.W. KINZLER. 2004. Cancer genes and the pathways they control. Nat. Med. 10: 789-799.
    • (2004) Nat. Med , vol.10 , pp. 789-799
    • VOGELSTEIN, B.1    KINZLER, K.W.2
  • 69
    • 0033052269 scopus 로고    scopus 로고
    • Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis
    • GONG, Y. et al. 1999. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat. Genet. 21: 302-304.
    • (1999) Nat. Genet , vol.21 , pp. 302-304
    • GONG, Y.1
  • 70
    • 25844513102 scopus 로고    scopus 로고
    • Animal models of fibrodysplasia ossificans progressiva
    • KAPLAN, F.S. et al. 2005. Animal models of fibrodysplasia ossificans progressiva. Clin. Rev. Bone Miner. Metab. 3: 229-234.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 229-234
    • KAPLAN, F.S.1
  • 71
    • 0036088603 scopus 로고    scopus 로고
    • C2C12 myoblast/osteoblast transdifferentiation steps enhanced by epigenetic inhibition of BMP2 endocytosis
    • RAUCH, C. et al. 2002. C2C12 myoblast/osteoblast transdifferentiation steps enhanced by epigenetic inhibition of BMP2 endocytosis. Am. J. Physiol. Cell Physiol. 283: 235-243.
    • (2002) Am. J. Physiol. Cell Physiol , vol.283 , pp. 235-243
    • RAUCH, C.1
  • 72
    • 34249275353 scopus 로고    scopus 로고
    • Phenotypic plasticity and the epigenetics of human disease
    • FEINBERG, A.P. 2007. Phenotypic plasticity and the epigenetics of human disease. Nature 447: 433-440.
    • (2007) Nature , vol.447 , pp. 433-440
    • FEINBERG, A.P.1
  • 73
    • 33847000890 scopus 로고    scopus 로고
    • Genetics and epigenetics - nature's penand-pencil set
    • GOSDEN, R.G. & A.P. FEINBERG. 2007. Genetics and epigenetics - nature's penand-pencil set. N. Engl. J. Med. 356: 731-733.
    • (2007) N. Engl. J. Med , vol.356 , pp. 731-733
    • GOSDEN, R.G.1    FEINBERG, A.P.2
  • 74
    • 34249279527 scopus 로고    scopus 로고
    • Stability and flexibility of epigenetic gene regulation in mammalian development
    • REIK, W. 2007. Stability and flexibility of epigenetic gene regulation in mammalian development. Nature 447: 425-432.
    • (2007) Nature , vol.447 , pp. 425-432
    • REIK, W.1
  • 75
    • 33947509956 scopus 로고    scopus 로고
    • Hypoxic adipocytes pattern early heterotopic bone formation
    • OLMSTED-DAVIS, E. et al. 2007. Hypoxic adipocytes pattern early heterotopic bone formation. Am. J. Pathol. 170: 620-632.
    • (2007) Am. J. Pathol , vol.170 , pp. 620-632
    • OLMSTED-DAVIS, E.1
  • 76
    • 26244464704 scopus 로고    scopus 로고
    • Dexamethasone and recovery of contractile tension after a muscle injury
    • HAKIM, M. et al. 2005. Dexamethasone and recovery of contractile tension after a muscle injury. Clin. Orthop. Rel. Res. 439: 235-242.
    • (2005) Clin. Orthop. Rel. Res , vol.439 , pp. 235-242
    • HAKIM, M.1
  • 77
    • 17844371316 scopus 로고    scopus 로고
    • Muscle injuries: Biology and treatment
    • JÄRVINEN, T.A.H. et al. 2005. Muscle injuries: biology and treatment. Am. J. Sports Med. 33: 745-764.
    • (2005) Am. J. Sports Med , vol.33 , pp. 745-764
    • JÄRVINEN, T.A.H.1
  • 78
    • 33847350691 scopus 로고    scopus 로고
    • Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases
    • WYNN, T.A. 2007. Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J. Clin. Invest. 117: 524-529.
    • (2007) J. Clin. Invest , vol.117 , pp. 524-529
    • WYNN, T.A.1
  • 79
    • 33847263056 scopus 로고    scopus 로고
    • Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification
    • VANDEN BOSSCHE, L.C. et al. 2007. Free radical scavengers are more effective than indomethacin in the prevention of experimentally induced heterotopic ossification. J. Orthop. Res. 25: 267-272.
    • (2007) J. Orthop. Res , vol.25 , pp. 267-272
    • VANDEN BOSSCHE, L.C.1
  • 80
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1 alpha is essential for chondrocyte growth arrest and survival
    • SCHIPANI, E. et al. 2001. Hypoxia in cartilage: HIF-1 alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15: 2865-2876.
    • (2001) Genes Dev , vol.15 , pp. 2865-2876
    • SCHIPANI, E.1
  • 81
    • 0038325620 scopus 로고    scopus 로고
    • HIF-1-alpha controls extracellular matrix synthesis by epiphyseal chondrocytes
    • PFANDER, D. et al. 2003. HIF-1-alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J. Cell Sci. 116: 1819-1826.
    • (2003) J. Cell Sci , vol.116 , pp. 1819-1826
    • PFANDER, D.1
  • 82
    • 34248222569 scopus 로고    scopus 로고
    • Hif-1-alpha regulates differentiation of limb bud mesenchyme and joint development
    • PROVOT, S. et al. 2007. Hif-1-alpha regulates differentiation of limb bud mesenchyme and joint development. J. Cell Biol. 177: 451-464.
    • (2007) J. Cell Biol , vol.177 , pp. 451-464
    • PROVOT, S.1
  • 83
    • 34248223174 scopus 로고    scopus 로고
    • A new era for fibrodysplasia ossificans progressiva: A druggable target for the second skeleton
    • KAPLAN, F.S. et al. 2007. A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton. Exp. Opin. Biol. Ther. 7: 705-712.
    • (2007) Exp. Opin. Biol. Ther , vol.7 , pp. 705-712
    • KAPLAN, F.S.1
  • 84
    • 0035916929 scopus 로고    scopus 로고
    • Bone formation and inflammation in cardiac valves
    • MOHLER, E.R., III et al. 2001. Bone formation and inflammation in cardiac valves. Circulation 103: 1522-1528.
    • (2001) Circulation , vol.103 , pp. 1522-1528
    • MOHLER III, E.R.1
  • 85
    • 3042701421 scopus 로고    scopus 로고
    • Heterotopic ossification
    • KAPLAN, F.S. et al. 2004. Heterotopic ossification. J. Am. Acad. Orthop. Surg. 12: 116-125.
    • (2004) J. Am. Acad. Orthop. Surg , vol.12 , pp. 116-125
    • KAPLAN, F.S.1
  • 86
    • 25844492010 scopus 로고    scopus 로고
    • Nonhereditary heterotopic ossification: Implications for injury, arthropathy, and aging
    • PIGNOLO, R.J. & K.L. FOLEY. 2005. Nonhereditary heterotopic ossification: implications for injury, arthropathy, and aging. Clin. Rev. Bone Miner. Metab. 3: 261-266.
    • (2005) Clin. Rev. Bone Miner. Metab , vol.3 , pp. 261-266
    • PIGNOLO, R.J.1    FOLEY, K.L.2
  • 87
    • 33747806977 scopus 로고    scopus 로고
    • The genetics key to a rare disease and its impact on orthopedics
    • WOLF, J.M. 2006. The genetics key to a rare disease and its impact on orthopedics. Orthopedics 29: 672.
    • (2006) Orthopedics , vol.29 , pp. 672
    • WOLF, J.M.1
  • 88
    • 33847644415 scopus 로고    scopus 로고
    • Heterotopic ossification in the residual limbs of traumatic and combat-related amputees
    • POTTER, B.K. et al. 2006. Heterotopic ossification in the residual limbs of traumatic and combat-related amputees. J. Am. Acad. Orthop. Surg. 14: S191-S197.
    • (2006) J. Am. Acad. Orthop. Surg , vol.14
    • POTTER, B.K.1
  • 89
    • 37249088272 scopus 로고
    • Harvey. University of Pennsylvania Press. Philadelphia, PA
    • WILLIS, R. 1989. The Works of William Harvey. University of Pennsylvania Press. Philadelphia, PA.
    • (1989) The Works of William
    • WILLIS, R.1


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