Myelodysplastic syndrome with isolated deletion of chromosome 20q: An indolent disease with minimal morphological dysplasia and frequent thrombocytopenic presentation

British Journal of Haematology

Volumn 139, Issue 2, 2007, Pages 265-268

  Gupta, Raavi ^b   Soupir, Chad P ^a   Johari, Vandita ^c   Hasserjian, Robert P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b NewYork Presbyterian Hospital   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytogenetics; Histopathology; Idiopathic thrombocytopenic purpura; Myelodysplastic syndromes; Thrombocytopenia

Indexed keywords

ADULT; AGED; ANEMIA; ARTICLE; CHROMOSOME 20Q; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME ISOLATION; CONTROL GROUP; CONTROLLED STUDY; CYTOGENETICS; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; MORPHOLOGY; MYELODYSPLASIA; MYELODYSPLASTIC SYNDROME; PRIORITY JOURNAL; THROMBOCYTOPENIA;

AGED; AGED, 80 AND OVER; BASE SEQUENCE; CASE-CONTROL STUDIES; CYTOGENETICS; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; SEQUENCE DELETION; STATISTICS, NONPARAMETRIC; THROMBOCYTOPENIA;

EID: 34848904494     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06776.x     Document Type: Article

References (9)

1. Brunning, R.D., Bennett, J.M., Flandrin, G., Matutes, E., Head, D., Vardiman, J.W. Harris, N.L. (2001) Myelodysplastic syndromes. In : World Health Organization Classification of Tumours: Tumors of Haematopoietic and Lymphoid Tissues (ed. by E.S. Jaffe, N.L. Harris, H. Stein J.W. Vardiman pp. 61 73. IARC Press, Lyon.
2. George, J.N. (2004) Idiopathic thrombocytopenic purpura in adults: current issues for pathogenesis, diagnosis and management. The Hematology Journal, 5 (Suppl. 3 S12 S14.
3. George, J.N., Woolf, S.H., Raskob, G.E., Wasser, J.S., Aledort, L.M., Ballem, P.J., Blanchette, V.S., Bussel, J.B., Cines, D.B., Kelton, J.G., Lichtin, A.E., McMillan, R., Okerbloom, J.A., Regan, D.H. Warrier, I. (1996) Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood, 88, 3 40.
4. Greenberg, P., Cox, C., LeBeau, M.M., Fenaux, P., Morel, P., Sanz, G., Sanz, M., Vallespi, T., Hamblin, T., Oscier, D., Ohyashiki, K., Toyama, K., Aul, C., Mufti, G. Bennett, J. (1997) International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood, 89, 2079 2088.
5. Kurtin, P.J., Dewald, G.W., Shields, D.J. Hanson, C.A. (1996) Hematologic disorders associated with deletions of chromosome 20q: a clinicopathologic study of 107 patients. American Journal of Clinical Pathology, 106, 680 688.
6. Liu, Y.C., Ito, Y., Hsiao, H.H., Sashida, G., Kodama, A., Ohyashiki, J.H. Ohyashiki, K. (2006) Risk factor analysis in myelodysplastic syndrome patients with del(20q): prognosis revisited. Cancer Genetics and Cytogenetics, 171, 9 16.
7. Menke, D.M., Colon-Otero, G., Cockerill, K.J., Jenkins, R.B., Noel, P. Pierre, R.V. (1992) Refractory thrombocytopenia. A myelodysplastic syndrome that may mimic immune thrombocytopenic purpura. American Journal of Clinical Pathology, 98, 502 510.
8. Sashida, G., Takaku, T.I., Shoji, N., Nishimaki, J., Ito, Y., Miyazawa, K., Kimura, Y., Ohyashiki, J.H. Ohyashiki, K. (2003) Clinico-hematologic features of myelodysplastic syndrome presenting as isolated thrombocytopenia: an entity with a relatively favorable prognosis. Leukemia and Lymphoma, 44, 653 658.
9. Steensma, D.P., Dewald, G.W., Hodnefield, J.M., Tefferi, A. Hanson, C.A. (2003) Clonal cytogenetic abnormalities in bone marrow specimens without clear morphologic evidence of dysplasia: a form fruste of myelodysplasia Leukemia Research, 27, 235 242.