Kinetics of Hallmark biochemical changes in paclitaxel-induced apoptosis

AAPS PharmSci

Volumn 1, Issue 3, 1999, Pages 7-14

  Au, Jessie L S ^a,c   Wientjes, M Guill ^a   Kumar, Rajee R ^b   Li, Dong ^b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c NONE   (United States)

Author keywords

Anoikis; Apoptosis; Caspase activation; DNA fragmentation; Paclitaxel; PARP cleavage

Indexed keywords

EID: 33947098532     PISSN: 15221059     EISSN: None     Source Type: Journal    
DOI: 10.1208/ps010308     Document Type: Article

References (27)

1. Arbuck SG, Blaylock BA. Taxol: Clinical results and current issues in development. In: Suffness M, ed. Taxol: Science and Applications. Boca Raton, FL: CRC Press; 1995:379-415.
2. Sciff PB, Horwitz SB. Taxol stabilizes microtubules in mouse fibroblast cells. Proc Natl Acad Sci U S A. 1980;77:1561-1565.
3. Bhalla K, Ilerado AM, Tourkina E, Tang C, Mahoney ME, Huang Y. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells. Leukemia. 1993;7:563-568.
4. Kerr JFR, Wyllie AH, Curie AR. Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer. 1980;26:239-257.
5. Patel T, Gores GJ, Kaufmann SH. The role of proteases during apoptosis. FASEB J. 1996;10:587-597.
6. Arends MJ, Morris RG, Wyllie AH. Apoptosis: The role of endonucleases. Am J Pathol. 1990;136:593-608.
7. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (London). 1980;284:555-556.
8. Neamati N, Fernandez A, Wright S, Kiefer J, McConkey DJ. Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte neclei. J Immunol. 1995;154:3788-3795.
9. Lazebnik YA, Takahashi A, Moir RD, Goldman RD, Poirier GG, Kaufmann SH, Earnshaw WC. Studies of the lamin protease reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci U S A. 1995;92:9042-9046.
10. Voelkel-Johnson C, Entingh AJ, Wold WSM, Gooding LR, Laster SM. Activation of intracellular proteases is an early event in TNF-induced apoptosis. J Immunol. 1995;153:4247-4255.
11. Wen LP, Fahrni JA, Troie S, Guan JL, Orth K, Rosen GD. Cleavage of focal adhesion kinase by caspases during apoptosis. J Biol Chem. 1997;272:26056-26061.
12. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 1993;53:3976-3985.
13. Kothakota S, Azuma T, Reinhard C, Klippel A, Tang J, Chu K, McGarry TJ, Kirchner MW, Koths K, Kwiatkowski DJ, Williams LT. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis. Science. 1997;278:294-298.
14. Rudel T, Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science. 1997;276:1571-1574.
15. Liu X, Zou H, Slaughter C, Wang X. DFF, a heterodimeric protein that functions downstream of caspase 3 to trigger DNA fragmentation during apoptosis. Cell. 1997;89:175-184.
16. Collins JA, Schandl CA, Young KK, Vesely J, Willingham MC. Major DNA fragmentation is a late event in apoptosis. J Histol Cytometry. 1997;45:923-934.
17. Droin N, Dubrez L, Eymin B, Renvoize C, Breard J, Dimanche-Boitrel MT, Solary E. Upregulation of CASP genes in human tumor cells undergoing etoposide-induced apoptosis. Oncogene. 1998;16:2885-2894.
18. Benjamin CW, Hiebsch RR, Jones DA. Caspase activations in MF7 cells responding to etoposide treatment. Mol Pharmacol. 1998;53:446-450.
19. Marcelli M, Cunningham GR, Haidacher SJ, Padayatty SJ, Sturgis L, Kagan C, Denner L. Caspase 7 is activated during lovastatin-induced apoptosis of the prostate cancer cell line LNCaP. Cancer Res. 1998;58:76-83.
20. Ibrado AM, Huang Y, Fang G, Bhalla K. Bcl-xL overexpression inhibits taxol-induced Yama protease activity and apoptosis. Cell Growth Differ. 1996;7:1087-1094.
21. Au JL-S, Li D, Gan Y, Gao X, Johnson AL, Johnson J, Millenbaugh NJ, Jang SH, Kuh H-J, Chen C-T, Wientjes MG. Pharmacodynamics of immediate and delayed effects of paclitaxel: role of slow apoptosis and intracellular drug retention. Cancer Res. 1998;58:2141-2148.
22. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (London). 1994;371:346-347.
23. Cohen GM. Caspases: The executioners of apoptosis. Biochem J. 1997;326:1-16.
24. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol. 1992;119:493-501.
25. Moos PJ, Fitzpatrick FA. Taxanes propagate apoptosis via two cell populations with distinctive cytological and molecular traits. Cell Growth Differ. 1998;9:687-697.
26. Frisch SM, Francis H. Disruption of epithelial cell-matrix interaction induces apoptosis. J Cell Biol. 1994;124:619-626.
27. Frisch SM, Vuori K, Kelaita D, Sicks S. A role for Jun-N-terminal kinase in anoikis: suppression by Bcl-2 and crmA. J Cell Biol. 1996;135:1377-1382.